5,440 projects

Date from new to old

MILPAAHEL-Miljøpåvirkning og helse

Dioxin-like Organohalogen Carcinogenesis

Dioxin-like organohalogens include polychlorinated dibenzodioxins, dibenzofurans and 11 planar bifenyls (PCB). In addition, brominated flame retardants (PCDE) may share many of their characteristics. They are persistent environmental pollutants which acc umulate in food chains. Human exposure oc...

Awarded: NOK 2.3 mill.

Project Period: 2007-2012

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

The roles of microRNAs and transcription factors in gene regulation and tissue specific expression

MicroRNAs (miRNAs) were identified as a large group of regulatory genes in 2001, and increasing research has revealed these genes to be important in development, including differentiation, proliferation, and apoptosis. Many miRNAs seem to have tissue-spec ific expression patterns, which suggest t...

Awarded: NOK 7.0 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Regulation of Nuclear Receptor Function by Posttranslational Modifications

Nuclear receptors (NRs), together with coregulatory proteins, coordinate the transcription of gene networks in response to ligand binding and cellular signaling in such diverse biological programs as reproduction, development, nutritent uptake, metabolism and excretion. PMTs have proven to be es...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Understanding brain systems by cell type-specific changes in gene expression

Despite impressive advances in almost every field of neuroscience, our understanding of brain function remains largely confined to its building blocks at the microscopic level, and to phenomenological descriptions at the macroscopic level. The introductio n of transgenic mice has provided neurosc...

Awarded: NOK 10.0 mill.

Project Period: 2007-2010

Location: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

Understanding the System of Neurotransporters

The proposed project is a system-biology approach to transport across brain plasma membranes focusing on neurotransmitter inactivation and water transport. The primary aim is to prepare the ground for a large scale approach to understand what all the hund reds of transporter and ion channels do t...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Contextual Regulation of Cell Proliferation & Differentiation in Angiogenesis: Integrated Functional Genomic Discovery &Validation Approach

Angiogenesis, the formation of new blood vessels from extant vasculature, is a fundamental homeostatic process and a key factor in the progression of many pathological conditions. Angiogenesis is defined by the growth and differentiation of endothelial ce lls. We conceptualize angiogenesis as a c...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

O-LINKED PROTEIN GLYCOSYLATION IN BACTERIA

Protein glycosylation is a pivotal element of biological systems not only because it is one of the major post-translational modifications but also because it has significant effects on protein properties and functions. We have recently discovered, and par tially characterized, the first general O...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

FOLKEHELSE-Folkehelse

Physical activity and chronic pain in HUNT 3 - A prospective cohort study

Regular physical activity promotes health. An inactive lifestyle may alter gene expression, influence negatively on several organ systems and thereby cause chronic disease and increase mortality. These conditions may be reversed by regular activity and in creased level of physical fitness. Physic...

Awarded: NOK 5.0 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

SFF-Sentre for fremragende forskning

Centre for Cancer Biomedicine, CCB

The founding idea of CCB was to join cell biological research aimed at discovering new mechanisms in carcinogenesis and tumour suppression with translational cancer research aimed at discovering novel molecular and phenotypic hallmarks of cancers that can be exploited in diagnostics, prognostics ...

Awarded: NOK 120.6 mill.

Project Period: 2007-2018

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Alkaline shock and excitotoxicity in epilepsy: RNAi in vivo - tools for investigation and prospects for therapy

Epilepsy is one of the most common forms of brain disorders, affecting about 1 % of the population. Alkaline shock, the rise of intracellular pH, is one of the few basic explanations of seizures that are now gaining a clear mechanistic description. Very r ecently a direct link between seizures, C...

Awarded: NOK 6.0 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

FOLKEHELSE-Folkehelse

Working Hours Arrangements and Physical Activity among Primary Health-Care Workers

The main barrier to exercise is lack of time or perceived lack of time. Few occupational groups experience higher health risks (whether to somatic or mental health) than health-care workers, as measured by levels of sick-leave and disability pensioning. D ifferent working-hours arrangements and a...

Awarded: NOK 2.0 mill.

