0 projects

FRIMED-Klinisk medisin og folkehelse

Cognition and plasticity throughout the human lifespan - Neuroanatomical, neurophysiological and neuropsychological markers and mechanisms

The present proposal seeks to uncover the markers and mechanisms underlying changes in brain and cognitive behavior throughout the lifespan, and whether, and how, we ourselves can initiate, enhance or slow such changes. The goal is to detail the nature of age changes in both brain anatomy, activ...

Awarded: NOK 4.2 mill.

Project Period: 2008-2011

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cellular interactions underlying organization of cortical circuits

A major question in neuroscience is how appropriate connections are formed when the brain develops and how these connections are modified with experience. It is well established that neural circuits are fine-tuned by experience during 'critical periods' i n early postnatal life. In the visual sys...

Awarded: NOK 2.7 mill.

Project Period: 2008-2012

Location: Oslo

TJENESTER-Helse- og omsorgstjenester

Mapping the Normative Terrain of An Ethics of Care

This project is based on an assumption that health care prioritisations raise substantially ethical difficult choices. Further it is presumed that an ethics of care which take the relation to particular patients to be salient might provide important norma tive arguments to the benefit of individu...

Awarded: NOK 3.0 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Activity-dependent plasticity in visual cortex

A major question in neuroscience is how appropriate connections are formed when the brain develops. It is well established that neural circuits are fine-tuned by experience during 'critical periods' in early postnatal life. In the visual system, closing o ne eye for only a few days during a criti...

Awarded: NOK 2.7 mill.

Project Period: 2008-2012

Location: Oslo

FOLKEHELSE-Folkehelse

VIOLENCE AGAINST WOMEN-A public health problem Prospective populationsbased cohortstudies on general and reproductive health consequence

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Awarded: NOK 4.3 mill.

Project Period: 2008-2014

Location: Trøndelag - Trööndelage

FRIMED-Klinisk medisin og folkehelse

Night work, circadian gene polymorphisms and breast cancer risk among female nurses. A nested case-control study

Less than half of all breast cancers can be explained by known risk factors. Results from recent epidemiological studies have been largely consistent in suggesting a positive association between night work and increased risk of breast cancer in women. Th ese findings suggest a role of circadian ...

Awarded: NOK 3.2 mill.

Project Period: 2008-2011

Location: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Nasjonalt stamcelleforskningssenter i Helse Sør-Øst RHF - se også prosjektnr 230000 hvor midler for ny periode ligger.

Nasjonalt senter for stamcelleforskning ble etablert i 2008 ved Oslo universitetssykehus (Rikshospitalet) etter et direktiv fra Helsedepartementet og midler administrert av Norges Forskningsråd. Senterets primærhensikter har vært å øke tempoet i norsk stamcelleforskning, etablere en platform ...

Awarded: NOK 34.3 mill.

Project Period: 2008-2019

Location: Innlandet

SYKEFRAVÆR-Forskn.om årsaker til sykefrav

Facilitating and inhibiting factors and effect of interventions in return to work for patients with neck- and low back pain

Fremmende og hemmende faktorer og effekt av intervensjon for tilbakegang til arbeid hos pasienter sykemeldt for nakke- og ryggsmerter. Hensikten med prosjektet var å undersøke faktorer som påvirker sykefravær og tilbakegang til arbeid samt effekt av intervensjon sett fra et arbeidsrelatert, b...

Awarded: NOK 10.0 mill.

Project Period: 2008-2015

Location: Oslo

PSYKISK-Psykisk helse

Mothers of children with congenital heart disease (CHD): psychosocial problems from pregnancy through child age 3 years

Background: Mothers that are pregnant with, give birth to and take care of an infant with congenital heart disease (CHD) are at risk to develop serious psychological and social problems. Today, advanced surgery saves the life of ever more severely affecte d children with CHD. Yet, we know little ...

Awarded: NOK 6.4 mill.

Project Period: 2008-2012

Location: Oslo

NAERINGSPH-Nærings-phd

Gene regulatory effect of disease-associated DNA mutations

Menneskets genom viser stor grad av individuell variasjon, og ulike varianter er assosiert med blant annet forskjellig sykdomsutvikling. Assosiasjonsstudier og molekylærgenetisk kartlegging er viktige verktøy for identifikasjon av genomiske endringer rela tert til sykdom. Kunnskap om de biologisk...

