0 projects

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Functional understanding of Ras-Ral signaling in development and cancer

Ras er en liten GTPase som ofte er mutert i ulike kreftformer. All kunnskap om hvordan Ras påvirker cellene våre kan potensielt komme til nytte for å bekjempe kreft. Flere av signalveiene nedstrøms for Ras er godt kjent, mens andre er mindre kartlagt. En av de sistnevnte involverer Ral, som selv ...

Awarded: NOK 2.7 mill.

Project Period: 2013-2017

Location: Ukjent Fylke

GLOBVAC-Global helse- og vaksin.forskn

GMMnet: Genome Maintenance Meeting-based network

GMMnet Aim and Scope: The stability of microbial genomes and gene pools will constantly be challenged by horizontal gene transfer and recombination, as well as DNA damage induced by endogenous as well as exogenous agents. Mechanisms for rapid genome varia tion, adaptation and maintenance are a ne...

Awarded: NOK 0.30 mill.

Project Period: 2013-2014

Location: Ukjent Fylke

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The Changing Brain - International Neuropsychological Society/Nordic Meeting in Neuropsychology - Oslo, 27-30 juni 2012

I samarbeid med International Neuropsychological Society (http://www.the-ins.org/) og de Nordiske Nevropsykologiforeningene arrangerer Norsk Nevropsykologisk Forening (http://www.nevropsyk.org/) 27-30 juni, 2012 konferansen "The Changing Brain". Samtlige er non-profit foreninger. Intervensjon ...

Awarded: NOK 0.10 mill.

Project Period: 2012-2013

Location: Ukjent Fylke

NEVRONOR-Nasjonal satsing på nevrovitenskap f

EUROCORES: Genetics of the Rare Epilepsy Syndromes (EuroEPINOMICS)

Genetisk kartlegging av sjeldne epilepsisyndromer Epilepsi er en gruppe hyppig forekommende sykdommer med mange ulike årsaker. De siste tiår har det imidlertid vist seg at arv spiller en viktig rolle og at mange epilepsiformer faktisk skyldes feil i ett gen alene. Dette doktorgradsprosjektet har...

Awarded: NOK 3.0 mill.

Project Period: 2011-2015

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EUROCORES: Genetic targets of epileptogenesis and pharmacoresistance in brain glial cells - a translational research project on the genetic

Hensikten med prosjektet er å studere hvordan temporallappsepilepsi (TLE) utvikler seg over tid, og dernest hvordan dette kan forhindres. TLE er den vanligste epilepsiformen hos mennesker, men utvikler seg svært forskjellig. Mens enkelte får en lett form som enkelt kan kontrolleres med medisiner...

Awarded: NOK 3.0 mill.

Project Period: 2011-2015

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Neil3, a novel function for self-renewal and proliferation of neural progenitor cells

The major cell types comprising the mammalian central nervous system arise from neural stem cells (NSC) and progenitor cells (NPC), including neurons, astrocytes and oligodendrocytes. In this proposal we aim to characterize a novel gene function, Neil3, r equired for neural stem/progenitor cell m...

Awarded: NOK 3.8 mill.

Project Period: 2011-2015

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Small RNAs and DNA repair in Mycobacterium tuberculosis adaptive responses

Tuberkulose (TB) er en av verdens mest utbredte infeksjoner, som tar nesten 1.3 millioner liv og forårsaker 8.7 millioner infeksjonstilfeller årlig. Årsaken er Mycobacterium tuberculosis (Mtb), som infiserer 1/3 av verdens befolkning og har forårsaket flere dødsfall enn noen annen mikrobe. Behand...

Awarded: NOK 3.8 mill.

Project Period: 2011-2014

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Biomechanical characteristics of patients with hip osteoarthritis with mild to moderate pain: A prospective, randomized clinical trial

This project funding proposal concerns a personal postdoctoral fellowship within the area of clinical research. The project will investigate the effect of exercise therapy and patient education compared to patient education alone on lower extremity biomec hanics during gait, sit-to-stand, and one...

Awarded: NOK 2.4 mill.

Project Period: 2011-2014

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The identification of new genetic causes of Parkinson's disease

Parkinson disease (PD) is a common neurological disorder affecting about 1% of the population aged 60 or older. The disorder is causing high costs to society and reduced quality of life in patients and caregivers. Like many other neurological illnesses, P D is chronic, progressive and only sympto...

Awarded: NOK 7.0 mill.

