0 projects

IS-NAD-Samarbeid med NORAD-land

Nilsen, Odd Georg. Norsk spesialist til Kina 2011

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Awarded: NOK 10,000

Project Period: 2011-2011

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Base excision repair proteins in DNA repair and early steps of adaptive immunity

DNA is continuously damaged by cellular and environmental agents. Five main DNA repair pathways correct such lesions. These are important in cancer prevention, but surprisingly, also for adaptive immunity. Our research group concentrates on base excision repair (BER) and direct repair of damage....

Awarded: NOK 5.3 mill.

Project Period: 2011-2014

Location: Trøndelag - Trööndelage

STAMCELLER-Stamcelleforskning

Influence of inflammation and cancer on mesenchymal stem cell function

Impaired mesenchymal stem cell function and dysregulated osteoblastogenesis is a common feature of diseases such as multiple myeloma, breast cancer metastasizing to bone and some autoimmune diseases. The consequences for the affected patients are pain, fr equent fractures and severely reduced qua...

Awarded: NOK 3.4 mill.

Project Period: 2009-2013

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Membrane trafficking of Toll-like receptors in inflammatory reactions

Intracellular membrane trafficking plays key roles in cell signalling and immune responses. Endocytosis and subsequent endolysosomal trafficking of immune receptors constitute a crucial mechanism for receptor signal attenuation and antigen presentation. F or innate immunity against gram-negative ...

Awarded: NOK 3.4 mill.

Project Period: 2009-2012

Location: Trøndelag - Trööndelage

IS-BILAT-Mobilitet Norge-USA /Canada

Whole genome association analyses on a pre-eclampsia cohort-maternal genetic susceptibility and cardiovascular genetic/clinical profile

Pre-eclampsia (PE) is the most common pregnancy-associated complication in the Western world. The syndrome is a major contributor to maternal and fetal illness/death. No therapeutic treatment exists. The mechanisms involved in development of PE remain to be elucidated. The strong familial compo...

Awarded: NOK 0.25 mill.

Project Period: 2008-2009

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Mechanism of mammalian DNA repair

DNA repair prevents cancer and early aging and is essential for the immune system. Our objective is to obtain a detailed understanding of the mechanism of base excision repair (BER) and direct base damage repair. BER is a template-dependent multistep proc ess initiated by a DNA glycosylase. The U...

Awarded: NOK 4.0 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

YFF-Yngre, fremragende forskere

Lipocalin 2 - a novel antimicrobial protein: Role in mycobacterial disease, urinary tract infection and in wound healing

Infectious diseases remain the main cause of premature death worldwide and antimicrobial resistance is increasing. Consequently, the WHO stresses that there is an urgent need for new drugs and supplementary treatment regimens against infectious agents. We have recently discovered a novel mechani...

Awarded: NOK 8.2 mill.

Project Period: 2007-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

The roles of microRNAs and transcription factors in gene regulation and tissue specific expression

MicroRNAs (miRNAs) were identified as a large group of regulatory genes in 2001, and increasing research has revealed these genes to be important in development, including differentiation, proliferation, and apoptosis. Many miRNAs seem to have tissue-spec ific expression patterns, which suggest t...

Awarded: NOK 7.0 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

IS-BILAT-Mobilitet Norge-USA /Canada

Determination of the naïve human EC cell transcriptome and identification of neoplastic genes in small intestinal carcinoids

Neuroendocrine tumors of the gut (carcinoids) represent a form of cancer that has not been rigorously studied, hence as a group such tumors are poorly understood, usually misdiagnosed and a logical treatment rationale is lacking. Small intestinal (EC) car cinoids, deriving from the enterochromaff...

Awarded: NOK 0.25 mill.

Project Period: 2007-2008

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Hepatocyte Growth Factor in the Pathogenesis of Multiple Myeloma

Since our original publications in 1996 showing that malignant plasma cells (MM cells) usually express both HGF and its receptor c-Met, a growing number of reports have implicated HGF/c-Met in the biology of MM. For instance, high levels of HGF in serum o f an MM patient predict a bad prognosis a...

Awarded: NOK 1.8 mill.

