5,618 projects

Date from new to old

FUGE-Funksjonell genomforskn.i Norg

IMAGING GENETICS OF SCHIZOPHRENIA. A WHOLE GENOME - BRAIN MRI STUDY

Schizophrenia is a severe psychiatric disorder characterized by psychotic symptoms, cognitive dysfunction and poor outcome, and is a major public health problem with a high cost for society. Brain imaging studies have shown structural abnormalities and dy sfunction in specific brain regions. The ...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Epigenetic gene regulation: The 'conspiracy' between chromatin modification and transcription factors.

An important aspect of gene regulation involves the interconversion between transcriptionally permissive euchromatin and repressive heterochromatin, which in part is regulated by post-translational modifications of the nucleosomal histone tails. The patte rns of histone modification (the histone ...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Single Cell Profiling of Phospho-Protein Networks in Health and Disease - From Signalling Profiles to Future Biomarkers

This proposal describes plans for a research project to be undertaken by a strong concortium of PI's (Gjertsen, Lorens, UoB; Torgersen, Aandahl, Tasken, UoO) and aiming to characterize key events in intracellular signalling networks that regulate cellular properties and behaviour in health and d...

Awarded: NOK 10.0 mill.

Project Period: 2007-2012

Location: Vestland

NANOMAT-Nanoteknologi og nye materialer

Pure and ultra-fine grained Titanium for biomedical applications

A high strength to weight ratio, corrosion resistance and biocompatibility are properties which have made Ti-alloys the preferred metallic material for medical implants/prostheses. Depending on the type of implant, these alloys range from highly ductile a nd commercially pure variants, where a hi...

Awarded: NOK 5.6 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

NANOMAT-Nanoteknologi og nye materialer

NANOTRUST: Ethical conditions for a socially robust use of nanobiotechnology in aquaculture

A keyword in the proposed project is trust. We take the starting point that trust is a necessary prerequisite for social robust development and application of nanotechnology. New technologies as nanotechnology are framed by scientific uncertainty and igno rance both regarding positive and negativ...

Awarded: NOK 4.6 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

GASSMAKS-Økt verdiskaping fra naturgass

Recovery of CO2 from high pressure gas with membranes

In the current project the aim is to develop further a CO2-selective membrane to be applied for removal of CO2 from high pressure natural gas. The membrane is based on the polymer polyvinlylamine (PVAm) where the fixed amine group (NH2) in the material w ill function as a carrier for CO2 when t...

Awarded: NOK 5.4 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

GASSMAKS-Økt verdiskaping fra naturgass

Zeolite membranes for CO2 separation

Zeolites are microporous minerals with the potential for utilization in novel applications, i.e. zeolite membranes. This project is a collaboration between the research groups led by professors Lillerud at University of Oslo (OU), Norway and Hedlund at Lu leå University of Technology (LTU), Swede...

Awarded: NOK 2.5 mill.

Project Period: 2007-2013

Location: Oslo - Oslove

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The genetically-defined Parkinson's disease. A study of biomarkers in patients and healthy carriers of the Park8 G2019S mutation.

The mechanisms behind the development of PD are still obscure, but it is clear that PD is heterogeneous both in terms of cause, phenotype, progression, and response to treatment. Reproducible biomarkers for PD susceptibility and/or progression that are se nsitive and specific have long been sough...

Awarded: NOK 1.2 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

BIA-Brukerstyrt innovasjonsarena

New strategies for efficient development of microbial bioprocesses

This project is a collaboration between SINTEF Materials and Chemistry, Department of Biotechnology, the Department of Biotechnology at NTNU and Alpharma AS. The project builds on the existing competence among the project partners in developing industrial bioprocesses and will make use of state ...

Awarded: NOK 6.4 mill.

Project Period: 2007-2012

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Functional genomics in ascidians through insertional mutagenesis and homologous recombination

Ascidians, or sea squirts, are marine invertebrate chordates. Their critical evolutionary position as basal chordates and the simplicity of their embryogenesis have attracted great attention from developmental and evolutionary biologists. Recently, ascid ians have become one of the most promisin...

Awarded: NOK 6.0 mill.

