660 projects

Date from new to old

STAMCELLER-Stamcelleforskning

Stamceller - Nettverksmøte 2015, 2016, 2017

The Norwegian Center for Stem Cell Research organises the Annual Norwegian Stem Cell Networking Meeting at Soria Moria Hotel & Conference Center outside of Oslo. The meeting brings together Center core group members and associate members, non-Center stem cell researchers who had received funding ...

Awarded: NOK 0.73 mill.

Project Period: 2015-2017

Location: Oslo - Oslove

BIA-Brukerstyrt innovasjonsarena

Fra Nobel til Næring for hjernen -Nansen Neuroscience Network:et forskning og innovasjonsnettverk som kobler toppforskning med næringslivet

Nansen Neuroscience Network is an organization committed to accelerating innovation from neuroscience research. We are a public private partnership, and supported by the main universities, hospitals, biopharma companies and Norwegian Research Council. We have an extensive network in neuroscience...

Awarded: NOK 2.9 mill.

Project Period: 2015-2018

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Aging starts in the womb: Lifespan mediators and moderators of healthy brain and cognition

The main purpose of the project was to identify effects of early-life factors on lifespan neurocognitive changes, and test how variances are affected by later-life factors. An eighty-year-old person may show superior cognitive function, while another may experience severe decline and dementia. Th...

Awarded: NOK 7.1 mill.

Project Period: 2015-2022

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Lamin-genome interactions in the development of Familial Partial Lipodystrophy

Mutations in molecules of the envelope that protects chromosomes, called lamins, cause diseases that result in a melting of fat tissue in lower parts of the body, accumulation of fat in the abdomen and metabolic complications often leading to diabetes. This disease is called a partial lipodystrop...

Awarded: NOK 8.1 mill.

Project Period: 2015-2018

Location: Oslo - Oslove

FORNY20-FORNY2020

A blood test for improved clinical management of prostate cancer

Prostate cancer is the second most common cancer in men, with an estimated 1.1 million new cases and 307,000 deaths in 2012. Limitations in the current clinical tools for management of prostate cancer have resulted in over-diagnosis and costly overtreatment, which is affecting the outcomes and qu...

Awarded: NOK 1.7 mill.

Project Period: 2015-2017

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

B7-H3/PTEN: a new axis for novel anti-cancer therapies in prostate cancer

Searching for new therapies for prostate cancer. Estimations are that one out of two men will get cancer along his lifetime, the most common type of cancer in men being prostate cancer. Each year almost 5000 men in Norway get the message that they have prostate cancer, and around 1000 men die ...

Awarded: NOK 3.2 mill.

Project Period: 2015-2020

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Notch signalling in inflammation

The vascular endothelium is the thin layer of cells that lines the interior surface of all blood vessels. These cells regulate the migration of white blood cells out from blood vessels to the tissues during inflammation. Today, millions of people worldwide suffer from inflammatory diseases, and m...

Awarded: NOK 4.2 mill.

Project Period: 2015-2021

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Protective immunity to Streptococcus pneumoniae

Streptococcus pneumoniae causes severe diseases in millions and yearly kills about 1 million children. In high income countries, the elderly is the most affected group. Despite their effectiveness, current pneumococcal vaccines do not target all S. pneumoniae. The limited coverage, compounded by ...

Awarded: NOK 7.7 mill.

Project Period: 2015-2019

Location: Oslo - Oslove

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

A life without SCHAD: Novel implications for insulin-body weight interplay

The hormone insulin is important for correct regulation of the blood sugar level. The aim of this project is to obtain a better understanding of how insulin production is controlled in the body. We are studying a rare, inherited disease denoted congenital hyperinsulinism of infancy. Children with...

Awarded: NOK 8.6 mill.

Project Period: 2015-2019

Location: Vestland

FORNY20-FORNY2020

Cardiac Arrhythmia Biomarker

Methanol leads to a large number of poisonings each year worldwide. Large outbreaks leads to significant deaths and inflict permanent brain damage and blindness. Patients are usually poisoned by drinking ethanol diluted with methanol. The toxicological principles of methanol are well known ; met...

Awarded: NOK 5.8 mill.

Project Period: 2015-2017

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Metaflammation in cardiovascular disease

Inflammation is an important mediator in cardiovascular disorders (CVD), but several questions remain unresolved. The mechanisms for the activation of the inflammatory pathways and the balance between resolving and non-resolving mediators need to be better understood. Like the response to microbe...