Project Period: 2006-2008

Location: Trøndelag - Trööndelage

BIOMOL-Molekylær biovitenskap og bioteknologi

ESF Workshop/School: Microarray Gene Expression Analysis: Power and Potential of Standardisation

During the school, the participants will learn and discuss microarray gene expression analysis with an emphasis on standardisation and benchmarking. Curriculum includes central biological issues in transcript profiling, introduction to experimental design and data analysis, laboratory training i...

Awarded: NOK 59,999

Project Period: 2005-2006

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Mechanisms behind pathogen activation and evasion of Toll-like receptor signaling

Toll-like receptors (TLRs) are signaling receptors of the innate immune system, sensing a variety of bacterial and viral components. Our central hypothesis is that immune cell recognition of invading pathogens starts with an interaction between microbial structures and TLRs. The following immune ...

Awarded: NOK 2.4 mill.

Project Period: 2005-2011

Location: Trøndelag - Trööndelage

KREFTSATS-Særutlysning kreftmidler, historikk

GENOME MAINTENANCE MECHANISMS AND THEIR ROLE IN PREVENTING CANCER DEVELOPMENT

DNA repair genes represent a class of tumor suppressor genest hat have proven increasingly important in preventing cancer development in humans. This is not unexpected as DNA repair has been demonstrated to have a crucial role in maintaining genome stabil ity. DNA damage induced by cellular expos...

Awarded: NOK 6.6 mill.

Project Period: 2005-2007

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Molecular mechanisms of mammalian DNA repair

Mutations are the fundamental cause of all forms of cancer and a number of different, but integrated processes operate to prevent such genetic changes from occurring. DNA repair is of fundamental importance in limiting the occurrence of mutations. We will carry out comprehensive studies on the m...

Awarded: NOK 2.8 mill.

Project Period: 2005-2009

Location: Trøndelag - Trööndelage

TU-Tungt utstyr

Optical imaging core facility at the Medical Faculty, NTNU.

Our confocal microscope was purchased in 1999 (Zeiss LSM 510) and was upgraded with a META detector and a new software in 2002.This equipment has proven to be of immense importance in the cell biology research at IKM and has contributed strongly in a numb er of scientific publications from IKM du...

Awarded: NOK 4.0 mill.

Project Period: 2005-2006

Location: Trøndelag - Trööndelage

FRIMED-Klinisk medisin og folkehelse

Immune mechanisms and genetics associated with development of pre-eclampsia/eclampsia(PE/E)

PE is regarded as a two-step disease, with poor placentation and placental hypoperfusion as the first step in pathogenesis. The recognition of fetal trophoblasts by maternal uterine (uNK) cells is fundamental in placental development. Observations suggest that the superficial trophoblast invasio...

Awarded: NOK 2.0 mill.

Project Period: 2005-2007

Location: Trøndelag - Trööndelage

BIOFYS-Fysiologiske og anatomiske fag

Effects of nicotine on beta-cell function: mechanisms and diabetogenic influence

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Awarded: NOK 0.30 mill.

Project Period: 2004-2005

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Genregulering i biologiske responsar: Fokus på gastrinresponsar i nevroendokrine celler i mage-tarmkananlen

Gastrin er ein sentral regulator av funksjon og vekst av mageslimhinne og er postulert å spela ein rolle i autokrin vekstregulering av gastrointestinale kreftsvulstar og stamcelle-deriverte kreftsvulstar. Prosjektet vil bruke DNA mikroarray teknologi og datavitenskapelege metodar til genom-skal...

Awarded: NOK 2.3 mill.

Project Period: 2004-2008

Location: Trøndelag - Trööndelage

KREFTSATS-Særutlysning kreftmidler, historikk

Opioids, Symptom Management and Palliation Research Group

The group was formally established in 2002 thanks to a research grant from Norwegian Research Council (NFR) (2001-2003). The group consist of core personnel in permanent positions at The Faculty of Medicine, NTNU and personnel supported by the above NFR grants and other grants including NFR. T...

Awarded: NOK 8.8 mill.

Project Period: 2004-2009

Location: Trøndelag - Trööndelage