0 projects

FRIBIO-Biologi og biomedisin

The study of translocation of extragenous growth factors into cells- mechanisms and biological function of intracellular growth factors.

The growth, development and repair of cells and organs are controlled by a variety of hormones, growth factors and cytokines. Many of these factors are proteins that bind to specific molecules (receptors) at the cell surface. These receptors reside in the plasma membrane. Lipid membranes control...

Awarded: NOK 3.1 mill.

Project Period: 2006-2011

Location: Oslo

FRIBIO-Biologi og biomedisin

Modulation of a PKA-Csk-Lck inhibitory pathway in T cell lipid rafts by CD28-mediated recruitment of a b-arrestin/phosphodiesterase complex

The goal of this project is to understand the molecular mechanisms for cAMP inhibition of lymphocyte proliferation and immune functions. Specifically, we want to understand the molecular interactions and spatio-temporal regulation of the newly mapped PKA- type I-Csk inhibitory pathway regulating ...

Awarded: NOK 2.9 mill.

Project Period: 2006-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

The role of regulatory T cells in allergy

A dramatic increase in prevalence of allergy observed within the last two decades has been associated with better hygiene, increased use of antibiotics and improved vaccination. Infections are important for the induction of regulatory elements within the immune system, and it has been suggested t...

Awarded: NOK 2.7 mill.

Project Period: 2006-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Degradation of insoluble carbohydrate polymers: how do microbial chitinolytic machineries work?

Enzymatic degradation of abundant insoluble carbohydrate polymers such as cellulose and chitin is of tremendous biological and biotechnological importance. Microbes produce numerous enzymes to hydrolyze these polymers, but the question of how they manage to disrupt the crystalline structure of th...

Awarded: NOK 2.8 mill.

Project Period: 2006-2009

Location: Akershus

FRIBIO-Biologi og biomedisin

Opioidergic signaling mechanisms in pain and dependence: PET opioid receptor binding. I. animal studies.

We are all naturally dependent on opioids for our emotional health. The opioid system is activated during the experience of pain, and opioids are used as analgesia and for abuse. Intentionally, opioid analgesia in pain and opioid drug abuse are contrary t o each other, but there are several commo...

Awarded: NOK 2.8 mill.

Project Period: 2006-2009

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Effect of environmental DNA exposure on bacterial adaptation rates

The increasing amount of DNA sequence data available reveals that horizontal gene transfer (HGT) events have been frequent in most bacterial species. This observation identifies HGT as a major driving force in bacterial evolution. Whereas many studies hav e addressed the dynamics and mechanisms o...

Awarded: NOK 2.8 mill.

Project Period: 2006-2010

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

The control of growth by insulin and TOR pathways in Drosophila: identification and characterisation of modifiers of starvation through a ge

This research projects aim to characterising some general mechanisms of growth control. Growth is a complex process, which depends both on internal cues, or genetic parameters, and external influences, like nutrition, exercise or temperature. It is well r ecognized that nutritional input is of gr...

Awarded: NOK 1.6 mill.

Project Period: 2006-2011

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Hemoglobin polymorphism in Atlantic cod - finally unravelling the old puzzle

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Awarded: NOK 3.1 mill.

Project Period: 2006-2010

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Biological Role of Regulatory Catalytic RNA in Eukaryotic Protein Gene Expression

A new main category of catalytic RNA (the GIR1 ribozyme) has been discovered and is under investigation in our laboratory. The group I-like ribozyme (GIR1; approx. 200 nt) is a unique example of a naturally occurring ribozyme with an evolved biological fu nction. GIR1 generates the 5'-end of a nu...

Awarded: NOK 2.8 mill.

Project Period: 2006-2011

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Molecular characterization of embryonic microenvironment that stimulates adult human hematopoietic stem cells to differentiate into neurons

Recent research from the applicant and colleagues has shown that adult human hematopoietic stem cells, derived from bone marrow biopsies, can be stimulated to differentiate into nerve cells by placing them into the injured spinal cord of a chicken embryo. The injured embryonic spinal cord regen...

Awarded: NOK 2.9 mill.