Project Period: 2007-2009

Location: Trøndelag - Trööndelage

PSYKISK-Psykisk helse

Folate and fatty acids in early life and neurodevelopmental disorders: developmental language delay as an early marker

We intend to study the relationship between intake of folate and fatty acids during early life and the risk of neurodevelopmental disorders (ND) such as autism and attention deficit/ hyperactivity disorder (ADHD). Having language problems at the age of three is a strong predictor for neurodevel...

Awarded: NOK 5.2 mill.

Project Period: 2007-2013

Location: Oslo - Oslove

TJENESTER-Helse- og omsorgstjenester

Multiple drug therapy and coordination of drug prescription for the elderly

From the literature we know that the use of drugs in general and the occurrence of polypharmacy (usually defined as concomitant use of five or more drugs) in particular, has increased dramatically among elderly in the population. Often hospitals, private practising specialists and general practit...

Awarded: NOK 2.1 mill.

Project Period: 2007-2011

Location: Akershus

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Senter for rus- og avhengighetsforskning - SERAF

The funding from the RCN makes it possible for SERAF to conduct clinical drug research at a high international level. Our research has contributed to a better, more evidence-based treatment of substance use disorders, and has achieved important results. We maintain a strong focus on our tradition...

Awarded: NOK 100.9 mill.

Project Period: 2007-2020

Location: Oslo - Oslove

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Brain and brain cell injury in newborn infants

The main objective of the proposed project is to investigate basic mechanisms for regulation of brain injury and brain cell death in newborn infants. Specifically, we propose to study these mechanisms as they relate to two common causes of brain damage in the newborn period, namely asphyxia (hyp...

Awarded: NOK 2.5 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Imaging of memory circuitry to evaluate memory loss in Alzheimer's disease models

Memory loss is among the first signs of Alzheimer's disease, and it progresses to encompass all aspects of a person's past and present life experiences. The severity of Alzheimer's disease and its increasing incidence with changing demographics require a tremendous effort in finding treatments. P...

Awarded: NOK 1.00 mill.

Project Period: 2007-2009

Location: Trøndelag - Trööndelage

NEVRONOR-Nasjonal satsing på nevrovitenskap f

DELAYED SLEEP PHASE SYNDROME. PREVALENCE, DEVELOPMENTAL HISTORY, PERSONALITY AND TREATMENT

Delayed sleep phase syndrome (DSPS) is a circadian rhythm sleep disorder assumed to peak in adolescence and young adulthood. It is characterized by a delay in the sleep wake-rhythm which causes prolonged sleep onset latency and problems getting up in the morning. The disorder often has negative i...

Awarded: NOK 2.0 mill.

Project Period: 2007-2012

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

The Interactomics of DNA Repair

The single most important factor for the correct functioning of genomes is that their coding information is maintained intact and transferred unperturbed to future generations. DNA repair is highly coordinated- and integrated with other fundamental cellul ar processes such as transcription, repli...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Epigenetic surveying in immune-mediated diseases. A twin study.

Background: Genetically complex diseases, e.g. immune-mediated diseases are caused by a complex interplay between susceptibility genes and environment. The impact of environmental factors is clearly demonstrated in twin studies showing concordance rates i n MZ twins well below 100%. One impact of...

Awarded: NOK 8.0 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

FRIMED-Klinisk medisin og folkehelse

Mitochondrial disease: generating models, investigating mechanisms and exploring treatments.

The project will establish laboratory models to study two types of mitochondrial disease, one primary mtDNA mutation in MTND5 and one secondary mtDNA disease caused by mutations in the mitochondrial DNA polymerase (POLG). Transgenic mouse models for the P OLG mutations, A467T & W748S, and cell cu...

Awarded: NOK 4.7 mill.

Project Period: 2007-2010

Location: Ukjent Fylke

KLINISK-Klinisk forskning

Functioning disturbance in chronic back pain: Altered muscle activation pattern, muscle metabolism and pain-cognitions.

There is evidence that individuals with chronic non-specific back pain (CNSBP) show altered muscle activation patterns. It is unknown why these alterations in activation pattern occur, which consequences this may have for muscle metabolism and how they ar e linked to pain experience and developme...

Awarded: NOK 2.0 mill.

