248 projects

Date from new to old

BANEBRYTENDE-BANEBRYTENDE

Network dynamics during encoding and recall of episodic memories in humans

Remember your last birthday party: the guests at the door, the tasty food, the small pile of presents. Those memories are called episodic memories. They are memories of events that happen in a particular place (“where”) and in a particular order (“when”). To form these memories, the brain must s...

Awarded: NOK 22.0 mill.

Project Period: 2026-2031

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Identifying drivers of Klebsiella pneumoniae colonisation in critically ill patients using advanced genomics

When critically ill patients are in hospital, especially in intensive care units (ICUs), they are highly vulnerable to infections from bacteria. One such bacterium is Klebsiella pneumoniae, which can be unknowingly carried in the gut and upper airways of many people. However, infections caused by...

Awarded: NOK 10.0 mill.

Project Period: 2026-2029

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

The role of Striatal Interneurons in Action Selection

When you are trying to open a door, how does your brain decide whether to push or pull? How do you direct your hand to grab the door handle? A region in our brains called the striatum plays a key role making these decisions. When we are not sure what to do, whether to move or stay still, to push ...

Awarded: NOK 10.0 mill.

Project Period: 2025-2029

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

PEAK: Plasmid Evolution and Antimicrobial resistance in Klebsiella pneumoniae

Antimicrobial resistance (AMR) is a serious threat to human health which is predicted to increase in the future. One of the most common ways that bacteria evolve resistance to antibiotics is by acquiring resistance genes; these are often carried on pieces of DNA called plasmids. Plasmids carrying...

Awarded: NOK 5.9 mill.

Project Period: 2025-2029

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Bayesian Rank-based unsupervised Integration of multi-source Data in cancer Genomics and the digital Economy

The data revolution is changing the foundations of biomedicine radically, so that modern biostatistics is becoming one of the fundamental pillars of research success. The internet, sensors on smartphones and wearable devices, and cheap data transfers make it easy to collect data rapidly and exten...

Awarded: NOK 12.0 mill.

Project Period: 2025-2029

Location: Oslo - Oslove

HELSEFORSKNING-Helseforskning

B-vitamins and omega-3 fatty acids to modulate brain ageing in European citizens through improved nutrition: the BOOMERANG project

A poor nutrition status can promote cognitive decline and dementia. Evidence links low status of certain B-vitamins and omega-3 fatty acids with a greater risk of cognitive decline and dementia. Although these dietary components are typically investigated separately, there are evidence for that t...

Awarded: NOK 4.3 mill.

Project Period: 2025-2028

Location: Oslo - Oslove

HELSEFORSKNING-Helseforskning

Fungal Genomics and Antagonistic Community Interactions

Fungal pathogens within the Candida genus, including C. albicans, C. parapsilosis and C. auris, represent a growing public health concern on a global scale. Resistance to key antifungal drugs, particularly azoles and echinocandins, is on the rise. Increased virulence or resistance is driven by m...

Awarded: NOK 3.4 mill.

Project Period: 2025-2028

Location: Oslo - Oslove

TEKNOLOGIKONVER-TEKNOLOGIKONVER

Integrated convergent technology for precision human tissue and disease modeling

Advancing the study and treatment of disease is being accelerated by integrating and converging different types of technologies. Combining the use of patient-specific stem cells, innovative materials and micro/nanotechnology to create laboratory models of diseases has shown particular promise. Ef...

Awarded: NOK 15.0 mill.

Project Period: 2025-2029

Location: Oslo - Oslove

VELFERDTEMA-VELFERDTEMA

Improving causal inference for individual working life trajectories from registry data: studying interventions, estimands and heterogeneity

Interventions that facilitate a well-functioning, inclusive and adaptive working life, with high employment and reduced absence from work, is of high priority for employers and policymakers. In Norway, one such major intervention is the Agreement for a more inclusive working life (the IA agreemen...

Awarded: NOK 12.0 mill.

Project Period: 2025-2029

Location: Oslo - Oslove

UTVIKLING-UTVIKLING

Rapid diagnosis of key aetiologies of sepsis and associated infections in LMICs using CRISPR-based assays

Invasive bacterial infections are a major cause of mortality and morbidity globally, with the highest disease burden in low-and-middle-income-countries (LMICs). Rise of infections from antimicrobial resistant (AMR) bacteria is disproportionately affecting public health in these countries, given t...

