5,635 projects

Date from new to old

FUGE-Funksjonell genomforskn.i Norg

Epigenetic gene regulation: The 'conspiracy' between chromatin modification and transcription factors.

An important aspect of gene regulation involves the interconversion between transcriptionally permissive euchromatin and repressive heterochromatin, which in part is regulated by post-translational modifications of the nucleosomal histone tails. The patte rns of histone modification (the histone ...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Single Cell Profiling of Phospho-Protein Networks in Health and Disease - From Signalling Profiles to Future Biomarkers

This proposal describes plans for a research project to be undertaken by a strong concortium of PI's (Gjertsen, Lorens, UoB; Torgersen, Aandahl, Tasken, UoO) and aiming to characterize key events in intracellular signalling networks that regulate cellular properties and behaviour in health and d...

Awarded: NOK 10.0 mill.

Project Period: 2007-2012

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Mechanisms mediating transfer and persistence of antibiotic resistance, and dissemination of virulence genes in streptococci and enterococci

The present project will study mechanisms for genome variation and maintenance in two closely related groups of bacteria Streptocococcus pneumonia and Enterococcus (E. faecalis and E. faecium). While S. pneumonia is considered as a sole pathogen, though 4 0% of humans carry this species, the two ...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Secretomes of lactobacilli and enterococci and their impact on bacterial adaptation and human health

Lactic acid bacteria belonging to the genera Lactobacillus and Enterococcus are normal inhabitants of fermented food products and of the human gastrointestinal tract. The impact of these bacteria on human health varies from beneficial to harmful. We will conduct genome-wide studies of surface-loc...

Awarded: NOK 5.3 mill.

Project Period: 2007-2014

Location: Akershus

GASSMAKS-Økt verdiskaping fra naturgass

A new generation of catalysts for activation and functionalization of light alkanes: Probing of catalyst / reactant interactions

Direct conversion or functionalisation of the highly unreactive methane molecule is one of the holy grails in chemistry. In spite of considerable research efforts worldwide, there is as yet no industrial process for the direct activation of CH4. One deca de ago, the group of Prof. Tilset at the ...

Awarded: NOK 2.4 mill.

Project Period: 2007-2010

Location: Oslo - Oslove

FOLKEHELSE-Folkehelse

Physical activity and chronic pain in HUNT 3 - A prospective cohort study

Regular physical activity promotes health. An inactive lifestyle may alter gene expression, influence negatively on several organ systems and thereby cause chronic disease and increase mortality. These conditions may be reversed by regular activity and in creased level of physical fitness. Physic...

Awarded: NOK 5.0 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

NANO2021-Nanoteknologi, nanovitenskap, mikroteknologi og avanserte materialer

Novel catalysts and oriented oxide thin films from exfoliated nanosheets of layered materials

The aim of the present project is to utilize colloidal dispersions of nanosheets for preparation of novel materials. We have chosen to focus on two main classes of materials, where we believe we can contribute significantly. We intend to prepare novel and improved catalyst materials consisting o...

Awarded: NOK 9.7 mill.

Project Period: 2007-2012

Location: Oslo - Oslove

EVITA-eVitenskap

eSysbio - an e-science environment for systems biology

We propose to develop eSysbio - an e-science environment for supporting systems biology research - and use it to drive Norwegian research within this field. We will conduct research on Web service and semantic technology, and use the results to build a co llaborative virtual workspace that will f...

Awarded: NOK 18.4 mill.

Project Period: 2007-2012

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Potential clinical relevance of radiation-induced signaling pathways

Radiation therapy is a commonly used treatment modality for cancer. Although in the past decades radiation therapy has shown to be a very successful treatment form, it still can be improved. One problem is that some tumors are particularly resistant to th e cytotoxic effects of radiation and resp...

Awarded: NOK 3.1 mill.