Awarded: NOK 9.0 mill.

Project Period: 2015-2018

Location: Oslo - Oslove

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Internet gaming disorders among youth: Prevalence, course, predictors, outcome and evaluation of diagnostic criteria

It has for long been acknowledged that excessive and problematic use of Internet games may have serious consequences for some young people. Accordingly, Internet gaming disorder (IGD) was listed as an Addendum to DSM-5 as a condition for further study, and diagnostic criteria were suggested. Our ...

Awarded: NOK 4.0 mill.

Project Period: 2015-2018

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The neurobiology of the patient-clinician interaction, and its impact on treatment outcome

When meeting a clinician, we are often nervous, uneasy, and distressed about the situation. Many of us are anxious about what the doctor is about to tell us, and hope she/he will be reassuring and show genuine engagement in attempting to treat the illness or discomfort. Multiple studies have docu...

Awarded: NOK 3.2 mill.

Project Period: 2015-2019

Location: Oslo - Oslove

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

POTENTIAL EARLY DIAGNOSTIC MOLECULAR MARKERS OF ADHD: Analysis of miRNA profiles and DNA methylation status in triads.

Attention-deficit/hyperactivity disorder (ADHD) is the most common neuropsychiatric disorder in childhood affecting 5-6% of children, which often begins during childhood persisting into adulthood in the majority of patients, and is associated with poor academic and social outcomes. The core areas...

Awarded: NOK 8.7 mill.

Project Period: 2015-2020

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Cytotoxic lymphocyte function in regulation of human autoimmunity

Cytotoxic lymphocytes have evolved to combat intracellular pathogens. Moreover, they also make pivotal contributions to maintaining a balance of the immune system through elimination of other activated immune cells. According to our objectives, we have generated a large biobank of material from p...

Awarded: NOK 7.0 mill.

Project Period: 2015-2019

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Proteoglycan Signaling Induces Myocardial Fibrosis and Diastolic Heart Failure

Heart failure is a major killer in Western world countries, estimated to be present in 2-3% of the population. Reduced filling of the heart is an important cause of heart failure, and is mainly due to a stiffer heart caused by increased connective tissue and fibrosis. There is currently no effect...

Awarded: NOK 9.0 mill.

Project Period: 2015-2018

Location: Oslo - Oslove

BIOTEK2021-Bioteknologi for verdiskaping

Norwegian Genomics Consortium meeting 2015

Norwegian Genomics Consortium (NGC) skal arrangere et nettverksseminar i oktober, hvor consortiet tar sikte på å utveksle erfaringer og videreutvikledet nasjonale samarbeidet mellom genomikk forskningsmiljøer i Norge, med spesiell fokus på exomsekvensering. Seminaret går over to dager. Det vil b...

Awarded: NOK 51,999

Project Period: 2015-2016

Location: Trøndelag - Trööndelage

FRIPRO-Fri prosjektstøtte

Rare Genetic Variants in Childhood Diabetes: Improving Diagnostics and Treatment of Childhood Diabetes by Next-Generation Sequencing

Diabetes is a major health burden (WHO). Diabetes is currently classified in four types; type 1 diabetes, type 2 diabetes, gestational diabetes, and monogenic/other types of diabetes. Mutations in around 20 genes cause monogenetic forms of diabetes. With the new genetic technology in which the wh...

Awarded: NOK 9.0 mill.

Project Period: 2015-2024

Location: Vestland

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

Defining relevant targets for personalizing gynecologic cancer treatment

At time of metastatis gynaecological cancer need new and more targeted treatment. The study examines the effects of such new and more targeted medications. In addition we investigate promising new biomarkers that can be used to prevent over-treatment with associated side effects in patients with ...

Awarded: NOK 9.0 mill.

Project Period: 2015-2021

Location: Vestland

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

Preventing Atopic Dermatitis and ALLergy in children

PreventADALL has two main objectives; to investigate if atopic dermatitis (AD) and or food allergy can be prevented by skin-and/or food interventions in the first year of life, and identify factors early in life that implicated in development of non-communicable diseases, including asthma and oth...

Awarded: NOK 9.0 mill.

