5,400 projects

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FRIMED-Klinisk medisin og folkehelse

Psychosocial effects and understanding of increased risk for Type 1 Diabetes

With the rapid development in biotechnology and increasing knowledge about the relation between diseases and genetic variability, we are faced with both new opportunities and new dilemmas. Onset of a disease is dependent on several factors as genetic pene trance, combinations of genotypes and env...

Awarded: NOK 2.8 mill.

Project Period: 2007-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

Elucidation of downstream signaling events of cAMP using new tools distinguishing the roles of EPAC and PKA

The present project will receive Epac and PKA modulating cAMP analogs. I. We will test selected new analogs in a newly developed and unique assay for binding to PKA holoenzyme II. The best activators (current or novel) will be used, separately and jointl y, to define effect of Epac and PKA activ...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Vestland

FRIBIO-Biologi og biomedisin

The role of excitatory amino acid in Parkinson's disease

Parkinson's disease is characterised by death of dopamine containing neurons in the substantia nigra. Long term levo-dopa treatment has severe side effects and is potentially toxic for neurons. The need for alternative treatments in Parkinson's disease is urgent. To accomplish this, further rese...

Awarded: NOK 2.3 mill.

Project Period: 2007-2010

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

NucPro: Epigenetics of nuclear programs - from genome-wide landscapes to individual factor mechanisms

This Proposal outlines research plans for global epigenetic and transcription factor studies at an already established Functional Genomics (FUGE) Consortium for studies of nuclear programs at the University of Oslo (UiO). The consortium is a joint effort from four independent research groups to e...

Awarded: NOK 11.0 mill.

Project Period: 2007-2011

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The Norwegian Multiple Sclerosis Registry and Biobank

Multiple sclerosis (MS) is an immune-mediated, inflammatory disease of the central nervous system (CNS) in genetically susceptible individuals. It is a disabling disease of young adults, with no curable treatment available. There is growing knowledge of s everal aspects of the disease, but the et...

Awarded: NOK 4.5 mill.

Project Period: 2007-2010

Location: Vestland

BIA-Brukerstyrt innovasjonsarena

DualPET-MR

The main objective for this project is to develop dual-modality PET-MR for molecular biology and medicine which will allow for the combined and simultaneous use of positron emission tomography (PET) and magnetic resonance (MR). In such a combined machine the PET provides information from molecula...

Awarded: NOK 5.1 mill.

Project Period: 2007-2009

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Proposal for a National consortium in Fish Genomics - FishGen

The present proposal describes the establishment of a National Consortium in fish genomics (FishGen). The main partners in the FishGen are; Institute of Marine Research (IMR), University of Bergen (UoB), National institute of nutrition and seafood researc h (NIFES), University of Tromsø (UiTø), N...

Awarded: NOK 14.0 mill.

Project Period: 2007-2010

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

THE HORDALAND WOMEN'S COHORT STUDY. A planned 15-year (1997-2012) follow up incidence study of urinary incontinence, and associated factors

Urinary incontinence (UI) is a common condition with a prevalence of about 25% of adult women, that affects the physical, psychosocial, and economic well-being. Longitudinal studies of incidence, remission and natural history are scarce. The Hordaland wo men's cohort study is an ongoing 15-year ...

Awarded: NOK 2.5 mill.

Project Period: 2007-2011

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Exposure expression profiles in a prospective cancer study - The Norwegian Women and Cancer postgenome cohort

From 1991 women in Norway has been recruited to participate in NOWAC by postal questionnaires. They are drawn at random from the population through the central person register. Follow-up on cancer and death is based on linkage to national registers. Altog ether 150 000 women aged 30-70 years at r...

Awarded: NOK 1.6 mill.

Project Period: 2007-2010

Location: Troms - Romsa - Tromssa

FRINAT-Matematikk og naturvitenskap

Investigation of equiaxed dendritic alloy solidification by in-situ synchrotron X-radiography and phase-field modelling

Important aspects of alloy solidification is poorly understood due to lack of means to observe the microstructure formation processes in situ during solidification. A new method, developed by the applicant, for in-situ acquisition of high resolution sync hrotron X-radiograms will be used to obta...

Awarded: NOK 6.9 mill.

Project Period: 2007-2010

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Does ovarian fluid favour MHC-dissimilar sperm?

