0 projects

BIA-Brukerstyrt innovasjonsarena

Designer Internal Standards

Hovedmålet med prosjektet er å designe og syntetisere et universelt sett av 10-20 syntetiske internstandarder til bruk ved analyse av legemidler i biologisk materiale, med serum og blod som primær prøvematriks. Ideen og det nye er at internstandardene "de signes" og syntetiseres etter en matrisem...

Awarded: NOK 3.8 mill.

Project Period: 2006-2009

Location: Trøndelag - Trööndelage

BIA-Brukerstyrt innovasjonsarena

Immunmodulatorer brukt som hjelpestoff ved immunterapeutisk behandling

Prosjektet bygger på omfattende studier i de siste 15 år av den sykdomsforebyggende virkning av immunstimulerende beta-glukaner. Grunnleggende forskning har klarlagt sammenhenger mellom kjemisk struktur og immunologisk virkning av denne stoffgruppen. Tekn ologisk utviklingsarbeid har gjort det mu...

Awarded: NOK 12.6 mill.

Project Period: 2006-2011

Location: Troms - Romsa - Tromssa

BIA-Brukerstyrt innovasjonsarena

Development and testing of drug candidates for male contraceptives

This project is a drug discovery R&D effort aiming at developing and testing drug candidates for male contraceptives. The project will be performed in a collaboration between Spermatech AS, the University of Oslo, the Norwegian Biotechnology Center, the U niversity of Tromsø, and the National Hos...

Awarded: NOK 7.3 mill.

Project Period: 2006-2009

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional Genomics of Regulatory T cells - Novel Therapeutic Strategies for Immunomodulation

The main goal of the research plan is to understand how the immune system controls immune reactivity and balances self-tolerance versus an efficient immune defence. This could potentially lead to new understanding of key factors in the pathogenesis of hum an disease. Specifically, we aim to inves...

Awarded: NOK 7.0 mill.

Project Period: 2006-2010

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Utvikling av analysemetode/analysekit for påvisning av bakterier involvert ved patogenese av osteoartritt

Osteoartritt (OA) er en leddsykdom som rammer 7-8% av befolkningen i den industrialiserte verden. OA affiserer leddenes beskyttende brusklag, og bryter dette ned over tid. Årsaken(e) til OA er ikke kjent. Det finnes ingen effektiv metodikk for diagnose e ller behandling av sykdommen. Diagnostikk...

Awarded: NOK 9.7 mill.

Project Period: 2006-2010

Location: Troms - Romsa - Tromssa

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Utnytting av molekylære metoder i miljøvennlig bekjempelse av sjukdommer i gulrot

Prosjektet omfatter optimal utnyttelse av bioteknologiske metoder (PCR) for å bekjempe plantesjukdommer i gulrot, som er en av de viktigste grønnsakvekstene i Norge med førstehåndsverdien på ca 150 mill. kr. årlig. Soppsjukdommer er årsak til store tap b åde under produksjon og omsetning av gulr...

Awarded: NOK 2.7 mill.

Project Period: 2006-2009

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Proteomic and bioinformatic studies of Mycobacterium tuberculosis

Tuberculosis (TB) is a major communicable disease linked to poverty with a substantial death toll of about 2 million cases annually. Research is needed to develop novel diagnostic tools, novel preventive measures such as vaccines and novel antibiotics. To do so it is of paramount importance to k...

Awarded: NOK 6.2 mill.

Project Period: 2006-2010

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Genesis of B lymphomas studied by functional genomics

Background: Idiotypes (Id) are antigenic determinants in the variable regions of immunoglobulins (Ig). We have previously demonstrated that B lymphocytes partially degrade their endogenous Ig and present Id-peptides on their Major Histocompatibility Compl ex (MHC) class II molecules to CD4+ T cel...

Awarded: NOK 5.8 mill.

Project Period: 2006-2010

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Combination of chemotherapy, radiation and immunotherapy in patients with non-small cell lung cancer; improving cancer vaccine efficacy.

GemVax is in the international forefront in the development of peptide based active immunotherapy for treatment of cancer. GV1001 is a telomerase based cancer vaccine which in principle can act as a universal cancer vaccine. GV1001 is GemVax' lead com pound. The product has been developed in ...

Awarded: NOK 2.9 mill.

Project Period: 2006-2009

Location: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Festulolium with improved forage quality and winter survival for Norwegian farming

"Development of Festulolium with improved forage quality and winter survival for Norwegian farming" is a five year research project aiming to assess forage quality and winter survival of Festulolium in Norway and develop germplasm for selection of cultiva rs with superior adaptation to Norwegian ...