Project Period: 2015-2020

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Methylation supernegative colorectal cancers - a key to unlocking the secrets of the DNA (de)methylation machinery

Although the cells in our body basically contain the same DNA, they have different functions and appearances depending on which genes they express. DNA methylation is a chemical modification that helps regulate the gene expression and ultimately decides whether they are turned on or off. In canc...

Awarded: NOK 7.0 mill.

Project Period: 2015-2019

Location: Oslo - Oslove

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Identification of genetic markers involved in development of metastases and second cancers in melanoma

There are three main types of skin cancer, of which malignant melanoma is the most serious. Each year over 1,700 Norwegians are diagnosed with melanoma. During recent years new and very promising treatments have become available, but still around 20% of melanoma patients die from the disease. Peo...

Awarded: NOK 2.4 mill.

Project Period: 2015-2019

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Mitochondrial dysfunction in the pathogenesis of Parkinsons disease: elucidating disease mechanisms and identifying therapeutic targets

Parkinson disease (PD) is one of the most common neurodegenerative disorders with an increasing prevalence and a world-wide socioeconomic impact. The need for understanding and treating this debilitating disorder has never been more urgent. We believe that dysfunction of mitochondria, the energy...

Awarded: NOK 7.0 mill.

Project Period: 2015-2018

Location: Vestland

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Translational research on tertiary prevention in cancer patients

Colorectal cancer (CRC) is the second leading cause of cancer death. At the same time, the number of survivors of CRC in the population continues to increase. Many cancer patients resort to taking nutritional supplements, assuming potentially beneficial effects. However, in the case of folate thi...

Awarded: NOK 2.8 mill.

Project Period: 2015-2018

Location: Vestland

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

A randomized placebo controlled phase II study with Metformin in metabolic-unbalanced breast cancer survivors at higher risk for recurrence

Metabolic imbalance such as metabolic syndrome, weight gein, obesity, elevated insulin and blood sugar, and insulin resistance are strongly associated with breast cancer recurrence and poorer prognosis. A recent pre-clinical study has demonstrated effect of 4 weeks of metformin to reduce Ki-67 (a...

Awarded: NOK 3.1 mill.

Project Period: 2015-2021

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Resolving complex genetic causes of Movement Disorders

Genetic studies within families has been used to identify genetic causes of disease. Modifiers of disease risk have been identified by comparing genetic markers between groups of patients and control invididuals. Genetic risk factors have a modest effect and seldom increase the disease risk by mo...

Awarded: NOK 7.0 mill.

Project Period: 2015-2019

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

NORGUT: EXPLORING THE METABOLIC SIGNATURES OF DISEASE AND DRUG ASSOCIATED GENOMIC FEATURES OF THE GUT MICROBIOTA IN NORWAY

The gut microbiota could be considered a separate organ system, which influences our health by modulating the immune system, digestion and other process. In the NORGUT project, we investigated the gut microbiota of diseases with manifestations in and symptoms from the gastrointestinal tract. ...

Awarded: NOK 6.9 mill.

Project Period: 2015-2020

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Overcoming insomnia. From genes to long-term impact on health and work. A large RCT of online cognitive-behavioral therapy for insomnia.

This first aim of this study was to evaluate the effect of a cost-effective, more accessible alternative treatment approach for insomniacs. Traditional CBT-I has been adapted to an online intervention system, so individuals can access a personalized treatment when they want. This newly developed ...

Awarded: NOK 6.7 mill.

Project Period: 2015-2021

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Follicular regulatory T cells. Probing their mode of suppression by a novel technique

Project 1: Regulatory T (Treg) cells play an important role in modulating our immune system, from the detrimental, to the beneficial. Treg cells have the capacity to inhibit successful tumor rejection, but on the beneficial side, the same T cells prevent lethal self-reactivity. So, understanding ...

Awarded: NOK 3.1 mill.

Project Period: 2015-2020

Location: Oslo - Oslove

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

Identification of molecular mechanisms and biomarkers of Multiple Sclerosis

Our primary objective is to identify molecular mechanisms and novel biomarkers of MS, paving the road for improved personalized medicine for MS patients. This project extends from ongoing research performed by the MS research group at OUS/UiO led by prof. Harbo in collaboration with local, nation...

Awarded: NOK 8.7 mill.

Project Period: 2015-2020

Location: Oslo - Oslove

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