0 projects

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FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Small RNAs and DNA repair in Mycobacterium tuberculosis adaptive responses

Tuberkulose (TB) er en av verdens mest utbredte infeksjoner, som tar nesten 1.3 millioner liv og forårsaker 8.7 millioner infeksjonstilfeller årlig. Årsaken er Mycobacterium tuberculosis (Mtb), som infiserer 1/3 av verdens befolkning og har forårsaket flere dødsfall enn noen annen mikrobe. Behand...

Awarded: NOK 3.8 mill.

Project Period: 2011-2014

Location: Oslo

PES-INST-Prosjektetablererstøtte EU (FoU)

Prosjektetableringsstøtte for EU søknader ved Oslo universitetssykehus HF

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Awarded: NOK 0.41 mill.

Project Period: 2011-2013

Location: Oslo

IS-DAAD-Forskerutveksling Norge-Tyskland

Molecular signatures of long non-coding RNAs in breast cancer patients

Of the ~3.3 billion bases of the human genome, only about 2% code for proteins and until very recently, the remaining 98% have been considered to be 'junk'. However, large transcriptomic studies have shown that around 90% of the genome is actively transcr ibed of which a significant fraction may ...

Awarded: NOK 37,386

Project Period: 2011-2013

Location: Oslo

IS-DAAD-Forskerutveksling Norge-Tyskland

Dissecting the developing vestibulo-ocular reflex circuit: Pharmacogenetic and optogenetic manipulation

A fundamental question in neuroscience is how neuronal circuits are assembled during embryonic and fetal development. Critical features include the establishment of functionally appropriate patterns of synaptic connections and a proper balance between exc itatory and inhibitory connections. Senso...

Awarded: NOK 34,661

Project Period: 2011-2013

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Biomechanical characteristics of patients with hip osteoarthritis with mild to moderate pain: A prospective, randomized clinical trial

This project funding proposal concerns a personal postdoctoral fellowship within the area of clinical research. The project will investigate the effect of exercise therapy and patient education compared to patient education alone on lower extremity biomec hanics during gait, sit-to-stand, and one...

Awarded: NOK 2.4 mill.

Project Period: 2011-2014

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The identification of new genetic causes of Parkinson's disease

Parkinson disease (PD) is a common neurological disorder affecting about 1% of the population aged 60 or older. The disorder is causing high costs to society and reduced quality of life in patients and caregivers. Like many other neurological illnesses, P D is chronic, progressive and only sympto...

Awarded: NOK 7.0 mill.

Project Period: 2011-2016

Location: Oslo

EU-STRA-EU - Strålevern

Epidemiological study to quantify risks for paediatric computerized tomography and to optimise doses

EPI-CT er et stort, internasjonalt samarbeidsprosjekt. Formålet med studien er å etablere en europeisk kohort av barn under 20 år som har gjennomgått en eller flere CT-undersøkelser, for i første omgang å estimere risiko for leukemi og hjernesvulst. Etter lenger oppfølging planlegges også analyse...

Awarded: NOK 1.6 mill.

Project Period: 2011-2018

Location: Oslo

IS-BILAT-Mobilitet Norge-USA /Canada

Molecular heterogeneity of breast carcinomas; clinical implication of tumor subclones.

Breast carcinomas are considered a heterogeneous tumor type both at the clinical, pathological and molecular level, and individual tumors can display a wide range of molecular variation. Recent work separating tumor cells into subfractions based on differ entially expressed cell surface markers h...

Awarded: NOK 0.21 mill.

Project Period: 2010-2011

Location: Oslo

ELSA-Etiske,rettslige og samf.m. as

Social and ethical dimensions of fMRI: Anorexia as a case study

The case of fMRI research on anorexia can be seen as emblematic of a broader set of processes which critics have called the ?biologisation? of child development and behaviour. Neuroethicists and sociologists have raised important concerns about young peop le?s exposure to neuroscience technologie...

Awarded: NOK 0.94 mill.

Project Period: 2010-2013

Location: Oslo

STAMCELLER-Stamcelleforskning

Mapping of histone modifications in totipotent and pluripotent cells in vivo and characterization of a novel epigenetic mark

This project focuses on revealing the epigenetic basis of in vivo pluripotency and totipotency, characterizing a putative novel epigenetic mark with relevance to pluripotency and the characterization of candidate enzymes for the regulation of this mark. Fertilization produces a totipotent zygo...

Awarded: NOK 3.0 mill.

