0 projects

Date from new to old

HAVBRUKS-Havbruk - en næring i vekst

Skeletal deformities and cardiac growth dynamics in underyearling Atlantic salmon smolts (out-of-season, 0+ smolts)

The proposal addresses the topic of production related problems identified as a priority in the strategic plan for "Havbruk" published by the Norwegian Research Council. Deformities in fish are a recurrent problem in aquaculture, and the industry is face d with loss of money as well as a bad rep...

Awarded: NOK 2.3 mill.

Project Period: 2005-2010

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Studies on Copper Homeostasis in Methylococcus Capsulatus based on the complete genomic sequence

Copper is an essential element required by all living systems. Copper can also cause serious cell damage through radical formation. Therefore, careful regulation of the intracellular copper concentration is required. Essentially no free copper is availabl e in the cytoplasm; the copper ions are b...

Awarded: NOK 2.6 mill.

Project Period: 2005-2009

Location: Vestland

FRIBIO-Biologi og biomedisin

Male sperm control

Mutations in the male germ-line are common and in highly monogamous species males may benefit from selecting against own, mutated sperm. This will, in turn, reduce a male’s chance of fertilizing, but, on the other hand, prevent loss of DNA order down the family line. The importance of sperm selec...

Awarded: NOK 2.4 mill.

Project Period: 2005-2010

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

An Environmentally Induced FRQ-Independent 24 hour Rhythm in Neurospora crassa

Circadian rhythms (from latin circa, about; and dies, day) play an important role in the adaptation of organisms to their natural environment. It is assumed that by measuring day length, the circadian clock participates in the initiation of important dail y processes, for example sleep or activit...

Awarded: NOK 1.8 mill.

Project Period: 2005-2012

Location: Rogaland

HAVBRUKS-Havbruk - en næring i vekst

Developmental and growth dynamics of the vertebral column in farmed Atlantic salmon

It is well known from birds and mammals that skeletal tissues are dynamic and sensitive to factors such as exercise and nutrition. In the present proposal, we wish to elucidate the effects of mechanic stimulation of vertebrae through exercise, and the eff ects of fast growth on vertebral architec...

Awarded: NOK 1.3 mill.

Project Period: 2005-2009

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

The role of Peptidyl Arginine Deiminase and protein citrullination in the pathogenesis of rheumatoid arthritis

Rheumatoid arthritis (RA) is a common multifactorial inflammatory disorder. It is characterised by a chronic synovial inflammation that destroys the affected joints and causes disability. The molecular basis of RA is largely unknown, but it is clear that the main genetic contribution to RA is by ...

Awarded: NOK 2.1 mill.

Project Period: 2005-2010

Location: Oslo

HAVBRUKS-Havbruk - en næring i vekst

Differential protein expression in relation to dietary amino acid composition: a proteomic approach towards understanding growth in fish

Growth is essentially protein deposition. Therefore, optimisation of growth depends on the understanding of amino acid (AA) metabolism. The complexity and possible interactions between the various metabolic processes and regulatory pathways are enormous. It is evident that growth in a living anim...

Awarded: NOK 3.0 mill.

Project Period: 2005-2009

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Diet, vitamin A and K, genetics and orofacial clefts

Several factors have been shown to promote orofacial clefting eg genetic factors, teratogenes, maternal alcohol and cigarette use, herbicides and nutrient intake like folate and other B-vitamins. Our primary aim is to study the association between materna l dietary intakes of the first three mont...

Awarded: NOK 2.3 mill.

Project Period: 2005-2010

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Novel modulators and downstream targets of the cAMP receptors Epac and PKA

I: Obtain genomic DNA suitable for recombinant deletion of Epac1 in ES cells, produce Epac1 null mice. II: a) Use mapping data of more than 100 cAMP analogs for PKA type I,II and Epac to predict effect of cAMP modifications on binding. Design new discriminating analogs. b) Identify new ATP-site...

Awarded: NOK 4.0 mill.

Project Period: 2005-2012

Location: Vestland

FRIBIO-Biologi og biomedisin

Interactions between foreign DNA and SECs (scavenger endothelial cells) in vitro and in vivo

Nucleic acid (NA) molecules (DNA and RNA) in food/feed are taken up from the intestines and circulate in the bloodstream of mammals. Isogenic NA shed from apoptotic and necrotic cells are also released into the blood circulation. DNA is usually very rapid ly cleared from the bloodstream, and degr...

