0 projects

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The adaptive evolution of arthropod and vertebrate aquaporins: Deciphering the differential basis of water homeostasis

Innledende studier fokusert på å identifisere de genomiske repertoar av akvaporiner i et bredt spekter av prokaryote og eukaryote organismer for å legge grunnlaget for å forstå den evolusjonære historien til superfamilen, og for å identifisere alle akvaporin gener i lakselusa og sin vert, den atl...

Awarded: NOK 9.6 mill.

Project Period: 2011-2015

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Surviving without oxygen - from the role of hypoxia inducible factor to rebuilding a naturally damaged brain

While medical science has had a very limited success in counteracting the deleterious effects of ischemia/hypoxia in humans, evolution has repeatedly solved this problem. The best studied examples of anoxia tolerant animals are some North American freshwa ter turtles (genera Trachemys and Chrysem...

Awarded: NOK 6.4 mill.

Project Period: 2010-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Intrinsic limitation of the field metabolic rate in a free-ranging Arctic seabird: the role of oxidative stress

The rate of energy expenditure integrates nearly all aspects of the ecology of a species, and knowledge of the factors limiting energy expenditure is of paramount importance for a better understanding of the evolution of life-history traits in free-living species. One factor which may exert a po...

Awarded: NOK 3.9 mill.

Project Period: 2010-2013

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Maturation of the electrophysiological and intracellular signaling systems in teleost gonadotropes during puberty

Hovedmålet til dette prosjektet er å belyse hvordan reguleringsmekanismen til de hormonproduserende gonadotrope cellene i hypofysen modnes under pubertetsutviklingen, med fokus på komponenter som deltar i elektrofysiologisk signalisering trigget av frigjø ringshormonet GnRH. Vi bruker torsk og me...

Awarded: NOK 6.6 mill.

Project Period: 2009-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Exploiting the plasticity in social life history; physiology of extreme longevity in honeybee diutinus workers

Our studies have documented direct effects of vitellogenin on stress resistance and longevity during summer. However, although vitellogenin RNAi in workers living under favorable ambient conditions provides functional insight, it does not directly address the role of vitellogenin in extreme work...

Awarded: NOK 3.4 mill.

Project Period: 2008-2013

Location: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Surviving without oxygen: from mitochondrial function to ethanol production

While medical science has had a very limited success in counteracting the deleterious effects of ischemia/hypoxia in humans, evolution has repeatedly solved this problem. The best studied examples of anoxia tolerant animals are some North American freshwa ter turtles (genera Trachemys and Chrysem...

Awarded: NOK 5.2 mill.

Project Period: 2008-2012

Location: Oslo

FRIBIO-Biologi og biomedisin

Olfactory pathways connecting defined glomeruli of the macroglomerular complex to higher integration centres in the heliothine moth brain

The olfactory coding mechanism responsible for reproductive behaviour have been thoroughly investigated in heliothine moths. This sub-family is particularly fascinating since the individuals communicate both within and across the species. Thus, the males possess receptor neurons detecting pheromo...

Awarded: NOK 2.4 mill.

Project Period: 2007-2010

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Does ovarian fluid favour MHC-dissimilar sperm?

When males provide nothing but genes, female choice of mates is expected to favour individuals that can best increase offspring survival. This selection process may not only occur at an individual level, but also on the gamete level. Recent studies have i ndicated that the ova may select sperm on...

Awarded: NOK 2.7 mill.

Project Period: 2007-2010

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Metabolic scaling in teleosts

Metabolic scaling is a widely recognised problem in biology. The underlying causes for the disproportionate relationship between the metabolic rate of an organism and its body size have long puzzled scientists, and continue to be controversial. In recent years this fascinating subject has been tr...

Awarded: NOK 3.1 mill.

Project Period: 2007-2010

Location: Vestland

FRIBIO-Biologi og biomedisin

NEURONES FORMING FUNCTIONAL NETWORKS IN THE MOTH BRAIN

We are searching to uncover the neuronal network involved in chemosensory coding and appetitive learning in insects, using moths of the subfamily Heliothinae as model organisms. The focus in the present project is to characterise physiologically and morph ologically neurones in the primary and th...

Awarded: NOK 2.4 mill.

Project Period: 2006-2009

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Surviving without oxygen - from heart function to DNA replication

While most vertebrates die within minutes of anoxia (no oxygen), a few species can tolerate anoxia about 1000 times longer. These include the crucian carp (Carassius carassius, No: karuss), a common fish in Norway, and some turtles. Anoxia and ischemia related diseases are the major killers in ...

