43 projects

Date from new to old

BEDREHELSE-Bedre helse og livskvalitet

Environmental noise and childrens`s sleep and health - using the MoBa cohort

Is there an association between nocturnal road traffic noise (NRTN) and children`s sleep duration? And between NRTN and children`s memory, attention and BMI? Few studies have studied these questions, which are the main questions in the present study. Some studies on adults, and a few on childr...

Awarded: NOK 4.1 mill.

Project Period: 2013-2017

Location: Oslo

BEDREHELSE-Bedre helse og livskvalitet

Immunotoxic effects of prenatal and childhood exposure to perfluoroalkyl substances

The environmental pollutants perfluoroalkyl substances (PFASs) are ubiquitously distributed in wildlife, and studies have shown that the PFASs can cross the human placenta and reach the foetus. In our birth cohort BraMat, prenatal exposure to PFASs was associated with a reduced vaccination respon...

Awarded: NOK 5.5 mill.

Project Period: 2013-2019

Location: Oslo

BEDREHELSE-Bedre helse og livskvalitet

Inhalation and prenatal exposure to phthalates: influence on airway immunology

Phthalates are a class of chemicals that leak out of the plastic products that surround us in our everyday life. They are present in most indoor environments, where we are exposed through inhalation and dermal uptake. We are also exposed to phthalates through ingestion of food and beverages and a...

Awarded: NOK 5.8 mill.

Project Period: 2013-2017

Location: Oslo

BEDREHELSE-Bedre helse og livskvalitet

Inflammation by Mixtures - Exploring the fundamentals of proinflammatory responses by complex combustion-derived pollutants

Diesel exhaust particles (DEP) and other combustion particles constitute an important fraction of ambient air pollutants in urban environments. Such particles may cause or exacerbate inflammatory responses in the body. Chronic, low-grade inflammation is considered a central mechanism for developm...

Awarded: NOK 4.1 mill.

Project Period: 2013-2018

Location: Oslo

BEDREHELSE-Bedre helse og livskvalitet

Signaling Impairments GeNerated by Endocrine Disruptors.

Environmental pollutants like persistent organic pollutants (POPs) are man-made chemicals that are omnipresent in our environment. We previously reported that POPs present in fatty fish (e.g. farmed Atlantic salmon) could contribute to insulin resistance, a hallmark of type 2 diabetes. We have no...

Awarded: NOK 5.9 mill.

Project Period: 2013-2016

Location: Vestland

BEDREHELSE-Bedre helse og livskvalitet

Do environmental pollutants interact with stress responses?

Contaminants in the environment is can cause adverse effects on human and animal health. Persistent organic pollutants (POPs) accumulate in the food chain and has created elevated levels of contaminants in organs, blood serum and breast milk in humans and animals. It has in recent years been a gr...

Awarded: NOK 3.7 mill.

Project Period: 2012-2016

Location: Akershus

BEDREHELSE-Bedre helse og livskvalitet

INSULIN RESISTANCE AND OBESITY The sweet aftertaste of exposure to dietary environmental persistent organic pollutants.

Environmental contaminants bioaccumulating in the seafood web are associated with development of life style diseases like obesity and diabetes. Mice fed a diet added the most prominent persistent organic pollutants (POPs) present in seafood over time have been evaluated for the development of obe...

Awarded: NOK 5.9 mill.

Project Period: 2012-2016

Location: Vestland

BEDREHELSE-Bedre helse og livskvalitet

Effects of realistic mixtures of mould and mycotoxins on the immune system and assessment of human exposure

-Monocytes are immune cells that may be differentiated into macrophages or dendritic cells (DC), depending on environmental conditions. Macrophages exist in minimum two different forms, proinflammatory M1 and anti-inflammatory M2 cells and the functioning of the immune system is dependent on the ...

Awarded: NOK 5.0 mill.

Project Period: 2012-2016

Location: Akershus

BEDREHELSE-Bedre helse og livskvalitet

Pre-and postnatal exposure to environmental toxicants and child health with main focus on growth/obesity

According to a recent WHO/UN report, pollutants with hormone-causing effects are a major threat to human health. We are exposed to an ever-increasing number of such chemicals. One of the many potential adverse health effects is obesity. In this project we found strong evidence for an effect on we...

Awarded: NOK 5.0 mill.

