0 projects

KLINISK-Klinisk forskning

The Prescription Peer Academic Detailing (Rx-PAD) study. A cluster-randomized educational intervention to improve GPs' prescription practice

The study will be employed as a cluster randomized study targeting 80 general practice (GP) continuous medical education (CME) groups (about 500 GPs) which will be randomized to recieve one out of two interventions - being controls for the other. Furtherm ore, an extended control group comprised ...

Awarded: NOK 4.3 mill.

Project Period: 2008-2013

Location: Oslo

RUSMIDDEL-Rusmiddelforskning

VALIDAD Pilot - Development of a valid test battery for assessing driving ability when influenced by drugs

Road traffic safety is a significant issue for society. In the European Union there are approximately 45 000 traffic fatalities annually. The majority of these accidents are caused by human error, and the use of drugs (both prescribed and illegal compound s) is a significant contributor in this r...

Awarded: NOK 1.00 mill.

Project Period: 2008-2009

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Epigenetic and transcription factor patterns in regulation of cancer-stroma-vascular interactions of human urogenital cancer

In cancer increased cell proliferation outweighs apoptosis and the cancer cells lose contact inhibition and invade surrounding stroma. Genomic instability provides substrate for the evolution and selection of increasingly aggressive cells that invade and metastasize. We have previously reported p...

Awarded: NOK 5.0 mill.

Project Period: 2008-2011

Location: Vestland

GLOBHELS-Global helse

Phase IIb-Test of Concept Clinical Trial of the Peptide-based HIV-1 Therapeutic Vaccine Candidate Vacc-4x

Combination antiretroviral therapy (ART), the daily life long treatment for human immunodeficiency virus (HIV) infection is costly and associated with adverse side effects following long term use (e.g. metabolic toxicity). This study will further the cli nical development of the peptide-based HI...

Awarded: NOK 5.0 mill.

Project Period: 2008-2009

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Change in clinically significant behavior during pharmacological augmented treatment of anxiety disorders

There has been enormous progress in the treatment of anxiety disorders, yet about 40% patients with chronic posttraumatic stress disorder do not recover after receiving daily medication or psychotherapy. PTSD is characterized by hyperarousal, coupled with emotional avoidance. Non-reinforced expo...

Awarded: NOK 3.6 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

TJENESTER-Helse- og omsorgstjenester

A new clinical pathway for patients with fractured neck of femur -The orthopaedics operate, the geriatricians manage the medical work-up

Each year 9000 persons undergo surgery for hip fractures in Norway. The epidemic of hip fractures is associated with high morbidity, mortality, disability and subsequent hospital and social costs as well as impairment of quality of life. Hip fracture pati ents tend to be old and above all charact...

Awarded: NOK 3.0 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

RUSMIDDEL-Rusmiddelforskning

Biological bases of addiction: investigating norepinephrine and brain stress systems using PET in abstinent alcoholics

This project constitutes progress toward the specific goal of solving the complex biomedical problem of addictive behaviors. It will finance a Norwegian post. doc. (the project manager) to take part in an interdisciplinary research consortium at Yale Univ ersity on stress, self control and addict...

Awarded: NOK 2.6 mill.

Project Period: 2008-2010

Location: Oslo

PSYKISK-Psykisk helse

Resource-oriented music therapy for psychiatric patients with low therapy motivation: Randomised controlled trial

Background Previous research has shown positive effects of music therapy for people with schizophrenia and other mental disorders. In clinical practice, music therapy is often offered to psychiatric patients with low therapy motivation, but little resear ch exists about this population. The aim ...

Awarded: NOK 6.1 mill.

Project Period: 2008-2011

Location: Vestland

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Randomized trial for evaluation of mortality and morbidity of coronary revascularization with drug-eluting stent versus bare metal stent

NorStent er forskerinitiert, industriuavhengig, randomisert, norsk multisenterstudie som inkluderer 9013 pasienter med hjertesykdom. Hensikten er å sammenlikne langtidsresultat etter utblokking av hjertets kranspulsårer med to forskjellige metoder. Avleiringer i hjertets kranspulsårer fører ti...

Awarded: NOK 18.5 mill.

Project Period: 2008-2016

Location: Troms - Romsa - Tromssa

KLINISK-Klinisk forskning

Understanding early events in Alzheimer disease (AD) pathogenesis: Integration of molecular, functional and structural imaging

This project will develop and employ integrated imaging techniques in the longitudinal study of patients with mild cognitive impairment (MCI). We aim to study mechanisms for Alzheimer disease induction, and to determine factors predictive for cognitive de cline and conversion to dementia. Fracti...

