192 projects

Date from new to old

FRIPROSJEKT-FRIPROSJEKT

Multiomic 4-dimensional identification of novel treatment targets for bile duct inflammation

Primary sclerosing cholangitis (PSC) is a severe and chronic bile duct disorder without medical treatment. Therefore, there is a critical need for new targets for treatment, to define these properly an increased understanding of the disease process is needed. In general, development of disease is...

Awarded: NOK 12.0 mill.

Project Period: 2021-2028

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Epitranscriptomic regulation and genome stability in meiosis and the preimplantation embryo

One of the most profound changes in the life of an organism is the remarkable reprogramming of mRNA transcripts during meiosis and in the early preimplantation embryo. mRNA is a messenger molecule between the gene located on the DNA molecule (chromosome) and the protein to be synthesized. The rel...

Awarded: NOK 12.0 mill.

Project Period: 2021-2026

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Causes, consequences, and life-course trajectories of personality pathology - a longitudinal extended children-of-twins study

Personality disorders affect the way a person thinks, feels, and acts, and can be destructive in many areas of life. They may manifest as extreme mistrust, intense mood swings, impulsive behavior, or paralyzing perfectionism. Such disorders affect not only the individual but also families and clo...

Awarded: NOK 12.3 mill.

Project Period: 2021-2027

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Developing and Applying New Statistical Models to Test for Transgenerational Effects of Environmental Exposures in Pregnancy

Women from poorer backgrounds are more likely to have infants who are born preterm (prematurely) and have low birth weight. Previous research shows this might be because of poorer diets and women from poorer backgrounds being more likely to smoke or drink alcohol during pregnancy. More controvers...

Awarded: NOK 10.0 mill.

Project Period: 2021-2029

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Animal Model for evaluation of Innovative immunotherapy DEsigns - (AMIDE)

The recent approval by the American Federal Drug Agency (FDA) and the European Medicines Agency (EMA) of new immunotherapies for blood cancers has opened new hopes and avenues for the treatment of patients with cancer. Two new drugs, called YEScarta and Kymriah, use the patient’s own T-cells gene...

Awarded: NOK 12.0 mill.

Project Period: 2021-2026

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Deciphering Heterogeneity to provide treatment for metastatic Endometrial cancers

Endometrial cancer (EC) is the most common pelvic gynecological malignancy in industrialized countries. Although most women are cured of their disease, approximately 20% either present with metastatic disease or develop metastases after initial therapy. In these cases, the cancer is universally f...

Awarded: NOK 11.3 mill.

Project Period: 2021-2027

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Engineering NK cells for improved functionality in immunotherapy

Cancer survival rates have improved significantly over the past century, yet many types of cancer remain challenging to treat with traditional methods. Recently, harnessing the immune system has shown promise in fighting cancer. Our research group is interested in a cell type of the immune system...

Awarded: NOK 12.0 mill.

Project Period: 2021-2026

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Targeting lung cancer cells by selective translation of mRNA therapeutics

Many of the cellular functions are carried out by proteins. mRNA therapeutics are man-made molecules which - when introduced into cells - act as a blueprint to make these proteins. Virtually any protein of choice can be made using this technique, but the current methods to predesignate which cell...

Awarded: NOK 12.0 mill.

Project Period: 2021-2025

Location: Trøndelag - Trööndelage

FRIPROSJEKT-FRIPROSJEKT

Decoding psychotic disorders into patterns of polygenic pleiotropy

The relationship between cannabis use and psychiatric disorders has been widely debated. Cannabis is a psychoactive and addictive drug which sometimes produces psychosis-like symptoms. Psychiatric disorders such as schizophrenia and bipolar disorder are characterized by a severely disturbed perce...

Awarded: NOK 12.0 mill.

Project Period: 2021-2025

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Decoding tumor cell invasive switching

A major milestone of the project has been passed. We have performed two screens in parallel, or more accurately, one screen from two different data sources. One data source is broadly based on the cancer literature, likely genes that will affect tumour cell growth and potentially metastasis. The ...