Project Period: 2007-2011

Location: Vestland

SFF-Sentre for fremragende forskning

Centre for Ecological and Evolutionary Synthesis, CEES

Highlights 2007-2017 CEES´ research activities have been organized in four colloquia. Colloquium 1 explored concepts vs. measurements (e.g. Houle et al., Q. Rev. Biol. 2011) and has been a foundation for the sequential research. Colloquium 2 coupled genomics and evolutionary theory. Our seque...

Awarded: NOK 102.5 mill.

Project Period: 2007-2018

Location: Oslo - Oslove

BIA-Brukerstyrt innovasjonsarena

A Combinatorial Mutagenesis Approach to Improve Microbial Expression Systems

Proteins have a broad range of medical and industrial applications, and today the majority of all commercial proteins are produced recombinantly, most often by using bacteria and yeast as production hosts. The scientific literature on microbial recombinan t protein production is comprehensive, bu...

Awarded: NOK 13.0 mill.

Project Period: 2007-2012

Location: Trøndelag - Trööndelage

NANOMAT-Nanoteknologi og nye materialer

Nanoscale Control of Mineral Deposition within Polysaccharide Gel Networks

Controlled deposition of minerals within polysaccharide gels offers a new route to improve properties of gel based materials as well as to make new composites. By deposition of the mineral component within soft and compliant gel matrix, we will create new composite materials with controlled mech...

Awarded: NOK 4.6 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

GNBIO-Grunnleggende næringsrettet bioteknologi

Exploring the T cell receptor genome - the next generation cancer immunotherapeutics

We will generate recombinant T cell receptors (TCRs) that recognize cancer cells. DNA encoding the receptors forms basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) T cells that recognize telomerase have been isolated ...

Awarded: NOK 2.3 mill.

Project Period: 2007-2012

Location: Oslo - Oslove

GNBIO-Grunnleggende næringsrettet bioteknologi

Targeting of a PKA-AKAP18d-phospholamban signalling complex in the heart as therapy for chronic heart failure

The adrenalin-beta-adrenergic receptor-cAMP-protein kinase A signalling pathway regulates heart rate and contractility. Although changes in cardiac myocyte contractility either cause or are associated with cardiovascular disease, surprisingly few drugs ar e available that modulate the cardiac myo...

Awarded: NOK 2.8 mill.

Project Period: 2007-2012

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

From comparative genomics to systems biology - unravelling novel principle virulence mechanisms in pathogenic spore-forming bacteria

In the past decade, our research group has been involved in the characterization of virulence mechanisms in Bacillus cereus group bacteria. Here we propose to study two processes connected to development of resistance to antimicrobial compounds - the func tion and cellular response of multidrug r...

Awarded: NOK 8.0 mill.

Project Period: 2007-2012

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Secretomes of lactobacilli and enterococci and their impact on bacterial adaptation and human health

Lactic acid bacteria belonging to the genera Lactobacillus and Enterococcus are normal inhabitants of fermented food products and of the human gastrointestinal tract. The impact of these bacteria on human health varies from beneficial to harmful. We will conduct genome-wide studies of surface-loc...

Awarded: NOK 5.3 mill.

Project Period: 2007-2014

Location: Akershus

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Potential clinical relevance of radiation-induced signaling pathways

Radiation therapy is a commonly used treatment modality for cancer. Although in the past decades radiation therapy has shown to be a very successful treatment form, it still can be improved. One problem is that some tumors are particularly resistant to th e cytotoxic effects of radiation and resp...

Awarded: NOK 3.1 mill.

Project Period: 2007-2013

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Neurogenetics of attention in the aging brain

Aging was recently described as a ?neurocatastrophe? involving increased oxidative stress, disturbed energy homeostasis, accumulation of damaged proteins, and lesions in nucleic acids (Mattson & Magnus, 2006), making aging the primary risk factor for deve lopment of neurodegenerative diseases. Ag...

Awarded: NOK 2.9 mill.

Project Period: 2007-2012

Location: Oslo - Oslove

SFF-Sentre for fremragende forskning

Centre for Cancer Biomedicine, CCB

The founding idea of CCB was to join cell biological research aimed at discovering new mechanisms in carcinogenesis and tumour suppression with translational cancer research aimed at discovering novel molecular and phenotypic hallmarks of cancers that can be exploited in diagnostics, prognostics ...