Awarded: NOK 3.1 mill.

Project Period: 2008-2011

Location: Akershus

KLINISK-Klinisk forskning

Rehabilitation after severe traumatic brain injury. A national multicentre study

In Norway, the annual rate of hospital admission caused by head trauma is around 200 per 100 000 inhabitants. About 15 % of the patients admitted to a neurosurgical department with traumatic brain injury, are in the severe group according to the Glasgow C oma Scale score. These patients demand in...

Awarded: NOK 3.1 mill.

Project Period: 2008-2012

Location: Oslo

BIONÆR-Bionæringsprogram

Marine omega-3 fatty acids and health - use of systems biology in controlled dietary intervention studies

Intake of fatty fish and cod liver oil has been part of a healthy diet in Norway for many years due to the high availability of fish. Omega-3 fatty acids from cod liver oil are used by the Norwegian food industry to develop new healthy food for the consum ers. To understand the beneficial health ...

Awarded: NOK 3.9 mill.

Project Period: 2008-2013

Location: Oslo

PSYKISK-Psykisk helse

Longitudinal studies of Major Depression Disorder and cognitive functioning and emotional information processing: predictors for relapse?

Kognitiv funksjon hos pasienter som opplever sin første episode av depresjon: Det foreliggende prosjektet har inkludert en gruppe mennesker som opplever å bli deprimert for første gang i sitt liv, og undersøkt kognitive funksjoner hos denne gruppen samm enliknet med en gruppe som ikke har vært d...

Awarded: NOK 3.2 mill.

Project Period: 2008-2015

Location: Vestland

PSYKISK-Psykisk helse

Effectiveness of group and individual treatment of childhood anxiety disorders in ordinary community clinics. A randomized controlled trial.

Anxiety disorders (ADs) in childhood are common, may cause great suffering, and may persist into adulthood. Few children with an AD receive psychiatric treatment for their illness compared to children with ADHD and behavorial disorders. Knowledge of effec tive treatments and predictors of positiv...

Awarded: NOK 6.4 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Phenotypic heterogeneity of glucokinase-diabetes mutations: Studies of structure, function and regulatory mechanisms leading to treatment

Glucokinase (GK) is the major glucose sensor in the pancreatic beta-cell where it catalyses the first step of glycolysis. Mutations in human GK (hGK) can be inactivating or activating. Heterozygous inactivating mutations lead to a mild form of diabetes, M ODY2, while homozygous inactivating mutat...

Awarded: NOK 5.1 mill.

Project Period: 2008-2012

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular therapy of maligngant glioma with lentiviral vectors and tumor infiltrating progenitor cells

The aim of the project is to establish a stable packaging cell line for lentiviral vectors based on bone marrow derived tumor infiltrating progenitor cells (BM-TIC) for the treatment of malignant glioma. In previous studies, we have shown that BM-TIC migr ate and distribute efficiently within mal...

Awarded: NOK 3.0 mill.

Project Period: 2008-2012

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Frontal lobe injury and cognitive control

The main goal of this project is to investigate the neural substrate and cognitive mechanisms that are involved in a set of higher-order "executive" functions that are necessary for goal-directed thinking and behavior. At present there is no unitary model that accounts for all aspects of executi...

Awarded: NOK 4.0 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Therapies for genetic diseases associated to aromatic amino acid hydroxylases

It is increasingly recognized that intracellular protein misfolding and aggregation are common to many disorders, notably associated to neurodegeneration. Many inherited diseases are also caused by the enhanced tendency of mutant proteins to misfold and t o undergo proteasomal degradation or dele...

Awarded: NOK 8.3 mill.

Project Period: 2008-2013

Location: Vestland

KLINISK-Klinisk forskning

Is beta cell rest by insulin treatment beneficial in preserving beta cell function in latent autoimmune diabetes of the adult ( LADA)?

Latent Autoimmune Diabetes LADA) er en hyppig form av diabetes. Det er vist at mellom 5 og 10 % av alle pasienter med diabetes har LADA. Selv om denne formen av diabetes altså er hyppig er mye mindre kjent om hva som er beste behandling enn hva som er kjent for type2 diabetes (aldersdiabetes) ell...

Awarded: NOK 3.0 mill.

