13,423 projects

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FRIMED-Klinisk medisin og folkehelse

Multi-modal imaging: The importance of fiber connections for cognitive function, brain activity and brain structure in research and clinic

The main objectives of this project are 1) integration of informations from different neuroimaging methods (diffusion tensor imaging [DTI], structural MRI, functional MRI [fMRI], event-related potentials [ERP]) and refined cognitive measures, 2) use these methods to understand the biological fou...

Awarded: NOK 2.4 mill.

Project Period: 2007-2011

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Effects of Pregnancy, Lactation and Menopause on Bone Health

Fragility fractures are a common public health problem particularly in Scandinavia. The pathogenesis of bone fragility is multi-factorial. Two factors will be studied ? the effect of pregnancy and menopause. Whether pregnancy and lactation result in bo ne loss is not clear, and if so, whether ...

Awarded: NOK 3.1 mill.

Project Period: 2007-2010

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Immunopathogenic mechanisms in coronary artery disease

Despite state of the art cardiovascular treatment, coronary artery disease (CAD) with development of acute coronary syndromes are still common manifestations of atherosclerosis, suggesting that important pathogenic mechanisms remain active and unmodified by the present treatment modalities. Based...

Awarded: NOK 2.3 mill.

Project Period: 2007-2011

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Targeting occult tumor cell dissemination in localised breast cancer

For the future, a better treatment of patients with breast cancer is dependent upon a better assessment of the individual risk of harbouring minimal residual disease after the completion of the surgical treatment. The aim is to separate very low risk pati ents from high risk patients for future m...

Awarded: NOK 2.5 mill.

Project Period: 2007-2012

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

The Tromsø Pain Study: Causes and consequences of individual differences in pain sensitivity

Human pain sensitivity is subject to very large inter-individual variation. It is known that pain sensitivity is heritable, but the genes involved are largely unknown. Hypersensitivity to pain may be an important risk factor in the development, maintenanc e and consequences of chronic pain. Reduc...

Awarded: NOK 3.7 mill.

Project Period: 2007-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Tissue engineering in bone defects: Development of porous copolymer scaffolds stimulating stem cell growth and bone regeneration

For the repair of bone defects, tissue engineering would be to combine cells capable of osteogenic activity with an appropriate scaffold. Mesenchymal stem cells are multipotential cells that are capable of differentiating into different type of cells dep ending on culture condition. The selectio...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Molecular and clinical aspects of cancer

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Awarded: NOK 1.5 mill.

Project Period: 2007-2009

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Physical activity level, determinants of physical activity, physical fitness, fatness and health in Norwegian children

INTRODUCTION: The obesity epidemic in the Western World is well known, and even if the prevalence of obesity in Norway is much lower than in countries such as USA and England body weight has increased in Norwegian children during the last decades. Althoug h weight gain is a consequence of higher ...

Awarded: NOK 0.38 mill.

Project Period: 2007-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Improving Patient-Provider Communication in Cancer Care

Improving shared decision making (SDM)and patient-provider communication, and incorporating patients' illness experiences and preferences into patient care are high priority health policy goals. However, this is difficult to accomplish without methods and systems that assist patients in sharing ...

Awarded: NOK 2.6 mill.

Project Period: 2007-2011

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Pregnancies and cancer risk - a prospective study based on Norwegian register data

In this project, associations between pregnancies and cancer risk will be examined. Focus will be on cancer forms known to be hormone-related, and also on some cancer types with less evidence for being susceptible to hormonal exposure. Our study is based on information from the Population registe...

Awarded: NOK 2.3 mill.

Project Period: 2007-2010

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Hepatocyte Growth Factor (HGF)-signalling as target for treatment of multiple myeloma

Multiple myeloma is due to clonal expansion of malignant plasma cells. The incidence in the Nordic countries is approximately 6 new cases per 100,000 per year, which corresponds to nearly 20% of hematological cancers. Approximately 300 persons are given t his diagnosis each year in Norway. An imp...