Awarded: NOK 1.3 mill.

Project Period: 2005-2010

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Functional studies of S100A4 - A Calcium-binding Protein with Metastasis-promoting Capacity

The calcium-binding protein S100A4 has convincingly been linked to the metastatic process, butt he exact mechanism of action is still unknown. The main purpose of the project is to study the molecular mechanisms behind some of the biological functions th at have been suggested tor the protein, a...

Awarded: NOK 7.3 mill.

Project Period: 2005-2010

Location: Oslo

YFF-Yngre, fremragende forskere

Molecular portraits of breast cancer: Translating genomics to the clinical practice

By using hierarchical clustering of global gene expression data, we were the first to identify five subtypes of breast tumors characterized by specific expression patterns. Our existing work has generated a rich and unique resource and knowledgebase from which to continue research. We will apply ...

Awarded: NOK 7.4 mill.

Project Period: 2005-2010

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Regulation of intracellular traffic by PI3P-binding proteins - a functional and ultrastructrural study

Many important cellular processes such as intracellular transport, signaling through growth hormone receptors, cell motility and apoptosis are regulated directly or indirectly by phosphatidylinositol (PI)-3-kinases. These kinases have different reaction products, one of these being PI-3-phosphat...

Awarded: NOK 7.6 mill.

Project Period: 2005-2009

Location: Ukjent Fylke

YFF-Yngre, fremragende forskere

Fundamentals of Nano-scale Systems

This research project will explore spin and charge flow in nanostructures. We propose to improve theoretical methods for describing transport phenomena, and other physical effects, and plan to use these methods to increase our understanding of experiments . We will study the properties of novel s...

Awarded: NOK 7.2 mill.

Project Period: 2005-2011

Location: Trøndelag - Trööndelage

YFF-Yngre, fremragende forskere

GENOMIC PLASTICITY

Directly turning a differentiated cell into a pluripotent cell would be beneficial for producing isogenic replacement cells. It would also present societal benefits by eliminating the use of cells of embryonic or fetal origin. Altering cell fate involves a reprogramming of nuclear function. We ha...

Awarded: NOK 7.0 mill.

Project Period: 2005-2010

Location: Oslo

SIPOENER-SIP-OED Energi-sektoren

Electronic Processes for breakdown and ageing in high voltage electric insulating liquids above and below freezing point

New materials and improvement of old materials for high voltage insulation are requested to increase operational stresses, improve compatibility and cope with demands due to environmental aspects (e.g. removing polyaromates, biodegradability), high tempe rature applications and resistance to fir...

Awarded: NOK 14.4 mill.

Project Period: 2005-2010

Location: Trøndelag - Trööndelage

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Interaction between alginate and whey proteins

Protein-polysaccharide interactions play a significant role in the structure and stability of many processed foods, and the control or manipulations of these macromolecular interactions are a key factor in the development of novel food processes and produ cts. Functional properties of food protei...

Awarded: NOK 1.9 mill.

Project Period: 2005-2010

Location: Akershus

GNBIO-Grunnleggende næringsrettet bioteknologi

Enzyme evolution and advanced strain engineering in biorprocess development

...

Awarded: NOK 8.2 mill.

Project Period: 2005-2011

Location: Trøndelag - Trööndelage

STORFORSK-Store forskerinitierte prosjekter

Environmental Triggers of Type 1 Diabetes: The MIDIA Study (MIDIA is the Norwegian acronym for "Environmental Triggers of Type 1 Diabetes")

Type 1 diabetes is one of the most prevalent chronic diseases in childhood, and is the end-stage of a destructive inflammation of the insulin producing beta-cells in the pancreas. The disease is caused by unknown environmental factors affecting individu als at genetic risk. In contrast to other...

Awarded: NOK 19.6 mill.

Project Period: 2005-2011

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Generation, reproduction and birth outcome

Causes for disease late in life can be found in events around birth, but also in events before the birth itself. A huge interest in the determinants of birthweight has recently re-emerged due to consistent results showing increased risk of poor health out comes for individuals born with low birth...

Awarded: NOK 2.0 mill.

