0 projects

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FRIBIO-Biologi og biomedisin

The role of autophagy and Alfy in degradation of protein aggregates associated with neurodegenerative disease

Protein conformational disorders are associated with the accumulation of insoluble ubiquitin-containing protein aggregates in the central nervous system (CNS). The traditional view is that such aggregates are degraded by proteasomes, but recent evidence i mplicates autophagy in this process as we...

Awarded: NOK 0.90 mill.

Project Period: 2005-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Phosphoinositides in attenuation of growth factor signalling

Most growth factors control cellular functions by activating specific receptor tyrosine kinases (RTKs). While overactivation of RTK signalling pathways is strongly associated with carcinogenesis, it is becoming increasingly clear that impaired deactivatio n of RTKs may also be a mechanism in canc...

Awarded: NOK 1.8 mill.

Project Period: 2005-2008

Location: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

Nasjonalt forskerkurs ved NCS

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Awarded: NOK 52,999

Project Period: 2005-2005

Location: Oslo

FRIBIO-Biologi og biomedisin

Studies on Copper Homeostasis in Methylococcus Capsulatus based on the complete genomic sequence

Copper is an essential element required by all living systems. Copper can also cause serious cell damage through radical formation. Therefore, careful regulation of the intracellular copper concentration is required. Essentially no free copper is availabl e in the cytoplasm; the copper ions are b...

Awarded: NOK 2.6 mill.

Project Period: 2005-2009

Location: Vestland

FRIBIO-Biologi og biomedisin

The role of tunneling nanotubes in cell to cell communication

Project title: The role of tunneling nanotubes in cell to cell communication Recently we have discovered that cells are connected by thin membrane tubes. These tubes referred to as tunneling nanotubes (TNTs), are a continuation of the cell membrane and are formed de novo when filopodia-like p...

Awarded: NOK 3.0 mill.

Project Period: 2005-2008

Location: Vestland

MILGENHEL-Miljø, gener og helse

Severe Streptococcus pyogenes infections in Norway - Molecular genetic analysis of antibiotic resistance and virulence determinants

Group A streptococci is one of the most common human pathogens that can produce a variety of diseases ranging from mild pharyngitis ("strep throat") to life-threatening toxic shock syndrome and necrotizing fasciitis. The incidence of invasive streptococca l disease has been increasing in Norway i...

Awarded: NOK 1.8 mill.

Project Period: 2005-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Timing of initiation of replication in E. coli

The research project described here is aimed at understanding the molecular mechanisms that govern timing of DNA replication in E. coli. We have shown that DNA replication is tightly coupled to cell growth in wild type E. coli cells. Initiation of replica tion occurs precisely at the same point i...

Awarded: NOK 2.7 mill.

Project Period: 2005-2008

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Novel modulators and downstream targets of the cAMP receptors Epac and PKA

I: Obtain genomic DNA suitable for recombinant deletion of Epac1 in ES cells, produce Epac1 null mice. II: a) Use mapping data of more than 100 cAMP analogs for PKA type I,II and Epac to predict effect of cAMP modifications on binding. Design new discriminating analogs. b) Identify new ATP-site...

Awarded: NOK 4.0 mill.

Project Period: 2005-2012

Location: Vestland

BIOMOL-Molekylær biovitenskap og bioteknologi

Use of genome-based microarray analyses to understand the oxidative stress response of an anaerobic microorganism growing at 100°C

Aerobic organisms require molecular O2 for energy conservation. This is a mixed blessing, however, as extremely reactive O2 derivatives (ROS) are produced during normal metabolism that can damage all cellular components. ROS have been implicated in a wide variety of human diseases, including can...

Awarded: NOK 2.4 mill.

Project Period: 2005-2009

Location: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

Norwegian Center for Stem Cells, dekning av reiseutgifter

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Awarded: NOK 31,499

Project Period: 2005-2006

Location: Oslo

FRIBIO-Biologi og biomedisin

Interconnection of human Sprouty 2 (hSpry2), Cbl, and the EGF receptor (EGFR): impact on endocytosis of the EGFR from clathrin-coated pits

Growth factor receptors control cellular growth and differentiation by transmitting signals from outside the cell to the cell interior, particularly the nucleus. Signal transmission can be modulated in several ways. To control signaling, down-regulation o f receptors from the cell surface is impo...

Awarded: NOK 2.0 mill.

Project Period: 2005-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Endocytosis and intracellular transport of protein toxins

Errors in trafficking and signalling are associated with different diseases, including cancer. This project aims at increasing our knowledge about intracellular transport processes to provide a more rational basis for treatment and prevention of disease. Protein toxins such as Shiga toxin and the...

Awarded: NOK 1.5 mill.

Project Period: 2005-2008

Location: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

Genetic dissection of maternal effects in early embryo and endosperm development

Seed development is an interplay of different tissues that execute different transcriptional programmes. By double fertilization two haploid sperm cells fuse with the haploid egg cell and the diploid central cell of the female gametophyte to produce the d iploid embryo and the triploid endosperm,...

Awarded: NOK 4.2 mill.

Project Period: 2005-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Molecular mechanisms of mammalian DNA repair

Mutations are the fundamental cause of all forms of cancer and a number of different, but integrated processes operate to prevent such genetic changes from occurring. DNA repair is of fundamental importance in limiting the occurrence of mutations. We will carry out comprehensive studies on the m...