Awarded: NOK 7.2 mill.

Project Period: 2021-2027

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Unravelling the role of oxytocin in behavioural flexibility

Behavioural flexibility, which is the ability to appropriately adjust one’s behaviour in response to a changing environment, is associated with improved quality of life and a higher resilience to stressors. Conversely, behavioural inflexibility is linked with several psychiatric illnesses, such a...

Awarded: NOK 12.0 mill.

Project Period: 2021-2027

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Randomized clinical trial assessing balloon occlusion of the aorta for controlling life-threatening postpartum bleeding in Africa

The leading direct cause of maternal mortality worldwide is heavy bleeding after birth or postpartum haemorrhage (PPH). Every day, over 150 women are dying in the world because of PPH, equivalent to one plane crash per day. Many of these deaths happens in low- and middle-income countries. Many ti...

Awarded: NOK 12.5 mill.

Project Period: 2021-2027

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Cell-based therapy for inherited bleeding disorders

Hereditary factor VII deficiency is a rare bleeding disorder that occurs more frequently in Norway than in most other countries. The condition is caused by mutations in the F7 gene, leading to lower FVII activity in the blood and acute bleeding episodes of varying severity. The only available tre...

Awarded: NOK 12.0 mill.

Project Period: 2021-2026

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Does sleep duration affect the brain?

There is concern that insufficient sleep is a negative factor for physical, mental, and cognitive health in society. Some have even argued that our modern world suffers from a “sleeplessness epidemic.” After reviewing the scientific evidence, we find no convincing research showing that short slee...

Awarded: NOK 12.0 mill.

Project Period: 2021-2028

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Mitochondria transfer in malignant brain tumors

Mitochondria are the power houses of the cell, involved in energy production and many other cellular functions. Mitochondria in cancer cells are often less functional compared to normal cells. Cancer cells can compensate for this drawback as they often rely on glycolysis for energy production eve...

Awarded: NOK 11.7 mill.

Project Period: 2021-2027

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Mind the gap: fusing brain imaging and genetics data to reveal mechanisms underlying psychiatric disorders

Psychiatric disorders are among the main contributors to morbidity and disability globally. While the past few decades have provided first insights, our understanding of the biological processes underlying the disordered brain is still limited. BRAINGAP seeks to build up a mechanistic understandi...

Awarded: NOK 12.0 mill.

Project Period: 2021-2028

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

New concepts of protein regulation in health and disease

All aspects of the life of a human cell are controlled by proteins. Proteins can be modified by different chemical groups functioning as tags controlling protein function. One particular chemical group, acetyl, is coupled to nearly every single protein in our cells. Our research group at UiB has ...

Awarded: NOK 12.0 mill.

Project Period: 2021-2026

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Targeting Aryl Hydrocarbon Receptor for Breast Cancer Treatment and Improved Immunotherapy

Breast cancers, like many other cancers, develop through a complex set of events, including DNA mutations and changes in the way the immune system fights cancer. The immune system plays an important role in protecting us from cancer, but these protective mechanisms are lost when tumours are forme...

Awarded: NOK 12.0 mill.

Project Period: 2021-2025

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Exploring the transformation potential of haematopoietic stem cells under niche pressure, and its therapeutic targeting.

Acute myeloid leukaemia (AML) is a deadly disease characterised by aberrant myeloid lineage proliferation and differentiation. Our previous work has shown that IL-1 receptor antagonist (IL-1RN), contributes to myeloproliferation in health and in presence of known malignant mutations in mouse mode...

Awarded: NOK 12.0 mill.

Project Period: 2021-2027

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Digital Lives: Impact of Social Media Use on Psychological and Social Development from Childhood to Adulthood

Almost all adolescents use social media. How does social media use affect psychological and social development from childhood to adulthood? What characterizes social media use that promotes or hampers such development? This project aims to provide answers to these questions. To generate such know...

Awarded: NOK 12.0 mill.

