5,639 projects

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FUGE-Funksjonell genomforskn.i Norg

Cancer-targeted T cell Receptors - the next generation immunotherapeutic drugs

The aim is to generate recombinant T cell receptors (TcRs) that recognize cancer cells. DNA encoding the receptors forms basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) T cell s that recognize common cancer proteins, ...

Awarded: NOK 5.3 mill.

Project Period: 2008-2013

Location: Oslo - Oslove

GNBIO-Grunnleggende næringsrettet bioteknologi

Development of assays for diagnostics of viral diseases in farmed salmon: New tools for disease control based on host-pathogen interaction

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Awarded: NOK 1.7 mill.

Project Period: 2008-2011

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Pathogenesis of complex genetic diseases, using pre-eclampsia as a model

Pre-eclampsia (PE) is the most common pregnancy-associated complication in the Western world. The syndrome is a major contributor to maternal and fetal illness/death. No therapeutic treatment exists. The mechanisms involved in development of PE remain to be elucidated. Observations suggest immu...

Awarded: NOK 8.5 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Detection of gene products in cells; An advanced imaging FUGE2 platform node

We here propose the establishment of a FUGE node in Imaging. This node is based on the imaging expertise in the research groups at the Department of Molecular Biosciences (IMBV), the Institute of Basic Medical Sciences (IMB), and the Department of Biochem istry, the Radium Hospital, DNR/RH at the...

Awarded: NOK 6.9 mill.

Project Period: 2008-2013

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Host-virus interactions in Atlantic salmon

Infectious pancreatic necrosis virus (IPNV) and infectious salmon anemia virus (ISAV) are viruses causing threatening diseases in Norwegian aquaculture. Certainly, one of the most challenging problems in designing control strategies against these viruses is to define the specific factors, both in...

Awarded: NOK 12.0 mill.

Project Period: 2008-2011

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Towards a systems level understanding of responses to endogenous DNA damage in Caenorhabditis elegans

The impact of genomic instability on human health underscores the importance of understanding the mechanisms that coordinate responses to DNA damage in order to preserve genomic stability. There is a disparity between our knowledge of the cellular respons es to endogenous DNA damage and the impac...

Awarded: NOK 6.0 mill.

Project Period: 2008-2012

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

A novel checkpoint regulating the cell cycle of fission yeast

In this project we shall further study and characterise a novel mechanism of checkpoint regulation that we have recently discovered (Tvegård et al, Genes Dev, 2007). Checkpoints are important regulators of the cell cycle. Cancer development is frequently associated with the lack of checkpoints an...

Awarded: NOK 5.3 mill.

Project Period: 2008-2011

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Norwegian Molecular Imaging Consortium - Subnode: Subcellular interactions and imaging - NTNU

Knowledge about protein-protein interactions as well as interactions between other molecules is of critical importance for functional genomics. By providing the state-of-the-art technologies to study inter-and intramolecular interactions, the national res earch community will be able to move func...

Awarded: NOK 7.4 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Postgenome glycomics: The structures, interactions, and functions of complex sugars attached to proteins and lipids

Glycome is a term meant to cover the whole set of glycans produced in a single organism (or tissue) in analogy to genome and proteome. This concept follows as a consequence of the development in the post-genome era, since glycans play critical roles in di verse biological phenomena. It seems evid...

Awarded: NOK 8.0 mill.

Project Period: 2008-2011

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Salmon louse genome sequencing and functional studies on host parasite interactions

Copepods comprise the largest animal marine biomass but they have been poorly studied by molecular tools and no genome has so far been sequenced. Copepods are common as parasites on fishes and the salmon louse (Lepeophtheirus salmonis) is the most importa nt species in terms of economical signifi...

Awarded: NOK 6.0 mill.

Project Period: 2008-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

National-wide service and competence from the Rikshospitalet-Radiumhospitalet Proteomics Core Facility in a Norwegian proteomics consortium

The Proteomics Core Facility at Rikshospitalet-Radiumhospitalet (RR-PCF) is a core facility platform organized jointly by Rikshospitalet-Radiumhospitalet HF (RR) and the University of Oslo (UiO) through "Felles Forskningsutvalg" at the hospital. The RR-PC F is engaged in the development of proteo...

Awarded: NOK 1.5 mill.

Project Period: 2008-2012

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Norwegian Molecular Imaging Consortium - Bergen

The present-day Molecular Imaging Center in Bergen (MIC) is an open facility that offers a collection of state-of-the-art microscopy equipment and image processing tools. MIC initiated its services in 2003 and was set up as a cooperation between NTNU in T rondheim and the University of Bergen to ...

Awarded: NOK 9.2 mill.

Project Period: 2008-2012

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Oslo Animal MRI unit - a node in the FUGE NorMIC consortium

The MR technology now allows for in vivo imaging to a resolution of microns which is even less than the size of many cell types. MRI has therefore become an invaluable tool for molecular imaging and translational research. Scientists in Oslo have used the FUGE MIC animal MR unit in Trondheim unt...

Awarded: NOK 1.00 mill.

Project Period: 2008-2012

Location: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

A National Service Platform for Global Analysis of Genome Structure and Function. The Norwegian Microarray Consortium (NMC)

The FUGE Microarray Platform is run by the Norwegian Microarray Consortium (NMC), based on a formal institutional collaboration between RR/UiO, NTNU, and UiB. We offer in-house production of standard and custom arrays, expression and genomic profiling ser vices (RNA or DNA in-DATA out) with diffe...

Awarded: NOK 9.7 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Towards personalized therapy for breast cancer

Purpose of the project: Few protocols have so far been designed with attempts to characterize the systems biology of cancer. The objective of the project is to translate information obtained from integrative molecular analysis of material collected from i ndividual cancer patients, through valida...

