5,400 projects

Date from new to old

FUGE-Funksjonell genomforskn.i Norg

Mouse models for studying oxidative demethylation of DNA and RNA

It was recently discovered that the AlkB protein from E. coli uses a novel mechanism, termed oxidative demethylation, to remove deleterious methyl lesions from DNA and RNA. Eight mammalian AlkB homologues, denoted ABH1 - ABH8 (mABH1-8 in mice), exist, and two of these, ABH2 and ABH3, have been s...

Awarded: NOK 10.0 mill.

Project Period: 2006-2012

Location: Oslo

FRIBIO-Biologi og biomedisin

Functional genetic networks that maintain genomic stability in mammalian cell lines and in Caenorhabditis elegans

The spontaneous formation of lesions in DNA is among the most significant threats to genomic integrity. We are using genetic and biochemical methods in the model organism Caenorhabditis elegans (C.elegans) and DNA repair deficient mouse cell lines to stud y the biological consequences of accumula...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Oslo

SAM-EU-Samfinansiering EU-kontoret

New Automotive components Designated for and manufactured by Intelligent processing and Light Alloys

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Awarded: NOK 2.1 mill.

Project Period: 2006-2012

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Studies of growth control and gene expression in normal and neoplastic B-lymphoid cells

Malignant lymphomas represent a heterogeneous group of diseases with variable clinical course. The complex biology and the variety of genetic and epigenetic factors involved in the pathogenesis make lymphomas a challenging disease for translational resear ch. There a clear need for the developmen...

Awarded: NOK 2.3 mill.

Project Period: 2006-2012

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Cell-specific brain imaging with viral vectors

Modern brain imaging methods have contributed enormously to contemporary knowledge about the particular brain systems involved in specific cognitive functions. Unfortunately, mechanistic insights have lagged behind, largely because brain mapping in humans lacks the spatial resolution required to...

Awarded: NOK 3.0 mill.

Project Period: 2006-2009

Location: Trøndelag - Trööndelage

NORDAM-SAM-Samarbeidet Norge – Nord- Amerika

Dr.stipendiat til prosj. 173277 Reduced risk of Fusarium and mycotoxin contamination in Norwegian cereals by the development of a..

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Awarded: NOK 2.1 mill.

Project Period: 2006-2009

Location: Akershus

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Mother's neurological disease as a risk factor for the child

The neurological diseases myasthenia gravis (MG), multiple sclerosis (MS) and epilepsy can influence pregnancy, the process of giving birth and the child. Genetic factors, pathogenic mechanisms, disease symptoms and therapy can be responsible. The Medical Birth Registry of Norway contains inform...

Awarded: NOK 2.2 mill.

Project Period: 2006-2010

Location: Vestland

FRIBIO-Biologi og biomedisin

Interplay between DNA repair mechanisms in yeast and their crosstalk with other cellular processes

DNA repair is essential for the maintenance of genomic integrity and defect repair is associated with diseases as cancer, neurological disorders and aging. Unraveling the mechanism of DNA repair is therefore of fundamental importance and the present proje ct seeks to broaden our understanding of ...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Oslo

SAM-EU-Samfinansiering EU-kontoret

Functional Metal Organic Frameworks as Heterogeneous Catalyst

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Awarded: NOK 1.2 mill.

Project Period: 2006-2010

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Endocytosis and intracellular transport of protein toxins

Errors in trafficking and signalling are associated with different diseases, including cancer. This project aims at increasing our knowledge about intracellular transport processes to provide a more rational basis for treatment and prevention of disease. Protein toxins such as Shiga toxin and the...

Awarded: NOK 4.3 mill.

Project Period: 2006-2011

Location: Oslo

FRINAT-Matematikk og naturvitenskap

Point Contact Investigations of Structured Magnetic Materials

The research proposed here will provide information on transport properties through thransport measurements through magnetic structures utilising laterally resolved point contact measurements. We will use the combined powers of surface science technique s, lithography, optical characterisation ...

Awarded: NOK 5.2 mill.

