848 projects

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FRIPROSJEKT-FRIPROSJEKT

Chronic wasting disease prions from Norwegian cervids: Assessing the pathogenesis, shedding, spillover and zoonotic potential

The persistent spread of Chronic Wasting Disease (CWD) still represents a threat for cervid populations in North America, and its uncertain zoonotic potential is a public health concern. Since the first case of CWD detected in Norwegian reindeer and moose in 2016, the disease is found in several ...

Awarded: NOK 9.6 mill.

Project Period: 2023-2029

Location: Akershus

FRIPROSJEKT-FRIPROSJEKT

The illusion of empty blind zones: How things may seem to appear out of nowhere in magic shows and road accidents

In previous investigations, we have described a novel recently discovered illusion that evokes a strong feeling that the blind spot behind an obstruction of view is empty. This illusion of empty blind spots plays a pivotal role in stage magic and the art of conjuring. Because the blind zone behin...

Awarded: NOK 9.6 mill.

Project Period: 2023-2027

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Neurodevelopmental cascades and resilience in the context of the family environment

Five to ten percent of children and young people have neurodevelopmental conditions such as autism and ADHD. People with neurodevelopmental conditions can lead healthy, meaningful and happy lives, but early and high-quality support is important to achieve these outcomes for as many as possible. M...

Awarded: NOK 8.0 mill.

Project Period: 2023-2027

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Parenthood, childlessness, and mental health in times of falling fertility

In general, parents and people in stable relationships have better mental health than the childless and single. In the last decades, however, more people than before are single or childless. These societal changes could have consequences for the mental health of the population, but it is largely ...

Awarded: NOK 10.1 mill.

Project Period: 2023-2027

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Epigenetic Control of Obesity-induced Tumor Initiation in Breast Cancer

Being obese increases our risk of developing 13 types of cancer – these are cancers that non-obese individuals may not develop. Consequently, being obese is estimated to be the underlying reason for about 500 000 cancer cases each year. This project aims to find out why. And further, if we can de...

Awarded: NOK 9.6 mill.

Project Period: 2023-2027

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Boosting the bee: Leveraging the structural capabilities of the lipoprotein Vitellogenin to support honey bee (Apis mellifera) health.

Vitellogenin (Vg) is an important protein: it is as old as multicellular animal life on Earth, about 700 million years old. Today, it is present in almost all animals that lay eggs. Vg is essential for eggs to be viable. But what is more: Our previous work revealed that it also can be a major pla...

Awarded: NOK 10.1 mill.

Project Period: 2023-2027

Location: Akershus

FRIPROSJEKT-FRIPROSJEKT

FlickerPRINT for Monitoring Intracellular Droplet Organelles

Historically, a central paradigm in cellular organisation is that the cell is compartmentalised into functionally specialised membrane-bound organelles such as the nucleus, mitochondria, lysosomes and vacuoles. However, in recent years it has been shown across all branches of life that another i...

Awarded: NOK 9.6 mill.

Project Period: 2023-2027

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Early Life SocioEconomic status, mental health, and educational performance: an evaluation of sensitivity to the environment (ELiSE)

Social inequality plays out in the neighborhood in which the child lives. Poverty in both families and neighborhoods is linked to poor mental health and school difficulties in children. Together, these factors help to determine a child's future health and completion of education in adulthood. We ...

Awarded: NOK 9.6 mill.

Project Period: 2023-2029

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Decoding the intracellular complement system in inflammatory reactions

We have previously demonstrated that intracellular complement, particularly the C5 system, contributes to NLRP3 inflammasome activation upon sensing of danger signals in monocytes and macrophages. However, the exact mechanisms by which intracellular complement regulates this process have not been...

Awarded: NOK 9.6 mill.

Project Period: 2023-2026

Location: Trøndelag - Trööndelage

FRIPROSJEKT-FRIPROSJEKT

Unlocking molecular diversity in the brain-to-body gateway: spatial transcriptomics and proteomics of brainstem-to-spinal cord projections

Packed with an intricate assembly of neurons and circuits serving vital functions (motor, respiratory, cardiovascular, hormonal regulation, temperature and pain regulation, sleep) the brainstem is the LEAST expendable part of the brain. These multiple, critical functions are mediated by a large p...

Awarded: NOK 9.6 mill.

