660 projects

HELSEFORSKNING-Helseforskning

Enhanced cryoimmunotherapy against urogenital cancers

Dendritic cells (DCs) are central coordinators of the immune system. They detect foreign antigens - from bacteria, viruses, or aberrant cancer cells - and present them to lymphocytes. This instruction is essential: without DCs, lymphocytes cannot mount a targeted attack on cancer cells that conta...

Awarded: NOK 16.3 mill.

Project Period: 2019-2025

Location: Vestland

IKTPLUSS-IKT og digital innovasjon

Data-driven Framework for Personalised Cancer Screening

Cancer is a major cause of morbidity and mortality worldwide. In Norway alone, there are more than 33,000 new cancer patients each year, and 11,000 cancer-associated deaths in 2017. A large proportion of these incidents are preventable. For example, a mass-screening program against cervical cance...

Awarded: NOK 12.4 mill.

Project Period: 2019-2023

Location: Oslo

HELSEFORSKNING-Helseforskning

Impact of Molecular Point-of-Care Testing on Improved Diagnosis, Treatment and Management of CAP in NORWAY: a pragmatic RCT

Community-acquired pneumonia (CAP) remains a leading cause of hospital admission and death in older adults. A core problem is diagnostic delay: clinicians start broad-spectrum antibiotics before they know the culprit microbe, which can fuel antimicrobial resistance and expose patients to side eff...

Awarded: NOK 14.9 mill.

Project Period: 2019-2027

Location: Vestland

IKTFORSKNING-IKTFORSKNING

Improved Pathology Detection in Wireless Capsule Endoscopy Images through Artificial Intelligence and 3D Reconstruction

The project "Improved Pathology Detection in Wireless Capsule Endoscopy Images through artificial Intelligence and 3D Reconstruction" aims to facilitate more accurate and efficient detection of intestinal diseases through capsule endoscopy, leading to better healthcare. Accurate and efficient too...

Awarded: NOK 16.0 mill.

Project Period: 2019-2025

Location: Trøndelag - Trööndelage

BIA-Brukerstyrt innovasjonsarena

Mikrobiell produksjon av terapeutiske antistoffragmenter

The purpose of the project has been to solve challenges linked to the use of the bacterium Escherichia coli for the production of therapeutic proteins based on antibody fragments (Fabs). This is a group of proteins that have great potential for use in the treatment of a number of diseases such as...

Awarded: NOK 2.5 mill.

Project Period: 2019-2024

Location: Trøndelag - Trööndelage

BIA-Brukerstyrt innovasjonsarena

INSIGHT: Automated retinal imaging and diagnostics

The Oivi camera is envisioned to be a monocular that is automated and easy to use. It will allow for fully automated image capture and diagnostics through use of AI, requiring minimal training of the primary care physician or doctor's assistant. No dilating eye drops are required and the retinal ...

Awarded: NOK 12.0 mill.

Project Period: 2019-2021

Location: Oslo

NANO2021-Nanoteknologi, nanovitenskap, mikroteknologi og avanserte materialer

3D Bioprinting of biomimetic pancreas with tunicate nanocellulose and human pancreatic islets

Diabetes is a disease that affects millions of people worldwide. The World Health Organization (WHO) is predicting that 400 million people will develop diabetes before 2030. Patients suffering from type 1 diabetes lack the hormone insulin, responsible for proper glucose regulation, which is prod...

Awarded: NOK 6.0 mill.

Project Period: 2019-2021

Location: Akershus

BIA-Brukerstyrt innovasjonsarena

BioAlert; Biosensor for organdiagnostikk under kirurgi

The BioAlert project aimed to develop medical sensor equipment based on bioimpedance measurements that in real time can diagnose organ pathology during surgery (peroperatively) to avoid serious postoperative complications. In case of critical low blood supply to the intestine, it is difficult to ...

Awarded: NOK 5.9 mill.

Project Period: 2019-2021

Location: Vestfold

BIA-Brukerstyrt innovasjonsarena

Wound dressing with soluble beta-glucan

Biotec BetaGlucans AS has developed a soluble version of beta-glucan (SBG) which is an active pharmaceutical ingredient used in the wound product Woulgan Gel®. SBG is a biopolymer from yeast that has been shown to stimulate immune cells and especially phagocytic cells that are central in both inf...

Awarded: NOK 1.8 mill.

Project Period: 2019-2020

Location: Troms - Romsa - Tromssa

BIA-Brukerstyrt innovasjonsarena

HoloCare Cloud

Through HoloCare Cloud, we have developed a fully scalable platform for holographic visualisation of medical image data from CT to hologram, using AI technology. The platform is intended to support clinicians in surgical planning. In this project, we have focused on two areas of highly specialise...