Project Period: 2011-2016

Location: Ukjent Fylke

ELSA-Etiske,rettslige og samf.m. as

Social and ethical dimensions of fMRI: Anorexia as a case study

The case of fMRI research on anorexia can be seen as emblematic of a broader set of processes which critics have called the ?biologisation? of child development and behaviour. Neuroethicists and sociologists have raised important concerns about young peop le?s exposure to neuroscience technologie...

Awarded: NOK 0.94 mill.

Project Period: 2010-2013

Location: Ukjent Fylke

STAMCELLER-Stamcelleforskning

Mapping of histone modifications in totipotent and pluripotent cells in vivo and characterization of a novel epigenetic mark

This project focuses on revealing the epigenetic basis of in vivo pluripotency and totipotency, characterizing a putative novel epigenetic mark with relevance to pluripotency and the characterization of candidate enzymes for the regulation of this mark. Fertilization produces a totipotent zygo...

Awarded: NOK 3.0 mill.

Project Period: 2010-2014

Location: Ukjent Fylke

STAMCELLER-Stamcelleforskning

STEM CELL DNA INTEGRITY AND PLURIPOTENCY

Stem cell metabolism is characterized by low respiratory activity and high glycolytic flux, which maintain cells in a reductive state. This is important to prevent damage to cellular genomes (nuclear and mitochondrial DNA). In addition and like differenti ated cells and other somatic cells, stem ...

Awarded: NOK 3.0 mill.

Project Period: 2010-2013

Location: Ukjent Fylke

GLOBHELS-Global helse

Novel vaccine candidates against meningococcal disease

Meningococcal disease is a leading cause of meningitis and septicaemia globally, most often striking small children and teenagers. Due to the lack of efficient vaccines, serogroup B meningococcal disease is currently emerging on a worldwide basis. The rat ional design of outer membrane protein-ba...

Awarded: NOK 4.0 mill.

Project Period: 2010-2013

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The AlkB family of hydroxylases; unique roles in DNA, RNA and histone hydroxylation/demethylation.

This project is partly based upon the intriguing phenotype and breeding pattern of Alkbh1, Alkbh4 and Alkbh7 (AlkB homolog 1, 4 and 7) targeted mice. Alkbh1 targeting in mice cause sex-ratio distortion and asymmetric left-right eye development. Alkbh1 is highly expressed in embryonic stem (ES) c...

Awarded: NOK 6.8 mill.

Project Period: 2010-2015

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EUROCORES: The functions of phosphoinositides in tissue morphogenesis and cancer

Membrane dynamics modulate cell polarity, vesicular trafficking, migration, growth, proliferation, differentiation, and more. Of all membrane lipids, phosphoinositides play a central role in these processes (Wymann & Marone 2005 Curr Opin Cell Biol; Lindm o & Stenmark 2006 J Cell Sci; Simonsen & ...

Awarded: NOK 2.8 mill.

Project Period: 2010-2013

Location: Ukjent Fylke

NEVRONOR-Nasjonal satsing på nevrovitenskap f

SOBER 2 - Sex On Brain European Research 2 Effects of Gonadotropin Releasing Hormone Receptor blockage on brain development and behaviour

This study is designed to enhance our understanding of sex specific brain development during puberty and adolescence and its implication for the aging process of the brain. Gonadotropin Releasing Hormone receptor (GnRHR) blockage pauses not only reproduct ive ability, but may also have significan...

Awarded: NOK 1.5 mill.

Project Period: 2010-2013

Location: Ukjent Fylke

PSYKISK-Psykisk helse

Co-morbid Diabetes and Eating Disorders - an exploration of prevalence, psychological correlates and diabetic control

Dette prosjektet er en delstudie av Barnediabetesregisteret og har undersøkt spiseproblemer ved type 1 diabetes. Forekomsten av spiseproblemer hos 770 gutter og jenter med type 1 diabetes i alderen 11-19 år var 18% i hele utvalget, 9% blant guttene og 28% blant jentene. Vi fant at forekomsten økt...

Awarded: NOK 3.0 mill.

Project Period: 2010-2014

Location: Ukjent Fylke

STAMCELLER-Stamcelleforskning

Molecular differences between embryonal carcinomas and embryonic stem cells: Implications for cancer

We see comparative and experimental studies involving embryonic stem (ES) cells and embryonal carcinoma (EC) cells in tandem as important in understanding both stem cell and germ cell tumour biology, and as potentially important as a source of stemness/pl uripotency markers relevant to other type...

Awarded: NOK 2.0 mill.

Project Period: 2009-2013

Location: Ukjent Fylke

STAMCELLER-Stamcelleforskning

Epigenetic and genetic programs of mesenchymal stem cell differentiation: a genome-wide integrative approach

The progression from a stem cell state to a more differentiated progeny is determined by the specific activation of transcriptional programs, as a consequence of orchestrated epigenetic and genetic events. The current application aims to identify and char acterise transcriptional programs active ...

