0 projects

FRIMED-Klinisk medisin og folkehelse

Non-invasive Assessment of Right Ventricular Function in Patients With Tetralogy of Fallot

Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease (CHD). Surgical treatment (total repair) has been available for 50 years, with favorable outcome in most patients. We are now, however, faced with an increasing number of patients presenting with right ventricu...

Awarded: NOK 1.5 mill.

Project Period: 2006-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

The significance of therapist and patient characteristics in psychotherapy

Therapeutic alliance is considered to be one of the central aspects of the relationship between therapists and patients in psychotherapy, as well as therapy process and outcome. Therapeutic alliance includes three central aspects: the goals of therapy, ho w to proceed to reach the goals, and the ...

Awarded: NOK 1.1 mill.

Project Period: 2006-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Pathophysiological role of inflammatory mechanisms in heart failure

Chronic heart failure (HF) is an important and increasing cause of cardiovascular morbidity and mortality. Several lines of clinical and experimental evidence indicate that inflammation may play an important role in the development of HF, a notion that ha s opened up for new treatment principles ...

Awarded: NOK 2.5 mill.

Project Period: 2006-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Injury in newborn infants. Basic mechanisms related to oxidative stress and bilirubin encephalopathy

In this project we plan to continue our long term studies regarding basic mechanisms of brain injury in newborn infants. We have previously shown that oxidative stress both in preterm and term infants induces long term potential harmful effects that may affect growth and development. As the f...

Awarded: NOK 3.0 mill.

Project Period: 2006-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Novel therapeutic strategies for immunostimulation in HIV targeting CD25+ T-regulatory cells.

Regulatory T cells (Treg) represent 5-10% of the CD4 T cells and are identified by constitutively expressing CD25. Treg are subdivided into naturally occuring Treg devolped in the thymus, and adaptive Treg that are induced in the periphery from naïve CD4 T cells. Naturally occuring Treg are intst...

Awarded: NOK 2.4 mill.

Project Period: 2006-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Development of male contraceptive through manipulation of CaS

The project is aimed at developing male contraceptives on a collaborative basis between the Institute of Basic Medical Sciences (project leader Bjørn Steen Skålhegg) and the Department of Andrology, The National University Hospital of Norway (research lea der Dr. Peter Fedorcsak and head of depar...

Awarded: NOK 4.1 mill.

Project Period: 2006-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

The relative role of complement and LPS in sepsis/SIRS: a rational for combined treatment with complement- and CD14/TLRs inhibitors.

The complement system is an essential part of innate immunity protecting the host against infection. However, it is a double-edged sward in the sense that inappropriate activation may damage host tissue. Uncontrolled systemic activation of complement, as seen in sepsis, may contribute to the brea...

Awarded: NOK 1.5 mill.

Project Period: 2006-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Spontaneous preterm birth and genetics

Preterm birth (PTB) is the main cause of perinatal mortality and short- and long-term morbidity. The pathophysiology of spontaneous PTB remains poorly understood. Infection and inflammation, fetal growth, uterine distention and decidual haemorrhage are be lieved to be part of the mechanisms resul...

Awarded: NOK 2.2 mill.

Project Period: 2006-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

NOVEL BIOTHERAPEUTIC STRATEGIES FOR IMPROVING IMPLANT PERFORMANCE IN BONE

The purpose of this project is to characterize mechanisms for bone regeneration and healing and to use this knowledge to develop new strategies for improving the performance of loaded metal implants used to restore function in compromised skeletal structu res. From the clinical perspective skelet...

Awarded: NOK 4.5 mill.

Project Period: 2006-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Identification of genetic and environmental factors contributing to disease susceptibility and clinical presentation of multiple sclerosis

The aim of this project is to identify factors contributing to development of multiple sclerosis (MS) in a PhD project. MS is a debilitating inflammatory disease of the central nervous system. The etiology is unknown, but both genetic and environmental fa ctors are involved. Identification of the...

