0 projects

FRIMED-Klinisk medisin og folkehelse

Psychosocial effects and understanding of increased risk for Type 1 Diabetes

With the rapid development in biotechnology and increasing knowledge about the relation between diseases and genetic variability, we are faced with both new opportunities and new dilemmas. Onset of a disease is dependent on several factors as genetic pene trance, combinations of genotypes and env...

Awarded: NOK 2.8 mill.

Project Period: 2007-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Retinopathy and AMD in a general population. The Tromsø Study 2007.

The Tromsø VI survey is scheduled to take place October 2007- through 2008. A total of 11,000 - 16,000 adults in Tromsø will be invited (depending on funding). Many of those have participated in previous surveys, and data from those surveys will be used f or longitudinal analyses. As a subproject...

Awarded: NOK 1.4 mill.

Project Period: 2007-2010

Location: Troms og Finnmark - Romsa ja Finnmárku - Tromssa ja Finmarkku

FRIMED-Klinisk medisin og folkehelse

Gene-environment interaction analyses and oral clefts in Norway

Norway has several large epidemiological studies with genetic bio-banks that may be used in etiologic research. Examples are the CONOR-cohort and the MoBa-cohort of children with mothers and fathers. Optimal analysis of such studies requires integration o f both genetic and environmental effects....

Awarded: NOK 2.8 mill.

Project Period: 2007-2011

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

THE HORDALAND WOMEN'S COHORT STUDY. A planned 15-year (1997-2012) follow up incidence study of urinary incontinence, and associated factors

Urinary incontinence (UI) is a common condition with a prevalence of about 25% of adult women, that affects the physical, psychosocial, and economic well-being. Longitudinal studies of incidence, remission and natural history are scarce. The Hordaland wo men's cohort study is an ongoing 15-year ...

Awarded: NOK 2.5 mill.

Project Period: 2007-2011

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Exposure expression profiles in a prospective cancer study - The Norwegian Women and Cancer postgenome cohort

From 1991 women in Norway has been recruited to participate in NOWAC by postal questionnaires. They are drawn at random from the population through the central person register. Follow-up on cancer and death is based on linkage to national registers. Altog ether 150 000 women aged 30-70 years at r...

Awarded: NOK 1.6 mill.

Project Period: 2007-2010

Location: Troms og Finnmark - Romsa ja Finnmárku - Tromssa ja Finmarkku

FOLKEHELSE-Folkehelse

Is osteoporosis related to the risk of atherosclerosis and cardiovascular disease?

Cardiovascular disease (CVD) and osteoporosis are major causes of morbidity and mortality among elderly people. The two conditions have generally been considered unrelated. However, studies have indicated that arterial calcification is an active, organise d, regulated process similar to bone mine...

Awarded: NOK 2.5 mill.

Project Period: 2006-2009

Location: Troms og Finnmark - Romsa ja Finnmárku - Tromssa ja Finmarkku

MILGENHEL-Miljø, gener og helse

Food from the sea - health effects of organic pollutants and essential nutrients from marine food. The Norwegian Women and Cancer Study.

In the Norwegian Women and Cancer study (NOWAC), detailed dietary information is available in addition to a large biobank. Altogether 68 000 women aged 41-70 years at recruitment have been followed up for cancer incidence and mortality through linkages to national registers based on the unique n...

Awarded: NOK 2.7 mill.

Project Period: 2006-2009

Location: Troms og Finnmark - Romsa ja Finnmárku - Tromssa ja Finmarkku

FOLKEHELSE-Folkehelse

The Hordaland Homocysteine and Health Studies - biobanks and follow-up studies

This is a joint application to cover staff (0.5 position) for project and data management, statistical and laboratory services plus running project expences for the Hordaland Homocysteine Study and the Hordaland Health Study. The Norwegian Research Counci l has previously provided such support an...

Awarded: NOK 2.0 mill.

Project Period: 2006-2009

Location: Vestland

FOLKEHELSE-Folkehelse

The epidemiology of prescription drug use. A record-linkage study in Norway

Three surveys will form the basis of this project: a) The Cardiovascular Survey Progamme in Norway 1972-2004, b) The Youth part of a) 2000-2004, c) Norwegian Epidemiological Osteoporosis Studies (NOREPOS) 1994-2001. The information in these databases wil l be supplemented with information on soc...

Awarded: NOK 4.4 mill.