Awarded: NOK 2.2 mill.

Project Period: 2007-2008

Location: Trøndelag - Trööndelage

FRIMED-Klinisk medisin og folkehelse

Retinopathy and AMD in a general population. The Tromsø Study 2007.

The Tromsø VI survey is scheduled to take place October 2007- through 2008. A total of 11,000 - 16,000 adults in Tromsø will be invited (depending on funding). Many of those have participated in previous surveys, and data from those surveys will be used f or longitudinal analyses. As a subproject...

Awarded: NOK 1.4 mill.

Project Period: 2007-2010

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Gene-environment interaction analyses and oral clefts in Norway

Norway has several large epidemiological studies with genetic bio-banks that may be used in etiologic research. Examples are the CONOR-cohort and the MoBa-cohort of children with mothers and fathers. Optimal analysis of such studies requires integration o f both genetic and environmental effects....

Awarded: NOK 2.8 mill.

Project Period: 2007-2011

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

THE HORDALAND WOMEN'S COHORT STUDY. A planned 15-year (1997-2012) follow up incidence study of urinary incontinence, and associated factors

Urinary incontinence (UI) is a common condition with a prevalence of about 25% of adult women, that affects the physical, psychosocial, and economic well-being. Longitudinal studies of incidence, remission and natural history are scarce. The Hordaland wo men's cohort study is an ongoing 15-year ...

Awarded: NOK 2.5 mill.

Project Period: 2007-2011

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Exposure expression profiles in a prospective cancer study - The Norwegian Women and Cancer postgenome cohort

From 1991 women in Norway has been recruited to participate in NOWAC by postal questionnaires. They are drawn at random from the population through the central person register. Follow-up on cancer and death is based on linkage to national registers. Altog ether 150 000 women aged 30-70 years at r...

Awarded: NOK 1.6 mill.

Project Period: 2007-2010

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Combined structural, microvascular and functional mapping of brain tumors for improved diagnosis and treatment planning

During recent years, the department of radiology at Rikshospitalet-Radiumhospitalet (RR) Medical Center has had a strong focus on functional MRI (Magnetic Resonance Imaging) research; including perfusion/ diffusion MRI and spectroscopy, with the aim of br inging novel MR techniques into early cli...

Awarded: NOK 2.2 mill.

Project Period: 2007-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Psychosocial effects and understanding of increased risk for Type 1 Diabetes

With the rapid development in biotechnology and increasing knowledge about the relation between diseases and genetic variability, we are faced with both new opportunities and new dilemmas. Onset of a disease is dependent on several factors as genetic pene trance, combinations of genotypes and env...

Awarded: NOK 2.8 mill.

Project Period: 2007-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

L-Ornithine and phenylacetate: A novel and effective therapy for hepatic encephalopathy

Background: The major therapeutic target for the treatment of hepatic encephalopathy is ammonia. Our extensive investigations in animal models and also in humans with cirrhosis support the view that the major organ removing ammonia in patients with cirrho sis is the muscle, converting ammonia to ...

Awarded: NOK 1.3 mill.

Project Period: 2007-2009

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Emotional factors and individual differences in placebo analgesia. Psychophysiological experiments.

The relationship between the pain stimulus (wounds, lesions, external stimuli) and experienced pain can be modified by the context in which pain occurs: Some patients can have intolerable pain but without any physiological sign of damage. On the other han d, severe wounds may not cause pain under...

Awarded: NOK 2.5 mill.

Project Period: 2006-2010

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Genetic and environmental influences on reading development and reading disability: A longitudinal twin study

The proposed research will complete the first international longitudinal twin study of genetic and environmental influences on pre-reading and early reading and related skills from preschool (age 5) through the end of kindergarten, 1st, and 2nd grades, wh en children "learn to read", and at the e...

Awarded: NOK 2.1 mill.

