0 projects

Date from new to old

FRIMED-Klinisk medisin og folkehelse

Tracking and prediction of health-related behaviour and physiological risk factors: 27 years follow up of a prospective cohort study

Worldwide the prevalence of overweight and obesity have increased the last decades. Obesity is associated with increased mortality, reduced life expectancy and an increase in several chronic diseases. It is important to identify risk factors for obesity t o make effective prevention strategies. O...

Awarded: NOK 2.9 mill.

Project Period: 2006-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

Sperm morphology and function in passerine birds

The prime function of sperm cells is to fertilize eggs. Despite this common purpose, there is a tremendous diversity among animal taxa in sperm phenotypes. Part of the variation can be attributed to phylogenetic relatedness, and sperm are often used as di agnostic traits in taxonomy. But there is...

Awarded: NOK 5.0 mill.

Project Period: 2006-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

Effect of environmental DNA exposure on bacterial adaptation rates

The increasing amount of DNA sequence data available reveals that horizontal gene transfer (HGT) events have been frequent in most bacterial species. This observation identifies HGT as a major driving force in bacterial evolution. Whereas many studies hav e addressed the dynamics and mechanisms o...

Awarded: NOK 2.8 mill.

Project Period: 2006-2010

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Opioidergic signaling mechanisms in pain and dependence: PET opioid receptor binding. I. animal studies.

We are all naturally dependent on opioids for our emotional health. The opioid system is activated during the experience of pain, and opioids are used as analgesia and for abuse. Intentionally, opioid analgesia in pain and opioid drug abuse are contrary t o each other, but there are several commo...

Awarded: NOK 2.8 mill.

Project Period: 2006-2009

Location: Ukjent Fylke

RENERGI-Fremtidens rene energisystemer

Bruk av skruekompressor i hybrid varmepumpe med NH3/H2O som arbeidsmedium

Hybrid Energy AS ble stiftet i mai 2004 for å avdekke muligheter og bygge systemer for redusert energibruk i industri og større varmesystemer. Det installerte produktet vil være den hybride varmepumpen som er utviklet ved IFE de siste 9 år. Hybrid Energy AS har avdekket flere prosjekter med god n...

Awarded: NOK 0.91 mill.

Project Period: 2006-2010

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Proteomic and bioinformatic studies of Mycobacterium tuberculosis

Tuberculosis (TB) is a major communicable disease linked to poverty with a substantial death toll of about 2 million cases annually. Research is needed to develop novel diagnostic tools, novel preventive measures such as vaccines and novel antibiotics. To do so it is of paramount importance to k...

Awarded: NOK 6.2 mill.

Project Period: 2006-2010

Location: Vestland

KLINISK-Klinisk forskning

Treatment of diabetes mellitus. Improvement of pancreatic beta-cell mass and function in clinical islet transplantation.

Diabetes mellitus is a rapidly increasing global problem leading to severe morbidity and early death. Insulin replacement is necessary for all patients with type-1 diabetes. Significant advances in human pancreatic islet transplantation have been achieved since the turn of the century and an 80%...

Awarded: NOK 3.6 mill.

Project Period: 2006-2010

Location: Oslo

NANOMAT-Nanoteknologi og nye materialer

Nanostructured Polymer and Composite Particles: Mechanical Properties

In Norway there is a renewed interest in extending the Ugelstad method based polymer particle technology to microsystem applications by producing nanostructured (conductive) polymer and composite particles. In these applications, the characterization, ana lysis and control of mechanical propertie...

Awarded: NOK 2.1 mill.

Project Period: 2006-2011

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

FUNCTIONAL SIGNIFICANCE OF INTRACELLULAR REGULATION OF GLUTAMINE TRANSPORTERS IN NORMAL AND MALIGNANT CELLS

Glutamine, the most abundant amino acid in plasma and cerebrospinal fluid, is important for many metabolic processes, e.g. biosynthesis of amino acids, purines and pyrimidines. Glutamine is a major N- and C-donor involved in inter-organ and inter-cellular shuttling of metabolites. It is a signal...

Awarded: NOK 2.4 mill.

Project Period: 2006-2009

Location: Oslo

ESRF-ESRF – Program for synkrotronforskning

A comparative structure/function study at an atomic level Comparing enzymes from the fish-pathogen Vibrio salmonicida and the radiation

The project will perform a structure/function study at an atomic level where protein targets will be selected from the extremophilic ("being able to survive under extreme conditions") bacterias Deinococcus radiodurans and Vibrio salmonicida. The target se lection will be mainly based on results f...

