117 projects

Date from new to old

HELSEFORSKNING-Helseforskning

Principles of choroid plexus-mediated brain-body interactions in the context of systemic and peripheral pathologies

Peripheral injuries have an impact on brain function. For instance, chronic pain (e.g., due to joints inflammation) can lead to depression, anxiety and cognitive deficits, thereby reducing the life quality of patients. To date, the sequence of events that link the initial injury to dysfunction in...

Awarded: NOK 3.4 mill.

Project Period: 2025-2028

Location: Trøndelag - Trööndelage

PESORDNING-PESORDNING

Etablere full prosjektsøknad i Eurostars 3.

Prosjektet skal lede frem til en ferdig utarbeidet søknad for Eurostars 3. Dette skal gjennomføres i samarbeid med prosjektpartnerne Nord universitet og MariHealth Solutions (Sør-Afrika) i form av felles workshops og fordeling av arbeidsoppgaver i full søknad.

Awarded: NOK 99,999

Project Period: 2025-2025

Location: Nordland - Nordlánnda

INNO-NAERING-INNO-NAERING

E!55:BabySensor-Pre: An innovative contactless health monitor to protect premature babies and reassure new parents

Innovative Technology for Vulnerable Infants: The PreCare-Eurostar Project In a world where preterm births have increased by 36% since the 1980s and 1 in 10 babies in Europe are now born prematurely, the need for innovative solutions in health monitoring has never been more pressing. Preterm inf...

Awarded: NOK 5.5 mill.

Project Period: 2022-2025

Location: Vestfold

LANDBASERT-LANDBASERT

HESTEFORSK Optimize canagliflozin doses - decrease hyperinsulinemia and prevent laminitis H-21-47-641

Equine metabolic syndrome (EMS) is a collective term used to describe risk factors for development of endocrine laminitis in horses. Laminitis is a frequently occurring, and very painful condition of the horses feet; of which only palliative treatment is available. The fatality of laminitis is hi...

Awarded: NOK 1.4 mill.

Project Period: 2022-2025

Location: Akershus

FORNY20-FORNY2020

KVAL: Artificial liver organoids

The innovative method is suitable for large-scale production of vascularized liver organoids comprising differentiated hepatocytes. Furthermore, the method is suitable for upscaling and can be performed based on supplementing culture media with small molecules only. The products may serve as an ...

Awarded: NOK 0.33 mill.

Project Period: 2021-2023

Location: Oslo

HAVBASERT-HAVBASERT

NordForsk - Intelligent farming and health control in landbased recirculating aquaculture systems

The overall aim of IntelliRAS was to investigate what it would require for Precision Fish Farming (PFF) to be applied in RAS farming. In the project, we have evaluated how variables important for production are measured and controlled in RAS. We have used the theory behind the concept PFF as an o...

Awarded: NOK 2.6 mill.

Project Period: 2021-2025

Location: Akershus

LANDBASERT-LANDBASERT

HESTEFORSK: "Objektiv måling av øvre luftvegs obstruksjon i Norsk og Svenske travhester" H-19-47-472

Upper respiratory tract (URT) obstruction (collapse) during exercise is one of the most common causes of poor performance in sporting horses worldwide. Evaluation of laryngeal/ pharyngeal collapse during exercise in horses and humans is currently graded subjectively by visual evaluation of videoe...

Awarded: NOK 1.6 mill.

Project Period: 2020-2025

Location: Akershus

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Building cardiomyocytes at the nanoscale

The contraction of the heart is dependent on the contraction of single muscle cardiac cells, which in turn is dependent on cellular structure called t-tubules and building blocks called dyads. Dyads are assembled gradually in the developing heart to meet its increasing workload as babies grow. Ho...

Awarded: NOK 3.4 mill.

Project Period: 2019-2023

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Evolution of umami taste receptor (T1R1-T1R3) system in vertebrates and its role in gut-brain axis communication

The ability to taste umami and sweetness depends on receptors that can detect the taste molecules, so-called taste receptors type 1 (T1R). In mammals, the umami taste receptor (T1R1-T1R3) is involved in sensing amino acids, while the sweet taste receptor (T1R2-T1R3) is involved in sensing carbohy...