Awarded: NOK 120.6 mill.

Project Period: 2007-2018

Location: Oslo - Oslove

FRIBIO-Biologi og biomedisin

Oil induced autoimmune arthritis

We here present evidence that a novel class of genes encoding regulatory leukocytereceptors may be of clinical importance in autoimmune diseases elicited by environmental exposure to immunoadjuvants, in particular mineral oils. The evidence is based on th e structural identification of the rat Oi...

Awarded: NOK 3.4 mill.

Project Period: 2007-2010

Location: Oslo - Oslove

EVITA-eVitenskap

eSysbio - an e-science environment for systems biology

We propose to develop eSysbio - an e-science environment for supporting systems biology research - and use it to drive Norwegian research within this field. We will conduct research on Web service and semantic technology, and use the results to build a co llaborative virtual workspace that will f...

Awarded: NOK 18.4 mill.

Project Period: 2007-2012

Location: Vestland

MILPAAHEL-Miljøpåvirkning og helse

Dioxin-like Organohalogen Carcinogenesis

Dioxin-like organohalogens include polychlorinated dibenzodioxins, dibenzofurans and 11 planar bifenyls (PCB). In addition, brominated flame retardants (PCDE) may share many of their characteristics. They are persistent environmental pollutants which acc umulate in food chains. Human exposure oc...

Awarded: NOK 2.3 mill.

Project Period: 2007-2012

Location: Oslo - Oslove

MILPAAHEL-Miljøpåvirkning og helse

Germ cell DNA damage and its impact on early embryo development

An apparent decline in semen quality has occurred during the past half century which is most likely related to environmental exposure; however, the agent(s) responsible have not been identified. Endocrine disruptors acting prenatally may be responsible bu t have yet to be shown as relevant for hu...

Awarded: NOK 3.1 mill.

Project Period: 2007-2012

Location: Oslo - Oslove

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Imaging of memory circuitry to evaluate memory loss in Alzheimer's disease models

Memory loss is among the first signs of Alzheimer's disease, and it progresses to encompass all aspects of a person's past and present life experiences. The severity of Alzheimer's disease and its increasing incidence with changing demographics require a tremendous effort in finding treatments. P...

Awarded: NOK 1.00 mill.

Project Period: 2007-2009

Location: Trøndelag - Trööndelage

NANO2021-Nanoteknologi, nanovitenskap, mikroteknologi og avanserte materialer

Novel catalysts and oriented oxide thin films from exfoliated nanosheets of layered materials

The aim of the present project is to utilize colloidal dispersions of nanosheets for preparation of novel materials. We have chosen to focus on two main classes of materials, where we believe we can contribute significantly. We intend to prepare novel and improved catalyst materials consisting o...

Awarded: NOK 9.7 mill.

Project Period: 2007-2012

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Alkaline shock and excitotoxicity in epilepsy: RNAi in vivo - tools for investigation and prospects for therapy

Epilepsy is one of the most common forms of brain disorders, affecting about 1 % of the population. Alkaline shock, the rise of intracellular pH, is one of the few basic explanations of seizures that are now gaining a clear mechanistic description. Very r ecently a direct link between seizures, C...

Awarded: NOK 6.0 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Epigenetic surveying in immune-mediated diseases. A twin study.

Background: Genetically complex diseases, e.g. immune-mediated diseases are caused by a complex interplay between susceptibility genes and environment. The impact of environmental factors is clearly demonstrated in twin studies showing concordance rates i n MZ twins well below 100%. One impact of...

Awarded: NOK 8.0 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

The Interactomics of DNA Repair

The single most important factor for the correct functioning of genomes is that their coding information is maintained intact and transferred unperturbed to future generations. DNA repair is highly coordinated- and integrated with other fundamental cellul ar processes such as transcription, repli...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

A systems biology approach to for modelling of plant signalling and host defence.

The whole-systems approches have created new opportunities for studying and modelling how cellular processes are regulated/coordinated to meet the organism/cell demands. We propose to use a whole-system approach to develop methods for modelling of plant c ellular processes. In addition to generat...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Trøndelag - Trööndelage

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