5,400 projects

FRIBIO-Biologi og biomedisin

Quantification and Characterization of Microbial Communities in Air.

There is a serious lack of knowledge concerning the presence, activity and dispersal of airborne microorganisms. Most studies describing the prevalence of airborne microorganisms have only applied traditional microbiological methods and evaluated the occu rrence of culturable bacteria, which is k...

Awarded: NOK 2.6 mill.

Project Period: 2007-2009

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Proposal for a National consortium in Fish Genomics - FishGen

The present proposal describes the establishment of a National Consortium in fish genomics (FishGen). The main partners in the FishGen are; Institute of Marine Research (IMR), University of Bergen (UoB), National institute of nutrition and seafood researc h (NIFES), University of Tromsø (UiTø), N...

Awarded: NOK 14.0 mill.

Project Period: 2007-2010

Location: Vestland

FRIBIO-Biologi og biomedisin

Mechanism of cargo selectivity in axonal transport Isolation and characterization of kinesin light chain associated vesicles

The aim of this project is to gain knowledge about how the motor protein kinesin-I interacts with its vesicle cargo, and what the nature is of the vesicles that are transported by kinesin-I through neurons. The role of neuronal transport in neurodegenerat ive diseases such as Alzheimer's disease,...

Awarded: NOK 2.5 mill.

Project Period: 2007-2011

Location: Oslo

FRIBIO-Biologi og biomedisin

Dynamics of synaptic transmission in the rod pathway of the retina

A considerable challenge in neuroscientific research is to explain processes at the systems level in terms of mechanisms at cellular and molecular levels. The retina serves as an ideal model system amenable to experimental approaches that directly aim to bridge this gap. With respect to the senso...

Awarded: NOK 3.0 mill.

Project Period: 2007-2010

Location: Vestland

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Verification of traceability data of marine oils with emphasis on species,geographical origin and processing conditions

The Norwegian Food Safety Authoritiy (NFSA) is responsible for inspection of the marine oils that are part of the Norwegian trade. Necessary for that task, and nowadays unfortunately unavailable, there must be effective routines and analytical methods sui table to verify the authenticity of the o...

Awarded: NOK 3.1 mill.

Project Period: 2007-2009

Location: Trøndelag - Trööndelage

SFI-Sentre for forskningsdrevet innovasjon

SIMLab - Structural Impact Laboratory

App for borerigger neste Ved årsskiftet er forskningssenteret SIMLab på NTNU historie. Målet er nådd: Å bli best i verden på beskyttelse. Nå vil partnerne videre. De ser for seg apper for biler og borerigger. I tur og orden banket de på døra: Renault, Audi, BMW, Toyota, Honda og GM. Alle de...

Awarded: NOK 80.0 mill.

Project Period: 2007-2014

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Protein aggregation and degradation in aging and disease: Role of polyubiquitination and autophagy

Hundreds of proteins encoded by the human genome have the propensity to form cytoplasmic aggregates under certain conditions. Although the mechanisms of intracellular protein aggregation are poorly understood, it is well known that deposits of aggregatete d proteins are highly associated with agi...

Awarded: NOK 8.6 mill.

Project Period: 2007-2011

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Fe-S Cluster Biogenesis in Plastids and Mitochondria in Plants

Iron-sulfur (Fe-S) clusters are essential, inorganic cofactors of Fe-S proteins involved in numerous vital developmental processes. Although simple in structure Fe-S clusters are not formed spontaneously but require an intricate interplay of a number of p roteins and in plants Fe-S cluster biogen...

Awarded: NOK 3.1 mill.

Project Period: 2007-2010

Location: Rogaland

FRIBIO-Biologi og biomedisin

Dynamics underlying astrocyte behaviour

For a long time astrocytes, the most abundant glial cell species, have been considered passive bystanders of neural activity. The picture that is now emerging is that astrocytes are critically involved in regulating brain function. Despite extensive exper imental efforts, a thorough understanding...

Awarded: NOK 2.6 mill.

Project Period: 2007-2009

Location: Akershus

FRIBIO-Biologi og biomedisin

Competence-induced cell lysis in Streptococcus pneumoniae: Implications for horizontal gene transfer and virulence

Streptococcus pneumoniae have the ability to enter a transient phenotype termed competence for natural transformation, which enables the bacterial cells to take up free DNA from the surrounding environment. Recently, it was discovered that competent cells also aquire the ability to lyse neighbou...