Awarded: NOK 2.3 mill.

Project Period: 2006-2009

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

The control of growth by insulin and TOR pathways in Drosophila: identification and characterisation of modifiers of starvation through a ge

This research projects aim to characterising some general mechanisms of growth control. Growth is a complex process, which depends both on internal cues, or genetic parameters, and external influences, like nutrition, exercise or temperature. It is well r ecognized that nutritional input is of gr...

Awarded: NOK 1.6 mill.

Project Period: 2006-2011

Location: Ukjent Fylke

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Toxicological Mechanisms of Non-Dioxinlike Persistant Organic Pollutants: Tools for Risk Evaluation

Norway is a major producer of farmed fish, and produces about 650 000 ton yearly. 95% of this is exported. Recently, the levels of persistant organic pollutants (POP) in farmed salmon has raised concerns. Allthough levels of dioxins and dioxin-like PCBs i n Norwegian farmed salmon are well below ...

Awarded: NOK 3.6 mill.

Project Period: 2006-2010

Location: Oslo

HAVBRUKS-Havbruk - en næring i vekst

Cell mediated immune response against virus in Atlantic salmon measured by T cell interferon gamma production

There is a need for more and better methods to test viral vaccine efficacy in Atlantic salmon. The adaptive immune responses mounted after vaccination of vertebrates against pathogens are classified as humoral (antibody mediated) and cell mediated immune (CMI) mechanisms. Humoral immune mechanism...

Awarded: NOK 3.4 mill.

Project Period: 2006-2010

Location: Troms - Romsa - Tromssa

BIA-Brukerstyrt innovasjonsarena

Combination of chemotherapy, radiation and immunotherapy in patients with non-small cell lung cancer; improving cancer vaccine efficacy.

GemVax is in the international forefront in the development of peptide based active immunotherapy for treatment of cancer. GV1001 is a telomerase based cancer vaccine which in principle can act as a universal cancer vaccine. GV1001 is GemVax' lead com pound. The product has been developed in ...

Awarded: NOK 2.9 mill.

Project Period: 2006-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Activation of Toll-like receptors of the immune system studied by atomic force microscopy and confocal microscopy

Toll-like receptors (TLRs) trigger a fast response of the immune system to microbial particles that invade our body. TLRs recognize microbial conserved structures such as CpG-DNA or certain lipopolysaccharides, and are essential for our defense against mi crobes as well as for normal inflammatory...

Awarded: NOK 2.5 mill.

Project Period: 2006-2009

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Behavioral syndromes in salmonid fish: Ecological and evolutionary implications

Variation in the physiological stress response has been correlated to a number of major axes of variation in behavior, including activity, shyness-boldness, and aggression. Sih and co-workers recently coined the term behavioral syndromes for this phenomen on, and pointed out several important eco...

Awarded: NOK 2.3 mill.

Project Period: 2006-2009

Location: Akershus

FRIBIO-Biologi og biomedisin

The role of Natural Killer cells in defense against pathogens.

Natural Killer (NK) cells represent an efficient first line defense mechanism against infected cells and certain cancer cells. For this purpose each NK cell is equipped with an array of activating and inhibitory receptors recognizing MHC class I and other molecules on their target cells. Althoug...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Studies of mesenchymal cell function during development and disease using transgenic techniques.

Cells interact with collagens using specific cell surface protein receptors belonging to a family called integrins. We have identified one collagen-binding integrin (alpha11beta1), characterized its structure and are studying its function using genetical ly modified mice lacking alpha 11 integri...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Vestland

HAVBRUKS-Havbruk - en næring i vekst

Skeletal malformations in farmed salmon and cod: a functional approach to determine causalities and mechanisms

Skeletal deformities cause severe losses both in salmon and cod production. This research platform aims to gain further insight into the normal growth and development of the vertebral column of salmon, and how current culture techniques may disrupt norma l growth inducing bone related pathologic...

Awarded: NOK 16.0 mill.

Project Period: 2006-2010

Location: Troms - Romsa - Tromssa

BIA-Brukerstyrt innovasjonsarena

A novel antimicrobial agent for topical treatment of challenging infections caused by drug-resistant bacteria.

"Once life-saving medicines are increasingly having as little effect as a sugar pill. Since 1970, no new classes of antibacterials have been developed to combat infectious diseases. Microbial resistance to treatment could bring the world back to a pre-an tibiotic age." WHO Report 2000: Overcomi...

Awarded: NOK 8.8 mill.

