5,400 projects

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FRIBIO-Biologi og biomedisin

Study of cellular distribution and biological functions of neonatal Fc receptor in immune cells

Immunoglobulin G (IgG) is the major class of immunoglobulins and the protein with the longest serum half-life. IgG is also actively transferred to the fetus, giving the full-term fetus IgG levels over maternal levels and protective immunity. The MHC class I related neonatal Fc receptor (FcRn) is...

Awarded: NOK 2.3 mill.

Project Period: 2007-2009

Location: Oslo

BIONÆR-Bionæringsprogram

Preclinical diagnosis of prion disease

Transmissible spongiform encephalopathies (TSEs) are a threat to food safety and to human and animal health. Diagnosis of these diseases and early detection of the infective agent is vital for future spread and prevention of disease. The identification of candidate molecules as biomarkers of pre...

Awarded: NOK 7.0 mill.

Project Period: 2007-2012

Location: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Stability and mobility of Shiga toxin-encoding bacteriophages in clinical and environmental strains of Escherichia coli O103

E. coli O103 belongs to a subset of serotypes of Shiga toxin-producing Escherichia coli (STEC) associated with severe human illnesses. Shiga toxin (Stx) production is essential but not sufficient for virulence in pathogenic STEC as factors involved in att achment, haemolysis and iron scavenging a...

Awarded: NOK 3.2 mill.

Project Period: 2007-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

EGF-induced Formation of Clathrin Coated Pits

Growth factor receptors control cellular growth and differentiation by transmitting signals from outside the cell to the cell interior, particularly the nucleus. Signal transmission can be modulated in several ways. To control signalling, down-regulation of receptors from the cell surface is impo...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Gene-environment interaction analyses and oral clefts in Norway

Norway has several large epidemiological studies with genetic bio-banks that may be used in etiologic research. Examples are the CONOR-cohort and the MoBa-cohort of children with mothers and fathers. Optimal analysis of such studies requires integration o f both genetic and environmental effects....

Awarded: NOK 2.8 mill.

Project Period: 2007-2011

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

THE HORDALAND WOMEN'S COHORT STUDY. A planned 15-year (1997-2012) follow up incidence study of urinary incontinence, and associated factors

Urinary incontinence (UI) is a common condition with a prevalence of about 25% of adult women, that affects the physical, psychosocial, and economic well-being. Longitudinal studies of incidence, remission and natural history are scarce. The Hordaland wo men's cohort study is an ongoing 15-year ...

Awarded: NOK 2.5 mill.

Project Period: 2007-2011

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Exposure expression profiles in a prospective cancer study - The Norwegian Women and Cancer postgenome cohort

From 1991 women in Norway has been recruited to participate in NOWAC by postal questionnaires. They are drawn at random from the population through the central person register. Follow-up on cancer and death is based on linkage to national registers. Altog ether 150 000 women aged 30-70 years at r...

Awarded: NOK 1.6 mill.

Project Period: 2007-2010

Location: Troms - Romsa - Tromssa

FRINAT-Matematikk og naturvitenskap

Investigation of equiaxed dendritic alloy solidification by in-situ synchrotron X-radiography and phase-field modelling

Important aspects of alloy solidification is poorly understood due to lack of means to observe the microstructure formation processes in situ during solidification. A new method, developed by the applicant, for in-situ acquisition of high resolution sync hrotron X-radiograms will be used to obta...

Awarded: NOK 6.9 mill.

Project Period: 2007-2010

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Does ovarian fluid favour MHC-dissimilar sperm?

When males provide nothing but genes, female choice of mates is expected to favour individuals that can best increase offspring survival. This selection process may not only occur at an individual level, but also on the gamete level. Recent studies have i ndicated that the ova may select sperm on...

Awarded: NOK 2.7 mill.

Project Period: 2007-2010

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

The role of T cell specific adapter protein in T cell activation and autoimmunity

Genetic variation in genes controlling T cell activation may be responsible for individual differences in fine-tuning of the immune response. Such variability may account for part of the genetic susceptibility to develop autoimmune diseases. Having a majo r interest in elucidating the aetiology o...

Awarded: NOK 3.1 mill.

Project Period: 2007-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Life history patterns in large carnivores and their application for management and conservation.

Life-history is an organism's pattern of growth, reproduction and mortality, formed by long-term evolutionary processes and by immediate responses to the environment. This project has 3 main objectives: 1) evaluate the patterns of lifetime reproductive su ccess of male and female brown bears; 2) ...

