0 projects

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FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Causes of autism spectrum disorders. Epidemiologic studies based on MoBa, the ABC Study and the Autism Database.

Autismespekterforstyrrelser (ASF) har fått mye oppmerksomhet den senere tid som følge av observert økt forekomst i høyinntektsland, og spekulasjoner rundt en mulig årsakssammenheng med vaksiner eller andre eksponeringsfaktorer i miljøet. Kunnskapen om årsaker til ASF er imidlertid begrenset. Heru...

Awarded: NOK 4.0 mill.

Project Period: 2009-2016

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Changes over time in cancer survival and mortality in an ageing Norwegian population and the significance of sociodemographic conditions

The substantial increase in the number of very old persons in Norway over the last decades has had a marked impact on the burden of cancer in our society. This project aims to generate knowledge on changes over time in cancer survival and mortality among the very old, here defined as persons 75 ...

Awarded: NOK 3.1 mill.

Project Period: 2009-2012

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The Comparative History of Antimicrobial Resistance in Norway 1945-1998

Anti microbial resistance (AMR) has been a challenge for clinical medicine, pharmacology and public health since World War II. It has gone through a career from a rare clinical problem in the 1950s to being a major public health threat. Initially being di scussed in expert circles it gradually be...

Awarded: NOK 3.0 mill.

Project Period: 2009-2013

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Identification of host and microbe determinants for Staphylococcus aureus colonisation of healthy individuals - targets for intervention

Staphylococcus aureus is an important pathogen in human disease causing a wide range of infections that require extensive use of antibiotics and are associated with significant costs for the patient and the community. Antibiotic resistance is a perpetual challenge to our defence against serious ...

Awarded: NOK 6.4 mill.

Project Period: 2009-2014

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Gene-environment interactions in childrens social competence: Differential susceptibly or differential vulnerability?

Starting in 2002 a series of findings has demonstrated that some individuals, also children, who share common polymorphisms, primarily related to the serotonergic and dopaminergic systems face greater risk of developing psychopathology when exposed to neg ative environments (e.g. negative life ev...

Awarded: NOK 8.6 mill.

Project Period: 2009-2014

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Neurogenetics of aging: impact of DNA repair on Alzheimer disease

The genetic background for cognitive loss, dementia and aging processes is poorly described, and multidisciplinary research is needed to increase this knowledge. Alzheimer disease (AD) is by far the most important contributor to cognitive decline and deme ntia worldwide. Incidence may quadruple s...

Awarded: NOK 4.1 mill.

Project Period: 2009-2013

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Neoadjuvant Avastin in Breast Cancer (Neo-Ava) - an integrated molecular approach to treatment biology.

I kliniske studier hvor en ønsker å avdekke hvilke pasienter som har nytte av en spesifikk behandling, er detaljerte analyser av svulstvevet både i forkant, under og etter behandling, av stor betydning. Likeledes kan andre analyser også kaste lys over effekten av en slik behandling, slik som fors...

Awarded: NOK 4.4 mill.

Project Period: 2009-2015

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Congenital heart defects in Norway - A nation-wide study

Vi har benyttet nasjonale helse- og populasjonsregistre for å undersøke risikofaktorer for medfødte hjertefeil i Norge. Epidemiologiske studier av medfødte hjertefeil har tidligere ikke vært utført på ett nasjonal nivå grunnet manglende data. Slike studier er viktige fordi medfødte hjertefeil er ...

Awarded: NOK 5.2 mill.

Project Period: 2009-2017

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The development of attachment and social relations in young children: A transactional and contextual model

Establishing a secure attachment to caregiver(s) is considered one of the fundamental milestones in children's development. It is hypothesized that trough interaction with the caregiver the child forms mental representations of the self, others and the ou ter world, viz. inner working models. Mat...

Awarded: NOK 4.1 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Pelvic girdle pain in pregnancy: Endocrine risk factors, physical activity and prognosis.

Background: Pelvic girdle pain affects one in five pregnant women, gives rise to functional disabilities and is a major cause of sick leave in pregnancy. Hence, pelvic girdle pain should be regarded as a major women's health issue. Nevertheless, the aetio logy is poorly understood. Pregnancy repr...