Project Period: 2023-2027

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

DISTRIBUTE: Do Fundamental Resource Distribution Principles of Need, Effort & Coalition Size Manifest Even in the Infant Mind ?

DISTRIBUTE seeks to reveal which meaningful mechanisms for coordinating resource distribution are so basic that they manifest even in the preverbal mind. The distribution of resources, help, territory and priority decision rights are central dilemmas for group- living species and the core of poli...

Awarded: NOK 9.6 mill.

Project Period: 2023-2029

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Improving the monitoring, treatment and prevention of population drug abuse

Illegal drugs are a major public health concern and a top-ten cause of death and disability in Norway. The problem is hard to manage. Administrative registers identify only the users that have been unable or unwilling to to hide their use, there is only weak and limited data available regarding t...

Awarded: NOK 9.6 mill.

Project Period: 2023-2029

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

The machinery positioning chlorophyll in Cytochrome b6f

Photosynthesis, the process by which plants convert sunlight into energy, is fundamental to life on Earth. Chlorophyll, the light-capturing molecule, must be precisely positioned within proteins such as cytochrome b6f to drive energy transfer in photosynthesis. The cytochrome b6f complex regulate...

Awarded: NOK 9.6 mill.

Project Period: 2023-2026

Location: Rogaland

FRIPROSJEKT-FRIPROSJEKT

Paving the way for rational RNA-ligand design

The vast majority of targets for approved drugs are proteins. In recent years, it has been increasingly realized that also RNA molecules constitute promising targets. However, compared to protein targets, they are vastly underexplored. By targeting RNA, the functions of currently undruggable prot...

Awarded: NOK 9.6 mill.

Project Period: 2023-2027

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

ECHO - Evolutionary Convergence in Historical Oceans: The case of whales and ichthyosaurs

The research project ECHO aims to understand the phenomenon of convergent evolution through a classic example: whales and ichthyosaurs. Whales are mammals, while ichthyosaurs are extinct reptiles, and both had ancestors on land. We use data from the outside and inside of skeletons to answer how i...

Awarded: NOK 8.0 mill.

Project Period: 2023-2026

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Coordination between cell wall integrity and cell cycle activity in plants

Plant cell walls surround every plant cell and are mainly built from carbohydrates such as cellulose, which provides mechanical strength. Cellulose microfibres, with tensile strength comparable to steel, form the backbone of plant fibres used in food, textiles, and bio-based materials. Beyond the...

Awarded: NOK 7.9 mill.

Project Period: 2023-2026

Location: Trøndelag - Trööndelage

FRIPROSJEKT-FRIPROSJEKT

Biogeochemical processes governing boreal C cycling

Positive feedbacks will have a decisive impact on the climate by potentially amplifying the formation of greenhouse gases such as CO2 and CH4 (methane). BioGov focuses on the carbon cycle in northern boreal areas by examining the significance of forests, soil, and permafrost thawing for the trans...

Awarded: NOK 12.1 mill.

Project Period: 2022-2027

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Polygenic and psychosocial interplay in brain development across mental disorders

Mental disorders are caused by inherited vulnerability interacting with environmental factors. While most mental disorders are diagnosed in early adulthood, the disease processes emerge during childhood and adolescence. Nevertheless, most studies have focused on adults after the onset of the illn...

Awarded: NOK 12.5 mill.

Project Period: 2022-2027

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

SmartSense: Decoding metabolic and epigenetic disorders caused by adolescence sleep deprivation

Obesity and bad sleep habits among teenagers are two rising health concerns that seems intertwined. Indeed, many studies trace obesity to poor sleep hygiene. This is especially concerning because (i) adolescents get less and less sleep as screens invade their bedroom and (ii) obese children have ...

Awarded: NOK 12.5 mill.

Project Period: 2022-2027

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

AHeadForLife - Societal and environmental determinants of brain and cognition

Cognitive function – how we attend, remember, and reason – is critical to all aspects of human life. Cognitive function affects how we handle daily tasks, but also how we make sense of the world around us and build social relationships. Cognitive function has biological underpinnings, but is also...

Awarded: NOK 12.5 mill.

Project Period: 2022-2028

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Actin acetylation in cancer metastasis: a tale of a forgotten tumor suppressor

All aspects of the life of a human cell are controlled by proteins. Proteins can be modified by different chemical groups functioning as tags controlling protein function. One particular chemical group, acetyl, is coupled to nearly every single protein in our cells. Our research group at UiB has ...