Project Period: 2005-2010

Location: Vestland

FRIBIO-Biologi og biomedisin

Evolution of chloroplasts: addressing the genomic processes behind acquisition of secondary and tertiary organelles

The dinoflagellate chloroplasts (plastids) originate from eukaryotic photosynthetic endosymbionts. Rather than being derived from a single group (being monophyletic) the plastids of dinoflagellates are originate from several organism groups and are thus of polyphyletic origin. Most dinoflagellat...

Awarded: NOK 4.6 mill.

Project Period: 2005-2009

Location: Oslo

ELSA-Etiske,rettslige og samf.m. as

The moral status of human embryos with special regard to stem cell research and therapy

This is a multidisciplinary project with contributions from biology, medicine, philosophy and theology. The background for the project are the developments going on within the fields of basic and clinical research on and clinical use of human stem cells. These new biotechnological possibilities h...

Awarded: NOK 2.7 mill.

Project Period: 2005-2010

Location: Oslo

ELSA-Etiske,rettslige og samf.m. as

National moral landscapes: The Politics of Stemcells

Stemcells have occupied the centerstage of scientific, public and political awareness since its isolation in 1998. They produce golden hopes of finding future cures for a lot of diseases, but also provoke very heated and antagonistic public debates. It cr eates deep moral concers, involving the s...

Awarded: NOK 2.2 mill.

Project Period: 2005-2009

Location: Vestland

STORFORSK-Store forskerinitierte prosjekter

The TOP study - Identification of phenotypes and genetic susceptibility in severe mental disorders

Severe mental disorders (schizophrenia and bipolar/manic-depressive disorder) are major causes of disability worldwide, and rank as some of the most costly disorders to afflict humans. The etiology still remains elusive, but there is now overwhelming evid ence that genetic factors play a prominen...

Awarded: NOK 19.9 mill.

Project Period: 2005-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Tools for Microbial Nucleic Acid Sample Preparation for Diagnostic and Genomic Analyses

Access to high quality nucleic acid is imperative to conduct any form of genetic analysis. Working with micro-organisms that are difficult to cultivate and/or are embedded in complex materials is a particular challenge. The market is seeking more sensitiv e, simplified, rapid and efficient method...

Awarded: NOK 6.0 mill.

Project Period: 2005-2009

Location: Oslo

MATJORD-Program for forskning innenfor jordbruksog matproduksjon

Beskytter melkeprodukter mot metabolsk syndrom?

...

Awarded: NOK 0.67 mill.

Project Period: 2005-2009

Location: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

NKJ 122 Enhanced control of Potato mop-top virus in the Nordic and Baltic Sea region

Since 1980's, a disease manifested by necrotic symptoms inside potato tubers (spraing disease) has spread in an uncontrolled manner in all Nordic countries and constitutes the most severe quality problem in a commercial use of potatoes. In this project, n ovel biotechnological methods and tools w...

Awarded: NOK 2.4 mill.

Project Period: 2005-2009

Location: Akershus

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Testikkelaktivitet hos råne relatert til forekomst av androstenon i fett.

Kjønnslukt fra produkter av ukastrert hanngris skyldes høye konsentrasjoner av androstenon og skatol i fettet. Undersøkelen gjennomføres på dyr som inngår i Norsvins testingsprogram av råner. Grupper av råner med samme far vil bli undersøkt, eventuelt over flere generasjoner. Androstenon og te...

Awarded: NOK 10.4 mill.

Project Period: 2005-2009

Location: Oslo

KREFTSATS-Særutlysning kreftmidler, historikk

MOLECULAR AND BIOLOGICAL STUDIES OF CANCER METASTASIS

Metastasis, cancer spread to other organs, is the principle cause of death of cancer patients. Early detection of metastatic tumor cells, development of new treatment strategies and knowledge about how to prevent cancer metastasis are some of the most cha llenging tasks in cancer research. Our pr...

Awarded: NOK 6.0 mill.

Project Period: 2005-2009

Location: Oslo

CLIMIT-Program for CO2-håndtering

CLEAN ENERGY BY USING HIGH PERFORMANCE MEMBRANES

A FSC-membrane for selective CO2 removal is currently under development in the research group of the applicant; very promising results have been documented. Selectivities for CO2/CH4 > 1000 have been achieved, while the CO2-flux is currently measured at a pp. 0.014 m3(STP)/m2.bar.h. By succesful ...

Awarded: NOK 5.4 mill.

Project Period: 2005-2009

Location: Trøndelag - Trööndelage

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