149 projects

Date from new to old

FRIMED-Klinisk medisin og folkehelse

Life span development and decline in cognition- biological foundations

We focus on life span development and decline in cognition (attention,memory and executive functions) in healthy persons from 7 to 75 years. The projects include measures of structural MRI, functional imaging, genetics, cognitition and neuropsychology. Th e study builds on an established biobank ...

Awarded: NOK 3.5 mill.

Project Period: 2006-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Development of male contraceptive through manipulation of CaS

The project is aimed at developing male contraceptives on a collaborative basis between the Institute of Basic Medical Sciences (project leader Bjørn Steen Skålhegg) and the Department of Andrology, The National University Hospital of Norway (research lea der Dr. Peter Fedorcsak and head of depar...

Awarded: NOK 4.1 mill.

Project Period: 2006-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

The relative role of complement and LPS in sepsis/SIRS: a rational for combined treatment with complement- and CD14/TLRs inhibitors.

The complement system is an essential part of innate immunity protecting the host against infection. However, it is a double-edged sward in the sense that inappropriate activation may damage host tissue. Uncontrolled systemic activation of complement, as seen in sepsis, may contribute to the brea...

Awarded: NOK 1.5 mill.

Project Period: 2006-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Spontaneous preterm birth and genetics

Preterm birth (PTB) is the main cause of perinatal mortality and short- and long-term morbidity. The pathophysiology of spontaneous PTB remains poorly understood. Infection and inflammation, fetal growth, uterine distention and decidual haemorrhage are be lieved to be part of the mechanisms resul...

Awarded: NOK 2.2 mill.

Project Period: 2006-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

NOVEL BIOTHERAPEUTIC STRATEGIES FOR IMPROVING IMPLANT PERFORMANCE IN BONE

The purpose of this project is to characterize mechanisms for bone regeneration and healing and to use this knowledge to develop new strategies for improving the performance of loaded metal implants used to restore function in compromised skeletal structu res. From the clinical perspective skelet...

Awarded: NOK 4.5 mill.

Project Period: 2006-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Identification of genetic and environmental factors contributing to disease susceptibility and clinical presentation of multiple sclerosis

The aim of this project is to identify factors contributing to development of multiple sclerosis (MS) in a PhD project. MS is a debilitating inflammatory disease of the central nervous system. The etiology is unknown, but both genetic and environmental fa ctors are involved. Identification of the...

Awarded: NOK 2.0 mill.

Project Period: 2005-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

From Divided Objects to Whole Subjects. Holistic Philosophy in Medicine.

In the project From Divided Objects to Whole Subjects a theoretical study shall be carried out with the aim of developing and imparting a perspective in medicine that has been given little attention in today’s medicine. This perspective is the one that co ncerns the sick person and that attempts ...

Awarded: NOK 1.9 mill.

Project Period: 2005-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Norwegian Epidemiological Osteoporosis Studies. Why does the risk of osteoporotic fractures vary within Norway?

Norway has the world’s highest incidence of osteoporotic fractures. This large public health problem has severe consequences for the individual and for society. Bone mineral density (BMD) is the most widely used measure of bone strength. In spite of larg e regional differences in fracture risk, ...

Awarded: NOK 2.2 mill.

Project Period: 2005-2008

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Caesarean delivery; indications and consequences

In Norway the occurrence of caesarean section (CS) has increased from 1.8% in 1967 to 15.7% in 2002, when almost 9000 CSs were performed. The increase may be attributed to changing indications for CS, a changing panorama of implications during delivery, a nd changing attitudes among women. A CS i...

Awarded: NOK 1.8 mill.

Project Period: 2005-2008

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Pregnancy, one-carbon metabolism and related single nucleotide polymorphisms

The proposed project is possible/feasible because of two parallel ongoing scientific activities in Norway: First, the Norwegian Mother and Child Cohort Study (NMCCS) is currently collecting information on life-style, diet, anthropometric measures and bloo d samples and have recruited about 38,000...

Awarded: NOK 1.8 mill.

Project Period: 2005-2010

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

The role of Peptidyl Arginine Deiminase and protein citrullination in the pathogenesis of rheumatoid arthritis

Rheumatoid arthritis (RA) is a common multifactorial inflammatory disorder. It is characterised by a chronic synovial inflammation that destroys the affected joints and causes disability. The molecular basis of RA is largely unknown, but it is clear that the main genetic contribution to RA is by ...

Awarded: NOK 2.1 mill.

Project Period: 2005-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Infections, prepregnant diet and other environmental factors as possible causes of hyperemesis gravidarum (HG).

Hyperemesis gravidarum (HG) is defined as severe, intractable nausea and vomiting in early pregnancy. The HG-patient suffers from dehydration, weight loss, ketonuri and a nutritional deficiency. HG affects 0,5-2,0% of pregnant women, and the etiology is u nknown. Until recently HG was believed to...

Awarded: NOK 1.8 mill.

Project Period: 2005-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Mortality from cardiovascular disease- Is Norway still a high risk country and do we all need statins?

Population studies have demonstrated a striking effect of the combination of several risk factors, such as cholesterol, blood pressure and smoking, on the risk of cardiovascular disease (CVD). A measure of the combined effect, which can be used for scient ific purposes and clinical practice is im...

Awarded: NOK 2.4 mill.

Project Period: 2005-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Diet, vitamin A and K, genetics and orofacial clefts

Several factors have been shown to promote orofacial clefting eg genetic factors, teratogenes, maternal alcohol and cigarette use, herbicides and nutrient intake like folate and other B-vitamins. Our primary aim is to study the association between materna l dietary intakes of the first three mont...

Awarded: NOK 2.3 mill.