Awarded: NOK 2.0 mill.

Project Period: 2005-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Infections, prepregnant diet and other environmental factors as possible causes of hyperemesis gravidarum (HG).

Hyperemesis gravidarum (HG) is defined as severe, intractable nausea and vomiting in early pregnancy. The HG-patient suffers from dehydration, weight loss, ketonuri and a nutritional deficiency. HG affects 0,5-2,0% of pregnant women, and the etiology is u nknown. Until recently HG was believed to...

Awarded: NOK 1.8 mill.

Project Period: 2005-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

The role of Peptidyl Arginine Deiminase and protein citrullination in the pathogenesis of rheumatoid arthritis

Rheumatoid arthritis (RA) is a common multifactorial inflammatory disorder. It is characterised by a chronic synovial inflammation that destroys the affected joints and causes disability. The molecular basis of RA is largely unknown, but it is clear that the main genetic contribution to RA is by ...

Awarded: NOK 2.1 mill.

Project Period: 2005-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

MPECS to detect high risk colorectal adenomas

Colorectal cancer (CRSC) is one of the leading cancers and the mortality is high and hardly has changed over the past decades. It is believed that most CRCs are preceded by a pre-invasive phase, called colorectal adenoma (CRA). About 2-5% of all CRAs pro gress to cancer. It is therefore importan...

Awarded: NOK 1.7 mill.

Project Period: 2005-2008

Location: Rogaland

FRIMED-Klinisk medisin og folkehelse

Immune mechanisms and genetics associated with development of pre-eclampsia/eclampsia(PE/E)

PE is regarded as a two-step disease, with poor placentation and placental hypoperfusion as the first step in pathogenesis. The recognition of fetal trophoblasts by maternal uterine (uNK) cells is fundamental in placental development. Observations suggest that the superficial trophoblast invasio...

Awarded: NOK 2.0 mill.

Project Period: 2005-2007

Location: Trøndelag - Trööndelage

AKLIMED-Klinisk medisin

Development of methodology and equipment for assessing postural stability during standing and walking

Finegrained methods are needed to assess postural stability during standing and walking. Such measures must be reliable, valid and easy to use under real life conditions. The Balance and Gait Unit, University of Bergen is a member of the EC thematic netwo rk Prevention of Falls Network Europe (PR...

Awarded: NOK 0.40 mill.

Project Period: 2005-2006

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Induced Liver Hyperplasia

The liver strictly regulates its own volume relative to body mass. We aim to investigate and manipulate the mechanisms underlying this phenomenon. Based on increasing evidence that regeneration after partial hepatectomy (PHx) is triggered immediately by changes in hemodynamics, we have designe...

Awarded: NOK 1.2 mill.

Project Period: 2005-2007

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Pathophysiological and Immunological Aspects of Meconium Aspiration Syndrom A search for new understanding and therapy

Meconiumstained amniotic fluid is present in approximately 10-12% of all deliveries. Out of these approximately 5% develop respiratory problems called Meconium Aspiration Syndrom (MAS). This is caused by aspiration of fetal stools (meconium into the lungs ) and occur mainly in term or postterm in...

Awarded: NOK 1.8 mill.

Project Period: 2005-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

ACTIVE

Active is a prospective randomised trial of autologous chondrocyte transplantation compared with alternative treatments for patients who have had a failed primary treatment for chondral defect(s) in the knee. 660 patients in 14 cenres (12 in the UK, 2 in Norway) will be recruited over 2-3 years. ...

Awarded: NOK 0.90 mill.

Project Period: 2005-2007

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Zinc and common childhood infections - field trials in Nepal

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Awarded: NOK 2.2 mill.

Project Period: 2004-2007

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Venous thromboembolism in pregnancy

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Awarded: NOK 1.5 mill.

