0 projects

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MILPAAHEL-Miljøpåvirkning og helse

Oil induced autoimmune disease

We here present evidence that environmental exposure to immunoadjuvants in particular mineral oils, may precipitate autoimmune diseases in susceptible individuals, and that a novel class of genes encoding leukocyte regulatory receptors contribute to this susceptibility. The evidence is based on t...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Environmental mercury and human health in Arctic Norway

Persistent pollutants in Arctic areas have received much attention. It is well known that these contaminants accumulate in food webs and potentially cause severe physiological damages to top level predators including humans. People in Arctic regions tend to be more exposed to these pollutants due...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Hearing loss and tinnitus: genetic and environmental effects

Depending on the criteria used 1/3 - 1/6 of the population experience hearing impairment. Tinnitus is defined as the sensation of sound without any outer sound stimulus present. Environmental risk factors such as noise exposure are frequently described fo r both the diseases. A genetic component ...

Awarded: NOK 2.3 mill.

Project Period: 2008-2015

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Health effects related to environmental exposure in an industrial community

Environmental monitoring has shown relatively high levels of heavy metals like cadmium, mercury and lead in residential areas in the industrial town of Odda. The main objective of this project is to provide new knowledge about the association between envi ronmental exposure to chemical factors an...

Awarded: NOK 3.0 mill.

Project Period: 2008-2013

Location: Vestland

MILPAAHEL-Miljøpåvirkning og helse

Population exposure and health impact associated with indoor air pollution from household solid fuel burning in developing countries

Almost 3 billion people worldwide use traditional fuels for home cooking and heating. It is well documented that high levels of air pollution from solid fuel burning contribute to enhanced rates of acute and chronic respiratory diseases. According to the World Health Organization, smoke from soli...

Awarded: NOK 2.6 mill.

Project Period: 2007-2011

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Preventive vaccination against allergy: the effect in offspring of maternal allergen exposure and immune response

Allergy-related diseases affect in the order of 30% of the population, and represent one of the most common health problems caused by environmental factors in interplay with genetically and epigenetically determined susceptibility of the individual. The causes for allergy are largely unknown, a...

Awarded: NOK 3.0 mill.

Project Period: 2007-2011

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Germ cell DNA damage and its impact on early embryo development

An apparent decline in semen quality has occurred during the past half century which is most likely related to environmental exposure; however, the agent(s) responsible have not been identified. Endocrine disruptors acting prenatally may be responsible bu t have yet to be shown as relevant for hu...

Awarded: NOK 3.1 mill.

Project Period: 2007-2012

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Dioxin-like Organohalogen Carcinogenesis

Dioxin-like organohalogens include polychlorinated dibenzodioxins, dibenzofurans and 11 planar bifenyls (PCB). In addition, brominated flame retardants (PCDE) may share many of their characteristics. They are persistent environmental pollutants which acc umulate in food chains. Human exposure oc...

Awarded: NOK 2.3 mill.

Project Period: 2007-2012

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Health Effects of Dietary DNA from Novel foods

The major fraction of DNA present in the food (dietary DNA) is degraded in the gastrointestinal tract. However, it is a recent and novel finding that a substantial fraction of intact dietary DNA, several hundred base pairs long, is taken up from the gastr ointestinal tract and distributed to bloo...

Awarded: NOK 2.5 mill.

Project Period: 2007-2011

Location: Akershus

MILPAAHEL-Miljøpåvirkning og helse

Thermolysis of carbohydrates and intestinal cancer risk.

Increased colorectal cancer risk is associated with a Western style diet and several carcinogenic and hazardous compounds are formed during heat processing. Acrylamide is formed in µg/amounts during heating of sugar-rich foods, but 5-hydroxymethylfurfural (HMF) is produced in much larger quantit...

Awarded: NOK 3.0 mill.

Project Period: 2006-2011

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

The effect of polychlorinated biphenyls and brominated flame retardants on dopaminergic systems. A possible explanation for toxic effects.

The proposed project is to study in what way both molecular mechanisms and electrophysiological responses induced by treatment with PCB and BFR will affect the phosphorylation pattern of glutamate receptors in defined brain regions in controls and mice wi th deletion of the DARPP-32 gene.

Awarded: NOK 2.1 mill.

Project Period: 2006-2014

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Environmental noise

Det er tidligere dannet et konsortium av de sentrale norske støyforskningsmiljøene som gikk inn for en samordnet innsats for å nå det nasjonale støymålet: 25 % reduksjon av støyplagen frem mot 2010. Det er allerede klart at tidsaspektet i dette målet ikke vil oppfylles, men reduksjonsmålet anses...

Awarded: NOK 11.7 mill.

Project Period: 2006-2012

Location: Trøndelag - Trööndelage

MILPAAHEL-Miljøpåvirkning og helse

The Nordic-Swiss Childhood Brain Tumour Study

During the last decade, the use of mobile telephones has increased dramatically in large parts of the world. It has been hypothesized, that children should be more vulnerable to radio frequency electromagnetic field exposures from mobile telephones than a dults, but no epidemiological studies of ...

Awarded: NOK 1.8 mill.

Project Period: 2006-2011

Location: Oslo

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