Project Period: 2006-2011

Location: Trøndelag - Trööndelage

MILGENHEL-Miljø, gener og helse

The mechanisms behind toxic effects of POPs

Environmental exposure to persistent organic pollutants (POPs) such as dioxins, polychlorinated biphenyls (PCBs), organochlorine pesticides (OP) and brominated flame retardants (BFRs) is an emotive and sensitive subject. Questions have been raised among t he scientific community, policy makers an...

Awarded: NOK 2.6 mill.

Project Period: 2006-2010

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Genomics as a tool for detecting selection in farm Atlantic salmon and interactions between escaped farm and wild salmon

Norway is of unique importance for the Atlantic salmon, both as the largest producer of farmed salmon and a main reservoir of wild stocks. However, escaped farmed fish make up a significant portion of spawners in the wild, and there is concern that the ge netic constitution of wild stocks is dete...

Awarded: NOK 6.0 mill.

Project Period: 2006-2010

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Regulatory mechanisms and interactions of non-protein-coding RNAs

Genome sequencing has shown that the complexity of an organism is not primarily determined by the number of genes, but rather by the diversity of how these genes are regulated and processed. In particular non-protein-coding RNAs (ncRNA) have been shown to be involved in important aspects of gene...

Awarded: NOK 6.3 mill.

Project Period: 2006-2010

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Development of a Peptide-based Universal Influenza Vaccine

This study aims to develop a safe and effective peptide-based universal influenza vaccine targeting dendritic cells, that stimulates cell mediated immunity to reduce morbidity and mortality associated with influenza virus infection. Such a vaccine can be made in advance of a pandemic and can also...

Awarded: NOK 8.2 mill.

Project Period: 2006-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

The properties of thin, unmyelinated axons in mammalian brain

In order to better understand and control how neurons work we need more knowledge about thin, unmyelinated axons because: * They are the most common, but yet the least studied axonal type in the mammalian cortex. * They are the most excitable part of the neuron and are, therefore, very important ...

Awarded: NOK 2.2 mill.

Project Period: 2006-2010

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Host-pathogen interactions: In vitro and in vivo exploration of the quorum sensing system of the marine fish pathogen Vibrio salmonicida.

The genus Vibrio is among the most numerous and ubiquitous of marine bacteria and commonly found as etiological agents of diseases in both vertebrates and invertebrates throughout the world. Vibrio salmonicida, a halophilic and psychrophilic (cold adapted ) marine gram-negative bacterium, the eti...

Awarded: NOK 6.3 mill.

Project Period: 2006-2009

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Immune stimulating responses of biopolymers with particular reference to treatment of chronic wounds

Chronic wounds are a major world health problem; estimated to affect 3% of the population over the age of 65. There is a demand in the wound healing marked for new efficient products. The chronic wound bed represents a very complex system where bacteria a nd their products and degraded proteins c...

Awarded: NOK 4.0 mill.

Project Period: 2006-2009

Location: Akershus

MILPAAHEL-Miljøpåvirkning og helse

Thermolysis of carbohydrates and intestinal cancer risk.

Increased colorectal cancer risk is associated with a Western style diet and several carcinogenic and hazardous compounds are formed during heat processing. Acrylamide is formed in µg/amounts during heating of sugar-rich foods, but 5-hydroxymethylfurfural (HMF) is produced in much larger quantit...

Awarded: NOK 3.0 mill.

Project Period: 2006-2011

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The Parkinson study in Western Norway and Aust-Agder. Motor and non-motor problems in patients with Parkinson's Disease (PD)

Parkinson's disease is a progressive neurodegenerative disorder of unknown cause. In 2003 it was proposed a new hypothesis by neuropathologists which claims that the disease develops from the brain stem and thereafter to higher levels of the brain in a pr e-determined anatomical sequence. This hy...

Awarded: NOK 1.5 mill.

Project Period: 2006-2009

Location: Vestland

BIA-Brukerstyrt innovasjonsarena

DolphiSkin - Utvikling av en håndholdt ultralydskanner med 3D-visualisering for dermatologisk diagnostisering.