Awarded: NOK 14.8 mill.

Project Period: 2019-2023

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

AXL as a therapeutic target in fibrosis; biology and biomarkers

Fibrotic disease, the accumulation of connective tissue and scar tissue in organs or tissues, is a leading cause of morbidity and mortality worldwide. There is a significant unmet medical need for new treatments that ameliorate fibrotic disease. BerGenBio ASA is developing drugs that inhibit the ...

Awarded: NOK 10.7 mill.

Project Period: 2019-2023

Location: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Residual adrenocortical function in patients with autoimmune Addison`s disease

rimary adrenocortical insufficiency (Addison's disease) is a rare, but potentially lethal endocrine disorder. In spite best practice treatment, many patients experience reduced health and quality of life. Addison's disease is usually caused by autoimmune destruction of the adrenal cortex, and it ...

Awarded: NOK 9.6 mill.

Project Period: 2019-2023

Location: Vestland

BIA-Brukerstyrt innovasjonsarena

- Nye innovasjoner og bedrifter fra hjerneforskning

Nansen Neuroscience Network is an organization committed to accelerating innovation from neuroscience research. We are a public private partnership, and supported by the main universities, hospitals, biopharma companies and Norwegian Research Council. We have an extensive network in neuroscience ...

Awarded: NOK 0.80 mill.

Project Period: 2019-2019

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Longitudinal tracking and functional dissection of the cortical head direction network in a mouse model of Alzheimers disease

Alzheimer's disease affects millions of people worldwide. As the global population ages, it will put an increasing burden on patients, families and health care systems. Much of what we know about brain function in Alzheimer’s has come from human studies. However, tools for measuring brain activit...

Awarded: NOK 8.2 mill.

Project Period: 2018-2023

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Non-invasive electrical stimulation as a means for preserving vision

Can electrical stimulation improve vision? A team of researchers has been investigating the potential of electrical stimulation to improve visual function in patients with retinal diseases. Their findings suggest that electrical stimulation can reduce inflammation and improve visual function. Bl...

Awarded: NOK 10.0 mill.

Project Period: 2018-2023

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Optimalisering: Optimization of novel CSF1R inhibitors - New drugs for osteoporosis

During the project period, more than 350 new molecules intended as inhibitors of the receptor enzyme CSF1R have been prepared and characterized. Successful inhibition of this receptor may, among other things, have an effect in patients with osteoporosis. The effect of all molecules produced was t...

Awarded: NOK 7.7 mill.

Project Period: 2018-2021

Location: Trøndelag - Trööndelage

NANO2021-Nanoteknologi, nanovitenskap, mikroteknologi og avanserte materialer

NANO-ONCOLOGY: Nanotechnology and Nanomaterials in Combating Cancer

Oslo Cancer Cluster (OCC) would like to present a meeting focusing on Nanotechnology and its impact on Cancer. To achieve this, OCC would invite members of the industry working within nanotechnology and cancer research to give presentations and join topical discussions about how advances in techn...

Awarded: NOK 36,127

Project Period: 2018-2019

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Conference: "5th Genome Maintenance Meeting / 3rd Turning the Tide of Antimicrobial resistance meeting" (GMM5/TTA3)

In this joint conference "5th Genome Maintenance Meeting” / 3rd Turning the Tide of Antimicrobial resistance (AMR) meeting" (GMM5/TTA3), we will focus on genome dynamics, AMR and new drug design. The GMM5 / TTA3 meeting will highlight recent progress in the understanding of how DNA transfer pathw...

Awarded: NOK 99,999

Project Period: 2018-2019

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Enterococcal RseP as a target for new diagnostics and antibiotics

Vancomycin-resistant enterococci (VRE) are responsible for several human infections, and their treatment has become challenging because the bacteria have become resistant to most antibiotics. In this project, we started from a recently discovered antimicrobial peptide/bacteriocin called enterocin...

Awarded: NOK 10.4 mill.

Project Period: 2018-2023

Location: Akershus

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Host response to biomaterials - pathophysiological mechanisms and therapeutic inhibition in biomaterials science

Our goal was to understand the acute reactions in blood when human tissue comes in contact with biomaterials. We aimed to aid biomaterials treatment in applications ranging from the implantation of vascular devices to the administration of nanoparticles. The ability to replace an organ, tiss...

Awarded: NOK 7.9 mill.