Awarded: NOK 3.0 mill.

Project Period: 2006-2010

Location: Oslo

BIOFYS-Fysiologiske og anatomiske fag

Dissecting the physiological, sensory, cognitive, and social dynamic features of cellular aging in the honey bee worker brain

The honey bee is a key neurobiological model for understanding learning and memory formation. As a highly social invertebrate, moreover, the bee provides unique opportunities for cutting-edge research on aging and frailty because it opens up the interface between the individual and the social en...

Awarded: NOK 2.0 mill.

Project Period: 2006-2007

Location: Akershus

FRIBIO-Biologi og biomedisin

Molecular and electrophysiological characterization of the GnRH systems in Atlantic cod

Teleosts are unique among vertebrates regarding neural control of the adenohypophysis. The cells are directly innervated instead of receiving their input through a portal system. Furthermore, the distribution of the different cell types in the adenohypoph ysis in teleosts is highly regionalized, ...

Awarded: NOK 2.0 mill.

Project Period: 2005-2009

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

An Environmentally Induced FRQ-Independent 24 hour Rhythm in Neurospora crassa

Circadian rhythms (from latin circa, about; and dies, day) play an important role in the adaptation of organisms to their natural environment. It is assumed that by measuring day length, the circadian clock participates in the initiation of important dail y processes, for example sleep or activit...

Awarded: NOK 2.0 mill.

Project Period: 2005-2012

Location: Rogaland

FRIBIO-Biologi og biomedisin

Androgens and growth of previtellogenic oocytes in Atlantic cod: Identification and pattern of differentially expressed genes and proteins

The overall objective of the proposed project is to study the role and effect of androgens (e.g. 11-ketotestosterone; 11-KT) on the growth of previtellogenic oocytes through the characterization of androgen-responsive ovarian genes and proteins. Thus incr easing our understanding on the hormonal ...

Awarded: NOK 1.8 mill.

Project Period: 2005-2008

Location: Trøndelag - Trööndelage

BIOFYS-Fysiologiske og anatomiske fag

Adaptation of insects to extremely cold winters and extremely hot summers in Siberia

The present project is focused on adaptations which make insects able to survive the extremely cold winters and hot summers in inner Siberia. The studies will compare the features of insects in Yakutia with those of Scandinavia, preferably by comparing fe atures of the same species. The project w...

Awarded: NOK 1.2 mill.

Project Period: 2005-2008

Location: Trøndelag - Trööndelage

BIOFYS-Fysiologiske og anatomiske fag

Neuronal mechanisms conveying hypoxic tolerance to diving birds and mammals

We propose to use the in vitro brain slice technique with cortical and medullary-based (cerebellar) neuronal networks, to unravel adaptive neuronal mechanisms to hypoxia in higher vertebrates. In this context, we will also investigate the possible role of the respiratory pigment neuroglobin in t...

Awarded: NOK 1.2 mill.

Project Period: 2005-2007

Location: Troms - Romsa - Tromssa

BIOFYS-Fysiologiske og anatomiske fag

Living with little or no oxygen: from molecules to physiological biodiversity

While most vertebrates die within minutes of anoxia (no oxygen), a few species can tolerate anoxia about 1000 times longer. These include the crucian carp (Carassius carassius, No: karuss), a common fish in Norway, and some turtles. Anoxia and ischemia r elated diseases are the major killers in t...

Awarded: NOK 2.7 mill.

Project Period: 2005-2007

Location: Oslo

BIOEVO-Evolusjonsbiologi og økologi

Magnetoreception and magnetic compass orientation in the long distance migration of the European eel

The European eel, Anguilla anguilla, a common part of the fish community in European coastal and inland waters, spawns in the Sargasso Sea. The larvae drift or migrate with currents to the coasts of Europe and North Africa. Once there, large numbers of yo ung eels grow up in widely different habi...

Awarded: NOK 4.0 mill.

Project Period: 2004-2008

Location: Oslo

FRIMUF-Miljø- og utviklingsforskning

Spatial spread of invasive plants: linking demography, dispersal and spatial variation in niche opportunities.

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Awarded: NOK 1.7 mill.