Project Period: 2007-2015

Location: Vestfold

PSYKISK-Psykisk helse

EARLY BIPOLAR DISORDER: CLINICAL AND BIOLOGICAL CHARACTERISTICS IN FIRST EPISODE MANIA

Bipolar disorder (BPD) is a severe psychiatric disorder characterized by manic and depressive episodes with periods of normal mood in between. Recent lines of evidence suggest that BPD is a more severe illness that previously believed and it is regarded as one of the most important factors contr...

Awarded: NOK 4.7 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

KLINISK-Klinisk forskning

Patient education in patients with chronic obstructive pulmonary disease (COPD) and rheumatic disease: effect, experiences and costs

This is (hopefully) an improved version of an earlier application to NFR that was reviewed as both "a high quality research program" and "poorly written and non-competitive". The comments from the reviewers have been used to revise the project. Patient e ducation has become a task that is dictat...

Awarded: NOK 3.9 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

PSYKISK-Psykisk helse

Anxiety disorders in children- association with neurodevelopmental delay/disorder and temperament/personality. A clinical case-control study

Anxiety disorders (AD's) in childhood are common and may cause great suffering.Childhood AD's may persist into adulthood and knowledge of important risk factors for development and maintenance of these disorders is essential.The development of AD's is due to a complex interaction between biologi...

Awarded: NOK 5.4 mill.

Project Period: 2007-2010

Location: Oslo - Oslove

VERDIKT-Kjernekomp.og verdiskaping IKT

Ressursnettverk Trådløs pasient

Partnerne, representert ved Oslo Teknopol, ønsker å etablere Trådløs pasient initiativet som et ressursnettverk i VERDIKT-programmet. Øvrige partnere er Norsk senter for telemedisin, Universitetet i Tromsø, Intervensjonssenteret Rikshospitalet, SINTEF IKT Universitetet i Oslo og Høgskolen i Østf...

Awarded: NOK 2.4 mill.

Project Period: 2007-2010

Location: Oslo - Oslove

PENGESPILL-Kunnsk.gr.lag pengespill-probl

Contextualising adolescents' egaming

Adolescents' consumption and problems related to playing and gambling on electronic devices like tv, pc and the internet, here labelled egaming, are increasing. By using qualitative techniques, the proposed project aims to contextualise adolescents' egami ng and egaming problems. As such the proj...

Awarded: NOK 2.9 mill.

Project Period: 2007-2010

Location: Oslo - Oslove

SHP-Strategiske høgskoleprogram

Syn og aldring. Normale aldersendringer i menneskets netthinne: Studier av struktur-funksjonsforholdet i synsapparatet.

Det er forventet en betydelig økning av eldre i samfunnet. Dette krever ytterligere kunnskap om normale aldersendringer i øyet og synsfunksjonen. Svekkelse eller tap av synsfunksjonen er et problem for menneskene som rammes og deres livskvalitet, og samfu nnet forøvrig. Prosjektet inkluderer stu...

Awarded: NOK 6.0 mill.

Project Period: 2007-2012

Location: Buskerud

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Attention deficit /hyperactivity disorder (ADHD): Risk factors, comorbidity and gene-environment interactions.

Attention deficit hyperactivity disorder (hyperkinetic disturbance; ADHD) is a common condition in school age children (world-wide prevalence estimates 3-7 %). In addition most affected individuals will continue to show symptoms as adults. Still, it has l ong been considered a controversial diagn...

Awarded: NOK 3.0 mill.

Project Period: 2007-2011

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Statistical modelling for infectious disease

We want to build a viable research group in statistical and mathematical modelling of infectious disease. We wish to make important original contributions to statistical methodology for analysis on infectious disease data, for the further purpose of aidin g, monitoring and understanding the sprea...

Awarded: NOK 2.8 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Imaging and structural biology of molecular targets for psychotropic drugs

The research group has wide experience in using molecular graphics and other methods to study the molecular mechanisms of CNS active drugs. This application focuses on drugs acting on specific targets in brain, the serotonergic systems. The application wi ll enable further development and strengt...

Awarded: NOK 2.0 mill.

Project Period: 2007-2012

Location: Troms - Romsa - Tromssa

1 166 167 168 169 170 182