0 projects

FRIBIO-Biologi og biomedisin

Life history strategies in ungulates: an experimental approach

A crucial task in ecology is to quantify trade offs between competing processes. Due to environmental correlation, large individual variability in expression of traits and small variability in allocation between competing traits, carefully designed exper iments are needed to quantify these relati...

Awarded: NOK 3.7 mill.

Project Period: 2005-2008

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Evolution of chloroplasts: addressing the genomic processes behind acquisition of secondary and tertiary organelles

The dinoflagellate chloroplasts (plastids) originate from eukaryotic photosynthetic endosymbionts. Rather than being derived from a single group (being monophyletic) the plastids of dinoflagellates are originate from several organism groups and are thus of polyphyletic origin. Most dinoflagellat...

Awarded: NOK 4.6 mill.

Project Period: 2005-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Determinants of spatio-temporal outbreak dynamics of Geometrid moths populations

The cyclic outbreak dynamics of birch forest Geometrids in Fennoseandia (in particular the two species; the autumnal moth and the winter moth) is a very well—known phenomenon both among scientists aud lay people due its severe, large-scale impacts on the mountain birch forest ecosystem. Still imp...

Awarded: NOK 2.7 mill.

Project Period: 2005-2008

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Endocytosis and intracellular transport of protein toxins

Errors in trafficking and signalling are associated with different diseases, including cancer. This project aims at increasing our knowledge about intracellular transport processes to provide a more rational basis for treatment and prevention of disease. Protein toxins such as Shiga toxin and the...

Awarded: NOK 1.5 mill.

Project Period: 2005-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Adaptive food web models

For almost a century, mathematical studies of ecosystem dynamics have been based on the Lotka-Volterra differential equation approach. This approach has been able to integrate different actors, such as resources, producers, predators, decomposers and dise ase vectors. The great success has, howev...

Awarded: NOK 2.3 mill.

Project Period: 2005-2009

Location: Vestland

FRIBIO-Biologi og biomedisin

Evolution of mating type and vegetative incompatibility genes in fungi: The dry rot fungus Serpula lacrymans as a model species

In recent years an international research initiative focusing on the devastating dry rot fungus Serpula lacrymans has been established. Previous research suggests that S. lacrymans provides a unique model system to study evolutionary processes and life hi story traits in basidiomycetes, including...

Awarded: NOK 4.5 mill.

Project Period: 2005-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Adaptation of insects to extremely cold winters and extremely hot summers in Siberia

The present project is focused on adaptations which make insects able to survive the extremely cold winters and hot summers in inner Siberia. The studies will compare the features of insects in Yakutia with those of Scandinavia, preferably by comparing fe atures of the same species. The project w...

Awarded: NOK 1.2 mill.

Project Period: 2005-2008

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Characterization of oncogene candidates using small interfering RNA (siRNA)

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Awarded: NOK 2.0 mill.

Project Period: 2004-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Molekylærbiologisk assistert stadium-inndeling av kolorektal cancer

Innenfor de klinisk-patologiske stadiene Dukes B og C av kolorektal cancer (CRC) overlever kun halvparten 5 år. Det er derfor av stor betydning å kunne identifisere molekylære markører som kan forutsi sykdomsforløpet. CRC kan inndeles i to grupper relater t til genomisk ustabilitet. Majoriteten v...

Awarded: NOK 2.1 mill.

Project Period: 2004-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Molecular mechanism of DNA repair

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Awarded: NOK 1.7 mill.

Project Period: 2004-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Development and application of RNA interference technology for understanding the regulation of key somatic maintenance functions in honeybee

Due to its social attributes, ints learning capaabilities, and several facultative physiological and behavioural traits under social control, the honeybee provides opportunities for cutting-edge research not possessed by the Drosophila, Caenorhabditis elegans, zebrafish and the mice syste...

Awarded: NOK 2.6 mill.

Project Period: 2004-2008

Location: Akershus

FRIBIO-Biologi og biomedisin

Functional genomics of the malaria parasite Plasmodium falciparum

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Awarded: NOK 2.1 mill.

Project Period: 2004-2010

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Magnetoreception and magnetic compass orientation in the long distance migration of the European eel

The European eel, Anguilla anguilla, a common part of the fish community in European coastal and inland waters, spawns in the Sargasso Sea. The larvae drift or migrate with currents to the coasts of Europe and North Africa. Once there, large numbers of yo ung eels grow up in widely different habi...

Awarded: NOK 4.0 mill.

Project Period: 2004-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Hybridization in birds as studied by cross-fostering in the wild

Hybridization between species generally reduces fitness. However, hybridization, and subsequent back-crossing, may lead to the transfer of genes between species and represent an important factor as a source of new variability in the subsequent evolution o f the species. The importance of hybridiz...

Awarded: NOK 1.8 mill.

Project Period: 2004-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Stochastic dynamics of bird communities

The aim of the present project is to develop stochastic community models and statistical tools to estimate the model parameters. Such models will be of great practical use for detecting changes in community composition e.g. due anthropogenic influences or when trying to calculate areas necessary ...

Awarded: NOK 1.7 mill.

Project Period: 2004-2008

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Regulation of Protein Kinase C (PKC) membrane targeting and PKC-mediated activation of phosphatases

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Awarded: NOK 1.9 mill.

Project Period: 2004-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

The role of molecular motors and rab proteins in the maturation of secretory granules

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Awarded: NOK 2.2 mill.