Awarded: NOK 2.4 mill.

Project Period: 2007-2011

Location: Akershus

FRIMED-Klinisk medisin og folkehelse

Combined structural, microvascular and functional mapping of brain tumors for improved diagnosis and treatment planning

During recent years, the department of radiology at Rikshospitalet-Radiumhospitalet (RR) Medical Center has had a strong focus on functional MRI (Magnetic Resonance Imaging) research; including perfusion/ diffusion MRI and spectroscopy, with the aim of br inging novel MR techniques into early cli...

Awarded: NOK 2.2 mill.

Project Period: 2007-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

Characterization of Novel Insulin Regulated Pathways in Fat Synthesis in Liver and Adipose Tissue

Diets rich in lipids and carbohydrates together with a lack of physical exercise predispose individuals to multifunctional diseases such as atherosclerosis, hyperlipidemia, obesity, insulin resistance and diabetes type 2. Fat metabolism and glucose homeos tasis are inherently related, and insulin...

Awarded: NOK 2.2 mill.

Project Period: 2007-2010

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The ecological and evolutionary significance of seed banks in Arabidopsis thaliana

Many studies of the genetic structuring of annual, selfing Arabidopsis thaliana populations on various geographical scales have been performed in recent years. Some studies conclude that local populations may contain relatively high amounts of genetic var iability both in phenotypic traits and pu...

Awarded: NOK 2.5 mill.

Project Period: 2007-2012

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Fe-S Cluster Biogenesis in Plastids and Mitochondria in Plants

Iron-sulfur (Fe-S) clusters are essential, inorganic cofactors of Fe-S proteins involved in numerous vital developmental processes. Although simple in structure Fe-S clusters are not formed spontaneously but require an intricate interplay of a number of p roteins and in plants Fe-S cluster biogen...

Awarded: NOK 3.1 mill.

Project Period: 2007-2010

Location: Rogaland

BIONÆR-Bionæringsprogram

Safe grains: Mycotoxin prevention through resistant wheat and oats

In 2004 there were alarming levels of mycotoxins like DON and T-2/HT-2in Norwegian wheat and oats. In 2005 the latter levels in oats were prohibitive for e.g. horsefeed. The present proposal builds on a decade of Norwegian cereal breeding and research to introduce/identify resistance against the ...

Awarded: NOK 9.1 mill.

Project Period: 2007-2013

Location: Akershus

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Rapid DNA-based prediction of mycotoxin levels in food and feed

The major mycotoxin producers in foods in Norway and Europe are members of the genera Aspergillus, Fusarium and Penicillium. Two major classes of mycotoxins produced by Fusarium spp. are trichothecenes and fumonisins. The biosynthetic pathways involve gen es organised in (Tri- and Fum-) gene clus...

Awarded: NOK 2.6 mill.

Project Period: 2007-2011

Location: Akershus

BIONÆR-Bionæringsprogram

Technology and methods using high-density microarrays for detection of unknown genetic modifications in plants, fungi and bacteria

To ensure the safety of genetically modified organisms (GMOs) they are subjected to risk assessment prior to release into the environment and use in e.g. food production. Such known GMOs are considered to be as safe as conventional varieties. GMOs for whi ch publicly available descriptions are un...

Awarded: NOK 3.1 mill.

Project Period: 2007-2012

Location: Akershus

BIONÆR-Bionæringsprogram

Potential of muscle profiling on value-addition of products and consumer satisfaction under Norwegian beef production conditions

Matforsk deltar i et EU-prosjekt på kvalitet og sikkerhet av storfekjøtt hvor utnyttelsen av utradisjonelle stykningsdeler er en sentral del av prosjektet. Ny forskning i USA har vist at ved å bruke utradisjonelle metoder for nedskjæring og utbeining kan verdien av slaktet økes betydelig. I EU-p...

Awarded: NOK 7.8 mill.

Project Period: 2007-2012

Location: Akershus

FRIMED-Klinisk medisin og folkehelse

L-Ornithine and phenylacetate: A novel and effective therapy for hepatic encephalopathy

Background: The major therapeutic target for the treatment of hepatic encephalopathy is ammonia. Our extensive investigations in animal models and also in humans with cirrhosis support the view that the major organ removing ammonia in patients with cirrho sis is the muscle, converting ammonia to ...

Awarded: NOK 1.3 mill.

