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BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Using pluripotent stem cells (iPSC) to model mitochondrial disease, study tissue specific manifestations and investigate treatments

Mitokondrier er grunnleggende for ulike biologiske prosesser, inkludert energiproduksjon, apoptose og aldring. Mitokondriell dysfunksjon også spiller en rolle i utvikling av vanlige nevrodegenerative sykdommer som Parkinsons sykdom. Primære mitokondriesykdommer er de hyppigste medfødte stoffskift...

Awarded: NOK 3.9 mill.

Project Period: 2014-2018

Location: Vestland

FRIMED-Klinisk medisin og folkehelse

Mitochondrial disease: generating models, investigating mechanisms and exploring treatments.

The project will establish laboratory models to study two types of mitochondrial disease, one primary mtDNA mutation in MTND5 and one secondary mtDNA disease caused by mutations in the mitochondrial DNA polymerase (POLG). Transgenic mouse models for the P OLG mutations, A467T & W748S, and cell cu...

Awarded: NOK 4.7 mill.

Project Period: 2007-2010

Location: Ukjent Fylke