When males provide nothing but genes, female choice of mates is expected to favour individuals that can best increase offspring survival. This selection process may not only occur at an individual level, but also on the gamete level. Recent studies have i ndicated that the ova may select sperm on...

Awarded: NOK 2.7 mill.

Project Period: 2007-2010

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

The role of T cell specific adapter protein in T cell activation and autoimmunity

Genetic variation in genes controlling T cell activation may be responsible for individual differences in fine-tuning of the immune response. Such variability may account for part of the genetic susceptibility to develop autoimmune diseases. Having a majo r interest in elucidating the aetiology o...

Awarded: NOK 3.1 mill.

Project Period: 2007-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Life history patterns in large carnivores and their application for management and conservation.

Life-history is an organism's pattern of growth, reproduction and mortality, formed by long-term evolutionary processes and by immediate responses to the environment. This project has 3 main objectives: 1) evaluate the patterns of lifetime reproductive su ccess of male and female brown bears; 2) ...

Awarded: NOK 2.4 mill.

Project Period: 2007-2011

Location: Akershus

FRIMED-Klinisk medisin og folkehelse

Combined structural, microvascular and functional mapping of brain tumors for improved diagnosis and treatment planning

During recent years, the department of radiology at Rikshospitalet-Radiumhospitalet (RR) Medical Center has had a strong focus on functional MRI (Magnetic Resonance Imaging) research; including perfusion/ diffusion MRI and spectroscopy, with the aim of br inging novel MR techniques into early cli...

Awarded: NOK 2.2 mill.

Project Period: 2007-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

Characterization of Novel Insulin Regulated Pathways in Fat Synthesis in Liver and Adipose Tissue

Diets rich in lipids and carbohydrates together with a lack of physical exercise predispose individuals to multifunctional diseases such as atherosclerosis, hyperlipidemia, obesity, insulin resistance and diabetes type 2. Fat metabolism and glucose homeos tasis are inherently related, and insulin...

Awarded: NOK 2.2 mill.

Project Period: 2007-2010

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The ecological and evolutionary significance of seed banks in Arabidopsis thaliana

Many studies of the genetic structuring of annual, selfing Arabidopsis thaliana populations on various geographical scales have been performed in recent years. Some studies conclude that local populations may contain relatively high amounts of genetic var iability both in phenotypic traits and pu...

Awarded: NOK 2.5 mill.

Project Period: 2007-2012

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Fe-S Cluster Biogenesis in Plastids and Mitochondria in Plants

Iron-sulfur (Fe-S) clusters are essential, inorganic cofactors of Fe-S proteins involved in numerous vital developmental processes. Although simple in structure Fe-S clusters are not formed spontaneously but require an intricate interplay of a number of p roteins and in plants Fe-S cluster biogen...

Awarded: NOK 3.1 mill.

Project Period: 2007-2010

Location: Rogaland

FRIBIO-Biologi og biomedisin

Dynamics underlying astrocyte behaviour

For a long time astrocytes, the most abundant glial cell species, have been considered passive bystanders of neural activity. The picture that is now emerging is that astrocytes are critically involved in regulating brain function. Despite extensive exper imental efforts, a thorough understanding...

Awarded: NOK 2.6 mill.

Project Period: 2007-2009

Location: Akershus

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Enhanced safety of Norwegian type dry fermented sausage with focus on enterohemorrhagic Escherichia coli

This project concerns safe production of Norwegian type dry fermented sausages (DFS). Two outbreaks in Norway this year, caused by enterohemorrhagic Escherichia coli (EHEC) and Salmonella Kedougou in DFS, emphasize the need to focus on enhanced safety of such products. Outbreaks may cause severe ...

Awarded: NOK 11.9 mill.

Project Period: 2007-2011

Location: Akershus

MATPROG-Matprogrammet: Norsk mat fra sjø og land

A Study of Influenza Viruses in Their Natural Reservoir in Wild Birds in Norway

The major goal of this project is to better understand the dynamics of influenza A virus infections in wild birds in Norway. At the National Veterinary Institute, in the context of the surveillance for highly pathogenic avian influenza virus H5N1, a large collection of samples is being gathered ...

Awarded: NOK 5.2 mill.