Awarded: NOK 3.1 mill.

Project Period: 2017-2021

Location: Vestland

JPND-EU Joint Programme - Neurodegenerative Disease Research

The PrPC / PDK1 / TACE signaling axis at the cross-road of several aggregate-prone protein-associated neurodegenerative diseases

The project will investigate whether there are common underlying mechanisms that can cause neurodegenerative brain diseases, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, spinocerebellar ataxia and frontotemporal dementia. These diseases are all featured in that...

Awarded: NOK 2.0 mill.

Project Period: 2016-2019

Location: Oslo

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

Mechanisms for a Novel Muscle Memory

It is part of training studio folklore that if you have once been strong you can easily get strong again, even if you have neglected exercise for a long time. Previously this has been attributed to motor learning and technical skills. We have however provided a proof-of principle for a cellular m...

Awarded: NOK 9.0 mill.

Project Period: 2015-2020

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Investigating the role of Gonadotropin-releasing hormone(GnRH) and Neuropeptide Y(NPY) in modulation of brain circuits and animal behavior

Neuromodulators constantly modulate sensory representations in our brains depending on our internal states such as hunger or reproductive sates. In this project, we are investigating the function of a specific group of peptidergic neuromodulators namely Gonadotropin-releasing hormone (GnRH) and N...

Awarded: NOK 7.0 mill.

Project Period: 2015-2020

Location: Trøndelag - Trööndelage

FRIPRO-Fri prosjektstøtte

Encoding of non-spatial information in the hippocampus

The expression of fear in appropriate situations is critical for survival, and the ventral hippocampus has been identified as necessary for context-dependent fear responses. However, the specific contribution of this region is still unclear. In order to evaluate whether ventral hippocampus contr...

Awarded: NOK 3.9 mill.

Project Period: 2014-2024

Location: Troms - Romsa - Tromssa

VAM-Velferd, arbeidsliv og migrasjon

Health effects of different shift work arrangements in the petroleum- and health care sector

More and more employees work beyond what has been normal working hours. In the health care and petroleum sector different working arrangements are widespread, which has both positive and negative consequences. We know from previous research that shift and night work leads to a higher risk of slee...

Awarded: NOK 7.8 mill.

Project Period: 2014-2020

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Laminar segregation of top down and bottom up processes in primary auditory cortex.

Brains are fundamentally adapted to gathering information from the external world, and making sense of it. Some information coming through the senses occurs more frequently in conjunction with particular events or outcomes, making it useful for generating predictions. Predictions can be useful to...

Awarded: NOK 3.3 mill.

Project Period: 2014-2018

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Dissecting the role of a major class of inhibitory neurons in spatial memory

The healthy brain operates through a fine balance of excitation and inhibition. However, the functional roles of the large diversity of inhibitory neurons remain an enigma. In this project we have been studying how a major class of inhibitory neurons, the parvalbumin positive (PV) interneurons co...

Awarded: NOK 3.7 mill.

Project Period: 2014-2020

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The role of disinhibition in sensory processing

The brain is composed of billions of neurons that make trillions of synaptic connections. So how can we come to understand such a complicated organ? One way to deal with this complexity, is to study small components of the brain. Just like a computer, the brain is built of basic circuit componen...

Awarded: NOK 7.0 mill.

Project Period: 2014-2019

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Polygenetics of attention and effort: Uncovering brain circuit pathologies in schizophrenia

Schizophrenia is a severe mental disorder with high morbidity, large impact on patients and their families, and huge costs for society and the health care sector globally. Despite progress in genetic, brain imaging, and cognitive research, the biological deficiencies underlying schizophrenia are ...

Awarded: NOK 3.5 mill.

Project Period: 2014-2019

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

A hierarchy of oscillators? Interaction between temperature regulation, respiratory sinus arrhythmia and blood pressure variability

The project investigated two important parts of the cardiovascular control mechanisms; 1) Cerebral blood flow in interaction with circulation and respiration, and 2) The role of temperature regulation in human cardiovascular control. 1) Could the optimal interplay between breathing and heart be...