Awarded: NOK 10.0 mill.

Project Period: 2008-2012

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

A proteomics node at Ås campus

As part of the NorProteomics FUGE network, Ås campus will develop expertise in the areas listed below and make this expertise available to on-campus and off-campus projects. Our key areas are: 1. Proteomics in difficult matrices, primarily related to food chemistry (meat, cereals; i.e. analysis ...

Awarded: NOK 1.5 mill.

Project Period: 2008-2012

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

The Proteomics Core Facility at the University of Tromsø as a node in the national consortium of proteomics platforms (NorProteomics)

The core facility for Proteomics in Tromsø has been fully operational since the end of 2004. The main purpose of the facility has been to serve research labs in the FUGE North region. The facility has 3 Mass spectrometer systems from Waters/Micromass. A M ALDI Micro MX, a Q-TOF Ultima Global with...

Awarded: NOK 1.3 mill.

Project Period: 2008-2012

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

The Norwegian plant transcriptional profiling centre

The Norwegian Arabidopsis Centre (FUGE-NARC) was established as a part of FUGE I. NARC provided national service in plant functional genomics and the service activity was shared between Univeristy of Life Sciences (UMB, transformation/genotyping), Univers ity of Oslo (Y2H, in situ hyb) and Norwe...

Awarded: NOK 2.3 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

MILJØ2015-Norsk miljøforskning mot 2015

LAND: A new model approach to assess genetically modified plants: their ecotoxicity and potential interactions with environmental pollutants

Genetically modified (GM) plants from modern biotechnology have already a history as commercialised feed and food products. The agricultural industry using GM techniques is rapidly increasing and represents large scale options and challenges for both soci eties and ecosystems. Environmental impac...

Awarded: NOK 6.4 mill.

Project Period: 2008-2012

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Functional studies of tunneling nanotube-dependent cell-to-cell communication by high-throughput screening approaches

Intercellular communication is a major requirement for the development and maintenance of multicellular organisms. In the case of animals diverse mechanisms for the exchange of signals between cells have been established during evolution, including the se cretion of molecules as well as communica...

Awarded: NOK 4.0 mill.

Project Period: 2008-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Advanced MR imaging, MR metabolomics, proteomics and genetic mapping of breast cancer - Clinical tools for personalized patient treatment

Breast cancer has the highest incidence and mortality of all malignant diseases among women globally. The heterogeneous nature of breast cancer results in different clinical presentations and outcomes, and patients show a diverse range of responses to a g iven treatment. Processes leading to more...

Awarded: NOK 5.2 mill.

Project Period: 2008-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Norwegian Structural Biology Centre (NorStruct) Proposal for a continuation of the Centre for 2008-12

NorStruct will continue to offer state of the art services and collaboration in structural biology techniques to the Norwegian research community. The expertise and services will have a solid foundation in in-house research and national and international partners. The services will be organized i...

Awarded: NOK 23.0 mill.

Project Period: 2008-2013

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

A NATIONAL SERVICE PLATFORM FOR GLOBAL ANALYSIS OF GENOME STRUCTURE AND FUNCTION: THE NORWEGIAN MICROARRAY CONSORTIUM

Awarded: NOK 7.2 mill.

Project Period: 2008-2013

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Channel 2 application for continuation of FUGE MIC Trondheim in FUGE II period (2007-2011)

MIC Trondheim wants to continue in the FUGE II period with MR as the core technology, and will expand in capacity with acquisition of new MR equipment, and expand the high-level competence necessary for offering a wide variety of methods tailored to the u ser's research tasks. A goal is to establ...

Awarded: NOK 5.6 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

A FUGE Proteomics node at DMF, NTNU

Proteomics has become increasingly important within functional genomics to assess gene expression analyses, to identify biomarkers for disease, to understand how proteins functionally interact, and to identify post-translational modifications that drive the interactions and modify protein functi...

Awarded: NOK 3.4 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

A NATIONAL SERVICE PLATFORM FOR GLOBAL ANALYSIS OF GENOME STRUCTURE AND FUNCTION: THE NORWEGIAN MICROARRAY CONSORTIUM

Awarded: NOK 10.0 mill.

Project Period: 2008-2013

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Translational Research in Lung Cancer and Palliative Care - from genomics to symptom control

This project will perform functional genomic research with a translational approach that will bring new scientific knowledge into the health care system. The project will identify gene polymorphisms and gene expression profiles that may confer developmen t of lung cancer, and act as a prognostic...

Awarded: NOK 9.3 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

STAMCELLER-Stamcelleforskning

Factors predicting graft-versus host disease after allogeneic hematopoietic stem cell transplantation.

Allogeneic stem cell transplantation (ASCTx) represents the most commonly applied therapeutic use of stem cells from born individuals. The mortality and complication rate of ASCT is high, often preventing its use in less severe conditions than cancer. Th e aim of this project is to generate a be...

Awarded: NOK 3.4 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

GASSMAKS-Økt verdiskaping fra naturgass

Utilization of CO2 via Catalysis in Ionic Liquid Phases

This is a proposal for a three-year KMB project for the development and understanding of Supported Ionic Liquid Phase catalysts for the production of carbamates from CO2, arylamines and alcohols, and the production of dimethylcarbonate (DMC) from CO2 and methanol. Project support will come from ...

Awarded: NOK 3.8 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Opioid activated NMDA and opioid receptor mechanisms: studies of rodent and human brain using PET

The scope of the proposed project is to study the molecular mechanisms of opioid exposure. Within the financial framework, it will be focused on preclinical testing and validation as well as first human studies. Further studies depend on additional fundin g. Intentionally, opioid analgesia in p...

Awarded: NOK 1.8 mill.

Project Period: 2007-2011

Location: Akershus

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