Project Period: 2006-2009

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Structural Glycobiology

The aim of the present research project is to structurally and functionally characterize the basis of protein carbohydrate recognition, with the long-term goal of engineering the carbohydrate specificity of carbohydrate binding proteins. This research fie ld is central to many cellular processes ...

Awarded: NOK 3.4 mill.

Project Period: 2006-2011

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cell cycle regulation: the role of replication clamps and interacting proteins

DNA replication is executed by enzymes called polymerases. The polymerases are tethered to the DNA template by binding to so-called clamps, which are doughtnut-shaped protein complexes encircling the DNA. The clamps are being loaded onto the DNA by clamp loaders, another protein complex. All orga...

Awarded: NOK 2.3 mill.

Project Period: 2006-2013

Location: Oslo

FRIBIO-Biologi og biomedisin

Knock-in and conditional knock-out mice for studies on autoimmunity and cancer development

Variable (V) regions of immunoglobulins are highly diversified and contain antigenic determinants (idiotopes, abbreviated Id). A mouse myeloma (MOPC315) secretes an IgA myeloma protein with lambda2 light (L) chains. The particular lambda2 chain, lambda2(3 15), contains an Id-peptide (aa 91-101), ...

Awarded: NOK 0.22 mill.

Project Period: 2006-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Mechanisms of hyperglycemia-induced foam cell formation and atherosclerosis in type-2 diabetes. Role of the hexosamine biosynthetic pathway

Vascular disease is the most common cause of death in people suffering from type 2 diabetes. The high risk of atherosclerotic disease in type 2 diabetes can in part be accounted for by the diabetic state per se, such as hyperglycemia. Uptake of oxidised LDL and accumulation of cholesterol esters...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Features of developmental enhancers revealed by evolutionary processes in fish genomes: a computational and functional genomics approach

The loci of developmental transcriptional regulators are spanned by arrays of ultraconserved regulatory elements (UCRs), many of which exhibit high similarity across all vertebrates. This project aims to develop computational approaches for the generation of hypotheses about the function of thos...

Awarded: NOK 2.6 mill.

Project Period: 2006-2008

Location: Vestland

FRIBIO-Biologi og biomedisin

Activation of Toll-like receptors of the immune system studied by atomic force microscopy and confocal microscopy

Toll-like receptors (TLRs) trigger a fast response of the immune system to microbial particles that invade our body. TLRs recognize microbial conserved structures such as CpG-DNA or certain lipopolysaccharides, and are essential for our defense against mi crobes as well as for normal inflammatory...

Awarded: NOK 2.5 mill.

Project Period: 2006-2009

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Quorum sensing and transcriptional regulation in Gram-positive bacteria.

The bacteriocin production in Lactobacillus plantarum is regulated by the pln regulatory unit which is a quorum-sensing based signal transducing pathway. Such quorum-sensing based regulatory systems are of crucial importance in regulating gene expression in bacteria in response to environmental c...

Awarded: NOK 2.5 mill.

Project Period: 2006-2010

Location: Akershus

FRIBIO-Biologi og biomedisin

Functional Metagenomics to Study Prokaryotes from Arctic/ Sub-Arctic Springs of Hydrothermal Origin

The majority, in fact >99 % of the microorganisms on this planet have not yet been cultured in the laboratory and therefore have remained mostly uncharacterized and also unexploited for biotechnological purposes. Recent advancements in genomic technologie s, so called metagenomics, now allow to s...

Awarded: NOK 4.3 mill.

Project Period: 2006-2011

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Therapeutic approaches for the correction of misfolding mutations in pterin-dependent enzymes

Many inherited diseases are caused by the enhanced tendency of the mutant variant proteins to misfold and to either undergo proteasomal degradation or deleterious aggregation with plaque formation. For several of these diseases evidence has been accumulat ed that chemical or pharmacologic chapero...

Awarded: NOK 3.2 mill.

Project Period: 2006-2012

Location: Vestland

FRIBIO-Biologi og biomedisin

Developmental Biology of Dormancy Cycling

In perennial plants, like trees, the SAM is cycling between active and dormant states in synchrony with the season (Rinne et al. 2001; Rinne and van der Schoot 2003, 2004). The SD-induced development of dormancy and acclimation involves the obstruction of cellular contacts at the SAM, including ...

Awarded: NOK 2.4 mill.