Awarded: NOK 0.96 mill.

Project Period: 2008-2012

Location: Østfold

IT-FUNK-IT for funksjonshemmede

ALDERN - Individuelt tilpasset IKT for egenopplevd velvære og mestring for personer med demens i og rundt hjemmet

Målbildet som definert ovenfor, munner ut i følgende FoU-utfordringer: 1. Å utvikle ideer og skissere realiserbare IKT-løsninger som kan gi personer med demens økt velvære og mestring i hjemmet og i umiddelbar nærhet av hjemmet ("velværeassistent"). Løsni ngene skal være svært enkle og driftssikr...

Awarded: NOK 0.36 mill.

Project Period: 2008-2009

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Tidlig deteksjon av premaligne tilstander i kolon ved bruk av fluorescens koloskopi

Photocure utvikler innovative legemidler til diagnostikk og behandling av sykdom basert på fotodynamisk teknologi. Kolorektal cancer er den hyppigst forekommende kreftsykdommen i Norge. Antall nye tilfeller er beregnet til å øke med om lag 34 % frem til 2 020. Dette innbærer en økning fra dagens ...

Awarded: NOK 9.1 mill.

Project Period: 2008-2010

Location: Oslo

GLOBHELS-Global helse

Development of novel vaccine candidates to prevent primary or reactivated tuberculosis

Mycobacterium tuberculosis is among the major infectious pathogens in the world, and has a considerable impact on children and adults of disease endemic countries. Increasing spread of multi-drug-resistant tuberculosis and the general failure of the BCG v accine, have made vaccine development aga...

Awarded: NOK 78,999

Project Period: 2008-2010

Location: Vestland

GLOBHELS-Global helse

Improving Coverage of the EPI versus Inclusion of New Vaccines into the Existing Programme: Equity, efficiency and cost-effectiveness

We apply for NOK 200 000 through the GLOBVAC programme to establish a research project to look into equity, efficiency and cost-effectiveness implications of alternative policies to improve immunization in low income countries from a health systems perspe ctive. The main consortium members are U...

Awarded: NOK 0.20 mill.

Project Period: 2008-2010

Location: Vestland

MILPAAHEL-Miljøpåvirkning og helse

Importance of components and sources in particle-induced lung inflammation: Role of PAHs and metals

Ambient particulate matter (PM) contribute to the development of adverse health effects in the lung and cardiovascular systems. PM has a complex composition and may contain a variety of different organic compounds and metals. We will investigate the possi ble role of PAHs and metals in PM-induced...

Awarded: NOK 5.4 mill.

Project Period: 2008-2013

Location: Oslo

TJENESTER-Helse- og omsorgstjenester

Integrated care for chronic conditions: a multi-method controlled evaluation

The Central Norway Regional Health Authority (Helse Midt-Norge RHF) is to develop a structured collaboration between community and specialist care for people with chronic conditions. As an important part of this the patients will be mobilised by training and education to become more independent a...

Awarded: NOK 4.0 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

TJENESTER-Helse- og omsorgstjenester

Forskningsleder - TJENESTER - Olaug Lian

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Awarded: NOK 0.46 mill.

Project Period: 2008-2010

Location: Troms - Romsa - Tromssa

TJENESTER-Helse- og omsorgstjenester

Forskningsleder - TJENESTER - Lars Erik Kjekshus

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Awarded: NOK 0.70 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Development of a male contraceptive - from hit to drug candidate

The primary objective of the present project is to perform a hit-to-lead program (H2L) and further to develop a preclinical drug candidate. The outcome of the project is expected to be a preclinical drug candidate. Lead-backups will also be secured in cas e of future failure in a downstream proce...

Awarded: NOK 4.9 mill.

Project Period: 2008-2011

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Development of a peptide-based therapeutic vaccine to combat HIV disease (chronic immune stimulation)

This project aims to develop a novel therapeutic vaccine that induces nonneutralising antibodies to human immunodeficiency virus (HIV) to modulate disease rather than inhibit infection. Much evidence has now accumulated supporting the concept that acquire d immunodeficiency syndrome (AIDS) is an ...