Awarded: NOK 3.6 mill.

Project Period: 2008-2012

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Night work, circadian gene polymorphisms and breast cancer risk among female nurses. A nested case-control study

Less than half of all breast cancers can be explained by known risk factors. Results from recent epidemiological studies have been largely consistent in suggesting a positive association between night work and increased risk of breast cancer in women. Th ese findings suggest a role of circadian ...

Awarded: NOK 3.2 mill.

Project Period: 2008-2011

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Prediction of fetal growth restriction by maternal perception of fetal activity

Fetal growth restriction (FRG) is a major challenge in obstetric care, and a significant risk for severe disabilities and death. Risk is reduced by early detection, but prediction in antenatal care is poor. FGR is associated with decreased fetal movements (DFM). Pregnant women universally perfor...

Awarded: NOK 4.6 mill.

Project Period: 2008-2012

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Cognition and plasticity throughout the human lifespan - Neuroanatomical, neurophysiological and neuropsychological markers and mechanisms

The present proposal seeks to uncover the markers and mechanisms underlying changes in brain and cognitive behavior throughout the lifespan, and whether, and how, we ourselves can initiate, enhance or slow such changes. The goal is to detail the nature of age changes in both brain anatomy, activ...

Awarded: NOK 4.2 mill.

Project Period: 2008-2011

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Folate, Paternal Age and De Novo Genetic and Epigenetic Events.

De novo mutasjoner er endringer i arvematerialet (DNA) som oppstår i kjønnscellene eller tidlig i fosterutviklingen og som derfor er nye i den forstand at de ikke finnes hos foreldrene. Epigenetiske mekanismer er kjemiske endringer i arvematerialet som styrer hvorvidt et gen skrus av eller på, op...

Awarded: NOK 4.5 mill.

Project Period: 2008-2015

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Cancer-targeted T cell Receptors - the next generation immunotherapeutic drugs

The aim is to generate recombinant T cell receptors that recognize cancer cells. DNA encoding the receptors form basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) A large number of T cell clones recognizing common canc...

Awarded: NOK 3.2 mill.

Project Period: 2008-2015

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Molecular characterization of breast cancer: Combined genomics, metabolomics and MR imaging

Breast cancer has the highest incidence and mortality of all malignant diseases among women globally. The heterogeneous nature of breast cancer results in different clinical presentations and outcomes, and patients show a diverse range of responses to a g iven treatment. Processes leading to more...

Awarded: NOK 4.9 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FRIMED-Klinisk medisin og folkehelse

A Pilot Study to Develop a Model of Acute-on-Chronic Model of Liver Failure in Dog

Liver failure is a serious problem that carries a high mortality. Two common presentations of liver failure exist: acute liver failure (ALF) of previously healthy subjects, and acute-on-chronic liver failure of subjects with existing (cirrhotic) liver dis ease. These two presentations of liver fa...

Awarded: NOK 1.5 mill.

Project Period: 2008-2010

Location: Ukjent Fylke

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Phenotypic heterogeneity of glucokinase-diabetes mutations: Studies of structure, function and regulatory mechanisms leading to treatment

Glucokinase (GK) is the major glucose sensor in the pancreatic beta-cell where it catalyses the first step of glycolysis. Mutations in human GK (hGK) can be inactivating or activating. Heterozygous inactivating mutations lead to a mild form of diabetes, M ODY2, while homozygous inactivating mutat...

Awarded: NOK 5.1 mill.

Project Period: 2008-2012

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Molecular therapy of maligngant glioma with lentiviral vectors and tumor infiltrating progenitor cells

The aim of the project is to establish a stable packaging cell line for lentiviral vectors based on bone marrow derived tumor infiltrating progenitor cells (BM-TIC) for the treatment of malignant glioma. In previous studies, we have shown that BM-TIC migr ate and distribute efficiently within mal...

Awarded: NOK 3.0 mill.

Project Period: 2008-2012

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Frontal lobe injury and cognitive control

The main goal of this project is to investigate the neural substrate and cognitive mechanisms that are involved in a set of higher-order "executive" functions that are necessary for goal-directed thinking and behavior. At present there is no unitary model that accounts for all aspects of executi...