Project Period: 2004-2006

Location: Oslo

BIOFYS-Fysiologiske og anatomiske fag

Alarm reactions in crucian carp

The alarm reaction in cyprinids discovered by Karl von Frisch has been a challenge to neurophysiologists. In particular, the alarm substance has evaded proper identification, and the pathways mediating the reaction have been unknown. Due to previous resea rch programs supported by the Research Co...

Awarded: NOK 4.8 mill.

Project Period: 2004-2008

Location: Oslo

BIOFYS-Fysiologiske og anatomiske fag

Olfactory mediated reproductive behaviour in fish

The processing of olfactory information from the olfactory epithelium to the olfactory tract in relation to two different behaviours: food search and alarm behaviours has been established recently. However, olfactory processing of the reproductive behavio ur as to how sex odours are coded in the ...

Awarded: NOK 1.4 mill.

Project Period: 2004-2005

Location: Oslo

BIOFYS-Fysiologiske og anatomiske fag

Intraspecific variation in the basal metabolism of birds

For a certain biological trait to evolve (or change) through natural selection, three fundamental prerequisites must be fulfilled. Firstly, variation in the trait must necessarily be capable of influencing the inclusive fitness of individuals. Secondly, t he between-individual variation should be...

Awarded: NOK 1.8 mill.

Project Period: 2004-2008

Location: Trøndelag - Trööndelage

VILLAKS-Forskningsprogram om villaks

VANN: Effects of environmental variation on the importance of carotenoids for offspring production in Atlantic salmon

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Awarded: NOK 1.4 mill.

Project Period: 2004-2007

Location: Trøndelag - Trööndelage

BIOFYS-Fysiologiske og anatomiske fag

Taste receptor neurones inducing extension of the proboscis in heliothne moths

We are studying how olfactory and taste information is encoded in receptor and interneurones in the brain of insects and how learning of odours is realised via synapses of neurones connecting different brain compartments. As model organisms are used moths of the subfamily Heliothinae. In the pres...

Awarded: NOK 1.7 mill.

Project Period: 2003-2007

Location: Trøndelag - Trööndelage

NORKLIMA-Klimaendringer og konsekvenser for Norge

ENDOCLIMA - Interacting Effects of Climate Change and Endocrine Disrupters, additional support to the ENDOCLIMA Marie Curie.

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Awarded: NOK 1.3 mill.

Project Period: 2003-2007

Location: Trøndelag - Trööndelage

MARE-Marine ressurser,miljø og forv

Habitat choice and activity in relation to hypoxia and haemoglobin genotype in fish;comparisons across populations and species, Postdr.

We propose to combine experiments, molecular ecology and modelling to investigate influences of hypoxia on habitat choice, boldness, recovery from stress and swimming activity in relation to individual genotype and physiology in fish. Comparisons both wit hin (among different populations) and acr...

Awarded: NOK 2.6 mill.

Project Period: 2003-2006

Location: Vestland

BIOBIOT-Biologi, bioteknologi, Mat. Nat.

Stress and neurogenesis in rainbow trout

It is currently agreed that new neurons are added to continually growing structures and replace old and dying brain cells in adults of all major vertebrate taxa, a process known as neurogenesis. These structural processes may be highly important for behav iour, mood, and cognition in both animals...

Awarded: NOK 1.4 mill.

Project Period: 2003-2005

Location: Oslo

BIOFYS-Fysiologiske og anatomiske fag

Molecular analysis of a neuronal glutamine transporter, SA2, involved in transmitter recycling

Signalformidling mellom nerveceller skjer ved at kjemiske signalstoffer frigjort fra en nervecelle reagerer med spesifikke reseptorer på den andre og stimulerer eller hemmer dens aktivitet. Glutamat and GABA er henholdsvis viktigste stimulerende og hemmen de signalstoff i hjernen. De er oppkonsen...

Awarded: NOK 1.7 mill.

Project Period: 2002-2005

Location: Oslo

BIOFYS-Fysiologiske og anatomiske fag

Valg av beskyttelsesstrategier mot miljøstress: Betydningen av konkurranse om samme kjemiske ressurser

Organismer er utsatt for ulike typer stress, som ofte virker sammen. Enkelte av organismenes forsvarsmekanismer mot stress er basert på bruk av samme kjemiske ressurs, slik at det kan oppstå en konkurransesituasjon mellom mekanismene. Et eksempel på en sl ik konkurransesituasjon har man i organis...

Awarded: NOK 1.7 mill.

Project Period: 2002-2005

Location: Trøndelag - Trööndelage