Project Period: 2012-2022

Location: Oslo

BEDREHELSE-Bedre helse og livskvalitet

Transmaternal exposure to bisphenol A and phthalates and the development of type 1 diabetes

I have exposed mice (NOD mice), that spontaneously develop autoimmune diabetes type 1 (T1DM) to bisphenol A (BPA) and to a mixture of phthalates, mimicking human mixed exposure. Our results indicate that BPA, but not phthalates have negative effects in the pancreas (reduced macrophage function an...

Awarded: NOK 3.4 mill.

Project Period: 2012-2016

Location: Oslo

BEDREHELSE-Bedre helse og livskvalitet

Glycotoxins from food and their impact on widespread lifestyle diseases

Glyoxal and methylglyoxal, called glykotoxins are formed when sugar-containing foods are heat-treated, and are therefore found in many different foods and beverages. Glyoxal and methylglyoxal are also formed in the body and the formation is proportional to increasing blood glucose level. Diabetic...

Awarded: NOK 4.2 mill.

Project Period: 2012-2016

Location: Oslo

BEDREHELSE-Bedre helse og livskvalitet

Traffic noise, insomnia and risk factors in the pathway to cardiovascular disease

Increasing traffic and urbanization makes traffic noise a growing public health problem. About 1.5 million Norwegians are exposed to noise levels outside the residence that exceeds the recommended values of 55 dB. Estimates from the World Health Organization (WHO) show that traffic noise contri...

Awarded: NOK 5.6 mill.

Project Period: 2011-2016

Location: Oslo

BEDREHELSE-Bedre helse og livskvalitet

Perfluorinated compounds and type 2 diabetes: gene environment interactions in the Norwegian Women and Cancer study (NOWAC)

Awarded: NOK 4.1 mill.

Project Period: 2011-2016

Location: Troms - Romsa - Tromssa

BEDREHELSE-Bedre helse og livskvalitet

Persistent organic pollutants (POPs), development, and cancer - a multi-tiered approach (MultiPOP)

This project aimed to investigate potential adverse effects on development tumorogenesis resulting from combined exposure with persistent organic pollutants (POPs), including also perfluorinated compounds (PFC) and mixtures thereof, reflecting natural exposure scenarios. To explore this chain of ...

Awarded: NOK 4.5 mill.

Project Period: 2011-2017

Location: Akershus

MILPAAHEL-Miljøpåvirkning og helse

Searching the origin of the insulin resistance syndrome

Persistent organic pollutants (POPs) are toxic and hazardous chemicals omnipresent in our environment and food chains. These pollutants are of particular public health concern since their bio-accumulate in humans for many years because of their resistance to metabolic degradation. Recently, expo...

Awarded: NOK 2.0 mill.

Project Period: 2011-2013

Location: Vestland

BEDREHELSE-Bedre helse og livskvalitet

The influence of prenatal and postnatal exposure to dioxins and PCBs on ADHD related behaviour in Norwegian children

Exposure to dioxins and polychlorinated biphenyls (PCBs) during pregnancy and breastfeeding may lead to adverse health effects in children. The aim of this thesis was to study determinants of exposure to dioxins and PCBs during pregnancy and early childhood and examine associations between early ...

Awarded: NOK 5.5 mill.

Project Period: 2011-2016

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Endocrine disrupting chemicals in Norwegian infants and adolescents and the subsequent risk of asthma

The increased prevalence of asthma and allergy in the 'western world' during the last decades coincide with the production and use of phthalates (plasticizers) and bisphenol A (BPA) in consumer products. Toxicological and epidemiological studies have prev iously indicated an association between e...

Awarded: NOK 3.8 mill.

Project Period: 2011-2014

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Inflammatory, genotoxic and tumorigenic effects of multi-walled carbon nanotubes with emphasis on the interleukin-1 family

1) In vivo animal studies in IL1-KO mice We have been working on the 28 days exposure study performed in the IL1-WT and IL1-KO mice last year. We have extracted total RNA from the blood, lungs, liver and pleura. We have investigated the mRNA levels in pools from lung, pleura and blood on a Mouse...

Awarded: NOK 3.0 mill.

