0 projects

FRIBIO-Biologi og biomedisin

Quorum sensing and transcriptional regulation in Gram-positive bacteria.

The bacteriocin production in Lactobacillus plantarum is regulated by the pln regulatory unit which is a quorum-sensing based signal transducing pathway. Such quorum-sensing based regulatory systems are of crucial importance in regulating gene expression in bacteria in response to environmental c...

Awarded: NOK 2.5 mill.

Project Period: 2006-2010

Location: Akershus

HAVBRUKS-Havbruk - en næring i vekst

Application of genomics tools and resources to selective breeding for improved disease resistance and animal welfare in fish

Disease poses probably the greatest worldwide risk to the success of intensive aquaculture both through its effects on production and animal welfare. An animals resistance to or tolerance of disease can in some instances be improved through selective bree ding or with treatment such as vaccines, ...

Awarded: NOK 6.4 mill.

Project Period: 2006-2009

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Hemoglobin polymorphism in Atlantic cod - finally unravelling the old puzzle

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Awarded: NOK 3.1 mill.

Project Period: 2006-2010

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Therapeutic approaches for the correction of misfolding mutations in pterin-dependent enzymes

Many inherited diseases are caused by the enhanced tendency of the mutant variant proteins to misfold and to either undergo proteasomal degradation or deleterious aggregation with plaque formation. For several of these diseases evidence has been accumulat ed that chemical or pharmacologic chapero...

Awarded: NOK 3.2 mill.

Project Period: 2006-2012

Location: Vestland

HAVBRUKS-Havbruk - en næring i vekst

Wave and current loads on net panels and net cages

SINTEF Fisheries and Aquaculture (SFH) has over the last five years developed a numerical model (3dNet) of a three dimensional net structure exposed to waves and current. This activity has been financed by the Research Council of Norway through two projec ts: 3 Dimensional netpen movement and moo...

Awarded: NOK 4.9 mill.

Project Period: 2006-2009

Location: Trøndelag - Trööndelage

HAVBRUKS-Havbruk - en næring i vekst

Background levels: Occurrence and effective detection of cod pathogens

Cod farming is considered one of the areas with the highest potential for growth in Norwegian aquaculture. Most cod hatcheries use wild caught broodstock, which represent a danger for the contamination of the farm premises with pathogens (virus, bacteria, parasites); particularly those transmitt...

Awarded: NOK 3.0 mill.

Project Period: 2006-2009

Location: Vestland

GLOBHELS-Global helse

Development of a subunit vaccine for prevention of reactivation of tuberculosis

Mycobacterium tuberculosis causes tuberculosis and is one of the main killers among infectious pathogens in the world, and an important factor that sustain poverty in developing countries. Applied research for development of new vaccines is therefore need ed. Transmission of tuberculosis (TB) is ...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Vestland

HAVBRUKS-Havbruk - en næring i vekst

Algal toxins & polyunsaturated fatty acids: a polyketide genomic approach to safe and efficient utilisation of microalgae in bioproduction

Microalgal secondary metabolites have attracted attention for two main reasons: first, because they are source of toxins in harmful algal blooms and second, because they are potential rich source of polyunsaturated fatty acids. The dinoflagellates are hig hly diverse group of flagellated unicellu...

Awarded: NOK 3.9 mill.

Project Period: 2006-2010

Location: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Improved goat herd health - closing in on the goal

In Norway, caprine paratuberculosis is endemic in several regions in Norway and 5-10 % of the goat herds have official restrictions because of paratuberculosis. Thus, the disease can have a substantial negative impact on the economy of goat farming. In t he endemic regions, paratuberculosis has ...

Awarded: NOK 2.6 mill.

Project Period: 2006-2010

Location: Akershus

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Reduced risk of Fusarium and mycotoxin contamination in Norwegian cereals by the development of a rapid screening system

Fusarium infection in cereals has become a problem world-wide. Species of Fusarium produce mycotoxins that leave the grains unsuitable for consumption. In the 2004 harvest, alarming levels of the mycotoxin deoxynivalenol (DON) was registered in grain lots of Norwegian grown wheat and oats. This ...

Awarded: NOK 11.7 mill.

Project Period: 2006-2010

Location: Akershus

FRIBIO-Biologi og biomedisin

Mechanisms behind pathogen activation and evasion of Toll-like receptor signaling

Toll-like receptors (TLRs) are signaling receptors of the innate immune system, sensing a variety of bacterial and viral components. Our central hypothesis is that immune cell recognition of invading pathogens starts with an interaction between microbial structures and TLRs. The following immune ...

