0 projects

FRIBIO-Biologi og biomedisin

Structural characterization of neural network alterations in transgenic rat model of Huntington's disease

Huntingtons disease (HD) is an untreatable inherited neurodegenerative disease causing motor and cognitive dysfunction and premature death, due to loss of specific neurons in the basal ganglia. Having access to the first transgenic rat model of HD, the pr esent project seeks to conduct the first ...

Awarded: NOK 2.5 mill.

Project Period: 2007-2010

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Role of stromal cells in normal and pathological tissue homeostasis

The focus of this application is to study how the extracellular matrix can influence transcapillary transport of water and protein. The aim of this specific project is to develop an in vitro model system of loose connective tissue which can work in close parallel to our in vivo experiments. The u...

Awarded: NOK 2.3 mill.

Project Period: 2007-2010

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Olfactory pathways connecting defined glomeruli of the macroglomerular complex to higher integration centres in the heliothine moth brain

The olfactory coding mechanism responsible for reproductive behaviour have been thoroughly investigated in heliothine moths. This sub-family is particularly fascinating since the individuals communicate both within and across the species. Thus, the males possess receptor neurons detecting pheromo...

Awarded: NOK 2.4 mill.

Project Period: 2007-2010

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Oil induced autoimmune arthritis

We here present evidence that a novel class of genes encoding regulatory leukocytereceptors may be of clinical importance in autoimmune diseases elicited by environmental exposure to immunoadjuvants, in particular mineral oils. The evidence is based on th e structural identification of the rat Oi...

Awarded: NOK 3.4 mill.

Project Period: 2007-2010

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Astrocytes - guardians of neuroprotection

Astrocytes are the most abundant cell type in the human cerebral cortex but the focus on these cell types have been far neglected. In the later years it has become apparent that they play important roles in the homeostasis of the brain and evidence now al so suggests that they are essential compo...

Awarded: NOK 2.2 mill.

Project Period: 2007-2010

Location: Ukjent Fylke

BIOFYS-Fysiologiske og anatomiske fag

Scandinavian Physiological Society's Congress 2007

The Scandinavian Physiological Society will hold its Congress for 2007 in Oslo from the 10th to the 12th of August. Here we apply for financial support to arrange this Congress.

Awarded: NOK 0.20 mill.

Project Period: 2007-2008

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Dynamics of synaptic transmission in the rod pathway of the retina

A considerable challenge in neuroscientific research is to explain processes at the systems level in terms of mechanisms at cellular and molecular levels. The retina serves as an ideal model system amenable to experimental approaches that directly aim to bridge this gap. With respect to the senso...

Awarded: NOK 3.0 mill.

Project Period: 2007-2010

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Functions of hippocampus and entorhinal cortex studied with viral vectors

Modern brain imaging methods have contributed enormously to contemporary knowledge about the particular brain systems involved in specific cognitive functions. Unfortunately, mechanistic insights have lagged behind, largely because brain mapping in humans lacks the spatial resolution required to...

Awarded: NOK 1.5 mill.

Project Period: 2007-2009

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Entorhinal grid cells and hippocampal memory

More than 30 years of research have pointed to the hippocampus as a key component of the brain's circuit for spatial representation. Although place-specific firing is undoubtedly the most conspicuous behavioural correlate of hippocampal principal neurons, hippocampal neurons also respond to a va...

Awarded: NOK 4.3 mill.

Project Period: 2007-2009

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Metabolic scaling in teleosts

Metabolic scaling is a widely recognised problem in biology. The underlying causes for the disproportionate relationship between the metabolic rate of an organism and its body size have long puzzled scientists, and continue to be controversial. In recent years this fascinating subject has been tr...

Awarded: NOK 3.1 mill.

Project Period: 2007-2010

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

New therapeutic principles and biological mechanisms related to brain tumour cell invasion and angiogenesis

Primary gliomas represent one of the greatest challenges in neuro-oncology. Recent studies have identified so-called ?cancer stem cells? in several cancers. These cells have the capacity to proliferate and establish tumors in laboratory animals after inje ction of only a small number of cells. Mo...