Awarded: NOK 12.0 mill.

Project Period: 2024-2027

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Unlocking molecular diversity in the brain-to-body gateway: spatial transcriptomics and proteomics of brainstem-to-spinal cord projections

Packed with an intricate assembly of neurons and circuits serving vital functions (motor, respiratory, cardiovascular, hormonal regulation, temperature and pain regulation, sleep) the brainstem is the LEAST expendable part of the brain. These multiple, critical functions are mediated by a large p...

Awarded: NOK 9.6 mill.

Project Period: 2023-2027

Location: Oslo - Oslove

PETROLEUM-PETROLEUM

Exposure Assessment and Prevention of Death, Disease and Injuries among Offshore Petroleum Workers

Reporting period: 01.10.2024 – 30.09.2025 Work Package 1: The expert-based semi-quantitative benzene JEM scores have been linked to the database of personal measurements from 1993–2023, and quantitative estimates have been developed. A manuscript for this work has been in progress and is planned...

Awarded: NOK 10.0 mill.

Project Period: 2023-2028

Location: Oslo - Oslove

HELSEFORSKNING-Helseforskning

Invigorating immunity against brain metastases in lung and breast cancer patients

Brain metastases (BrMet) are a devastating complication in breast and lung cancer and a main cause of death. Novel immunotherapies have revolutionized treatment of cancer, but response rates are hard to predict, especially for BrMet patients. Our project partners have quantified immune cells in B...

Awarded: NOK 3.1 mill.

Project Period: 2023-2026

Location: Oslo - Oslove

HELSEFORSKNING-Helseforskning

Understanding brain circuit dysfunction in amblyopia using large-scale multimodal recordings in a new visuomotor task.

Some theories about brain function consider the brain as a prediction machine. Based on previous experience, our brains may perform an "autocompletion" function during pretty much every thing we do, and perhaps, think. Here we will study amblyopia, or best known as "lazy eye" in a mouse model to ...

Awarded: NOK 3.0 mill.

Project Period: 2022-2026

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

SmartSense: Decoding metabolic and epigenetic disorders caused by adolescence sleep deprivation

Obesity and bad sleep habits among teenagers are two rising health concerns that seems intertwined. Indeed, many studies trace obesity to poor sleep hygiene. This is especially concerning because (i) adolescents get less and less sleep as screens invade their bedroom and (ii) obese children have ...

Awarded: NOK 12.5 mill.

Project Period: 2022-2027

Location: Oslo - Oslove

HELSEFORSKNING-Helseforskning

The Norwegian Node of the International Neuroinformatics Coordinating Facility 2022-2027

Neuroinformatics focuses on integrating and analyzing diverse datasets across scales, techniques, and species to enhance our understanding of brain function and improve societal health and well-being. The International Neuroinformatics Coordinating Facility (INCF) is a global organization that pr...

Awarded: NOK 5.0 mill.

Project Period: 2022-2027

Location: Oslo - Oslove

HELSEFORSKNING-Helseforskning

Subpopulation heterogeneitY and MicroenvironMental Engagement as predictors for Treatment Resistance in lYmphoma

Lymphomas, like most other cancers, consist of multiple distinct cancer cell populations within each patient. These tumor subpopulations have distinct genetic and biological characteristics leading to different drug response profiles. The aim of this project is to characterize these tumor subpopu...

Awarded: NOK 3.1 mill.

Project Period: 2022-2026

Location: Oslo - Oslove

TEKNOLOGIKONVER-TEKNOLOGIKONVER

Wireless Neuroprobe-On-A-Chip

A billion people are estimated to suffer from neurologic or mental disorders across the world today. Poor countries, children, adolescents and elderly are disproportionally affected. The WHO alerts to a dire situation in low-income countries. Because most brain disorders result in long-term disab...

Awarded: NOK 20.0 mill.

Project Period: 2022-2027

Location: Oslo - Oslove

FORSTERK-Forsterkningsmidler

Supporting open sharing of FAIR Norwegian neuroscience data via the EBRAINS research infrastructure

The brain is the most complex structure we know, and intensive research efforts are invested to map brain structure and function, aiming to generate new knowledge that will allow us to better understand how the brain function. This knowledge and understanding may allow us to simulate brain functi...