Awarded: NOK 11.3 mill.

Project Period: 2008-2011

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Utveckling av analysmetod för kvantitativ bestämning av blodlipider i helblod.

Ett flertal epidemiologiska undersökningar har påvisat ett klart orsakssamband mellan nivåerna av vissa blodfetter och risk för hjärtkärlsjukdom. LDL (det dåliga kolesterolet) är den viktigaste riskfaktoren och höga LDL-nivåer ökar risken för att drabbas av hjärtkärlsjukdom. HDL (det goda koleste...

Awarded: NOK 2.9 mill.

Project Period: 2008-2010

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Utvikling og bruk av nye seleksjons og high throughput screeningsverktøy for effektiv stammeforbedring i prosesser for produksjon av antib

Prosjektet er et samarbeid mellom Alpharma AS, SINTEF materialer og kjemi og Institutt for Bioteknologi ved NTNU. Prosjektdeltagerne har arbeidet sammen i en rekke prosjekter de siste 15 årene og har i felleskap utviklet flere kommersielt lønnsomme biopro sesser for produksjon av ulike antibiotik...

Awarded: NOK 10.3 mill.

Project Period: 2008-2012

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Environmental mercury and human health in Arctic Norway

Persistent pollutants in Arctic areas have received much attention. It is well known that these contaminants accumulate in food webs and potentially cause severe physiological damages to top level predators including humans. People in Arctic regions tend to be more exposed to these pollutants due...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Folate, Paternal Age and De Novo Genetic and Epigenetic Events.

De novo mutasjoner er endringer i arvematerialet (DNA) som oppstår i kjønnscellene eller tidlig i fosterutviklingen og som derfor er nye i den forstand at de ikke finnes hos foreldrene. Epigenetiske mekanismer er kjemiske endringer i arvematerialet som styrer hvorvidt et gen skrus av eller på, op...

Awarded: NOK 4.5 mill.

Project Period: 2008-2015

Location: Oslo

PSYKISK-Psykisk helse

Ethnicity and mental health among youths: a longitudinal project

The research project will investigate social factors that may affect the development of mental health among youths from ethnic minority groups and from the majority population, with analyses distinguishing between the genders. Data will be collected in Dr ammen. Research indicates that perceived...

Awarded: NOK 2.4 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Bioinformatics platform for the pharmacogenomic analysis of sequence variation in complex diseases

Traditional studies of complex disease and drug response have utilized a one gene one drug strategy. However because of highthroughput technology , the future trend of personalized medicine lies in understanding and modulating the complex responses involv ing many genes, their sequence variation ...

Awarded: NOK 3.5 mill.

Project Period: 2008-2011

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Innovativ sårhelingsteknologi: Utvikling av nye produkter for sårheling og regenerering av hud

Business-konseptet er å utvikle, dokumentere og patentere et terapeutisk sårhelingsprodukt fra et ekstrakt av lakseegg. Produktet vil forbedre sårheling, stimulere regenerering av hudceller, regulere hudcelle-differensiering (celledelingsegenskaper) og st imulere kollagen-utskillelse. Pilotstudie...

Awarded: NOK 4.4 mill.

Project Period: 2008-2010

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Tissue Factor siRNA for treatment of melanoma metastasis

The project described herein covers the research and initial preclinical part of the project of developing a drug based on small interfering RNAs (siRNA) targeting Tissue Factor, a molecule known to be involved in the processes of blood clotting, metastas is and angiogenesis. The project has emph...

Awarded: NOK 1.9 mill.

Project Period: 2008-2011

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Salmon and contaminants: impacts on insulin sensitivity and metabolic diseases

Although marine food has long been known to have health properties, its roles and impacts on insulin sensitivity and metabolic diseases (e.g. type 2 diabetes, obesity, hypertension, coronary heart diseases etc.) remain still unclear and worldwide debated. Beside its potential health effects, rec...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Vestland

MILPAAHEL-Miljøpåvirkning og helse

Oil induced autoimmune disease

We here present evidence that environmental exposure to immunoadjuvants in particular mineral oils, may precipitate autoimmune diseases in susceptible individuals, and that a novel class of genes encoding leukocyte regulatory receptors contribute to this susceptibility. The evidence is based on t...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Oslo