Project Period: 2006-2010

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

The Nordic-Swiss Childhood Brain Tumour Study

During the last decade, the use of mobile telephones has increased dramatically in large parts of the world. It has been hypothesized, that children should be more vulnerable to radio frequency electromagnetic field exposures from mobile telephones than a dults, but no epidemiological studies of ...

Awarded: NOK 1.8 mill.

Project Period: 2006-2011

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

True exposure, measurement error and risk estimation in clinical and epidemiologic research

In epidemiology as well as in clinical studies our main interest lies in the estimation of the effect of exposure on disease. Most exposure data are subject to measurement error, and when ignored, they will bias our estimates of exposure-disease associati ons. It is important to understand the si...

Awarded: NOK 2.3 mill.

Project Period: 2006-2009

Location: Oslo

IS-BILAT-Mobilitet Norge-USA /Canada

Effect of SNPs in genes related to DNA stability and metabolism of fish and meat related mutagens on colorectal cancer risk

I propose to take advantage of an unique ongoing study to explore how polymorphisms in low penetrance metabolic and DNA repair genes may modulate diet-cancer associations. The study is carried out in USA and deals with colorectal cancer (CRC) in relation to fish- and meat related mutagens exposur...

Awarded: NOK 0.14 mill.

Project Period: 2006-2006

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Do socio-economic community factors affect mortality in Norway? An analysis based on unique multilevel longitudinal data.

The intention is to find out whether community characteristics exert an effect on an adult person's cause-specific mortality, above and beyond that of the person's individual characteristics. The focus will be on socio-economic community factors, such as average income and education and unemploym...

Awarded: NOK 0.90 mill.

Project Period: 2006-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Hormone replacement therapy, gene expression profile and breast cancer

The project is mainly a collaboration between the University of Tromsø and INSERM, France. We will pool together information from the E3N cohort of about 100 000 French female teachers with the 150 000 participants in the Norwegian Women and Cancer study , NOWAC, both started in the early nineti...

Awarded: NOK 2.5 mill.

Project Period: 2006-2008

Location: Troms og Finnmark - Romsa ja Finnmárku - Tromssa ja Finmarkku

AS-HEL-Samfunnsmedisin og helsetj.

Statistical methods for investigating disease candidate genes: SNP haplotype association analyses, with orofacial clefts as a case study

Background: Over the last few years the availability and use of densely spaced SNPs (Single Nucleotide Polymorphisms) in genetic mapping and association studies has exploded. The candidate genes suggested by full genome scans or by functional studies need to be tested in separate epidemiological...

Awarded: NOK 0.11 mill.

Project Period: 2005-2006

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Norwegian Epidemiological Osteoporosis Studies. Why does the risk of osteoporotic fractures vary within Norway?

Norway has the world’s highest incidence of osteoporotic fractures. This large public health problem has severe consequences for the individual and for society. Bone mineral density (BMD) is the most widely used measure of bone strength. In spite of larg e regional differences in fracture risk, ...

Awarded: NOK 2.2 mill.

Project Period: 2005-2008

Location: Vestland

PSYKISK-Psykisk helse

Long-term study #4 of the Norwegian survivors from the capsized oil rig in the North Sea, The "Alexander L Kielland"-Disaster

This will be the fourth study of the Norwegian survivors from the “Alexander L Kielland”-disaster. The study will draw data from prior studies with regards to disaster exposure, psychiatric symptoms, personality and childhood as well as health insurance d ata. Participants are survivors from th...

Awarded: NOK 1.7 mill.

Project Period: 2005-2012

Location: Trøndelag - Trööndelage

MILGENHEL-Miljø, gener og helse

Air pollution, pregnancy outcomes and complications in Oslo 1992-2002

There is increasing evidence that current levels of urban air pollution can cause adverse health effects in humans. So far, the scientific documentation of fetal effects of urban air pollution is limited. However, the research question if ambient air poll ution can increase the risk of perinatal ...

Awarded: NOK 1.9 mill.

Project Period: 2005-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Caesarean delivery; indications and consequences

In Norway the occurrence of caesarean section (CS) has increased from 1.8% in 1967 to 15.7% in 2002, when almost 9000 CSs were performed. The increase may be attributed to changing indications for CS, a changing panorama of implications during delivery, a nd changing attitudes among women. A CS i...

Awarded: NOK 1.8 mill.

Project Period: 2005-2008

Location: Vestland

AS-HEL-Samfunnsmedisin og helsetj.