Awarded: NOK 2.4 mill.

Project Period: 2007-2010

Location: Akershus

BIONÆR-Bionæringsprogram

Potential of muscle profiling on value-addition of products and consumer satisfaction under Norwegian beef production conditions

Matforsk deltar i et EU-prosjekt på kvalitet og sikkerhet av storfekjøtt hvor utnyttelsen av utradisjonelle stykningsdeler er en sentral del av prosjektet. Ny forskning i USA har vist at ved å bruke utradisjonelle metoder for nedskjæring og utbeining kan verdien av slaktet økes betydelig. I EU-p...

Awarded: NOK 7.8 mill.

Project Period: 2007-2012

Location: Akershus

FRIMED-Klinisk medisin og folkehelse

L-Ornithine and phenylacetate: A novel and effective therapy for hepatic encephalopathy

Background: The major therapeutic target for the treatment of hepatic encephalopathy is ammonia. Our extensive investigations in animal models and also in humans with cirrhosis support the view that the major organ removing ammonia in patients with cirrho sis is the muscle, converting ammonia to ...

Awarded: NOK 1.3 mill.

Project Period: 2007-2009

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Metabolic scaling in teleosts

Metabolic scaling is a widely recognised problem in biology. The underlying causes for the disproportionate relationship between the metabolic rate of an organism and its body size have long puzzled scientists, and continue to be controversial. In recent years this fascinating subject has been tr...

Awarded: NOK 3.1 mill.

Project Period: 2007-2010

Location: Vestland

FRIBIO-Biologi og biomedisin

New therapeutic principles and biological mechanisms related to brain tumour cell invasion and angiogenesis

Primary gliomas represent one of the greatest challenges in neuro-oncology. Recent studies have identified so-called ?cancer stem cells? in several cancers. These cells have the capacity to proliferate and establish tumors in laboratory animals after inje ction of only a small number of cells. Mo...

Awarded: NOK 1.5 mill.

Project Period: 2007-2009

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Physical activity level, determinants of physical activity, physical fitness, fatness and health in Norwegian children

INTRODUCTION: The obesity epidemic in the Western World is well known, and even if the prevalence of obesity in Norway is much lower than in countries such as USA and England body weight has increased in Norwegian children during the last decades. Althoug h weight gain is a consequence of higher ...

Awarded: NOK 0.38 mill.

Project Period: 2007-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

Vaccine development for HIV and influenza

Aim: Based on the vaccibody principle developed by us, we wish to generate novel vaccines for important infectious diseases such as HIV and influenza. Background: Vaccination has had an enormous impact on health and longevity of humans world-wide. However , for some important diseases such as HIV...

Awarded: NOK 3.1 mill.

Project Period: 2007-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

The Tromsø Pain Study: Causes and consequences of individual differences in pain sensitivity

Human pain sensitivity is subject to very large inter-individual variation. It is known that pain sensitivity is heritable, but the genes involved are largely unknown. Hypersensitivity to pain may be an important risk factor in the development, maintenanc e and consequences of chronic pain. Reduc...

Awarded: NOK 3.7 mill.

Project Period: 2007-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Tissue engineering in bone defects: Development of porous copolymer scaffolds stimulating stem cell growth and bone regeneration

For the repair of bone defects, tissue engineering would be to combine cells capable of osteogenic activity with an appropriate scaffold. Mesenchymal stem cells are multipotential cells that are capable of differentiating into different type of cells dep ending on culture condition. The selectio...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Cellular responses to meningococcal meningitis

Meningococcal disease is a leading cause of meningitis and septicaemia worldwide. Among the serious consequences of meningitis are brain edema and disturbed neuronal excitability. These effects are often the direct cause of death. Despite the serious comp lications, the molecular basis for these ...

Awarded: NOK 3.4 mill.

Project Period: 2007-2012

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Statistical tools for studying genetic architecture

Advances in molecular biology have revealed that most phenotypes are controlled by highly complex and interactive gene networks. This complex genetic basis is, however, not reflected in the rather simple genotype-phenotype maps postulated in population an d quantitative genetics. These models are...

Awarded: NOK 2.6 mill.