Awarded: NOK 1.5 mill.

Project Period: 2007-2009

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

The role of normal neighbouring keratinocytes and fibroblasts on clonal expansion of oral cancer (stem) cells

Recent studies, including ours, have shown that the invasive behaviour of cancer cells is not solely due to mechanisms intrinsic to the individual tumour cell. Genetic changes of individual cells in a specific tissue are not sufficient for invasive cancer to develop. Rather, there is a vivid cro...

Awarded: NOK 1.1 mill.

Project Period: 2007-2009

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Electrical signaling in thin dendrites and axons in the cortex

A major challenge in neuroscience is to understand the mechanisms of neuronal computation, much of which is carried out by electrical signals generated by ion channels in the cell membrane. Within the last decade, advances in patch-clamp and imaging techn iques have extended our knowledge of such...

Awarded: NOK 2.5 mill.

Project Period: 2007-2011

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

The role of excitatory amino acid in Parkinson's disease

Parkinson's disease is characterised by death of dopamine containing neurons in the substantia nigra. Long term levo-dopa treatment has severe side effects and is potentially toxic for neurons. The need for alternative treatments in Parkinson's disease is urgent. To accomplish this, further rese...

Awarded: NOK 2.3 mill.

Project Period: 2007-2010

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular and cellular mechanisms of the hippocampal memory system studied by in vivo recording in behaving animals

A major challenge in neuroscience is to explain behaviour in terms of molecular, cellular and neuronal network mechanisms. We will study mechanisms of the medial temporal lobe memory system by in vivo recording of hippocampal single unit and neuronal netw ork activity (EEG) in freely mowing rats ...

Awarded: NOK 2.3 mill.

Project Period: 2007-2013

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

The properties of thin, unmyelinated axons in mammalian brain

In order to better understand and control how neurons work we need more knowledge about thin, unmyelinated axons because: * They are the most common, but yet the least studied axonal type in the mammalian cortex. * They are the most excitable part of the neuron and are, therefore, very important ...

Awarded: NOK 2.2 mill.

Project Period: 2006-2010

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Surviving without oxygen - from heart function to DNA replication

While most vertebrates die within minutes of anoxia (no oxygen), a few species can tolerate anoxia about 1000 times longer. These include the crucian carp (Carassius carassius, No: karuss), a common fish in Norway, and some turtles. Anoxia and ischemia related diseases are the major killers in ...

Awarded: NOK 3.0 mill.

Project Period: 2006-2010

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

NEURONES FORMING FUNCTIONAL NETWORKS IN THE MOTH BRAIN

We are searching to uncover the neuronal network involved in chemosensory coding and appetitive learning in insects, using moths of the subfamily Heliothinae as model organisms. The focus in the present project is to characterise physiologically and morph ologically neurones in the primary and th...

Awarded: NOK 2.4 mill.

Project Period: 2006-2009

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Molecular Pathogenetic Mechanisms of Heart Failure - Dissecting GRK Function in The Heart

Heart failure, the final outcome of many cardiovascular disorders, is a major cause of morbidity and mortality in the Western Hemisphere. Indeed, the incidence and prevalence of heart failure in the Western Hemisphere are increasing due to altered demogra phics with increased proportion of elderl...

Awarded: NOK 2.4 mill.

Project Period: 2006-2009

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Mechanisms for transcapillary transport-from molecules to clinical application

Capillaries are highly permeable to water and small solutes but very restrictive towards protein. This arrangement is necessary to maintain fluid equilibrium between plasma and tissue. There is a slow transfer of protein to supply tissues with e.g. import ant bioactive molecules. How the transpor...

Awarded: NOK 2.2 mill.

Project Period: 2006-2009

Location: Ukjent Fylke

BIOFYS-Fysiologiske og anatomiske fag

Dissecting the physiological, sensory, cognitive, and social dynamic features of cellular aging in the honey bee worker brain

The honey bee is a key neurobiological model for understanding learning and memory formation. As a highly social invertebrate, moreover, the bee provides unique opportunities for cutting-edge research on aging and frailty because it opens up the interface between the individual and the social en...