Project Period: 2004-2008

Location: Vestland

FRIBIO-Biologi og biomedisin

Struktur og funksjon av SPBP ePHD: Avsløring av et protein-protein interaksjonsnettverk involvert i genregulering og DNA replikasjon

Prosjektgruppen har klonet og sekvensert full-lengde cDNA fra mus og menneske for SPBP (Stromelysin-1 PDGF-responsive element Binding Protein), som er et kjerneprotein på ca 220 kDa. Mus og humant protein er 92% identiske i aminosyresekvens. Genet uttrykk es i en rekke vev og alternativ spleising...

Awarded: NOK 0.49 mill.

Project Period: 2004-2008

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Kinaseregulering av EGF reseptor-signalisering og trafikkering

Formålet med prosjektet er å få en bedre forståelse av hvordan signalisering fra og trafikkering av EGFreseptoren er regulert. Aktivering av EGF-reseptoren via andre kinaser, og spesielt serine/treonin kinaser, er relativt lite kartlagt. Det er kjent at p rotein kinase A og C (PKA og PKC), og Ca<...

Awarded: NOK 2.3 mill.

Project Period: 2004-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Kroniske smerter: mekanismer i ryggmargen

Ved langvarige belastninger er smerter en viktig del av symptombildet. Smerter kan bli kroniske, og går i slike tilfeller ut over arbeidsevne og sosial funksjon. En slik smertetilstand skyldes en betydelig plastisitet i de delene av nervesystemet som beh andler smertesignaler og som gir opphav t...

Awarded: NOK 2.0 mill.

Project Period: 2004-2008

Location: Vestland

FRIBIO-Biologi og biomedisin

Genregulering i biologiske responsar: Fokus på gastrinresponsar i nevroendokrine celler i mage-tarmkananlen

Gastrin er ein sentral regulator av funksjon og vekst av mageslimhinne og er postulert å spela ein rolle i autokrin vekstregulering av gastrointestinale kreftsvulstar og stamcelle-deriverte kreftsvulstar. Prosjektet vil bruke DNA mikroarray teknologi og datavitenskapelege metodar til genom-skal...

Awarded: NOK 2.3 mill.

Project Period: 2004-2008

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Mucosal Vaccinology and Immunotherapy (General team support application for LIIPAT)

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Awarded: NOK 1.5 mill.

Project Period: 2004-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Modulation of chemokine expression: A potential therapeutic target in chronic inflammatory diseases

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Awarded: NOK 1.8 mill.

Project Period: 2003-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

Feeding interactions and growth of salmon parr and sculpins in a sub-Arctic river

The coexistence of sculpins and salmon parr in a wide range of river habitats gives rise to examine the realised ecological niche of sympatric species along different scales of resource diversity as benthos and habitat, and may display new mechanisms in s pecies coexistence. In this project growt...

Awarded: NOK 1.3 mill.

Project Period: 2003-2008

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Causes and consequences of spatio-temporal life history variation in semi-domesticated reindeer

Density-dependent regulation of mortality in winter, and inf1uences of climatic and habitat quality on fecundity are central processes in the population dynamics of ungulates in northern environments. However, the population level consequences of such ext ernal environmental influences are moulde...

Awarded: NOK 1.8 mill.

Project Period: 2003-2008

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Archaeal cell cycle regulation

Although the archaeal domain basically possesses a prokaryotic type of cell strueture, the archaebacteria share many molecular features with eukaryotes, in particular the mechanisms for chromosome replication and gene expression. Several homologs of cell. -cycle control (Cdc) proteins, which in e...

Awarded: NOK 1.8 mill.

Project Period: 2003-2008

Location: Vestland

FRIBIO-Biologi og biomedisin

Gene regulation in the immune system: The TdT and pIgR genes as models to study the role of chromatin in transcriptional regulation.

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Awarded: NOK 1.5 mill.

Project Period: 2003-2010

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Betydningen av apolipoprotein E polymorfismen for sykdomsutvikling

Apolipoprotein E (apoE) er et molekyl som er viktig for kolesteroltransport mellom celler. Molekylet produseres og skilles ut i blodet fra leveren, men dannes også i andre organer. Tre varianter, apoE2, apoE3 og apoE4, kodes av allelene e2, e3 og e4 i et lokus på kromosom 19. I forhold til det "...

Awarded: NOK 1.8 mill.

Project Period: 2003-2014

Location: Oslo

FRIBIO-Biologi og biomedisin

Regulatoriske proteiner i nervesystemet: Struktur-aktivitetsstudier og kliniske aspekter

Mange nevrodegenerative sykdommer oppstår på grunn av endret funksjon av viktige proteiner i nervesystemet. En antar at lignende forandringer finnes ved de alvorlige psykiatriske sykdommer, inkludert affektive lidelser og schizofreni. Prosjektet fokuserer på grunnleggende molekylære mekanismer i...

Awarded: NOK 2.1 mill.

Project Period: 2003-2008

Location: Vestland

FRIBIO-Biologi og biomedisin

The effect of sheep grazing on alpine plant communities, species and populations: what is the importance of plant life histories?

Grazing is an important factor for plant dynamics, but it has proved difficult to generalise about grazing impact, partly because of a lack of a good mechanistic framework linking the grazing impacts on certain life stages to the dynamics of the populatio ns. A functional classification of specie...

Awarded: NOK 1.8 mill.

Project Period: 2003-2008

Location: Oslo