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Learning across boundaries in elderly care (LABCare): Enabling expansive learning in and across vocational education and workplace practices

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Visualizing the Deep Sea in the Age of Climate Change

ARCREATE. An Archaeology of Creative Knowledge in Turbulent Times

Provenance Projected: Architecture Past and Future in the Era of Circularity

Refugee Settlement Locations and Long Run Outcomes

Persistence or change? Lessons from the introduction of enhetsskolen in Denmark and Norway

CLIMATE RIGHTS: Designing Visual Evidence for Climate Cases

Adaptive co-management to enhance biocultural diversity and sustainable development in coastal communities

REinventing STrategies for healthy Ageing; Recommendations and Tools (RESTART)
A randomized controlled trial (RCT)

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Professor

Protein glycosylation is a pivotal element of biological systems not only because it is one of the major post-translational modifications but also because it has significant effects on protein properties and functions. We have recently discovered, and par tially characterized, the first general O-linked protein glycosylation system to be found outside of eukaryotes. This occurs in the Gram negative human pathogen Neisseria gonorrhoeae, the aetiologic agent of gonorrhea. Biochemical characterization, geneti c manipulation and mass spectrometric analyses have led to the unambiguous identification of 8 of these glycoproteins. Remarkably, these proteins share few if gross features or functions (other than their targeting to the periplasm, the cellular compartme nt where glycan addition occurs). Additionally, all 8 proteins reside periplasmically and thus, this is the first example of a bacterial O-linked glycosylation system that targets intracellular proteins. Thus, this is the first bacterial system identified  in which O-linked glycans play intracellular roles. Given its reduced complexity and amenability to genetic manipulation, this bacterial system provides a unique opportunity to address a number of important, and as yet unresolved, questions relevant to f unctional genomics and glycobiology. Here, we propose to focus on the following: 1) to characterize the N. gonorrohoeae glycoproteome, 2) to define the properties and acceptor site sequences of glycosylation targets, and 3) to characterize and identify re lated O-linked glycosylation systems in other Proteobacteria species. Not only can these studies provide new insights into host - parasite interactions and disease pathogenesis, they may help understand glycosylation processes in complex eukaryotic system s and provide knowledge that can be exploited in glycoengineering.

O-LINKED PROTEIN GLYCOSYLATION IN BACTERIA

Integrated highly sensitive mycrosystem for identification of minority mutated alleles

Automatic Detection of Disease Related Molecular Cell Activity

MicroBUILDER - kontraktsforhandlinger

MicroActive - kontraktsforhandlinger

Integrated service actions, mixed-technology manufacturing of microfluidic systems

Microfabricated Point-of-care diagnostic system based on mRNA detection

0 projects

PES-INST-Prosjektetablererstøtte EU (FoU)

Integrated highly sensitive mycrosystem for identification of minority mutated alleles

Awarded: NOK 49,999

Project Period: 2007-2007

Location: Trøndelag - Trööndelage

SAM-EU-Samfinansiering EU-kontoret

Automatic Detection of Disease Related Molecular Cell Activity

Awarded: NOK 1.3 mill.

Project Period: 2006-2010

Location: Oslo

PES-INST-Prosjektetablererstøtte EU (FoU)

MicroBUILDER - kontraktsforhandlinger

Awarded: NOK 0.10 mill.

Project Period: 2005-2006

Location: Oslo

PES-INST-Prosjektetablererstøtte EU (FoU)

MicroActive - kontraktsforhandlinger

Awarded: NOK 50,000

Project Period: 2005-2005

Location: Trøndelag - Trööndelage

PES-EU-Prosjektetablererstøtte EU (bedrift)

Integrated service actions, mixed-technology manufacturing of microfluidic systems

Awarded: NOK 0.30 mill.

Project Period: 2005-2005

Location: Vestfold og Telemark

PES-EU-Prosjektetablererstøtte EU (bedrift)

Microfabricated Point-of-care diagnostic system based on mRNA detection

Awarded: NOK 49,999

Project Period: 2004-2005

Location: Viken