Awarded: NOK 4.0 mill.

Project Period: 2008-2012

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Diabetes and diabetes precursors: detection, classification, prediction, genetics, complications and prevention. The Tromsö Study.

The incidence and prevalence of diabetes mellitus are increasing in many populations, and diabetes is now one of the most prevalent chronic diseases worldwide. Diabetes carries a great disease burden in terms of morbidity, mortality and costs. Most cases are classified as Type 2 diabetes, which h...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Change in clinically significant behavior during pharmacological augmented treatment of anxiety disorders

There has been enormous progress in the treatment of anxiety disorders, yet about 40% patients with chronic posttraumatic stress disorder do not recover after receiving daily medication or psychotherapy. PTSD is characterized by hyperarousal, coupled with emotional avoidance. Non-reinforced expo...

Awarded: NOK 3.6 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FRIMED-Klinisk medisin og folkehelse

Qualitative research in health care practice: Challenges of methodology and implementation

Project summary The Nordic Interdisciplinary Conference on Qualitative Methods in the Service of Health conference is a bi-annual event that has been held in the Nordic countries since its launch in 2001. The Department of Health Studies at the Faculty of Social Sciences, University of Stavange...

Awarded: NOK 82,657

Project Period: 2008-2008

Location: Rogaland

FRIMED-Klinisk medisin og folkehelse

Basic and clinical studies of peptide-based immunotherapy in chronic HIV-1 infection

Immune based therapies represent new, promising approaches to the treatment of chronic HIV infection, aiming to enhance the patients own specific immune response against HIV and delay the immune impairment caused by the HIV-infection. The basis for this a pplication is two patient cohorts that ha...

Awarded: NOK 0.76 mill.

Project Period: 2007-2010

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Neurogenetics of attention in the aging brain

Aging was recently described as a ?neurocatastrophe? involving increased oxidative stress, disturbed energy homeostasis, accumulation of damaged proteins, and lesions in nucleic acids (Mattson & Magnus, 2006), making aging the primary risk factor for deve lopment of neurodegenerative diseases. Ag...

Awarded: NOK 2.9 mill.

Project Period: 2007-2012

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Mitochondrial disease: generating models, investigating mechanisms and exploring treatments.

The project will establish laboratory models to study two types of mitochondrial disease, one primary mtDNA mutation in MTND5 and one secondary mtDNA disease caused by mutations in the mitochondrial DNA polymerase (POLG). Transgenic mouse models for the P OLG mutations, A467T & W748S, and cell cu...

Awarded: NOK 4.7 mill.

Project Period: 2007-2010

Location: Ukjent Fylke

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Computational models of aberrant attribution of salience in schizophrenia and the effects of medication: An event related fMRI study

It has been known for decades that dopamine abnormalities are relevant to the pathophysiology of schizophrenia (mainly psychotic symptoms) and that blocking the dopamine system is associated with improvements in symptoms. How one gets from this neurochemi cal change to the expressed behavior abno...

Awarded: NOK 2.5 mill.

Project Period: 2007-2012

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Statistical modelling for infectious disease

We want to build a viable research group in statistical and mathematical modelling of infectious disease. We wish to make important original contributions to statistical methodology for analysis on infectious disease data, for the further purpose of aidin g, monitoring and understanding the sprea...

Awarded: NOK 2.8 mill.

Project Period: 2007-2011

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Improved individualized diagnosis and treatment monitoring of prostate and breast cancer by combining new MR and ultrasound technology

This project deals with combining new methods in medical ultrasound (US) and Magnetic Resonance (MR) imaging to improve individualized diagnosis and treatment monitoring of prostate and breast cancer. The project includes further development of new techno logy and taking this technology into clin...

Awarded: NOK 3.7 mill.

Project Period: 2007-2012

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Medication assisted rehabilitation and crime; how do MMT affect crime rates and patterns?

It is still not known fully to which extent MMT offers crime reduction as a mean of harm reduction for heroin addicts in Norway. New knowledge of crime reduction patterns based on cross-registry studies and in-dept studies on crime patterns will give impo rtant new knowledge for program planners ...

Awarded: NOK 2.7 mill.

Project Period: 2007-2012

Location: Oslo

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