KOSK-II-Katalyse og org.synt.kjemi II
Design and optimisation in organic synthesis: Methodologies for the optimisation of multi-step one-pot batch processes
Assume tha a three step one-pot reaction is tt be optimised:
Lay out a design to map the first step. Depending on how detailed information is desired, this can be a fractional factorial, factoral, D-optimal, or a response surface design for quardratic m odels. Run the experiments and detrmine t...