Project Period: 2010-2014

Location: Oslo

IKTPLUSS-IKT og digital innovasjon

Flexible Collaborative Networks and Patient-Provider Partnerships in Health Care: Critical Factors

Alle mål for prosjektet ble nådd. I tillegg har prosjektet dannet grunnlaget for flere nye innvilgede prosjektsøknader, konsolidering av forskningsprogrammet ved senter for pasientmedvirkning og samhandlingsforskning ved OUS, nye samarbeidsrelasjoner og signering av avtale med kommersiell partner...

Awarded: NOK 9.4 mill.

Project Period: 2010-2015

Location: Oslo

STAMCELLER-Stamcelleforskning

STEM CELL DNA INTEGRITY AND PLURIPOTENCY

Stem cell metabolism is characterized by low respiratory activity and high glycolytic flux, which maintain cells in a reductive state. This is important to prevent damage to cellular genomes (nuclear and mitochondrial DNA). In addition and like differenti ated cells and other somatic cells, stem ...

Awarded: NOK 3.0 mill.

Project Period: 2010-2013

Location: Oslo

GLOBHELS-Global helse

Novel vaccine candidates against meningococcal disease

Meningococcal disease is a leading cause of meningitis and septicaemia globally, most often striking small children and teenagers. Due to the lack of efficient vaccines, serogroup B meningococcal disease is currently emerging on a worldwide basis. The rat ional design of outer membrane protein-ba...

Awarded: NOK 4.0 mill.

Project Period: 2010-2013

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The AlkB family of hydroxylases; unique roles in DNA, RNA and histone hydroxylation/demethylation.

This project is partly based upon the intriguing phenotype and breeding pattern of Alkbh1, Alkbh4 and Alkbh7 (AlkB homolog 1, 4 and 7) targeted mice. Alkbh1 targeting in mice cause sex-ratio distortion and asymmetric left-right eye development. Alkbh1 is highly expressed in embryonic stem (ES) c...

Awarded: NOK 6.8 mill.

Project Period: 2010-2015

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

EUROCORES: The functions of phosphoinositides in tissue morphogenesis and cancer

Membrane dynamics modulate cell polarity, vesicular trafficking, migration, growth, proliferation, differentiation, and more. Of all membrane lipids, phosphoinositides play a central role in these processes (Wymann & Marone 2005 Curr Opin Cell Biol; Lindm o & Stenmark 2006 J Cell Sci; Simonsen & ...

Awarded: NOK 2.8 mill.

Project Period: 2010-2013

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Mechanisms that couple chromosome replication rate to cellular metabolism

Vi har kartlagt endringer i cellesyklus som følge av endringer i vekstmedium for E.coli bakterien og utformet et simuleringsverktøy til bruk i studier av cellesyklus hos bakterier. Vi har funnet ut at initiatorproteinet DnaA ikke er den eneste begrens ende faktoren i oppstarten av DNA kopiering...

Awarded: NOK 2.6 mill.

Project Period: 2010-2017

Location: Oslo

PSYKISK-Psykisk helse

Co-morbid Diabetes and Eating Disorders - an exploration of prevalence, psychological correlates and diabetic control

Dette prosjektet er en delstudie av Barnediabetesregisteret og har undersøkt spiseproblemer ved type 1 diabetes. Forekomsten av spiseproblemer hos 770 gutter og jenter med type 1 diabetes i alderen 11-19 år var 18% i hele utvalget, 9% blant guttene og 28% blant jentene. Vi fant at forekomsten økt...

Awarded: NOK 3.0 mill.

Project Period: 2010-2014

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

SOBER 2 - Sex On Brain European Research 2 Effects of Gonadotropin Releasing Hormone Receptor blockage on brain development and behaviour

This study is designed to enhance our understanding of sex specific brain development during puberty and adolescence and its implication for the aging process of the brain. Gonadotropin Releasing Hormone receptor (GnRHR) blockage pauses not only reproduct ive ability, but may also have significan...

Awarded: NOK 1.5 mill.

Project Period: 2010-2013

Location: Oslo

KREFT-Offentlig kreftprogram

CD20-specific T cell receptors in gene therapy of leukemia and lymphoma

T-cellereseptorer kan sammenlignes med målstyrte raketter, og utgjør den delen av T-cellene som gjør dem i stand til å gjenkjenne og drepe virusinfiserte celler med stor effektivitet og spesifisitet. Derfor kan T-celler effektivt kurere influensa uten bivirkninger. Prosjektet utnytter disse egens...

Awarded: NOK 7.6 mill.