Awarded: NOK 3.5 mill.

Project Period: 2014-2020

Location: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Network organization of the entorhinal space system

Recent advances in our understanding of spatial coding in the entorhinal cortex and hippocampus have made this network a powerful model system for neural computation in high-end cortices. With our discovery of grid cells as the brain´s metric for space in 2005, spatial navigation became one of th...

Awarded: NOK 5.0 mill.

Project Period: 2014-2018

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The role of binding proteins in compartmentation of cAMP and cGMP signalling in normal and failing hearts

The prevalence of severe heart disease in the population is increasing and we are in need for better therapy. Heart attack or increased blood pressure over a long period of time could cause heart failure. Heart failure is characterized by reduction in the hearts ability to pump blood properly. Th...

Awarded: NOK 3.5 mill.

Project Period: 2013-2017

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

ERC-Witter-The entorhinal connectome: a way to read the cortex

One important challenge of modern neuroscience is to causally relate the complex architecture of cortical networks to functional outcomes of cortical processing. Experimentally based rules on why and to what extent architecture causes function, with time, will i) be necessary to efficiently imple...

Awarded: NOK 13.7 mill.

Project Period: 2013-2018

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Role of the extracellular microenvironment and lymphatics in electrolyte and blood pressure regulation

Hypertension (high blood pressure) has been identified by the World Health Organization as the most important global health challenge. We investigate a new mechanism in blood pressure regulation, namely that the microenvironment of the fluid bathing the cells in skin and lymphatics draining fluid...

Awarded: NOK 8.6 mill.

Project Period: 2013-2017

Location: Vestland

KISN-Kavli Institute for Systems Neuroscience

Kavli Institute for Systems Neuroscience - strategisk institusjonsstøtte

Awarded: NOK 25.0 mill.

Project Period: 2013-2014

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Functional modularity in entorhinal grid cells

The aim of this project was to determine the organization of high-end cerebral cortices in mammals. During the past decades, neuroscientists have made great advances in the understanding of isolated parts of the cortex, such as in the visual cortex, and we are beginning to appreciate how sensory ...

Awarded: NOK 9.0 mill.

Project Period: 2013-2016

Location: Trøndelag - Trööndelage

SFF-Sentre for fremragende forskning

Centre for Neural Computation (CNC)

The vision of CNC is to understand the neural basis of high-level computation in cortical systems of the brain. For 2022, we wish to emphasize the following discoveries and developments: The Moser group has introduced and developed methods for high-resolution neural population recordings. With th...

Awarded: NOK 175.0 mill.

Project Period: 2013-2023

Location: Trøndelag - Trööndelage

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

Experience-induced synaptic plasticity and network activity in visual cortex

We have investigated how sensory information is processed and encoded into memories in the brain. There exists different kinds of learning involving different brain areas. Common for all is that learning induce lasting structural and functional changes in the contacts between neurons. In the proj...

Awarded: NOK 8.8 mill.

Project Period: 2012-2020

Location: Oslo

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

Neural processing and plasticity in cortical circuits of behaving animals

How can the brain be stable enough for memories to be stored and intact for decades but at the same time be plastic enough for us to learn throughout life? This seemingly paradox is one of the unresolved long-standing questions in neuroscience. One of the most well established models for studying...

Awarded: NOK 8.7 mill.

Project Period: 2011-2019

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

A spiking network model of neural pattern separation in the hippocampus

Can you remember your last birthday? -Then chances are you also remember where you were that day. Recent advances at the Center for the Biology of Memory (CBM) in Trondheim, Norway, have shed new light on why this is: a dedicated brain network continually keeps track of where we are -like a neur...

Awarded: NOK 1.6 mill.

Project Period: 2011-2014

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Biophysical properties underlying the representation of space in entorhinal cortex

In 2004-2005, behavioral unit recordings of rats exploring large open fields demonstrated that medial entorhinal cortex (mEC) 'grid cells' fire in spatially specific locations which repeat at regular intervals and form a hexagonal shape of firing activity and potentially provide the basic buildi...

Awarded: NOK 1.6 mill.

Project Period: 2011-2014

Location: Trøndelag - Trööndelage

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