Project Period: 2006-2009

Location: Akershus

FRIBIO-Biologi og biomedisin

The role of Natural Killer cells in defense against pathogens.

Natural Killer (NK) cells represent an efficient first line defense mechanism against infected cells and certain cancer cells. For this purpose each NK cell is equipped with an array of activating and inhibitory receptors recognizing MHC class I and other molecules on their target cells. Althoug...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

The Biosynthesis of NAD in Humans: Isozymes and Subcellular Compartmentation

NAD is essential for energy transduction. It is also a key molecule in a variety of central signaling pathways. Nevertheless, surprisingly little is not known about its biosynthesis. Our recent research has established that NAD biosynthesis is absent from the cytosol: the three human isoforms of...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Vestland

FRIBIO-Biologi og biomedisin

Studies of mesenchymal cell function during development and disease using transgenic techniques.

Cells interact with collagens using specific cell surface protein receptors belonging to a family called integrins. We have identified one collagen-binding integrin (alpha11beta1), characterized its structure and are studying its function using genetical ly modified mice lacking alpha 11 integri...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Vestland

FRIBIO-Biologi og biomedisin

PPAR activation and mitochondrial function in obesity related diseases.

Disorders of lipid metabolism are intimately connected to many common, life-style related diseases. Obesity and obesity-related disorders, often referred to as the metabolic syndrome, is a serious condition with the presence of a number of risk factors li ke overweight, dyslipidaemia, hypertensio...

Awarded: NOK 3.1 mill.

Project Period: 2006-2010

Location: Vestland

FRIBIO-Biologi og biomedisin

Coeliac disease (CD) and rheumatoid arthritis (RA); mapping the shared features in order to understand autoimmunity

There has been a huge advance in the understanding of coeliac disease (CD) in recent years. Our group has made several important contributions to this improved understanding. Research done by other groups has started to unravel aspects of the pathogenesis of rheumatoid arthritis (RA) that at sev...

Awarded: NOK 2.9 mill.

Project Period: 2006-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Mechanisms behind pathogen activation and evasion of Toll-like receptor signaling

Toll-like receptors (TLRs) are signaling receptors of the innate immune system, sensing a variety of bacterial and viral components. Our central hypothesis is that immune cell recognition of invading pathogens starts with an interaction between microbial structures and TLRs. The following immune ...

Awarded: NOK 2.4 mill.

Project Period: 2005-2011

Location: Trøndelag - Trööndelage

BIOMOL-Molekylær biovitenskap og bioteknologi

ESF Workshop/School: Microarray Gene Expression Analysis: Power and Potential of Standardisation

During the school, the participants will learn and discuss microarray gene expression analysis with an emphasis on standardisation and benchmarking. Curriculum includes central biological issues in transcript profiling, introduction to experimental design and data analysis, laboratory training i...

Awarded: NOK 59,999

Project Period: 2005-2006

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Endothelial cell differentiation - a key to future therapy of chronic inflammation and cancer

Much attention is focused on understanding the role of vascular endothelial cells in disease. In several fields of medicine, there is great interest in understanding the mechanisms that regulate the generation of new vessels and endothelial cell different iation, because the future ability to man...

Awarded: NOK 1.8 mill.

Project Period: 2005-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Functional sites in proteins: A combined proteomic and bioinformatical approach for improvement of a prediction system for linear motifs.

Functional sites in proteins are short stretches of amino acids that serve as binding sites, post-translational modification sites or proteolytic cleavage sites. Most functional features of proteins can be related to functional sites and/or globular domai ns. While there are several efficient met...

Awarded: NOK 3.1 mill.

Project Period: 2005-2009

Location: Vestland

MILGENHEL-Miljø, gener og helse

Genome diversity and plasticity in Enterococcus faecium and E. faecalis with emphasis on pathogenicity and antibiotic resistance

Evidence for increased cost, morbidity and mortality caused by infections with bacteria resistant to antimicrobial compounds is accumulating. In hospitals, Enterococcus faecalis and E. faecium represent promiscuous reservoirs of antimicrobial resistance d eterminants. They are considered “difficu...

Awarded: NOK 3.3 mill.

Project Period: 2005-2010

Location: Troms - Romsa - Tromssa