Awarded: NOK 12.5 mill.

Project Period: 2022-2028

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Hub Molecules Of Life

The previously established workflow among all partners has been further consolidated during the present project period. Besides regular online meetings, all partners have met in person end of September 2025 in Tromsø in conjunction with a Marie Skladowska Curie Action that three of the four partn...

Awarded: NOK 12.5 mill.

Project Period: 2022-2028

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Machine Intelligence in HEADaches - Artificial Intelligence and Machine Learning for Diagnostics and Treatment of Primary Headaches

Headache disorders such as migraine, tension-type headache and cluster headache are some of the most burdensome diseases worldwide. Yet, they are often neglected, and patients suffer in pain for a long time before they get a correct diagnosis and effective treatment. The headache disorders have...

Awarded: NOK 12.5 mill.

Project Period: 2022-2027

Location: Trøndelag - Trööndelage

FRIPROSJEKT-FRIPROSJEKT

Long-term effects of SARS-CoV-2 infection: An interdisciplinary observational and interventional study program

Long-term effects of COVID-19 have become increasingly recognized. Acute lung damage may be followed by chronic impairment of lung function. COVID-19 may also be associated with increased risk of chronic cardiac and vascular injury, and persistent shortness of breath may be a symptom of both pulm...

Awarded: NOK 12.5 mill.

Project Period: 2022-2027

Location: Oslo - Oslove

FRIPROSJEKT-FRIPROSJEKT

Understanding melanin-based visual signalling in Atlantic salmon: A multi-disciplinary exercise

Distinct pigmentation patterns formed by black spots or stripes are common in a range of species throughout the animal kingdom – from insects to mammals, birds, and fish. This project is about the characteristic black spots on the otherwise silvery skin of salmon. These spots consist of the black...

Awarded: NOK 5.7 mill.

Project Period: 2022-2027

Location: Ukjent Fylke

FRIPROSJEKT-FRIPROSJEKT

The role of Blastocystis in inflammatory bowel disease.

When people suffer from severe intestinal problems, the hospital often examines the patient's stool to look for clues. If the hospital lab finds small organisms called microbial eukaryotes, they are often thought to be the cause of the disease and the patient is given medication to eliminate thes...

Awarded: NOK 6.2 mill.

Project Period: 2022-2026

Location: Rogaland

FRIPROSJEKT-FRIPROSJEKT

Physiological basis of insect community responses to climate change

The earth’s climate is rapidly changing and predicting the biological response to these changes is a major scientific challenge. To date, most research has been focused only on understanding how warmer temperatures impact organisms. Yet, less is known about the combined impacts of rising tempera...

Awarded: NOK 12.0 mill.

Project Period: 2022-2027

Location: Trøndelag - Trööndelage

FRIPROSJEKT-FRIPROSJEKT

Unravelling fundamental mechanisms of bacterial exopolysaccharide catabolism for use in food and health applications

Bacteria produce many chemical compounds, including carbohydrates that play key biological roles. Exopolysaccharides (EPS) make bacteria smooth and slimy and are crucial for both bacteria and humans. Pathogens use EPS in biofilms to evade immunity and antibiotics, while in food production EPS imp...

Awarded: NOK 10.0 mill.

Project Period: 2022-2027

Location: Akershus

FRIPROSJEKT-FRIPROSJEKT

A climate for spruce? New forest management to mitigate bark beetle risks under climate change

Gran er et av de viktigste treslagene i Europa, både i økonomisk forstand og fordi gran bidrar med viktige økosystemtjenester slik som karbonbinding og produksjon av karbonnøytrale råvarer. Fremtiden til kommersielt granskogbruk trues imidlertid i mange land av enorme utbrudd av stor granbarkbill...

Awarded: NOK 12.5 mill.

Project Period: 2022-2027

Location: Akershus

FRIPROSJEKT-FRIPROSJEKT

Fragaria defence mechanisms and domestication of wild resistance genes

Both cultivated and wild plants can be attacked by microorganisms (pathogens) that cause disease, which is of great scientific and economic importance. Infections involve complex biological mechanisms with numerous gene products and signals in both the plant and the pathogen. To combat disease, w...

Awarded: NOK 9.0 mill.

Project Period: 2022-2027

Location: Akershus

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