Statistical Analysis of Complex Event History Data

Together with prof. Ørnulf Borgan, Institute of Mathematics, University of Oslo, the applicant has been invited to organize a research group named Statistical Analysis of Complex Event History Data at the Centre of Advanced Study, Norwegian Academy of Sci ence and Letters, during the academic yea...

Awarded: NOK 99,999

Project Period: 2005-2005

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Pregnancy, one-carbon metabolism and related single nucleotide polymorphisms

The proposed project is possible/feasible because of two parallel ongoing scientific activities in Norway: First, the Norwegian Mother and Child Cohort Study (NMCCS) is currently collecting information on life-style, diet, anthropometric measures and bloo d samples and have recruited about 38,000...

Awarded: NOK 1.8 mill.

Project Period: 2005-2010

Location: Vestland

FOLKEHELSE-Folkehelse

Attachment, risk and resilience among school-age children in a multi-cultural context

The aim of this study is to determine and model how mental health and mental disorders among young immigrants are influenced by their attachment patterns (quality of relationships with parents). This will be modeled as the interaction between attachment p atterns, ethnicity, family stress, social...

Awarded: NOK 2.1 mill.

Project Period: 2005-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Mortality from cardiovascular disease- Is Norway still a high risk country and do we all need statins?

Population studies have demonstrated a striking effect of the combination of several risk factors, such as cholesterol, blood pressure and smoking, on the risk of cardiovascular disease (CVD). A measure of the combined effect, which can be used for scient ific purposes and clinical practice is im...

Awarded: NOK 2.4 mill.

Project Period: 2005-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Generation, reproduction and birth outcome

Causes for disease late in life can be found in events around birth, but also in events before the birth itself. A huge interest in the determinants of birthweight has recently re-emerged due to consistent results showing increased risk of poor health out comes for individuals born with low birth...

Awarded: NOK 2.0 mill.

Project Period: 2005-2010

Location: Vestland

STORFORSK-Store forskerinitierte prosjekter

Environmental Triggers of Type 1 Diabetes: The MIDIA Study (MIDIA is the Norwegian acronym for "Environmental Triggers of Type 1 Diabetes")

Type 1 diabetes is one of the most prevalent chronic diseases in childhood, and is the end-stage of a destructive inflammation of the insulin producing beta-cells in the pancreas. The disease is caused by unknown environmental factors affecting individu als at genetic risk. In contrast to other...

Awarded: NOK 19.6 mill.

Project Period: 2005-2011

Location: Oslo

PSYKISK-Psykisk helse

Antisocial behavior at threshold of adolescence: A longitudinal study of precursors, risk and protective factors from early preschool years

Antisocial behavior among children and adolescents lead to great human costs for the youths, families, and local communities that are affected. The economical costs for the society at large are considerable. The principal objective of the current project is to contribute with knowledge about deve...

Awarded: NOK 2.2 mill.

Project Period: 2005-2013

Location: Oslo

PSYKISK-Psykisk helse

The Bergen Child Study. Diagnostic stability and prognosis of mental health problems in children from early to late primary school

This study (Wave 2;W2 of the Bergen Child study) consists of a two-step procedure, where children (at the time they are 10-12 year olds), will be screened on the same items as in Wave1 of the Bergen Child study, but also including a series of items on mil estones in pubertal development. All scr...

Awarded: NOK 0.20 mill.

Project Period: 2005-2007

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Structure and dynamics of sexual networks: Implications for the spread of sexually transmitted infections

Sexually transmitted infections (STIs) are a serious and increasing problem in the world with severe personal and public health consequences. In Norway the Chlamydia incidence is high and increasing among young adults, primarily transmitted through hetero sexual contact. Mathematical modelling a...

Awarded: NOK 2.2 mill.

Project Period: 2005-2008

Location: Oslo

AS-HEL-Samfunnsmedisin og helsetj.

Childhood diarrheal disease and nutrition prosject

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Awarded: NOK 0.23 mill.

Project Period: 2004-2005

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Inkluderende arbeidsliv: Hva betyr helseforhold tidlig i livet?

En kohort av alle levendefødte i Norge, 1967-76 (N=626928), er fulgt fra fødsel til 2001 ved hjelp av registerkoblinger i et retrospektivt longitudinelt design. Datakilder: 1. Medisinsk fødselsregister (helse, perinatale forhold) 2. Rikstrygdeverk et (pensjonsregister, årlige pensjonspoen...

Awarded: NOK 1.8 mill.

Project Period: 2004-2007

Location: Oslo