Project Period: 2004-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Genetikk i klinisk onkologi: Ætioilogiske og terapeutiske undersøkelser hos pasienter med malign germinalcelletumor (MGCT)

Ekstragonadale germinalcelle tumores (EGCCT) representerer en klinisk viktig og vitenskapelig meget interessant undergruppe av maligne germinalcelle tumores (MGCT). Norge er nummer 2 på verdenstoppen hva insidens av disse svulster angår, og antall per år er økende uten at årsaken for denne øknin...

Awarded: NOK 1.8 mill.

Project Period: 2004-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

A study of global gene expression analysis to evaluate mammographic densities and risk for breast cancer

Høy mammografitetthet er en av de sterkeste kjente risikofaktorene for brystkreft. En vet lite om hva høy mammografitetthet innebærer på det molekylære plan, selv om det hevdes at det avspeiler brystcelleproliferasjon. Prosjektet ønsker å undersøke om de t er sammenheng mellom mammografitetthet ...

Awarded: NOK 1.8 mill.

Project Period: 2004-2010

Location: Oslo

AKLIMED-Klinisk medisin

Temporomandibular Joint Disorders: Proposal of a new calssification system for severity using MR imaging

Pasienter med ansikts-/kjevesmerter og kjevefunksjonsforstyrrelser utgjør en stor og heterogen gruppe som kan ha tildels betydelige plager. Det er vel kjent at myalgi knyttet til "stress" er en stor undergruppe i denne pasientkategorien. Prosjektet ønsker å fortsette forskning vedrørende en anne...

Awarded: NOK 0.24 mill.

Project Period: 2004-2005

Location: Oslo

AKLIMED-Klinisk medisin

Utvikl. av Dobutamin STress Ekkokardiografi med en ny kvantitativ ultralydsmetode, Strain Rate Imaging Videreutvikling i Brisbane, Australia

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Awarded: NOK 0.29 mill.

Project Period: 2004-2005

Location: Trøndelag - Trööndelage

AKLIMED-Klinisk medisin

Rationale for væsketerapi hos premature barn - betydningen for hemodynamikk, shunter og cytokiner

Systemisk hypotensjon, enten som følge av hypovolemi eller nedsatt hjertefunksjon, er en viktig årsak til økt morbiditet/mortalitet hos premature barn. Umodne organsystemer gjør den kliniske vurderingen av årsaken til hypotensjonen vanskelig og det foreli gger ingen gode objektive metoder til å v...

Awarded: NOK 2.0 mill.

Project Period: 2004-2007

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Betydningen av interleukin (IL)-10 ved inflammasjon og aterosklerotisk hjerte- karsykdom

Hypotesen, som bl.a. baserer seg på egne originale funn, er at immunologiske og inflammatoriske mekanismer spiller en viktig patogenetisk rolle ved utvikling av koronar ischemisk hjertesykdom, både ved å påskynde den aterosklerotiske prosessen, og ved å m ediere utvikling av plakkruptur. Prosjekt...

Awarded: NOK 2.1 mill.

Project Period: 2004-2007

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Redusert skjelettmuskelfunksjon hos pasienter med hjertesvikt: biokjemiske forandringer i skjelettmuskel

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Awarded: NOK 1.3 mill.

Project Period: 2004-2007

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Stamceller fra voksen hjerne - ny behandling mot Parkinson sykdom

Parkinsons sykdom skyldes at dopaminproduserende nerveceller i hjernen dør. Behandlingen i dag er rettet mot symptomlindring, men en har forsøksvis implantert nerveceller fra humane fostre. Nyere forskning har imidlertid oppdaget umodne stamceller i den v oksne hjerne, og forskningsgruppen har gj...

Awarded: NOK 1.4 mill.

Project Period: 2004-2007

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Studies of colorectal cancer (CRC) metastasis

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Awarded: NOK 1.0 mill.

Project Period: 2004-2007

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Genetic and epidemiological studies of orofacial deft. in Norway

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Awarded: NOK 2.0 mill.

Project Period: 2004-2007

Location: Vestland