Project Period: 2007-2009

Location: Troms - Romsa - Tromssa

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Avl for bedre helse hos gris

Organisering og oppslutning i norsk svineavl er unikt internasjonalt. Tilslutningen til avlsarbeidet i næringa, faglig dyktighet i Norsvin samt aksept og støtte fra myndighetene har bidratt til at norsk avlsmatriale i dag er verdensledende på flere område r. Dette har resultert i at en internasjo...

Awarded: NOK 1.6 mill.

Project Period: 2007-2011

Location: Innlandet

FRIBIO-Biologi og biomedisin

cAMP signalling -novel downstream targets of PKA and Epac identified by phospho-proteomics.

I. Implement novel method for quantitative COFRADIC non-gel global phospho-proteomics through stay of candidate in the laboratory of prof. J. Vandenkerckhove at Univ. of Gent II. The phospho-proteome will be compared in cells in response to activation of PKA (by N6-MB-cAMP) or Epac (by 8-pCPT-2´-...

Awarded: NOK 3.2 mill.

Project Period: 2007-2011

Location: Vestland

NANOMAT-Nanoteknologi og nye materialer

Modeling of particle deposition phenomena in heat exchangers

This project will be a Norwegian contribution to the European MATERA FOULSURFACE program, dealing the the physics of fine particle deposition in heat exchengers. The work in the proposed Norwegain activity will be on the modeling of the particle flow in t urbulent thermal boundary layers. The ma...

Awarded: NOK 1.2 mill.

Project Period: 2007-2010

Location: Trøndelag - Trööndelage

BIA-Brukerstyrt innovasjonsarena

A new Computed Tomography (CT) detector with color/dual-energy features and substantially reduced patient X-ray dose

Computed Tomography (CT) is one of the most important medical diagnosis tools of today. World-wide there is a waste number of installations, a strong increase in sales, and it represents consequently a big industry for the manufacturers. The X-ray detecto r in the CT is the main part of the machi...

Awarded: NOK 6.3 mill.

Project Period: 2007-2010

Location: Oslo

RENERGI-Fremtidens rene energisystemer

Energieffektivt og miljøvennlig CO2-varmepumpesystem for næringsbygg

Målet med prosjektet er å utvikle, bygge og demonstrere et energieffektivt og miljøvennlig varmepumpesystem med karbondioksid (CO2) som arbeidsmedium for oppvarming og kjøling av næringsbygg. Gjennom dette skal det legges et kunnskapsmessig grunnlag for n orsk produksjon av denne type systemer. D...

Awarded: NOK 0.62 mill.

Project Period: 2007-2010

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Novel serotonin receptor ligands for medical use

It is well known that serotonin receptor ligands can be useful drugs for treatment of diseases outside the central nervous system (CNS). The main target organs for non-CNS indications are the gastrointestinal system, bladder and cardiovascular system. Sev eral serotonin receptor ligands are in de...

Awarded: NOK 4.9 mill.

Project Period: 2007-2009

Location: Oslo

STAMCELLER-Stamcelleforskning

Signaling in neural stem cells: implications for regenerative medicine and tumor biology

Stem cell biology is one of the most closely followed developments in biomedicine today. Stem cells may provide the foundation for rational regenerative therapeutics with far-reaching implications in the health sector, but give also new alleys in the unde rstanding of tumor biology. The central ...

Awarded: NOK 12.4 mill.

Project Period: 2007-2012

Location: Oslo

BIONÆR-Bionæringsprogram

NKJ 128 - Phenotypic and molecular characterisation of genetic resources of Nordic timothy (Phleum pratanese L.)

Timothy is the most important forage grass species in the northern part of the Nordic countries. However, serious winter damages, which significantly lower persistency and yields, occur regularly. The Nordic plant breeders have so far been quite successfu l in developing new, high-yielding variet...

Awarded: NOK 1.8 mill.

Project Period: 2007-2012

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

National resources for genomics, functional genomics and health research in Atlantic salmon and Atlantic cod. WP 3 (tidl del av177030)

...

Awarded: NOK 2.4 mill.

Project Period: 2007-2010

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Mouse models for studying oxidative demethylation of DNA and RNA

It was recently discovered that the AlkB protein from E. coli uses a novel mechanism, termed oxidative demethylation, to remove deleterious methyl lesions from DNA and RNA. Eight mammalian AlkB homologues, denoted ABH1 - ABH8 (mABH1-8 in mice), exist, and two of these, ABH2 and ABH3, have been s...

Awarded: NOK 10.0 mill.

Project Period: 2006-2012

Location: Oslo

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