Awarded: NOK 2.0 mill.

Project Period: 2006-2007

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

FUNCTIONAL SIGNIFICANCE OF INTRACELLULAR REGULATION OF GLUTAMINE TRANSPORTERS IN NORMAL AND MALIGNANT CELLS

Glutamine, the most abundant amino acid in plasma and cerebrospinal fluid, is important for many metabolic processes, e.g. biosynthesis of amino acids, purines and pyrimidines. Glutamine is a major N- and C-donor involved in inter-organ and inter-cellular shuttling of metabolites. It is a signal...

Awarded: NOK 2.4 mill.

Project Period: 2006-2009

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Glutamate and lactate: Jason-faced actors in neurology

Excitatory amino acids play dual roles in the brain: they are physiological transmitters but have the potential to damage brain tissue. The same may be true for lactate, an important intermediate in cell metabolism. The project will study the roles of exc itatory amino acids and lactate transport...

Awarded: NOK 3.0 mill.

Project Period: 2006-2009

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Adaptation of nanocrystals for in vivo use in tracking of single molecules at the neuromuscular junction

The project aims at developing nanocrystals or Quantum dot (QD) technology for in vivo use in general, and for tracking single molecules in particular. Quantum dots emit fluorescence and have emission spectra that are orders of magnitude more intense tha n conventional dyes. An antibody is usual...

Awarded: NOK 3.1 mill.

Project Period: 2006-2008

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

ORIGINS OF CANCER STEM CELLS IN GLIOBLASTOMA

Glioblastoma multiforme is the most malignant of the primary brain tumors with grave prognosis. Recent studies have identified so-called "cancer stem cells" in glioblastomas and other tumors. These cells have the capacity to proliferate and establish tu mors in laboratory animals after injectio...

Awarded: NOK 1.2 mill.

Project Period: 2006-2008

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

The dynamic interstitial matrix and transcapillary exchange: Normal function and pathophysiology

The focus of this application is how the extracellular matrix can influence transcapillary transport of water and protein. The separate projects are closely related and cover studies from the level of single cells and organs to the organism. The unifying concept is the hypothesis that extracellu...

Awarded: NOK 2.4 mill.

Project Period: 2006-2009

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Dynamic 3-D modelling of the synaptic environment: The roles of transporters in controlling receptor activation and water transport

Prevention and cure of neurological diseases are hampered by a lack of knowledge of the underlying pathogenetic mechanisms which involve a complex system of transporter proteins. The primary objective of this proposal is to uncover how transporters limit activation of brain neurotransmitter recep...

Awarded: NOK 2.2 mill.

Project Period: 2006-2009

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Innate and acquired immunity in myocardial adaptation to ischemia - possible therapeutic gains?

Atherosclerosis is our major cause of morbidity and mortality, causing cerebral stroke, myocardial infarction, lower extremity gangrene, renal infarctions etc. Atherosclerosis is a chronic process involving both innate and adaptive immunity in its develop ment, and is a subject for attempts of im...

Awarded: NOK 1.5 mill.

Project Period: 2006-2008

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Stem cells from adult humans develop into neurons in the chicken embryo spinal cord but are they functionally integrated in neural networks?

Neural cell transplantation for repair of CNS lesions is one of the most exciting new avenues in the field of Neuroscience. With regard to spinal cord injuries (SCI), however, neuronal replacement has received relatively little attention because SCI has b een thought to be a "white matter" probl...

Awarded: NOK 2.2 mill.

Project Period: 2006-2009

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Hepatocyte Growth Factor in the Pathogenesis of Multiple Myeloma

Since our original publications in 1996 showing that malignant plasma cells (MM cells) usually express both HGF and its receptor c-Met, a growing number of reports have implicated HGF/c-Met in the biology of MM. For instance, high levels of HGF in serum o f an MM patient predict a bad prognosis a...

Awarded: NOK 1.8 mill.

Project Period: 2006-2008

Location: Ukjent Fylke