Awarded: NOK 15.2 mill.

Project Period: 2006-2011

Location: Akershus

BIA-Brukerstyrt innovasjonsarena

A novel antimicrobial agent for topical treatment of challenging infections caused by drug-resistant bacteria.

"Once life-saving medicines are increasingly having as little effect as a sugar pill. Since 1970, no new classes of antibacterials have been developed to combat infectious diseases. Microbial resistance to treatment could bring the world back to a pre-an tibiotic age." WHO Report 2000: Overcomi...

Awarded: NOK 8.8 mill.

Project Period: 2006-2009

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

The importance of post-translational glycosylation in the secretory pathway for expansion of the functional repertoire of gene products

Most proteins in animal and plant cells are glycosylated, a fact that must be taken into account for all aspects of protein studies, because the glycan portion often influences protein activity and cellular targeting, and more practically, protein purific ation, crystallization and structural det...

Awarded: NOK 1.6 mill.

Project Period: 2006-2009

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Utvikling og klinisk uttesting av et implantat til bruk på pasienter med ileostomi (utlagt tynntarm)

I FoU-prosjektet skal det utvikles og klinisk uttestes et implantat som skal gi pasienter med ileostomi forbedringer hva gjelder både medisinske komplikasjoner og livskvalitet. Et velfungerende stomiimplantat med et tømmesystem som også kan tillate posef rie perioder, vil representere en betydel...

Awarded: NOK 6.5 mill.

Project Period: 2006-2010

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Entry of Nanoparticles into cells: Characterization of Nanoparticles as tools to study endocytic pathways..

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Awarded: NOK 2.7 mill.

Project Period: 2006-2010

Location: Ukjent Fylke

BIA-Brukerstyrt innovasjonsarena

Development of mechanism based, novel anti-inflammatory compounds

Avexxin AS (founded in Trondheim march 2005) introduces a novel therapeutic approach for the treatment of chronic diseases including psoriasis based on more than a decade of research at Prof. Berit Johansen?s group at the Norwegian University of Science a nd Technology. The new compound interfere...

Awarded: NOK 7.8 mill.

Project Period: 2006-2009

Location: Trøndelag - Trööndelage

BIA-Brukerstyrt innovasjonsarena

Høysensitiv nanopartikkelbasert homogen assayteknologi for analytter med høy molekylvekt

Det skal utvikles en høysensitiv nanopartikkelbasert homogen assayteknologi for konsentrasjonsbestemmelse av analyttermed høy molekylvekt. Slike immunoassays er raskere, og har mye større markedsvekst enn langsomme, kostbare separasjonsbaserte assays. De har tidligere blitt utviklet for analytter...

Awarded: NOK 2.9 mill.

Project Period: 2006-2009

Location: Østfold

SIP-Strategiske instituttprogram

Planning and Organisation for improved Public Health (POPHEALTH)

Preventive public health (PPH) aims at reducing causes of health risks while strengthening the conditions contributing to improved better health. PPH implies efforts to improve health by influencing individual life styles as well as the general conditions of life facilitated by the physical envi...

Awarded: NOK 9.5 mill.

Project Period: 2006-2010

Location: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Reduced risk of Fusarium and mycotoxin contamination in Norwegian cereals by the development of a rapid screening system

Fusarium infection in cereals has become a problem world-wide. Species of Fusarium produce mycotoxins that leave the grains unsuitable for consumption. In the 2004 harvest, alarming levels of the mycotoxin deoxynivalenol (DON) was registered in grain lots of Norwegian grown wheat and oats. This ...

Awarded: NOK 11.7 mill.

Project Period: 2006-2010

Location: Akershus

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Optimising the antioxidant effect of Se in wheat

Selenium (Se) is a key antioxidant of major importance to health of living organisms. A series of stressors (e.g. radiation, chemicals) can induce free radicals in living tissues and subsequently negative effects such as oxidative stress and DNA/RNA damag e occur. The antioxidant effect of Se is ...

Awarded: NOK 5.4 mill.

Project Period: 2006-2010

Location: Akershus

FRIBIO-Biologi og biomedisin

Mechanisms behind pathogen activation and evasion of Toll-like receptor signaling

Toll-like receptors (TLRs) are signaling receptors of the innate immune system, sensing a variety of bacterial and viral components. Our central hypothesis is that immune cell recognition of invading pathogens starts with an interaction between microbial structures and TLRs. The following immune ...

