5,401 projects

Date from new to old

FUGE-Funksjonell genomforskn.i Norg

Detection, characterization and differentiation of infectious pancreatic necrosis virus (IPNV) strains in farmed Atlantic salmon

IPN outbreaks are seen both in the freshwater and seawater phase of the production, resulting in severe annual losses, and has emerged as a severe threat to the economy of the fish-farming industry. According to recent estimates, the yearly losses due to IPN in Norway are NOK 1 billion. This pro...

Awarded: NOK 3.5 mill.

Project Period: 2007-2010

Location: Møre og Romsdal

STAMCELLER-Stamcelleforskning

Signaling in neural stem cells: implications for regenerative medicine and tumor biology

Stem cell biology is one of the most closely followed developments in biomedicine today. Stem cells may provide the foundation for rational regenerative therapeutics with far-reaching implications in the health sector, but give also new alleys in the unde rstanding of tumor biology. The central ...

Awarded: NOK 12.4 mill.

Project Period: 2007-2012

Location: Oslo

STAMCELLER-Stamcelleforskning

Cancer and Mesenchymal Stem Cells

Mesencymal stem cells (MSCs) isolated from the human bone marrow, have been suggested, based on their differentiation potential, to be used in tissue regeneration and repair strategies. While these cells may have a considerable therapeutic potential, it i s also possible that they may have unwant...

Awarded: NOK 3.5 mill.

Project Period: 2007-2010

Location: Vestland

FRIBIO-Biologi og biomedisin

cAMP signalling -novel downstream targets of PKA and Epac identified by phospho-proteomics.

I. Implement novel method for quantitative COFRADIC non-gel global phospho-proteomics through stay of candidate in the laboratory of prof. J. Vandenkerckhove at Univ. of Gent II. The phospho-proteome will be compared in cells in response to activation of PKA (by N6-MB-cAMP) or Epac (by 8-pCPT-2´-...

Awarded: NOK 3.2 mill.

Project Period: 2007-2011

Location: Vestland

FRIBIO-Biologi og biomedisin

The role of normal neighbouring keratinocytes and fibroblasts on clonal expansion of oral cancer (stem) cells

Recent studies, including ours, have shown that the invasive behaviour of cancer cells is not solely due to mechanisms intrinsic to the individual tumour cell. Genetic changes of individual cells in a specific tissue are not sufficient for invasive cancer to develop. Rather, there is a vivid cro...

Awarded: NOK 1.1 mill.

Project Period: 2007-2009

Location: Vestland

FRIBIO-Biologi og biomedisin

Electrical signaling in thin dendrites and axons in the cortex

A major challenge in neuroscience is to understand the mechanisms of neuronal computation, much of which is carried out by electrical signals generated by ion channels in the cell membrane. Within the last decade, advances in patch-clamp and imaging techn iques have extended our knowledge of such...

Awarded: NOK 2.5 mill.

Project Period: 2007-2011

Location: Oslo

FRIBIO-Biologi og biomedisin

Functions of hippocampus and entorhinal cortex studied with viral vectors

Modern brain imaging methods have contributed enormously to contemporary knowledge about the particular brain systems involved in specific cognitive functions. Unfortunately, mechanistic insights have lagged behind, largely because brain mapping in humans lacks the spatial resolution required to...

Awarded: NOK 1.5 mill.

Project Period: 2007-2009

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Entorhinal grid cells and hippocampal memory

More than 30 years of research have pointed to the hippocampus as a key component of the brain's circuit for spatial representation. Although place-specific firing is undoubtedly the most conspicuous behavioural correlate of hippocampal principal neurons, hippocampal neurons also respond to a va...

Awarded: NOK 4.3 mill.

Project Period: 2007-2009

Location: Trøndelag - Trööndelage

BIONÆR-Bionæringsprogram

Technology and methods using high-density microarrays for detection of unknown genetic modifications in plants, fungi and bacteria

To ensure the safety of genetically modified organisms (GMOs) they are subjected to risk assessment prior to release into the environment and use in e.g. food production. Such known GMOs are considered to be as safe as conventional varieties. GMOs for whi ch publicly available descriptions are un...

Awarded: NOK 3.1 mill.

Project Period: 2007-2012

Location: Akershus

HAVBRUKS-Havbruk - en næring i vekst

Påvirker avlsarbeidet for økt sjukdomsresistens forekomsten av vaksineskader, immunrespons og effekten av vaksinering ?

I de norske avlsprogrammene for laksefisk har det gjennom flere generasjoner blitt selektert for økt resistens mot infeksjonssjukdommene furunkulose og ILA og metoden, smittetest med uvaksinert presmolt, har blitt tatt i bruk for flere arter andre steder i verden. Det er vist at slik seleksjon øk...

Awarded: NOK 7.4 mill.