Project Period: 2007-2012

Location: Oslo

FRIBIO-Biologi og biomedisin

Elucidation of downstream signaling events of cAMP using new tools distinguishing the roles of EPAC and PKA

The present project will receive Epac and PKA modulating cAMP analogs. I. We will test selected new analogs in a newly developed and unique assay for binding to PKA holoenzyme II. The best activators (current or novel) will be used, separately and jointl y, to define effect of Epac and PKA activ...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Vestland

FRIBIO-Biologi og biomedisin

A novel signal transduction pathway regulating cell separation processes in plants - the IDA/IDL network and their predicted partners.

Signaling mediated by small peptides is important in cell-to-cell communication. Few peptide ligands involved in cell signaling are known from plants and even less is known about the peptide-ligand-receptor pairs. A group of small putative peptide-ligands have recently been characterized by the ...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

RENERGI-Fremtidens rene energisystemer

Hydrogen production from natural gas in high-temperature membrane reactors: Advanced catalysis from atoms to processes

The project deals with a development of a catalyst system in a high temperature hydrogen permeable membrane reactor, enabling production of hydrogen and CO2 simultaneously from natural gas. The active, stable and cheap catalysts will be developed by new c atalyst design through the combination of...

Awarded: NOK 3.9 mill.

Project Period: 2007-2012

Location: Trøndelag - Trööndelage

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Stability and mobility of Shiga toxin-encoding bacteriophages in clinical and environmental strains of Escherichia coli O103

E. coli O103 belongs to a subset of serotypes of Shiga toxin-producing Escherichia coli (STEC) associated with severe human illnesses. Shiga toxin (Stx) production is essential but not sufficient for virulence in pathogenic STEC as factors involved in att achment, haemolysis and iron scavenging a...

Awarded: NOK 3.2 mill.

Project Period: 2007-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

cAMP signalling -novel downstream targets of PKA and Epac identified by phospho-proteomics.

I. Implement novel method for quantitative COFRADIC non-gel global phospho-proteomics through stay of candidate in the laboratory of prof. J. Vandenkerckhove at Univ. of Gent II. The phospho-proteome will be compared in cells in response to activation of PKA (by N6-MB-cAMP) or Epac (by 8-pCPT-2´-...

Awarded: NOK 3.2 mill.

Project Period: 2007-2011

Location: Vestland

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Avl for bedre helse hos gris

Organisering og oppslutning i norsk svineavl er unikt internasjonalt. Tilslutningen til avlsarbeidet i næringa, faglig dyktighet i Norsvin samt aksept og støtte fra myndighetene har bidratt til at norsk avlsmatriale i dag er verdensledende på flere område r. Dette har resultert i at en internasjo...

Awarded: NOK 1.6 mill.

Project Period: 2007-2011

Location: Innlandet

FRINAT-Matematikk og naturvitenskap

Challenging atomistic processes in SiC

This proposal addresses fundamental issues regarding atomistic phenomena occurring during modification and processing of silicon carbide (SiC). SiC is a novel wide bandgap semiconductor with an outstanding potential beyond the silicon era. However, to rea lize this potential, a number of critical...

Awarded: NOK 4.8 mill.

Project Period: 2007-2011

Location: Oslo

FRINAT-Matematikk og naturvitenskap

Study of entanglement and quantum information in condensed matter systems.

The quantum computer is a hypothetical computer that utilizes the superposition principle of quantum mechanics to perform certain computational tasks much faster than any classical computer can. Entanglement is one of the most curious phenomena in Nature, which involves the collapse of the quant...

Awarded: NOK 2.1 mill.

Project Period: 2007-2009

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

EGF-induced Formation of Clathrin Coated Pits

Growth factor receptors control cellular growth and differentiation by transmitting signals from outside the cell to the cell interior, particularly the nucleus. Signal transmission can be modulated in several ways. To control signalling, down-regulation of receptors from the cell surface is impo...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Oslo

NANOMAT-Nanoteknologi og nye materialer

Entry of Nanoparticles into cells: Characterization of Nanoparticles as tools to study endocytic pathways and intracellular transport

Research on nanoparticles have evolved into biological applications with large expectations for the use of magnetic iron oxide nanoparticles and fluorescent Quantum dots in different imaging techniques both for tumor targeting and drug delivery in humans and as probes at the cellular level. In th...

Awarded: NOK 3.4 mill.

Project Period: 2006-2011

Location: Ukjent Fylke