Project Period: 2005-2010

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

MPECS to detect high risk colorectal adenomas

Colorectal cancer (CRSC) is one of the leading cancers and the mortality is high and hardly has changed over the past decades. It is believed that most CRCs are preceded by a pre-invasive phase, called colorectal adenoma (CRA). About 2-5% of all CRAs pro gress to cancer. It is therefore importan...

Awarded: NOK 1.7 mill.

Project Period: 2005-2008

Location: Rogaland

FRIMED-Klinisk medisin og folkehelse

Pathophysiological and Immunological Aspects of Meconium Aspiration Syndrom A search for new understanding and therapy

Meconiumstained amniotic fluid is present in approximately 10-12% of all deliveries. Out of these approximately 5% develop respiratory problems called Meconium Aspiration Syndrom (MAS). This is caused by aspiration of fetal stools (meconium into the lungs ) and occur mainly in term or postterm in...

Awarded: NOK 1.8 mill.

Project Period: 2005-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Generation, reproduction and birth outcome

Causes for disease late in life can be found in events around birth, but also in events before the birth itself. A huge interest in the determinants of birthweight has recently re-emerged due to consistent results showing increased risk of poor health out comes for individuals born with low birth...

Awarded: NOK 2.0 mill.

Project Period: 2005-2010

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Interactive effects of emotional valence and processing fluency on stimulus evaluation

Perceptual fluency is the subjective ease with which people can process incoming information. Several studies have shown that high perceptual fluency is affectively positive: experimental participants preferred stimuli that were easy to process. However, the existing studies with single exposure ...

Awarded: NOK 0.81 mill.

Project Period: 2005-2008

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

An Analysis of the Mechanisms that Determine the Effectiveness of Endorsement Advertisements

Many companies spend large sums of money on advertising, and effective vs. ineffective advertising can mean the difference between success and bankruptcy. Furthermore, even award-winning advertising campaigns sometimes fail to produce increases in product sales, suggesting that even industry exp...

Awarded: NOK 1.0 mill.

Project Period: 2005-2007

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Induced Liver Hyperplasia

The liver strictly regulates its own volume relative to body mass. We aim to investigate and manipulate the mechanisms underlying this phenomenon. Based on increasing evidence that regeneration after partial hepatectomy (PHx) is triggered immediately by changes in hemodynamics, we have designe...

Awarded: NOK 1.2 mill.

Project Period: 2005-2007

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Structure and dynamics of sexual networks: Implications for the spread of sexually transmitted infections

Sexually transmitted infections (STIs) are a serious and increasing problem in the world with severe personal and public health consequences. In Norway the Chlamydia incidence is high and increasing among young adults, primarily transmitted through hetero sexual contact. Mathematical modelling a...

Awarded: NOK 2.2 mill.

Project Period: 2005-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Negative thinking as dysfunctional habit

Persistent negative thinking about oneself is considered as pathological. Beck incorporated schematic negative thinking as a core element in his model of depression. However, the conceptual status of this phenomenon is less clear. While most stress the ne gative content of thinking, we propose to...

Awarded: NOK 0.54 mill.

Project Period: 2005-2007

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

High- and low-level mechanisms of human memory

The project represents a broad-scale approach to the study of human memory. Memory is studied in the laboratory and in everyday contexts, with experiments aiming at the various memory systems or formats of memory representation, and looking at how memory is embedded in emotional and social inform...

Awarded: NOK 2.1 mill.

Project Period: 2005-2007

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Immune mechanisms and genetics associated with development of pre-eclampsia/eclampsia(PE/E)

PE is regarded as a two-step disease, with poor placentation and placental hypoperfusion as the first step in pathogenesis. The recognition of fetal trophoblasts by maternal uterine (uNK) cells is fundamental in placental development. Observations suggest that the superficial trophoblast invasio...

Awarded: NOK 2.0 mill.

Project Period: 2005-2007

Location: Trøndelag - Trööndelage

FRIMED-Klinisk medisin og folkehelse

ACTIVE

Active is a prospective randomised trial of autologous chondrocyte transplantation compared with alternative treatments for patients who have had a failed primary treatment for chondral defect(s) in the knee. 660 patients in 14 cenres (12 in the UK, 2 in Norway) will be recruited over 2-3 years. ...

Awarded: NOK 0.90 mill.

Project Period: 2005-2007

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

The dynamics of fear

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Awarded: NOK 2.0 mill.

Project Period: 2004-2008

Location: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Zinc and common childhood infections - field trials in Nepal

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Awarded: NOK 2.2 mill.

Project Period: 2004-2007

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Venous thromboembolism in pregnancy

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Awarded: NOK 1.5 mill.

Project Period: 2004-2008

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Inkluderende arbeidsliv: Hva betyr helseforhold tidlig i livet?

En kohort av alle levendefødte i Norge, 1967-76 (N=626928), er fulgt fra fødsel til 2001 ved hjelp av registerkoblinger i et retrospektivt longitudinelt design. Datakilder: 1. Medisinsk fødselsregister (helse, perinatale forhold) 2. Rikstrygdeverk et (pensjonsregister, årlige pensjonspoen...

Awarded: NOK 1.8 mill.

Project Period: 2004-2007

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Genetikk i klinisk onkologi: Ætioilogiske og terapeutiske undersøkelser hos pasienter med malign germinalcelletumor (MGCT)

Ekstragonadale germinalcelle tumores (EGCCT) representerer en klinisk viktig og vitenskapelig meget interessant undergruppe av maligne germinalcelle tumores (MGCT). Norge er nummer 2 på verdenstoppen hva insidens av disse svulster angår, og antall per år er økende uten at årsaken for denne øknin...

Awarded: NOK 1.8 mill.

Project Period: 2004-2008

Location: Oslo

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