Project Period: 2007-2012

Location: Troms - Romsa - Tromssa

GLOBHELS-Global helse

Novel vaccine candidates and delivery systems for HIV and influenza

Aim: We wish to generate novel vaccines for important infectious diseases such as HIV (FRIBIOMOL)and influenza (GLOBVAC). Background: Vaccination has had an enormous impact on health and longevity of humans world-wide. However, for some important diseases such as HIV, there are no available vacc...

Awarded: NOK 2.0 mill.

Project Period: 2007-2011

Location: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Improved methods for detection and strain identification of Tobacco rattle virus in Norway

Potetproduksjonen I Norge har I flere år vært skadelidende på grunn av rustflekksjuke - brune ringer og flekker - i potetknollene. Disse symptomene gjør potetene uegnet både til matpotet, pommes frites og potetgullproduksjon. Rustflekksjuke er hovedsakeli g forårsaket av to virus: potetmopptoppvi...

Awarded: NOK 4.3 mill.

Project Period: 2007-2011

Location: Innlandet

FRIBIO-Biologi og biomedisin

Competence-induced cell lysis in Streptococcus pneumoniae: Implications for horizontal gene transfer and virulence

Streptococcus pneumoniae have the ability to enter a transient phenotype termed competence for natural transformation, which enables the bacterial cells to take up free DNA from the surrounding environment. Recently, it was discovered that competent cells also aquire the ability to lyse neighbou...

Awarded: NOK 2.4 mill.

Project Period: 2007-2010

Location: Akershus

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Kvalitet og mattrygghet i den pelagiske verdikjeden - verdioptimalisering gjennom økt kompetanse

Forskningsaktiviteten i det avsluttede prosjektet "Pelagisk kvalitet - fra hav til fat" har avdekket en rekke kritiske punkter, både ombord og i mottaksanlegg, som er av stor betydning for kvaliteten og mattryggheten for pelagisk fiskeråstoff. Et av de vi ktigste kriteriene for å kunne definere k...

Awarded: NOK 5.3 mill.

Project Period: 2007-2009

Location: Ukjent Fylke

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Identification of molecular markerks associated with winter survival in the cultivated strawberry

Vinterskade i jordbær er et stort problem for norske jordbærprodusenter. Det medfører, i gjennomsnitt, en årlig avlingsreduksjon på minst 20%. Av denne grunn er foredling av jordbærsorter med bedre resistens mot frost ett av de viktigste foredlingsmål i G raminors foredlingsprogram. Skandinavia e...

Awarded: NOK 1.6 mill.

Project Period: 2007-2011

Location: Innlandet

BIA-Brukerstyrt innovasjonsarena

Utvikling av prosess for industriell produksjon av medisinsk sopp og immunstimulerende produkter.

Sopp har tradisjon som mat i mange kulturer. I Østen har man imidlertid i lang tid også vært klar over at sopper har positive helseeffekter. Sopp som danner makroskopiske fruktlegemer og har en positiv helsemessig effekt, betegnes som medisinsk sopp. De a ktive stoffene er i hovedsak ulike glukan...

Awarded: NOK 2.3 mill.

Project Period: 2007-2009

Location: Østfold

BIA-Brukerstyrt innovasjonsarena

Novel serotonin receptor ligands for medical use

It is well known that serotonin receptor ligands can be useful drugs for treatment of diseases outside the central nervous system (CNS). The main target organs for non-CNS indications are the gastrointestinal system, bladder and cardiovascular system. Sev eral serotonin receptor ligands are in de...

Awarded: NOK 4.9 mill.

Project Period: 2007-2009

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Fotokjemisk internalisering for cellegiftterapi av kreft

PCI Biotech AS utvikler en patentert teknologi for levering av legemidler, kalt fotokjemisk internalisering (forkortet PCI). Sentralt i denne teknologien står en patentert kjemisk forbindelse, kalt TPCS2a, som PCI Biotech utvikler for utprøving i pasiente r i innledende kliniske studier i kombina...

Awarded: NOK 8.5 mill.

Project Period: 2007-2010

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Innovation on Signalling Disruptors - Development of drugs eliminating cAMP action in infectious disease (HIV/AIDS) and cancer

Compartmentalised cAMP-dependent signalling is involved in development of a number of diseases including HIV/AIDS, certain types of cancer, and other types of immunodeficiencies which affect several million citizens both in industrialised and developing c ountries each year. No organised approach...

Awarded: NOK 5.9 mill.

Project Period: 2007-2009

Location: Oslo

RENERGI-Fremtidens rene energisystemer

New Materials for Medium Voltage Switchgear

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Awarded: NOK 3.2 mill.

Project Period: 2007-2010

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

USE OF SNP-CHIPS AND SELECTIVE DNA POOLING FOR IDENTIFYING DISEASE RESISTANCE MARKERS IN ATLANTIC SALMON

The main objective of this project is to find molecular markers that can be implemented in a marker assisted selection program (MAS) to increase genetic resistance to infectious salmon anaemia (ISA) in the Norwegian Atlantic salmon breeding program. MAS h as a great potential to increase the rate...