Project Period: 2008-2015

Location: Trøndelag - Trööndelage

KLINISK-Klinisk forskning

Thalidomide versus Velcade in melphalan refractory multiple myeloma

Standard treatment of patients under the age of 65 with multiple myeloma is high dose melphalan followed by infusion of autologous blood stem cells (ASCT). Standard treatment of patients over the age of 65 is low dose melphalan and prednisolon. Most patie nts respond to this treatment, but patien...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Trøndelag - Trööndelage

PSYKISK-Psykisk helse

Preschool ADHD: Early characteristics, developmental trajectories, risk and protective factors in a prospective birth cohort

Background: ADHD is highly prevalent, characterized by age inappropriate levels of inattention, hyperactivity and impulsiveness. It represents a substantial threat to healthy social and academic development, and increased risk for psychiatric comorbidity. Knowledge about early characteristics, d...

Awarded: NOK 4.3 mill.

Project Period: 2008-2015

Location: Oslo

GLOBHELS-Global helse

Impact of a new and affordable conjugate meningococcal vaccine on carriage of serogroup A Neisseria meningitidis and disease transmission

Meningococcal meningitis is causing repeated massive epidemics in an area south of Sahara, termed the meningitis belt. The disease-causing bacteria are mainly serogroup A meningococci. These are transmitted between individuals by air-borne droplets and as ymptomatic carriers are the principal sou...

Awarded: NOK 11.1 mill.

Project Period: 2008-2011

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Diabetes and diabetes precursors: detection, classification, prediction, genetics, complications and prevention. The Tromsö Study.

The incidence and prevalence of diabetes mellitus are increasing in many populations, and diabetes is now one of the most prevalent chronic diseases worldwide. Diabetes carries a great disease burden in terms of morbidity, mortality and costs. Most cases are classified as Type 2 diabetes, which h...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Troms - Romsa - Tromssa

GLOBHELS-Global helse

Conference: Genetic vaccines - benefits and challenges

The Norwegian Biotechnology Advisory Board apply for financial support to arrange a state-of-the-art vaccine conference addressing the risks and benefits of new genetic vaccines, the need for these vaccines in developing countries and the regulatory chall enges Norwegian legislation puts on Norwe...

Awarded: NOK 0.20 mill.

Project Period: 2008-2009

Location: Vestland

PSYKISK-Psykisk helse

Immunity-linked genes in cognition and schizophrenia

Epidemiological data has clearly identified immune challenges during fetal and early life as a risk factor for developing psychiatric disorders such as schizophrenia and autism. Traditionally the brain was believed to be devoid of immunological responses as its ability to respond by the classical...

Awarded: NOK 5.0 mill.

Project Period: 2008-2010

Location: Vestland

GLOBHELS-Global helse

Phase III double blind placebo-controlled trial of infant periexposure prophylaxis with 3TC to prevent HIV-1 transmission by breastfeeding

Postnatal transmission of HIV-1 through breast milk remains an unsolved problem in many resource-poor settings. In Sub-Saharan Africa, especially in the rural areas, replacement feeding has proven a problematic alternative because of social, cultural, eco nomic and hygienic constraints. Moreover,...

Awarded: NOK 12.5 mill.

Project Period: 2008-2014

Location: Vestland

FORNY-3-Kommersialisering av FoUresultater

Kommersialiseringsstipend:Frikjøp av dr Andreas Barratt-Due for arbeid i prosjektet Prevention and Treatment of Sepsis

...

Awarded: NOK 0.78 mill.

Project Period: 2008-2009

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Mitochondrial Health and Neuronal Life

Lars Eide and Magnar Bjørås are joint applicants for this project. Mitochondria have central roles in neuronal homeostasis as they actively participate in energy production, calcium buffering and apoptosis control. Erosion of mitochondrial function is th ought to underlie the progressive neurona...

Awarded: NOK 4.0 mill.

Project Period: 2007-2011

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

THE PATHOPHYSIOLOGY OF AUDITORY HALLUCINATIONS IN SCHIZOPHRENIA - BRAIN IMAGING STUDIES

The present proposal attempts to respond to the challenges for neuroscience research in Norway and stated in the Nevronor Programme announcement January 2007. We specify six empirical , hypothesis-driven studies wher we attempt to: a) use fMRI and other MRI brain imaging measures to advance know...

Awarded: NOK 4.5 mill.

Project Period: 2007-2013

Location: Vestland

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The role of activity in synaptic development and plasticity in motor pathways: A multi-methodological dynamic imaging approach

This project addresses a major question in neuroscience: How activity in the nervous system regulates the organization of synaptic connections. It poses this question in the motor system, where activity-dependent regulation is less well understood than in sensory systems. To address this questio...

Awarded: NOK 2.0 mill.

Project Period: 2007-2011

Location: Oslo