Project Period: 2007-2013

Location: Oslo - Oslove

FRIBIO-Biologi og biomedisin

Oil induced autoimmune arthritis

We here present evidence that a novel class of genes encoding regulatory leukocytereceptors may be of clinical importance in autoimmune diseases elicited by environmental exposure to immunoadjuvants, in particular mineral oils. The evidence is based on th e structural identification of the rat Oi...

Awarded: NOK 3.4 mill.

Project Period: 2007-2010

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Signal transduction in cell separation processes- A novel, important signaling module in plants possibly involving RLKs, RopGEFs and RAC/ROP

Cell-to-cell communication is a necessity in plants during development and differentiation. Small peptides can function as signaling molecules. To function in cell-to-cell signaling theses small peptides must have properties that allow them to be transpor ted from the cytoplasma and out across th...

Awarded: NOK 8.6 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

NANOMAT-Nanoteknologi og nye materialer

Exploitation of naturally formed nanostructured surface films on aluminium alloys

Increased recycling of metals, in the present case aluminium alloys, is a necessity in view of increasing demand for the material and environmental concerns related to primary production. A consequence of recycling is an appreciable increase in the type and amount of impurity and trace elements ...

Awarded: NOK 5.7 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

The roles of microRNAs and transcription factors in gene regulation and tissue specific expression

MicroRNAs (miRNAs) were identified as a large group of regulatory genes in 2001, and increasing research has revealed these genes to be important in development, including differentiation, proliferation, and apoptosis. Many miRNAs seem to have tissue-spec ific expression patterns, which suggest t...

Awarded: NOK 7.0 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Alkaline shock and excitotoxicity in epilepsy: RNAi in vivo - tools for investigation and prospects for therapy

Epilepsy is one of the most common forms of brain disorders, affecting about 1 % of the population. Alkaline shock, the rise of intracellular pH, is one of the few basic explanations of seizures that are now gaining a clear mechanistic description. Very r ecently a direct link between seizures, C...

Awarded: NOK 6.0 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Epigenetic surveying in immune-mediated diseases. A twin study.

Background: Genetically complex diseases, e.g. immune-mediated diseases are caused by a complex interplay between susceptibility genes and environment. The impact of environmental factors is clearly demonstrated in twin studies showing concordance rates i n MZ twins well below 100%. One impact of...

Awarded: NOK 8.0 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Regulation of Nuclear Receptor Function by Posttranslational Modifications

Nuclear receptors (NRs), together with coregulatory proteins, coordinate the transcription of gene networks in response to ligand binding and cellular signaling in such diverse biological programs as reproduction, development, nutritent uptake, metabolism and excretion. PMTs have proven to be es...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Neurogenetics of attention in the aging brain

Aging was recently described as a ?neurocatastrophe? involving increased oxidative stress, disturbed energy homeostasis, accumulation of damaged proteins, and lesions in nucleic acids (Mattson & Magnus, 2006), making aging the primary risk factor for deve lopment of neurodegenerative diseases. Ag...

Awarded: NOK 2.9 mill.

Project Period: 2007-2012

Location: Oslo - Oslove

SFF-Sentre for fremragende forskning

Centre for Cancer Biomedicine, CCB

The founding idea of CCB was to join cell biological research aimed at discovering new mechanisms in carcinogenesis and tumour suppression with translational cancer research aimed at discovering novel molecular and phenotypic hallmarks of cancers that can be exploited in diagnostics, prognostics ...

Awarded: NOK 120.6 mill.

Project Period: 2007-2018

Location: Oslo - Oslove

FRIBIO-Biologi og biomedisin

Global expression of defence-related genes in Populus and transfer of knowledge to Norway spruce

Due to the great economic losses caused by the root and butt-rot pathogen Heterobasidion annosum, developments of efficient control measures are warranted. Considerable clonal variation has been recorded for Norway spruce in resistance towards H. annosum, but the defence mechanisms contributing ...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Akershus

MILPAAHEL-Miljøpåvirkning og helse

Dioxin-like Organohalogen Carcinogenesis

Dioxin-like organohalogens include polychlorinated dibenzodioxins, dibenzofurans and 11 planar bifenyls (PCB). In addition, brominated flame retardants (PCDE) may share many of their characteristics. They are persistent environmental pollutants which acc umulate in food chains. Human exposure oc...