Awarded: NOK 2.4 mill.

Project Period: 2005-2011

Location: Trøndelag - Trööndelage

NANOMAT-Nanoteknologi og nye materialer

Characterization of nanotubular networks on cell adhesive micro- and nano-patterned surfaces

Project: Characterization of nanotubular networks on cell adhesive micro- and nano-patterned surfaces Recently we have discovered that mammalian cells are connected by thin membrane tubes. These tubes with a diameter of 50 to 200 nm are referred to as tu nneling nanotubes (TNTs). They are a cont...

Awarded: NOK 3.2 mill.

Project Period: 2005-2010

Location: Vestland

FRIBIO-Biologi og biomedisin

Endothelial cell differentiation - a key to future therapy of chronic inflammation and cancer

Much attention is focused on understanding the role of vascular endothelial cells in disease. In several fields of medicine, there is great interest in understanding the mechanisms that regulate the generation of new vessels and endothelial cell different iation, because the future ability to man...

Awarded: NOK 1.8 mill.

Project Period: 2005-2009

Location: Oslo

FRINAT-Matematikk og naturvitenskap

Antimicrobial peptides targeted against multiresistant Staphylococcus aureus with engineered proteolytic stability.

The rate of multidrug-resistant infections is rapidly rising. Cationic antibacterial peptides are both active against resistant pathogens and have low propensity for resistance development, but due to their unfavourable medicinal properties cationic antib acterial peptides have yet been a limited...

Awarded: NOK 3.3 mill.

Project Period: 2005-2010

Location: Troms - Romsa - Tromssa

ELSA-Etiske,rettslige og samf.m. as

National moral landscapes: The Politics of Stemcells

Stemcells have occupied the centerstage of scientific, public and political awareness since its isolation in 1998. They produce golden hopes of finding future cures for a lot of diseases, but also provoke very heated and antagonistic public debates. It cr eates deep moral concers, involving the s...

Awarded: NOK 2.2 mill.

Project Period: 2005-2009

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Tools for Microbial Nucleic Acid Sample Preparation for Diagnostic and Genomic Analyses

Access to high quality nucleic acid is imperative to conduct any form of genetic analysis. Working with micro-organisms that are difficult to cultivate and/or are embedded in complex materials is a particular challenge. The market is seeking more sensitiv e, simplified, rapid and efficient method...

Awarded: NOK 6.0 mill.

Project Period: 2005-2009

Location: Oslo

YFF-Yngre, fremragende forskere

GENOMIC PLASTICITY

Directly turning a differentiated cell into a pluripotent cell would be beneficial for producing isogenic replacement cells. It would also present societal benefits by eliminating the use of cells of embryonic or fetal origin. Altering cell fate involves a reprogramming of nuclear function. We ha...

Awarded: NOK 7.0 mill.

Project Period: 2005-2010

Location: Oslo

KREFTSATS-Særutlysning kreftmidler, historikk

MOLECULAR AND BIOLOGICAL STUDIES OF CANCER METASTASIS

Metastasis, cancer spread to other organs, is the principle cause of death of cancer patients. Early detection of metastatic tumor cells, development of new treatment strategies and knowledge about how to prevent cancer metastasis are some of the most cha llenging tasks in cancer research. Our pr...

Awarded: NOK 6.0 mill.

Project Period: 2005-2009

Location: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Selection and characterization of novel cancer specific antibodies – utilization in diagnostic and therapeutic approaches

Objective: The main purpose is to identify and characterize novel breast cancer specific antibodies. Interesting candidates will be thoroughly characterized for their specificity. Fulfilling the specificity criteria their potential as diagnostic or progno stic markers will be investigated. Finall...

Awarded: NOK 4.0 mill.

Project Period: 2005-2010

Location: Ukjent Fylke

GNBIO-Grunnleggende næringsrettet bioteknologi

Novel biologically active molecules through a combined application of bioinformatics and genetic engineering

The proposed research project is intended to further develop and test a unique drug discovery platform created at the NTNU/SINTEF (Norway) and the Institute of Biomedical Chemistry (Russia), which is composed of a powerful new bioinformatics tool and a te chnology for gene manipulation of antibio...

Awarded: NOK 5.3 mill.

Project Period: 2005-2009

Location: Trøndelag - Trööndelage

GNBIO-Grunnleggende næringsrettet bioteknologi

Enzyme evolution and advanced strain engineering in biorprocess development

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Awarded: NOK 8.2 mill.

Project Period: 2005-2011

Location: Trøndelag - Trööndelage