Project Period: 2021-2026

Location: Trøndelag - Trööndelage

FRIPROSJEKT-FRIPROSJEKT

Pack a pill in a PACA: PACA nanomedicines for targeting age-related changes in liver endothelium to prevent age-related diseases

When we age, we have numerous reduced, or even loss of, bodily functions. The liver is no exception - despite being one of the most robust organs in the body, the liver also ages. One such age-affected function is the communication between the blood and the liver's major cells, the hepatocytes. I...

Awarded: NOK 12.3 mill.

Project Period: 2021-2026

Location: Troms - Romsa - Tromssa

FRIPROSJEKT-FRIPROSJEKT

Learning from Mistakes: A Longitudinal Neuroimaging-Cohort-Registry Study

Adolescence, the transitional period between childhood and adulthood, involves extensive developmental changes in the body, behavior, cognitive functions, and the brain. A key characteristic of this prolonged neurocognitive development is the maturation of self-regulation functions and underlying...

Awarded: NOK 12.1 mill.

Project Period: 2021-2028

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Biomimetic Proteolipid Multilayers – Structure and Properties

In order to fully understand biological phenomena, one must obtain detailed information on the structure and function of biomolecules. Proteins are large molecules that can also be considered to be biological nanoparticles. This project focuses on specific biological structures: molecular multila...

Awarded: NOK 13.6 mill.

Project Period: 2021-2026

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Exploring T cell – B cell collaboration resulting in autoimmunity

Autoimmune diseases occur when the body’s immune system starts attacking its own, healthy cells. Both genes and factors in the environment, which are often unknown, are involved in development of autoimmune diseases. In particular, so called MHC class II genes appear to be important. How these MH...

Awarded: NOK 12.0 mill.

Project Period: 2021-2025

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Homo sociabilis and genomics of the good life. Rethinking wellbeing and social relations – the role of genetic and environmental processes

Most people wish for a long and good life. In this innovative and genetically sensitive project, we investigate what creates wellbeing - experiences of joy, satisfaction, engagement, mastery, and meaning, as well as the absence of mental health problems. The central question is: Which processes a...

Awarded: NOK 11.5 mill.

Project Period: 2021-2027

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Epigenetic encoding of the thermogenic capacity of human adipose tissue

Fat tissue is a major area of research because fat tissue can store energy in the form of lipids in white fat cells (called white adipocytes), and dissipate energy by heat in another type of adipocytes (called brown adipocytes) that are thermogenic. Worldwide, more than 2 billion adults are overw...

Awarded: NOK 12.0 mill.

Project Period: 2021-2025

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

The BRIDGE study: Bridging pregnancy and fetal microchimerism with longterm female maternal cardiovascular and neurovascular health

Cardiovascular disease (CVD), including stroke, is a leading cause of premature death and disability in women, and is expected to increase substantially in years to come. The BRIDGE study aims to fill the knowledge gap surrounding CVD in women, and to identify new targets for early prevention and...

Awarded: NOK 12.0 mill.

Project Period: 2021-2025

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

DUCT chip – Immune studies using a bile duct on a chip

The interaction between the immune system and the environment is believed to be the driving force behind most inflammatory and auto-inflammatory diseases. In this project we will adapt these scientific questions to microfluidics system where pipes and pumps will represent the bile ducts and blood...

Awarded: NOK 12.0 mill.

Project Period: 2021-2028

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Neurophysiological Mechanisms of Human Auditory Predictions: From population- to single neuron recordings.

The ability to predict upcoming events is a core feature of human cognition. Even though predictions are widespread, we do not fully understand how they are computed in the brain. What are predictive processes, and why are they important to study? In a broad sense, predictive processes incorpora...

Awarded: NOK 12.0 mill.

Project Period: 2021-2026

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

Dissecting differentiation and diversification of gut macrophages

Macrophages are a subset of immune cells that are residing in all our organs. They are involved in both organ development and homeostasis and interact with cells such as parenchymal cells, endothelial cells, mesenchymal cells and nerves. Macrophages are also an integral part of our immune system....

Awarded: NOK 12.0 mill.

Project Period: 2021-2025

Location: Oslo

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