Awarded: NOK 0.80 mill.

Project Period: 2022-2024

Location: Oslo - Oslove

GLOBALBÆREKRAFT-Forskning for global bærekraft

JSPS stipend, Ryoko Higa

...

Awarded: NOK 0.41 mill.

Project Period: 2022-2023

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

CardioTarget: Development of targeted therapies for HFpEF

Heart failure with preserved ejection fraction (HFpEF) is a disease with few treatments that offer improved prognosis despite high mortality and incidence worldwide. Here, we have sought to develop a systems biology understanding of HFpEF, by utilizing two technical breakthroughs from our project...

Awarded: NOK 8.0 mill.

Project Period: 2021-2026

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Targeting Aryl Hydrocarbon Receptor for Breast Cancer Treatment and Improved Immunotherapy

Breast cancers, like many other cancers, develop through a complex set of events, including DNA mutations and changes in the way the immune system fights cancer. The immune system plays an important role in protecting us from cancer, but these protective mechanisms are lost when tumours are forme...

Awarded: NOK 12.0 mill.

Project Period: 2021-2026

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Decoding the B cell response in multiple sclerosis

Multiple sclerosis (MS) arises when the immune system attacks the brain and spinal cord. We still don’t know exactly which immune cells drive the disease or which molecules they target, and that slows the development of better tests and more precise treatments. We ask whether a subset of people w...

Awarded: NOK 8.0 mill.

Project Period: 2021-2027

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Epigenetic encoding of the thermogenic capacity of human adipose tissue

Recent advancements in understanding human adipose tissue have unveiled critical insights into the mechanisms regulating fat cell differentiation, particularly the transition from white to beige adipocytes. This project extensively investigates the epigenetic program that governs the thermogenic ...

Awarded: NOK 12.0 mill.

Project Period: 2021-2026

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Axonal dysfunctions in Dravet Syndrome

Dravet syndrome is a severe form of childhood epilepsy. During an initial period of normal development, infants suffering from Dravet syndrome develop epileptic seizures at about half a year of age, often in combination with fever (so called febrile seizures). During the first years of life, pati...

Awarded: NOK 8.0 mill.

Project Period: 2021-2025

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Integration of spatial and social memory in hippocampus CA2 and medial entorhinal cortex

Social interactions are essential for humans, and social memories are part of our autobiographical memories. It is well known that the brain area hippocampus is a key player for the formation of autobiographical memories, combining information about what happened in space and time into vivid memo...

Awarded: NOK 12.0 mill.

Project Period: 2021-2026

Location: Oslo - Oslove

HELSEFORSKNING-Helseforskning

Tactile sensory impairment of C-LTMR afferents in preterm children

Gentle touch is an important part of maternal care: it comforts, calms, and enables regulation of arousal in newborns. A special group of nerve fibers is crucial for humans - like other mammals - to perceive and enjoy slow, pleasant stroking. These are called C-LTMR nerve fibers. This project has...

Awarded: NOK 4.2 mill.

Project Period: 2021-2025

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Stochastic differential equations for robust evaluation of cancer treatments with registry data

We have discovered a general principle for statistical identification of distributions for potential outcomes in continuous time settings, based on consistency, positivity and exchangeability. In contrast to previous research in this field, our approach is based on martingale theory from the ver...

Awarded: NOK 11.8 mill.

Project Period: 2021-2026

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

What is the role of astroglial calcium signaling in hippocampal memory encoding?

How do you remember what you did yesterday or even twenty years ago? A landmark discovery in memory research revealed that neural activity patterns of daily life experiences repeat themselves when we are asleep. Such reactivations, or replay, are important for long-term memory and is a well-accep...

Awarded: NOK 8.0 mill.

Project Period: 2021-2025

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

NUCLEAR INTEGRITY: From Molecular Mechanism to Cell Fate

Every day, thousands of billions cells move, divide, interact, and reshape in order for our body to grow, replenish, repair and maintain normal organ function. These dynamic processes place significant stress on the nucleus that contains all genetic information encoded in chromosomes, called the ...

Awarded: NOK 11.4 mill.

Project Period: 2021-2026

Location: Oslo - Oslove

1 2 3 4 5 9