Project Period: 2006-2009

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Byggemetoder for 3D Heterogene Mikro / Nano systemer

Prosjektets overordnete idé er å videreutvikle SensoNor som Center of Excellence for Mikro / Nano systemteknologi (MNST). Dette gjelder både i Norge og innenfor SensoNors moderselskap Infineon Technologies. Utvikling av neste generasjons teknologiplattf orm for 3D heterogene mikro/nano systemer...

Awarded: NOK 31.5 mill.

Project Period: 2006-2010

Location: Vestfold

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Overvekt, insulinresistens og inflammasjon i relasjon til fettinntak og fettkvalitet

Det er en stadig økende forekomst av overvekt og type 2 diabetes mellitus i Norge og verden forøvrig. Som produsent av næringsmidler med høyt innhold av fett ønsker Mills å få økt kunnskap om fettets betydning for disse sykdommene med det formål å kunne u tvikle produkter som har forebyggende eff...

Awarded: NOK 1.7 mill.

Project Period: 2006-2010

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Utvikling av en nanoteknologisk blodsukkermåler for kontinuerlig in vivo måling av blodsukker hos pasienter med Diabetes mellittus

Formålet med prosjektet er å utvikle en miniatyrisert osmotisk trykksensor for automatisert kontinuerlig in vivo måling av blodsukker (glukose) hos pasienter med Diabetes mellittus. Enheten skal være liten nok til injeksjon uten bruk av kirurgi, den skal være inorganisk, og følgelig ikke nedbrytb...

Awarded: NOK 10.9 mill.

Project Period: 2006-2011

Location: Vestfold

FUGE-Funksjonell genomforskn.i Norg

The importance of post-translational glycosylation in the secretory pathway for expansion of the functional repertoire of gene products

Most proteins in animal and plant cells are glycosylated, a fact that must be taken into account for all aspects of protein studies, because the glycan portion often influences protein activity and cellular targeting, and more practically, protein purific ation, crystallization and structural det...

Awarded: NOK 1.6 mill.

Project Period: 2006-2009

Location: Oslo

SIP-NHD-Strategiske instituttprogram finansiert av NHD

Metabolic Engineering of Bacillus methanolicus: Understanding its C1 Metabolism as a basis for Directed Improvement of L-lysine Production

Metabolic engineering is the purposeful modification of cell metabolism by using recombinant DNA technology. The concept is to use available biochemical and genetic data to describe the metabolite flow in a metabolic network, and then use this to target s pecific genes for manipulations in order ...

Awarded: NOK 6.9 mill.

Project Period: 2006-2009

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Molecular characterization of embryonic microenvironment that stimulates adult human hematopoietic stem cells to differentiate into neurons

Recent research from the applicant and colleagues has shown that adult human hematopoietic stem cells, derived from bone marrow biopsies, can be stimulated to differentiate into nerve cells by placing them into the injured spinal cord of a chicken embryo. The injured embryonic spinal cord regen...

Awarded: NOK 2.9 mill.

Project Period: 2006-2009

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Structural Glycobiology

The aim of the present research project is to structurally and functionally characterize the basis of protein carbohydrate recognition, with the long-term goal of engineering the carbohydrate specificity of carbohydrate binding proteins. This research fie ld is central to many cellular processes ...

Awarded: NOK 3.4 mill.

Project Period: 2006-2011

Location: Oslo

NANOMAT-Nanoteknologi og nye materialer

Interdisciplinary Studies of Ethical and Societal Implications of Nanotechnology

This project will study long-term and broad-scoped ethical and societal issues related to a diverse set of nanotechnologies. Its mode of work consists of combining ethical and philosophical analysis with a workshop methodology emphasizing slow and broad d ialogue between ethicists, philosophers, ...

Awarded: NOK 2.2 mill.

Project Period: 2006-2009

Location: Vestland

FRIBIO-Biologi og biomedisin

Developmental Biology of Dormancy Cycling

In perennial plants, like trees, the SAM is cycling between active and dormant states in synchrony with the season (Rinne et al. 2001; Rinne and van der Schoot 2003, 2004). The SD-induced development of dormancy and acclimation involves the obstruction of cellular contacts at the SAM, including ...

Awarded: NOK 2.4 mill.

Project Period: 2006-2009

Location: Akershus

FRIBIO-Biologi og biomedisin

The Biosynthesis of NAD in Humans: Isozymes and Subcellular Compartmentation

NAD is essential for energy transduction. It is also a key molecule in a variety of central signaling pathways. Nevertheless, surprisingly little is not known about its biosynthesis. Our recent research has established that NAD biosynthesis is absent from the cytosol: the three human isoforms of...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Vestland

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