Awarded: NOK 3.5 mill.

Project Period: 2009-2014

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Evaluation of functional Magnetic Resonance in the Diagnosis of Brain Tumors for Assessment of Clinical Efficacy (EMBRACE)

In patients suggestive of intra-cranial brain tumors, Magnetic Resonance (MR) is the imaging modality of choice for tumor characterization prior to, during and after surgical intervention. At Rikshospitalet (Oslo, Norway), a multi-disciplinary project has been established with the aim of develop...

Awarded: NOK 7.1 mill.

Project Period: 2009-2013

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Regulation and organization of chromosome replication and segregation in Escherichia coli.

In Escherichia coli, reinitiation at new origins is prevented by two different control systems. First, a process called sequestration makes newly formed origins unavailable to the initiation apparatus. The sequestration process involves membrane component s, SeqA protein and methylation at GATC s...

Awarded: NOK 3.0 mill.

Project Period: 2009-2013

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Lung cancer - characterization of biological factors for use in diagnosis, prognostication and therapy

Lung cancer is the leading cause of cancer-related death. Treatment results depend on stage, but are overall poor, due to the fact that most patients are diagnosed with advanced disease, but also lack of understanding of involved cellular and molecular di sease mechanisms. From 2005, all lung can...

Awarded: NOK 5.6 mill.

Project Period: 2009-2014

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Neoadjuvant Avastin in Breast Cancer (Neo-Ava) - an integrated molecular approach to treatment biology.

I kliniske studier hvor en ønsker å avdekke hvilke pasienter som har nytte av en spesifikk behandling, er detaljerte analyser av svulstvevet både i forkant, under og etter behandling, av stor betydning. Likeledes kan andre analyser også kaste lys over effekten av en slik behandling, slik som fors...

Awarded: NOK 4.4 mill.

Project Period: 2009-2015

Location: Ukjent Fylke

STAMCELLER-Stamcelleforskning

Tissue engineering of hyaline cartilage

Cartilage injuries are frequent and lead to pain and disability. Unfortunately, articular cartilage shows a limited capacity for selfhealing and often goes on to osteoarthritis. Several surgical techniques have been developed to fill the cartilage defects , but so far none of them have been able ...

Awarded: NOK 7.7 mill.

Project Period: 2009-2013

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cancer-targeted T cell Receptors - the next generation immunotherapeutic drugs

The aim is to generate recombinant T cell receptors that recognize cancer cells. DNA encoding the receptors form basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) A large number of T cell clones recognizing common canc...

Awarded: NOK 3.2 mill.

Project Period: 2008-2015

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

A novel cell cycle checkpoint in fission yeast

In this project we shall further study and characterise a novel mechanism of checkpoint regulation that we have recently discovered (Tvegård et al, Genes Dev, 2007). Checkpoints are important regulators of the cell cycle and cancer development is frequent ly associated with the lack of checkpoint...

Awarded: NOK 3.0 mill.

Project Period: 2008-2013

Location: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

Cancer-targeted T cell Receptors - the next generation immunotherapeutic drugs

The aim is to generate recombinant T cell receptors (TcRs) that recognize cancer cells. DNA encoding the receptors forms basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) T cell s that recognize common cancer proteins, ...

Awarded: NOK 5.3 mill.

Project Period: 2008-2013

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular characterization and functional studies of human B cell lymphoma

Malignant lymphomas represent a heterogeneous group of diseases with variable clinical course. Our group aims at identifying genes/signalling pathways with prognostic, diagnostic or therapeutic potential in B cell lymphomas. We are one of 7 groups that co nstitute the newly established Centre for...

Awarded: NOK 3.2 mill.

Project Period: 2008-2013

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Potential clinical relevance of radiation-induced signaling pathways

Radiation therapy is a commonly used treatment modality for cancer. Although in the past decades radiation therapy has shown to be a very successful treatment form, it still can be improved. One problem is that some tumors are particularly resistant to th e cytotoxic effects of radiation and resp...

Awarded: NOK 3.1 mill.

Project Period: 2007-2013

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The role of mismatch repair proteins in origin sequestration

We have shown that DNA replication is tightly coupled to cell growth in wild type E. coli cells. Initiation of replication occurs precisely at the same point in the cell cycle, generation after generation. The molecular mechanisms behind the precise timin g of initiation of replication are not ye...

Awarded: NOK 2.9 mill.

Project Period: 2007-2014

Location: Ukjent Fylke