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Awarded: NOK 5.2 mill.

Project Period: 2006-2009

Location: Innlandet

FUGE-Funksjonell genomforskn.i Norg

Developing the SALBANK resource

The SALBANK population was set up as an experimental cross to detect QTLs and genes. By crossing strains that have been geographically isolated since the glacial period: the relict strain Byglandsbleka and the Norwegian elite population NLA followed by in ter crosses, family sets with an expected...

Awarded: NOK 1.4 mill.

Project Period: 2006-2009

Location: Troms - Romsa - Tromssa

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Stunning and Killing of Decapods

The scientific information on welfare of decapods is scarce. The killing methods used has drawn public attention. In some countries the animals are protected by the law, so there is a discrepancy between law and practices. From its biology there is little evidence that decapods are able to feel ...

Awarded: NOK 0.70 mill.

Project Period: 2006-2009

Location: Vestland

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Microbiocidal coatings based on Sphagnum biopolymers for extending the shelf-life of fresh fish (184255)

At present only 1 in 3 temperate marine fish is sold to the consumer (mostly export) as high-quality, high-profit fresh fish. The rest is sold as lower-grade, lower-profit processed fish. If the shelf-life of fresh fish can be extended by only 20-30 % (2- 3 days) then the economic and social (in ...

Awarded: NOK 6.9 mill.

Project Period: 2006-2010

Location: Trøndelag - Trööndelage

HAVBRUKS-Havbruk - en næring i vekst

Activation of immune mechanisms in Atlantic salmon (Salmo salar L.) by CpG oligonucleotides

Viral diseases cause severe problems for the aquaculture industry and development of efficient virus vaccines is a priority target. Cellular defence mechanisms, both innate and acquired, are especially important to combat viral infections. Therefore ident ification of adjuvants which promote stab...

Awarded: NOK 2.4 mill.

Project Period: 2006-2009

Location: Troms - Romsa - Tromssa

SHP-Strategiske høgskoleprogram

Miniatyr ultralydtransducere for medisinske anvendelser

Målet med prosjektet er å utvikle to typer små ultralyd-transducere for medisinske anvendelser. Begge er teknologisk basert på mikromaskinering av silisium. Transducerne skal brukes mot to forskjellige medisinske anvendelser. Synergien mellom de to konsep tene er så stor at det er fornuftig å koo...

Awarded: NOK 6.0 mill.

Project Period: 2006-2012

Location: Vestfold

SAM-EU-Samfinansiering EU-kontoret

e-CUBES 3-D Integrated micro/nano modules for easily adapted applications

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Awarded: NOK 2.2 mill.

Project Period: 2006-2010

Location: Trøndelag - Trööndelage

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Strategies for enhanced microbial safety of organic fermented sausages and herbal ingredients

The demand for organic foods is increasing. But still, the expressed political aim that 15% of foods from the agricultural sector in Norway shall be organically produced and sold within 2015 is a challenge. A prerequisite for the success of such products is that food producers are able to provide...

Awarded: NOK 5.4 mill.

Project Period: 2006-2010

Location: Akershus

KLINISK-Klinisk forskning

Autoimmune polyendokrine syndrome type I- model disease for autoimmunity

Autoimmune polyendocrine syndrome type I (APS-I) (OMIM 240300), is a rare autosomal recessive disorder caused by mutations in the autoimmune regulator (AIRE) gene. The disorder typically begins in early childhood and the patients gradually develop autoimm une destruction of different endocrine an...

Awarded: NOK 2.3 mill.

Project Period: 2006-2009

Location: Vestland

NANOMAT-Nanoteknologi og nye materialer

New innovative barrier solutions for targeted fresh food packaging applications

One of the primary challenges in food packaging business is the presence of oxygen contained in a produce or permeate through the packaging material, having a strong negative effects on the quality and shelf-life of the foodstuff. Effective barrier materi als are in general expensive multilayer s...

Awarded: NOK 4.5 mill.

Project Period: 2006-2009

Location: Trøndelag - Trööndelage

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