Project Period: 2006-2010

Location: Rogaland

FRIMED-Klinisk medisin og folkehelse

Non-invasive Assessment of Right Ventricular Function in Patients With Tetralogy of Fallot

Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease (CHD). Surgical treatment (total repair) has been available for 50 years, with favorable outcome in most patients. We are now, however, faced with an increasing number of patients presenting with right ventricu...

Awarded: NOK 1.5 mill.

Project Period: 2006-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Tracking and prediction of health-related behaviour and physiological risk factors: 27 years follow up of a prospective cohort study

Worldwide the prevalence of overweight and obesity have increased the last decades. Obesity is associated with increased mortality, reduced life expectancy and an increase in several chronic diseases. It is important to identify risk factors for obesity t o make effective prevention strategies. O...

Awarded: NOK 2.9 mill.

Project Period: 2006-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

The significance of therapist and patient characteristics in psychotherapy

Therapeutic alliance is considered to be one of the central aspects of the relationship between therapists and patients in psychotherapy, as well as therapy process and outcome. Therapeutic alliance includes three central aspects: the goals of therapy, ho w to proceed to reach the goals, and the ...

Awarded: NOK 1.1 mill.

Project Period: 2006-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

True exposure, measurement error and risk estimation in clinical and epidemiologic research

In epidemiology as well as in clinical studies our main interest lies in the estimation of the effect of exposure on disease. Most exposure data are subject to measurement error, and when ignored, they will bias our estimates of exposure-disease associati ons. It is important to understand the si...

Awarded: NOK 2.3 mill.

Project Period: 2006-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Pathophysiological role of inflammatory mechanisms in heart failure

Chronic heart failure (HF) is an important and increasing cause of cardiovascular morbidity and mortality. Several lines of clinical and experimental evidence indicate that inflammation may play an important role in the development of HF, a notion that ha s opened up for new treatment principles ...

Awarded: NOK 2.5 mill.

Project Period: 2006-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

NOVEL BIOTHERAPEUTIC STRATEGIES FOR IMPROVING IMPLANT PERFORMANCE IN BONE

The purpose of this project is to characterize mechanisms for bone regeneration and healing and to use this knowledge to develop new strategies for improving the performance of loaded metal implants used to restore function in compromised skeletal structu res. From the clinical perspective skelet...

Awarded: NOK 4.5 mill.

Project Period: 2006-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Injury in newborn infants. Basic mechanisms related to oxidative stress and bilirubin encephalopathy

In this project we plan to continue our long term studies regarding basic mechanisms of brain injury in newborn infants. We have previously shown that oxidative stress both in preterm and term infants induces long term potential harmful effects that may affect growth and development. As the f...

Awarded: NOK 3.0 mill.

Project Period: 2006-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Do socio-economic community factors affect mortality in Norway? An analysis based on unique multilevel longitudinal data.

The intention is to find out whether community characteristics exert an effect on an adult person's cause-specific mortality, above and beyond that of the person's individual characteristics. The focus will be on socio-economic community factors, such as average income and education and unemploym...

Awarded: NOK 0.90 mill.

Project Period: 2006-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Hormone replacement therapy, gene expression profile and breast cancer

The project is mainly a collaboration between the University of Tromsø and INSERM, France. We will pool together information from the E3N cohort of about 100 000 French female teachers with the 150 000 participants in the Norwegian Women and Cancer study , NOWAC, both started in the early nineti...

Awarded: NOK 2.5 mill.

Project Period: 2006-2008

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Novel therapeutic strategies for immunostimulation in HIV targeting CD25+ T-regulatory cells.

Regulatory T cells (Treg) represent 5-10% of the CD4 T cells and are identified by constitutively expressing CD25. Treg are subdivided into naturally occuring Treg devolped in the thymus, and adaptive Treg that are induced in the periphery from naïve CD4 T cells. Naturally occuring Treg are intst...

Awarded: NOK 2.4 mill.

Project Period: 2006-2008

Location: Oslo

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