Project Period: 2007-2011

Location: Akershus

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Attractive host plant volatiles and genetic regulation of the olfactory response in the control of apple fruit moth, Argyresthia conjugella

The apple fruit moth Argyresthia conjugella is regarded as the most important insect pest on apples in Fennoscandia. Until 2005 the organophosphorous compound azinphos-methyl (Gusathion) has been used in apple fruit moth control. The compound is now dereg istrated due to environmental concerns an...

Awarded: NOK 9.2 mill.

Project Period: 2007-2011

Location: Akershus

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Reduction/elimination of spore forming bacteria in lightly heat treated foods

The project seeks to identify processes which are able to strongly reduce spore forming bacteria in lightly heat treated (<98 ºC) foods. To solve this task, three research groups with different, complementary competence will cooperate. The project require s characterisation of potentially pathoge...

Awarded: NOK 7.2 mill.

Project Period: 2007-2010

Location: Oslo

BIONÆR-Bionæringsprogram

Potential of muscle profiling on value-addition of products and consumer satisfaction under Norwegian beef production conditions

Matforsk deltar i et EU-prosjekt på kvalitet og sikkerhet av storfekjøtt hvor utnyttelsen av utradisjonelle stykningsdeler er en sentral del av prosjektet. Ny forskning i USA har vist at ved å bruke utradisjonelle metoder for nedskjæring og utbeining kan verdien av slaktet økes betydelig. I EU-p...

Awarded: NOK 7.8 mill.

Project Period: 2007-2012

Location: Akershus

FRIMED-Klinisk medisin og folkehelse

L-Ornithine and phenylacetate: A novel and effective therapy for hepatic encephalopathy

Background: The major therapeutic target for the treatment of hepatic encephalopathy is ammonia. Our extensive investigations in animal models and also in humans with cirrhosis support the view that the major organ removing ammonia in patients with cirrho sis is the muscle, converting ammonia to ...

Awarded: NOK 1.3 mill.

Project Period: 2007-2009

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Vaccine development for HIV and influenza

Aim: Based on the vaccibody principle developed by us, we wish to generate novel vaccines for important infectious diseases such as HIV and influenza. Background: Vaccination has had an enormous impact on health and longevity of humans world-wide. However , for some important diseases such as HIV...

Awarded: NOK 3.1 mill.

Project Period: 2007-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

The Tromsø Pain Study: Causes and consequences of individual differences in pain sensitivity

Human pain sensitivity is subject to very large inter-individual variation. It is known that pain sensitivity is heritable, but the genes involved are largely unknown. Hypersensitivity to pain may be an important risk factor in the development, maintenanc e and consequences of chronic pain. Reduc...

Awarded: NOK 3.7 mill.

Project Period: 2007-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Tissue engineering in bone defects: Development of porous copolymer scaffolds stimulating stem cell growth and bone regeneration

For the repair of bone defects, tissue engineering would be to combine cells capable of osteogenic activity with an appropriate scaffold. Mesenchymal stem cells are multipotential cells that are capable of differentiating into different type of cells dep ending on culture condition. The selectio...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Cellular responses to meningococcal meningitis

Meningococcal disease is a leading cause of meningitis and septicaemia worldwide. Among the serious consequences of meningitis are brain edema and disturbed neuronal excitability. These effects are often the direct cause of death. Despite the serious comp lications, the molecular basis for these ...

Awarded: NOK 3.4 mill.

Project Period: 2007-2012

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Statistical tools for studying genetic architecture

Advances in molecular biology have revealed that most phenotypes are controlled by highly complex and interactive gene networks. This complex genetic basis is, however, not reflected in the rather simple genotype-phenotype maps postulated in population an d quantitative genetics. These models are...

Awarded: NOK 2.6 mill.

Project Period: 2007-2012

Location: Oslo

NANOMAT-Nanoteknologi og nye materialer

Entry of Nanoparticles into cells: Characterization of Nanoparticles as tools to study endocytic pathways and intracellular transport

Research on nanoparticles have evolved into biological applications with large expectations for the use of magnetic iron oxide nanoparticles and fluorescent Quantum dots in different imaging techniques both for tumor targeting and drug delivery in humans and as probes at the cellular level. In th...

Awarded: NOK 3.4 mill.

Project Period: 2006-2011

Location: Ukjent Fylke

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