Project Period: 2011-2015

Location: Oslo

BEDREHELSE-Bedre helse og livskvalitet

Substituted furans: A novel group of food processing contaminants and their influence on intestinal cancer development and human health risk

Heating of food increases the duration of foods and make the food safer by reducing the level of microorganisms. On the other hand, heat treatment of food for a prolonged time and at high temperature can produce unwanted and harmful substances in the foods. Some of these substances are well studi...

Awarded: NOK 4.4 mill.

Project Period: 2011-2016

Location: Oslo

BEDREHELSE-Bedre helse og livskvalitet

Fungal particles in indoor air: occurrence and toxic properties of viable and non-viable spores, hyphae and fragments

PhD1 Liberation of spores and hyphal fragments from fungal cultures (Aspergillus fumigatus (AF), Aspergillus versicolor (AV) and Penicillium chrysogenum (PC)) was studied using 2 aerosol generators, 3 culture media, 2 air velocities and 2 and 8 week old cultures. Sub-? particles were liberated f...

Awarded: NOK 7.6 mill.

Project Period: 2010-2019

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Internal exposure to bisphenol A and phthalates - Sources, pathways and relationship to effects

Phthalates and bisphenol A are commercially important classes of industrial chemicals used in a wide variety of consumer products. Many of these compounds have been identified as endocrine disruptors causing functional and structural impairment of reprodu ction and development. Furthermore, epide...

Awarded: NOK 5.4 mill.

Project Period: 2010-2014

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Air pollution, birth outcomes and early respiratory health - taking gene environmental interactions into account

The relationship between ambient air pollution and a number of health conditions has been studied extensively, but there are still uncertainties. This is particularly the case for the relationships between ambient air pollution exposure during pregnancy and maternal health during pregnancy, preg...

Awarded: NOK 3.6 mill.

Project Period: 2010-2016

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Neurodevelopmental toxicity caused by environmental exposure to phthalates and Bisphenol A

Awarded: NOK 3.0 mill.

Project Period: 2010-2015

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Researcher project: Interplay between environmental contaminants, genes and diet in obesity and intestinal cancer

Increased obesity and cancer are seen the last three decades. Obesity is a risk factor for intestinal cancer, but the mechanisms are not clear. Simultaneously, we are exposed to more environmental contaminants. We studied the association between obesity, caused by mutation or high fat diet, and i...

Awarded: NOK 4.8 mill.

Project Period: 2010-2014

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Nutrients, genes and epigenetic modification of DNA in relation to asthma and atopy.

This project is based on the Norwegian Mother and Child Cohort Study (MoBa). While limited human evidence is available on the association of childhood atopic diseases with maternal diet during pregnancy and gene methylation in the offspring, new murine st udies from our collaborators at the Natio...

Awarded: NOK 4.3 mill.

Project Period: 2008-2014

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Importance of components and sources in particle-induced lung inflammation: Role of PAHs and metals

Ambient particulate matter (PM) contribute to the development of adverse health effects in the lung and cardiovascular systems. PM has a complex composition and may contain a variety of different organic compounds and metals. We will investigate the possi ble role of PAHs and metals in PM-induced...

Awarded: NOK 5.4 mill.

Project Period: 2008-2013

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Salmon and contaminants: impacts on insulin sensitivity and metabolic diseases

Although marine food has long been known to have health properties, its roles and impacts on insulin sensitivity and metabolic diseases (e.g. type 2 diabetes, obesity, hypertension, coronary heart diseases etc.) remain still unclear and worldwide debated. Beside its potential health effects, rec...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Vestland

MILPAAHEL-Miljøpåvirkning og helse

Oil induced autoimmune disease

We here present evidence that environmental exposure to immunoadjuvants in particular mineral oils, may precipitate autoimmune diseases in susceptible individuals, and that a novel class of genes encoding leukocyte regulatory receptors contribute to this susceptibility. The evidence is based on t...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Environmental mercury and human health in Arctic Norway

Persistent pollutants in Arctic areas have received much attention. It is well known that these contaminants accumulate in food webs and potentially cause severe physiological damages to top level predators including humans. People in Arctic regions tend to be more exposed to these pollutants due...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Type 1 Diabetes and the Hygiene Hypothesis (helminths and parasites, and symptomatic virus infections)

Type 1 Diabetes (T1D) is one of the most prevalent chronic diseases with childhood onset. The incidence of T1D has increased with 25% during the last three years, and threefold during the last generation. The disease has a multifactorial aetiology and app ears after a long period where the immune...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Oslo

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