Awarded: NOK 2.4 mill.

Project Period: 2005-2011

Location: Trøndelag - Trööndelage

FRIMED-Klinisk medisin og folkehelse

Identification of genetic and environmental factors contributing to disease susceptibility and clinical presentation of multiple sclerosis

The aim of this project is to identify factors contributing to development of multiple sclerosis (MS) in a PhD project. MS is a debilitating inflammatory disease of the central nervous system. The etiology is unknown, but both genetic and environmental fa ctors are involved. Identification of the...

Awarded: NOK 2.0 mill.

Project Period: 2005-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Endothelial cell differentiation - a key to future therapy of chronic inflammation and cancer

Much attention is focused on understanding the role of vascular endothelial cells in disease. In several fields of medicine, there is great interest in understanding the mechanisms that regulate the generation of new vessels and endothelial cell different iation, because the future ability to man...

Awarded: NOK 1.8 mill.

Project Period: 2005-2009

Location: Oslo

NANOMAT-Nanoteknologi og nye materialer

Characterization of nanotubular networks on cell adhesive micro- and nano-patterned surfaces

Project: Characterization of nanotubular networks on cell adhesive micro- and nano-patterned surfaces Recently we have discovered that mammalian cells are connected by thin membrane tubes. These tubes with a diameter of 50 to 200 nm are referred to as tu nneling nanotubes (TNTs). They are a cont...

Awarded: NOK 3.2 mill.

Project Period: 2005-2010

Location: Vestland

STAMCELLER-Stamcelleforskning

EuroSTELLS Project: Translational Stem Cell Research: From Basic Biology to Regenerative Medicine

This project involves the joined forces of 13 research groups from 6 countries with common interests and complementary competence in developmental biology, stem cell biology and regenerative medicine and cancer biology. The consortium aims at elucidating the mechanisms that control self-renewal a...

Awarded: NOK 3.0 mill.

Project Period: 2005-2009

Location: Oslo

STORFORSK-Store forskerinitierte prosjekter

Multilevel analysis of memory formation in the entorhinal-hippocampal circuit

Neuronal networks within the medial temporal lobe are essential for fast encoding and storage of episodic memories in humans and other mammals. A key connection in this system is the perforant path (PP) which projects from the entorhinal cortex to the hip pocampus (including the dentate gyrus). S...

Awarded: NOK 19.6 mill.

Project Period: 2005-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

Functional sites in proteins: A combined proteomic and bioinformatical approach for improvement of a prediction system for linear motifs.

Functional sites in proteins are short stretches of amino acids that serve as binding sites, post-translational modification sites or proteolytic cleavage sites. Most functional features of proteins can be related to functional sites and/or globular domai ns. While there are several efficient met...

Awarded: NOK 3.1 mill.

Project Period: 2005-2009

Location: Vestland

FRIBIO-Biologi og biomedisin

Long term consequences of interspecific cross-fostering in the wild

The significance of learning has been relatively overlooked in studies of fundamental behavioural traits such as species recognition, mate choice and social dominance. I propose a project to investigate long term consequences of interspecific cross-foster ing in the wild in terms of such behaviou...

Awarded: NOK 2.5 mill.

Project Period: 2005-2009

Location: Oslo

STORFORSK-Store forskerinitierte prosjekter

Fundamentals of Condensed Matter

Modern condensed matter research requires a combination of expertise in different fields integrating semiconduc-tors and normal metals with magnetic and superconducting materials. Our research project will explore the fundamental physics of condensed matt er that is relevant for electronic device...

Awarded: NOK 14.4 mill.

Project Period: 2005-2010

Location: Trøndelag - Trööndelage

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Improved bone health for osteoporotic women by intake of dietary vitamin D and vitamin K from tailor-made Atlantic salmon

The indigenous Norwegian population has one of the world’s highest incidences of hip fracture, and their bone mineral density (BMD) is lower than comparable populations. Taking into account the expected increasing amount of elderly in the society over the next decades, the percentage of osteopor...

Awarded: NOK 3.0 mill.

Project Period: 2005-2009

Location: Vestland

HAVBRUKS-Havbruk - en næring i vekst

Alphavirus (Togaviridae) fra laksefisk i norsk oppdrett. Karakterisering, vertikal overføring og studie av vevs/celle-tropisme.

Salmon pancreas disease (SPD) ble først beskrevet fra Skottland i 1984, men var sannsynligvis tilstede i oppdrett av laks i Skottland så tidlig som i 1976. I 1990 ble det vist at sykdommen hadde en infeksiøs årsak. Senere, i 1995, ble det klart at sykdomm en skyldes et togaviruslignende agens som...