Project Period: 2018-2022

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Complement and toll-like receptors determine ischemia/reperfusion injury - universal mechanism and benefit of double inhibition

The injury that occurs in the course of ischemia (stop in blood supply) and reperfusion (restored blood supply) is a key-challenge in treatment of potentially life-threatening conditions like heart infarction, circulatory arrest, trauma, and organ transplantation. Activation of the inborn immune ...

Awarded: NOK 8.0 mill.

Project Period: 2018-2021

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Optimalisering: A corrective therapy for acute intermittent porphyria

Acute intermittent porphyria (AIP) is an inherited metabolic disease that causes symptoms related to the gastrointestinal and nervous systems and where the symptoms usually require hospitalization. The disease can also cause serious long-term complications such as liver cancer and kidney failure....

Awarded: NOK 8.0 mill.

Project Period: 2018-2021

Location: Vestland

NORGLOBAL2-Norge - Global partner

LeapAgri: European-African partnership for safe and efficient use of mycotoxin-mitigation strategies in sub-Saharan Africa

MycoSafe-South, the so-called "European-African Partnership for the Safe and Effective Use of Mycotoxin Reduction Strategies in Sub-Saharan Africa", intended to leverage the expertise and infrastructure available in Europe to strengthen the capacity of the African partners to tackle the mycotoxin...

Awarded: NOK 1.5 mill.

Project Period: 2018-2022

Location: Akershus

BEDREHELSE-Bedre helse og livskvalitet

Oral and Environmental Microbiome, Endotoxin and Lung Health; the United Airways concept extended

Dental health may influence disease risk or exacerbate inflammatory conditions in organs at distant sites. The association can be explained by transfer of oral bacteria directly to other organs such as the lungs, or by transport of inflammatory mediators in the bloodstream. In this project we ha...

Awarded: NOK 14.8 mill.

Project Period: 2018-2024

Location: Vestland

FRIPROSJEKT-FRIPROSJEKT

Sensory and motor networks in psychotic disorders: from brain structure and function to phenomenology

Psychotic disorders disrupt the core of our sense of reality, and include experiences such as hallucinations and delusions, feelings of unrealness, and of being overwhelmed by perceptual stimuli. Many of these symptoms can be understood as deficits in sensory processing. Despite the immense costs...

Awarded: NOK 8.6 mill.

Project Period: 2018-2025

Location: Oslo

FRIPROSJEKT-FRIPROSJEKT

When default is not default: Solutions to the replication crisis and beyond

Functional magnetic resonance imaging (fMRI) is a widely used method for studying brain functions, both in healthy participants as well as patients. The development of fMRI more than 25 years ago was a milestone in brain research, and has lead to several major discoveries of how the brain functio...

Awarded: NOK 12.2 mill.

Project Period: 2018-2025

Location: Vestland

BIOTEK2021-Bioteknologi for verdiskaping

ERA-NET: SysMed-COPD - Systems Medicine-based clinical decision support for COPD patients

COPD is a disease that kills 3.4 mill people around the world. Currently, there are no molecular diagnostic tools for the COPD disease, and diagnose relies on the doctor's experience, based on clinical data such as respiratory capability. The main challenge is to differentiate the COPD from other...

Awarded: NOK 4.0 mill.

Project Period: 2018-2023

Location: Trøndelag - Trööndelage

FRIPROSJEKT-FRIPROSJEKT

Exploring the genetics of neuropathic pain

Neuropathic pain is defined as "pain caused by a lesion or disease of the somatosensory nervous system". Neuropathic pain is a huge health problem worldwide, with an estimated prevalence of 7-8 % in the general population. In the present study we will search for new genetic variants relevant for ...

Awarded: NOK 10.2 mill.

Project Period: 2018-2025

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Human gut plasma cells live for decades: implications for vaccination and treatment of chronic inflammation

The mucosal surfaces of the intestinal tract contain large numbers of antibody-producing cells, so-called plasma cells. They produce grams of antibodies every day. The antibodies are transported into the gut lumen where they bind bacteria, viruses and other harmful constituents. We have recently ...

Awarded: NOK 9.1 mill.

Project Period: 2018-2023

Location: Oslo

IKTPLUSS-IKT og digital innovasjon

Efficient Trustworthy Computing with Blockchains and Biometrics

Blockchains are disrupting many areas of modern digital society, including financial markets and the health sector. Existing blockchains suffer from shortcomings that prevent their use in modern digital services that require high throughput and low latency, and does not waste energy. This projec...

Awarded: NOK 9.9 mill.

Project Period: 2018-2023

Location: Rogaland