Project Period: 2009-2015

Location: Oslo

STAMCELLER-Stamcelleforskning

Molecular differences between embryonal carcinomas and embryonic stem cells: Implications for cancer

We see comparative and experimental studies involving embryonic stem (ES) cells and embryonal carcinoma (EC) cells in tandem as important in understanding both stem cell and germ cell tumour biology, and as potentially important as a source of stemness/pl uripotency markers relevant to other type...

Awarded: NOK 2.0 mill.

Project Period: 2009-2013

Location: Oslo

STAMCELLER-Stamcelleforskning

Epigenetic and genetic programs of mesenchymal stem cell differentiation: a genome-wide integrative approach

The progression from a stem cell state to a more differentiated progeny is determined by the specific activation of transcriptional programs, as a consequence of orchestrated epigenetic and genetic events. The current application aims to identify and char acterise transcriptional programs active ...

Awarded: NOK 3.5 mill.

Project Period: 2009-2014

Location: Oslo

KREFT-Offentlig kreftprogram

Molecular and biological characterization of cancer metastases

Purpose: Metastasis is the principal cause of cancer death, and for most tumor types staging, prognostication and therapy is inadequate. Hence, new knowledge on how to prevent metastasis and identification of predictive markers is among the most important challenges in cancer research. Our strat...

Awarded: NOK 6.7 mill.

Project Period: 2009-2013

Location: Oslo

PETROMAKS2-Stort program petroleum

Chemical exposures and cancer incidence in Norwegian offshore oil industry workers

Epidemiological studies have shown associations between work in the oil related industry and a variety of adverse health outcomes. Less knowledge is ,however, available on health effects among workers on installations. The few reports that exist indicate an excess of certain diseases among oil an...

Awarded: NOK 3.4 mill.

Project Period: 2009-2013

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Evaluation of functional Magnetic Resonance in the Diagnosis of Brain Tumors for Assessment of Clinical Efficacy (EMBRACE)

In patients suggestive of intra-cranial brain tumors, Magnetic Resonance (MR) is the imaging modality of choice for tumor characterization prior to, during and after surgical intervention. At Rikshospitalet (Oslo, Norway), a multi-disciplinary project has been established with the aim of develop...

Awarded: NOK 7.1 mill.

Project Period: 2009-2013

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Regulation and organization of chromosome replication and segregation in Escherichia coli.

In Escherichia coli, reinitiation at new origins is prevented by two different control systems. First, a process called sequestration makes newly formed origins unavailable to the initiation apparatus. The sequestration process involves membrane component s, SeqA protein and methylation at GATC s...

Awarded: NOK 3.0 mill.

Project Period: 2009-2013

Location: Oslo

KREFT-Offentlig kreftprogram

Understanding Breast Cancer Genomics; Towards combined molecular profiles for better diagnosis and treatment

We seek to reach a more fundamental understanding of the biological dynamics of breast cancer. High-throughput molecular data at multiple levels (eg DNA, mRNA, miRNA and protein level) have become available on increasing numbers of patients, and various m olecular profiles have been associated wi...

Awarded: NOK 10.5 mill.

Project Period: 2009-2012

Location: Oslo

GLOBHELS-Global helse

Improved vaccination responses and optional immunomodulating therapy by adjuvant administration of COX-2 inhibitor in HIV-infected patients

This Proposal results from translational HIV research by the Applicants, ranging from basic research on signal transduction in lymphocytes that has firmly established cyclic AMP (cAMP) / protein kinase A type I alpha as a major inhibitor of antigen-specif ic activation; to basic clinical studies ...

Awarded: NOK 4.2 mill.

Project Period: 2009-2015

Location: Oslo

IS-NAD-Samarbeid med NORAD-land

Yosry, Mohammed. Egyptisk spesialist 2009

...

Awarded: NOK 20,515

Project Period: 2009-2009

Location: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Lung cancer - characterization of biological factors for use in diagnosis, prognostication and therapy

Lung cancer is the leading cause of cancer-related death. Treatment results depend on stage, but are overall poor, due to the fact that most patients are diagnosed with advanced disease, but also lack of understanding of involved cellular and molecular di sease mechanisms. From 2005, all lung can...

Awarded: NOK 5.6 mill.

Project Period: 2009-2014

Location: Oslo

KREFT-Offentlig kreftprogram

Somatic, translational and psychosocial research in long-term cancer survivors

Background: The number of long-term cancer survivors (LTCSs) (>5 years after primary treatment) is rapidly increasing and currently concerns >100,000 patients in Norway. Although frequently cured by their disease, the treatments and the cancers have late effects that impair the physical and ment...

Awarded: NOK 5.2 mill.

Project Period: 2009-2015

Location: Oslo

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