FRINATEK-Fri prosj.st. mat.,naturv.,tek

DEVELOPMENT OF AN ENANTIOSELECTIVE ORGANOCATALYZED IODOLACTONIZATION REACTION

Omega-3 polyumettede fettsyrer, ofte forkortet omega-3 fettsyrer, er ofte i media omtalt som vidundermiddel mot en rekke humane sykdommer. Hvorfor har omega-3 fettsyrer fått denne sterke statusen som kur for mange sykdommer? Det er kjent at de to omega-3 fettsyrene eikosapentaensyre (EPA) o...

Awarded: NOK 5.9 mill.

Project Period: 2014-2018

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

SYNTHESIS AND BIOLOGICAL EVALUATION OF THE POLYUNSATURATED NATURAL PRODUCT PROTECTIN D1 AND ANALOGS

This project will provide new lead compounds derived from marine natural products for the development of new remedies against inflammation. Inflammation is involved in numerous diseases such as cancer, cardiovascular diseases and inflammation. Our industr ial collaborator Pronova is conducting re...

Awarded: NOK 3.0 mill.

Project Period: 2013-2016

Location: Oslo

IS-BILAT-Mobilitet Norge-USA /Canada

BIOLOGICAL EVALUATION AND SYNTHESIS OF w-3 POLYUNSATURATED FATTY ACIDS: DEVELOPMENT OF NEW ANTI-INFLAMMATORY AGENTS

Project summary: 1) The first objective is to conduct biological evaluations at Harvard of the PUFA products prepared by the Oslo group. The biological significance of these compounds will be investigated during the applicant´s sabbatical period. The Ser han group has reported the isolation, str...

Awarded: NOK 0.16 mill.

Project Period: 2013-2013

Location: Oslo

KOSK-II-Katalyse og org.synt.kjemi II

Synthesis of resolvin D1 and analogs as potential anti-angiogenetic agents

Epidemiological studies have linked fat fish consumption to lower rates of several diseases such as cancer and Alzheimer's disease. Fish contains high levels of omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid and docosahexaenoic acid. Recently, the potential efficacy of...

Awarded: NOK 1.9 mill.

Project Period: 2011-2013

Location: Oslo

KOSK-II-Katalyse og org.synt.kjemi II

Synthesis, molecular modelling and biological evaluation of protectin D1 and analogs

Inntak av omega-3-fettsyrer som eicosapentaensyre (EPA) og docosaheksaensyre (DHA) har i flere studier vist å gi positive helseeffekter. Disse omega-3-fettsyrene finnes i tran og fet fisk. De eksakte molekylære årsakene til disse positive helseeffektene e r ennå ikke klarlagt. Ny forskning utfø...

Awarded: NOK 2.8 mill.

Project Period: 2010-2014

Location: Oslo

KOSK-II-Katalyse og org.synt.kjemi II

Synthesis of two polyunsaturated natural products using epa as starting material

With the advent of drug design, high throughput screening and combinatorial chemistry, medicinal chemists became less and less interested in natural products as a source for drugs. In the last two decades, medicinal chemists seemed inclined towards the ap parently more accessible synthetic produc...

Awarded: NOK 1.8 mill.

Project Period: 2009-2011

Location: Oslo

KOSK-II-Katalyse og org.synt.kjemi II

Organic Chemistry Wintermeeting 2009

The next Organic Winter Meeting, the 24rd, will take place January 8th-11th 2009 at Thon Hotel Skeikampen, Skeikampen. This conference is the national meeting in organic chemistry in Norway, and it is held under the umbrella of the Division of Organic Che mistry of the Norwegian Chemical Society....

Awarded: NOK 64,932

Project Period: 2009-2009

Location: Oslo

KOSK-II-Katalyse og org.synt.kjemi II

Synthesis of novel activators for procaspase-3: an approach to a personalised cancer treatment

Cancer is an important public health concern around the world. Chemotherapy is no doubt one of the most successful ways in which cancer can be treated. For years, chemotherapy has been indiscriminate warfare by using chemotherapeutic agents that are toxic to both normal and cancer cells. In this...

Awarded: NOK 1.7 mill.

Project Period: 2008-2010

Location: Oslo

INT-BILAT-BILAT-ordningen

NA - IDENTIFICATION OF NEW TUBULIN INHIBITORS USING IN SITU CLICK CHEMISTRY

Cancer is an important public health concern around the world. Chemotherapy is no doubt one of the most successful ways in which cancer can be treated, but still there exist a need for new cancer agents. In this research proposal we will apply in situ cli ck chemistry for the identification of ne...

Awarded: NOK 45,000

Project Period: 2006-2007

Location: Oslo