Awarded: NOK 2.8 mill.

Project Period: 2005-2009

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Characterization of oncogene candidates using small interfering RNA (siRNA)

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Awarded: NOK 2.0 mill.

Project Period: 2004-2008

Location: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

Organisation of the MGED8 meeting in Bergen Sept 2005

The MGED8 meeting will be held in Bergen Sept 8-10 2005 and will attract participants from all over the world and will include both experimentalists and bioinformatics developers and users. The MGED meeting series is one of the most important meeting plac es for development of standards, database...

Awarded: NOK 0.15 mill.

Project Period: 2004-2005

Location: Vestland

BIOMOL-Molekylær biovitenskap og bioteknologi

Antistoffbaserte reagenser i studier av spesifikke T cell responser

Prosjektet vil lage løselige T celle reseptormolekyler, som vil kunne benyttes innen forskning, diagnostikk og terapi. Forskning: Løselige TCR vil være en ny type reagens for spesifikk deteksjon av et gitt peptid på MHC, og vil kunne måle direkte det en nå måler indirekte, i T celleaktiv...

Awarded: NOK 2.1 mill.

Project Period: 2004-2007

Location: Oslo

FRIBIO-Biologi og biomedisin

Molekylærbiologisk assistert stadium-inndeling av kolorektal cancer

Innenfor de klinisk-patologiske stadiene Dukes B og C av kolorektal cancer (CRC) overlever kun halvparten 5 år. Det er derfor av stor betydning å kunne identifisere molekylære markører som kan forutsi sykdomsforløpet. CRC kan inndeles i to grupper relater t til genomisk ustabilitet. Majoriteten v...

Awarded: NOK 2.1 mill.

Project Period: 2004-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Molecular mechanism of DNA repair

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Awarded: NOK 1.7 mill.

Project Period: 2004-2008

Location: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

A study of homing endonucleases: Molecular evolution and gene discovery

Homing endonuclease genes (HEGs) encode highly specific DNases responsable for the mobility and spread of group 1 introns. They are divided into four families (His-Cys box, LAGLIDADG, GIY-YIG and HNH) based on conserved protein motifs. LAGLIDADG HEGs are most numerous and widespread, while the Hi...

Awarded: NOK 0.72 mill.

Project Period: 2004-2005

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Functional genomics of the malaria parasite Plasmodium falciparum

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Awarded: NOK 2.1 mill.

Project Period: 2004-2010

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Development and application of RNA interference technology for understanding the regulation of key somatic maintenance functions in honeybee

Due to its social attributes, ints learning capaabilities, and several facultative physiological and behavioural traits under social control, the honeybee provides opportunities for cutting-edge research not possessed by the Drosophila, Caenorhabditis elegans, zebrafish and the mice syste...

Awarded: NOK 2.6 mill.

Project Period: 2004-2008

Location: Akershus

BIOMOL-Molekylær biovitenskap og bioteknologi

TSLP (thymic stromal lymphopoietin) : a candidate target for treatment of allergy

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Awarded: NOK 2.4 mill.

Project Period: 2004-2007

Location: Oslo

STAMCELLER-Stamcelleforskning

Genome plasticity of somatic stem cells

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Awarded: NOK 1.5 mill.

Project Period: 2004-2006

Location: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

Evolution of chloroplast replacements

The most abundant dinoflagellate chloroplast type is characterised by using peridinin as the main accessory light harvesting pigment. Two small dinoflagellate groups, however, have replaced this peridinin-containing organelle with chloroplasts acquired fr om haptophytes and prasinophytes - these ...

Awarded: NOK 4.1 mill.

Project Period: 2004-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Regulation of Protein Kinase C (PKC) membrane targeting and PKC-mediated activation of phosphatases

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Awarded: NOK 1.9 mill.

Project Period: 2004-2009

Location: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

Endocytosis and intracellular transport of protein toxins

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Awarded: NOK 2.1 mill.

Project Period: 2004-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

The role of molecular motors and rab proteins in the maturation of secretory granules

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Awarded: NOK 2.2 mill.

Project Period: 2004-2008

Location: Vestland

FRIBIO-Biologi og biomedisin

Struktur og funksjon av SPBP ePHD: Avsløring av et protein-protein interaksjonsnettverk involvert i genregulering og DNA replikasjon

Prosjektgruppen har klonet og sekvensert full-lengde cDNA fra mus og menneske for SPBP (Stromelysin-1 PDGF-responsive element Binding Protein), som er et kjerneprotein på ca 220 kDa. Mus og humant protein er 92% identiske i aminosyresekvens. Genet uttrykk es i en rekke vev og alternativ spleising...

Awarded: NOK 0.49 mill.

Project Period: 2004-2008

Location: Troms - Romsa - Tromssa

BIOMOL-Molekylær biovitenskap og bioteknologi

Evaluering av tymus spesifikk serin protease som et kandidatgen for utvikling av type 1 diabetes og andre autoimmune sykdommer

Prosjektet ønsker å undersøke hvorvidt tymus spesifikk serin protease (PRSS16) genet er involvert i utviklingen av type 1 diabetes og andre autoimmune sykdommer som myastenia gravis, cøliaki og systemisk lupus erythematosus. Det foreligger en rekke indisi er på at dette er tilfellet. PRSS16 genet...

Awarded: NOK 1.7 mill.

Project Period: 2004-2007

Location: Oslo

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