Awarded: NOK 2.3 mill.

Project Period: 2007-2012

Location: Oslo - Oslove

MILPAAHEL-Miljøpåvirkning og helse

Germ cell DNA damage and its impact on early embryo development

An apparent decline in semen quality has occurred during the past half century which is most likely related to environmental exposure; however, the agent(s) responsible have not been identified. Endocrine disruptors acting prenatally may be responsible bu t have yet to be shown as relevant for hu...

Awarded: NOK 3.1 mill.

Project Period: 2007-2012

Location: Oslo - Oslove

NANO2021-Nanoteknologi, nanovitenskap, mikroteknologi og avanserte materialer

Environmental fate and ecotoxicity of manufactured nanoparticles

The increasing use of nanomaterials in recent years has caused public concern for risks related to environmental spreading of nanoparticles (NPs). This concern is partly due to a lack of knowledge on the properties and behaviour of NPs, and a lack of comm unication from the scientific community t...

Awarded: NOK 6.0 mill.

Project Period: 2007-2012

Location: Akershus

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Imaging of memory circuitry to evaluate memory loss in Alzheimer's disease models

Memory loss is among the first signs of Alzheimer's disease, and it progresses to encompass all aspects of a person's past and present life experiences. The severity of Alzheimer's disease and its increasing incidence with changing demographics require a tremendous effort in finding treatments. P...

Awarded: NOK 1.00 mill.

Project Period: 2007-2009

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

The Interactomics of DNA Repair

The single most important factor for the correct functioning of genomes is that their coding information is maintained intact and transferred unperturbed to future generations. DNA repair is highly coordinated- and integrated with other fundamental cellul ar processes such as transcription, repli...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

SYSTEMS BIOLOGY IN THE MARINE TUNICATE OIKOPLEURA DIOICA

Gene regulatory modules are central to the coordination of an organism's developmental program and responses to its environment and understanding of them is a key objective of modern molecular biology and medicine. The sophisticated cis-regulation of gene expression in higher metazoans often ext...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

A systems biology approach to for modelling of plant signalling and host defence.

The whole-systems approches have created new opportunities for studying and modelling how cellular processes are regulated/coordinated to meet the organism/cell demands. We propose to use a whole-system approach to develop methods for modelling of plant c ellular processes. In addition to generat...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Understanding brain systems by cell type-specific changes in gene expression

Despite impressive advances in almost every field of neuroscience, our understanding of brain function remains largely confined to its building blocks at the microscopic level, and to phenomenological descriptions at the macroscopic level. The introductio n of transgenic mice has provided neurosc...

Awarded: NOK 10.0 mill.

Project Period: 2007-2010

Location: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

Understanding the System of Neurotransporters

The proposed project is a system-biology approach to transport across brain plasma membranes focusing on neurotransmitter inactivation and water transport. The primary aim is to prepare the ground for a large scale approach to understand what all the hund reds of transporter and ion channels do t...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

FUGE-Funksjonell genomforskn.i Norg

Contextual Regulation of Cell Proliferation & Differentiation in Angiogenesis: Integrated Functional Genomic Discovery &Validation Approach

Angiogenesis, the formation of new blood vessels from extant vasculature, is a fundamental homeostatic process and a key factor in the progression of many pathological conditions. Angiogenesis is defined by the growth and differentiation of endothelial ce lls. We conceptualize angiogenesis as a c...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

O-LINKED PROTEIN GLYCOSYLATION IN BACTERIA

Protein glycosylation is a pivotal element of biological systems not only because it is one of the major post-translational modifications but also because it has significant effects on protein properties and functions. We have recently discovered, and par tially characterized, the first general O...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Oslo - Oslove

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