Awarded: NOK 2.4 mill.

Project Period: 2007-2010

Location: Vestland

TU-Tungt utstyr

Isothermal Titration Calorimeter

An important aspect within biological chemistry research projects at the University of Stavanger (UiS) is to identify and characterize protein-protein as well as protein-nucleic acid interactions. In these projects, including signal transduction in plant nitrogen metabolism (Prof. C. Lillo), ch...

Awarded: NOK 1.3 mill.

Project Period: 2007-2009

Location: Rogaland

SIP-NHD-Strategiske instituttprogram finansiert av NHD

Microtechnological research platform

The project utilizes the production facilities at SINTEF MiNaLab as a tool for University research. This production line is fully ISO sertified and offers state-of-the-art equipment for silicon based MEMS production. The project funds both production of d evices and training of students. The mai...

Awarded: NOK 21.0 mill.

Project Period: 2007-2010

Location: Trøndelag - Trööndelage

HAVBRUKS-Havbruk - en næring i vekst

Heart and skeletal muscle inflammation (HSMI) in Atlantic salmon: diagnosis, pathogenesis and epidemiology

Heart and skeletal muscle inflammation (HSMI) is a transmissible disease of viral aetiology affecting farmed Atlantic salmon. The disease appears to be spreading rapidly into new areas, and it is important to limit further spread. HSMI is characterized by severe inflammation in heart and red ske...

Awarded: NOK 4.2 mill.

Project Period: 2007-2011

Location: Akershus

HAVBRUKS-Havbruk - en næring i vekst

ONTOGENY OF LIPID DIGESTION AND EFFECTS OF FEEDING PRE-DIGESTED LIPIDS TO ATLANTIC COD (GADUS MORHUA) LARVAE

Lipids provide cod larvae with energy and essential fatty acids, the latter being structural components of biological membranes and precursors for the eicosanoids; signalling molecules which participate in regulation of a range of biological processes. Un til now, research on dietary lipids for m...

Awarded: NOK 2.9 mill.

Project Period: 2007-2009

Location: Vestland

BIONÆR-Bionæringsprogram

Safe grains: Mycotoxin prevention through resistant wheat and oats

In 2004 there were alarming levels of mycotoxins like DON and T-2/HT-2in Norwegian wheat and oats. In 2005 the latter levels in oats were prohibitive for e.g. horsefeed. The present proposal builds on a decade of Norwegian cereal breeding and research to introduce/identify resistance against the ...

Awarded: NOK 9.1 mill.

Project Period: 2007-2013

Location: Akershus

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Rapid DNA-based prediction of mycotoxin levels in food and feed

The major mycotoxin producers in foods in Norway and Europe are members of the genera Aspergillus, Fusarium and Penicillium. Two major classes of mycotoxins produced by Fusarium spp. are trichothecenes and fumonisins. The biosynthetic pathways involve gen es organised in (Tri- and Fum-) gene clus...

Awarded: NOK 2.6 mill.

Project Period: 2007-2011

Location: Akershus

PETROMAKS-Maksimal utnyttelse av petroleumsreserver

SMOOTHPIPE: Applied Surface Technology for Multiphase Pipelines

Pressure drop along the pipeline is the main obstacle to transportation of unprocessed or partly processed wellstream over long distances. Several parameters contribute to the pressure drop, e.g. liquid hold-up, precipitations, gas-liquid surface drag for ces and surface roughness. The project wi...

Awarded: NOK 7.2 mill.

Project Period: 2007-2010

Location: Trøndelag - Trööndelage

BIA-Brukerstyrt innovasjonsarena

Produksjon av solbeskyttende karotenoider fra bakterier.

Produksjon av solbeskyttende karotenoider fra bakterier. De fleste solkremer beskytter dårlig mot stråling ved 360-500 nm (langbølget UVA og synlig blått lys), selv om det i de senere år er blitt fokusert også på disse bølgelengdene i forbindelse med mela nom hudkreft, fotoaldring og andre solind...

Awarded: NOK 6.8 mill.

Project Period: 2007-2010

Location: Akershus

BIONÆR-Bionæringsprogram

Kartlegging av effekt av råstoff og produksjonsprosess på proteolytiske og lipolytiske endringer ved produksjon av langtidsmodnet spekeskin

Prosjektet, med kortnavn Enzymgris, har som hovedmål å kartlegge råstoffegenskaper i skinkeråstoff fra ulike svineraser ved ulike slaktealdre, for å bestemme hvilken rase og slaktealder som er best egnet til produksjon av norsk langtidsmodnet spekeskinke. Noe av det unike i prosjektet er det nøy...

Awarded: NOK 6.2 mill.

Project Period: 2007-2013

Location: Oslo

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