Awarded: NOK 1.9 mill.

Project Period: 2005-2010

Location: Vestland

MATJORD-Program for forskning innenfor jordbruksog matproduksjon

Improved quality and frost tolerance in transplants of vegetables

To successfully transplant agricultural species in the spring, hardening prior to transplanting is of great significance. In particular, in situations with fluctuating temperatures common to early spring, low temperature treatment leading to increased col d tolerance prior to transplanting, might...

Awarded: NOK 3.0 mill.

Project Period: 2005-2010

Location: Akershus

MATJORD-Program for forskning innenfor jordbruksog matproduksjon

Avl for friskere kyr

Et hovedmål med dette prosjektet er å utvikle bedre metoder for genetisk analyse og avlsverdiberegning av helseegenskaper generelt og mastitt spesielt. Dette er forskning med praktisk nytteverdi. I dette prosjektet vil det være et nært samarbeid med avlso rganisasjonen og resultatene kan raskt im...

Awarded: NOK 1.7 mill.

Project Period: 2005-2009

Location: Akershus

FRIBIO-Biologi og biomedisin

Molecular and electrophysiological characterization of the GnRH systems in Atlantic cod

Teleosts are unique among vertebrates regarding neural control of the adenohypophysis. The cells are directly innervated instead of receiving their input through a portal system. Furthermore, the distribution of the different cell types in the adenohypoph ysis in teleosts is highly regionalized, ...

Awarded: NOK 2.0 mill.

Project Period: 2005-2009

Location: Oslo

MATJORD-Program for forskning innenfor jordbruksog matproduksjon

Trygg mat frå småskala landbruksproduksjon

I ei tid med stadig større press på den tradisjonelle landbruksproduksjonen har mange sett etter alternative produksjonar som kan auka verdiskapinga på bygdene. Alt nå finst det døme på vellukka småskalaproduksjonar som skaper inntekt og arbeidsplassar ut i frå små ressursar. Mange ser på slike ...

Awarded: NOK 12.4 mill.

Project Period: 2005-2010

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

European Animal Disease Genomics Network of Excellence for Animal Health and Food Safety - EADGENE Delprosjekt 4: Mastitt hos storfe

Dette prosjektet representerer ett av fire prioriterte områder innenfor EU nettverket "European Animal Disease Genomics Network of Excellence for Animal Health and Food Safety" - EADGENE. Den endelige målsetningen er gjennom internasjonalt og nasjonalt sa marbeid å bidra til å identifisere gener,...

Awarded: NOK 0.40 mill.

Project Period: 2005-2009

Location: Akershus

NANOMAT-Nanoteknologi og nye materialer

High efficiency Si-based solar cells employing nanostructured layers

This proposal addresses key scientific issues associated with increasing the efficiency of high-performance Si-based solar cells. Two main routes will be explored; the first one concerns reduction of surface and interface charge carrier recombination by i ntroducing nano-structured buffer layers ...

Awarded: NOK 1.9 mill.

Project Period: 2005-2009

Location: Oslo

HAVBRUKS-Havbruk - en næring i vekst

Neuroendocrine and environmental control of puberty in fish

Early sexual maturation leads to a significant loss of body weight during the spawning season, and farmed Atlantic cod (Gadus morhua) of both sexes currently reach puberty as early as two years of age, before reaching commercial size. Photoperiod treatmen t has been the most efficient strategy to...

Awarded: NOK 3.0 mill.

Project Period: 2005-2009

Location: Oslo

HAVBRUKS-Havbruk - en næring i vekst

Effects of environmental and nutritional stress on gene regulation in the Atlantic cod Gadus morhua.

The main goal of this project is to develop a microarray platform for gene regulation studies in the Atlantic cod. Stress genes in cod exposed to waterborne pollutants and dietary undesirables and supplements, will be sequenced as expressed sequence tags (ESTs), and a cDNA microarray will be cons...

Awarded: NOK 2.7 mill.

Project Period: 2005-2009

Location: Vestland

BIONÆR-Bionæringsprogram

Soft flesh problems in farmed marine fish

Several factors such as the amount and quality of the feed, harvesting and slaughtering methods, and storage time after slaughter, can affect both technological and sensory properties of the fish fillet. Several factors such as the amount and quality of the feed, harvesting and slaughtering meth...

Awarded: NOK 2.4 mill.

Project Period: 2005-2012

Location: Troms - Romsa - Tromssa