301 projects

Date from new to old

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

A novel cross-disciplinary approach to solve an old enigma: the food-web transfer of the mass-blooming phytoplankter Phaeocystis.

-Big blooms of the phytoplankton species Phaeocystis pouchetii are commonly observed along the Norwegian coast and into the Barent Sea every spring during or right after, the seasonally occurring diatom bloom. The species is therefore (potentially) an important carbon source for zooplankton which...

Awarded: NOK 7.6 mill.

Project Period: 2011-2015

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Proteomic characterization of Escherichia coli

Escherichia coli is one of the key microbes that can cause disease in humans. It occurs in many different variants, each with a certain specialization. Some E. coli varieties are part of our normal flora and can thus be seen as both harmless. Other variants cause disease and is highly specialized...

Awarded: NOK 4.9 mill.

Project Period: 2011-2017

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Dissection and comparison of cell separation processes in plants

Plants are provided with cell separation mechanisms whereby entire organs become detached from the plant body when they have served their purpose. However natural, premature abscission of leaves, flowers, fruitlets, fruits or seeds results in quality loss in ornamentals and significant reduction ...

Awarded: NOK 4.2 mill.

Project Period: 2011-2016

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Non-invasive monitoring of carnivores: advancing methodology and ecological knowledge

Carnivores are among the most iconic and controversial wildlife species. Some carnivores also have tremendous ecological impacts, but their elusiveness and large home ranges make them difficult to study in the field. This is one reason why non-invasive methods are now popular and widely used for ...

Awarded: NOK 4.1 mill.

Project Period: 2011-2014

Location: Akershus

FRIBIO-Biologi og biomedisin

18th International Symposium on Chironomidae (Diptera)

De internasjonale symposia på Chironomidae (fjærmygg) har forløpt uavbrutt siden 1964 og er en konferanseserie som blir arrangert på rundgang, normalt hvert 3. år. På konferansene treffes kolleger fra ulike fagmiljø som økologi, genetikk, systematikk, pal eolimnologi, etc. for å få tilført aktuel...

Awarded: NOK 0.14 mill.

Project Period: 2011-2011

Location: Trøndelag - Trööndelage

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

Neural processing and plasticity in cortical circuits of behaving animals

How can the brain be stable enough for memories to be stored and intact for decades but at the same time be plastic enough for us to learn throughout life? This seemingly paradox is one of the unresolved long-standing questions in neuroscience. One of the most well established models for studying...

Awarded: NOK 8.7 mill.

Project Period: 2011-2019

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

From host plants to host ants: Evolution of phyto-predation in butterflies

The aim of this project has been to study the evolution of ant association, and especially parasitic associations, in butterflies using a phylogenetic approach. Many butterflies (especially in the families Lycaenidae and Riodinidae) are associated with ants in some way. These associations are mos...

Awarded: NOK 2.7 mill.

Project Period: 2011-2015

Location: Ukjent Fylke

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Peroxisome-Mediated Mechanisms of Plant Innate Immunity

Report period 1, 20120301 - 20130930 Not only humans but also plants possess an innate immune system that allows them to defend themselves against viral and bacterial pathogens, fungi, insects and nematodes. If we understand how this immune system works at the cellular in a model plant, we can po...

Awarded: NOK 4.2 mill.

Project Period: 2011-2017

Location: Rogaland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

EVOLUTION, MAINTENANCE, AND POPULATION DYNAMICS OF NATURAL COMPETENCE, CANNIBALISM, AND MARTYRDOM IN BACTERIA

In this proposal we set out to test alternative hypotheses for the evolution and maintenance of natural competence for transformation, as well as cannibalism and martyrdom in bacteria. These two processes are fascinating strategies for bacterial adaptatio n and survival. An increased understandin...

Awarded: NOK 6.3 mill.

Project Period: 2011-2015

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

A spiking network model of neural pattern separation in the hippocampus

Can you remember your last birthday? -Then chances are you also remember where you were that day. Recent advances at the Center for the Biology of Memory (CBM) in Trondheim, Norway, have shed new light on why this is: a dedicated brain network continually keeps track of where we are -like a neur...

Awarded: NOK 1.6 mill.

Project Period: 2011-2014

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Development of Bioinformatics Tools and Infrastructure for Quantitative Proteomics

The most important result of the project has been the establishment of a user-friendly and freely available platform for the analysis of proteomics data. A platform that can be used both to carry out the analysis and to visualize and validate the results. The platform supports both protein ident...

Awarded: NOK 2.7 mill.

Project Period: 2011-2014

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Genetic architecture in Drosophila - The role of the Y chromosome in gene expression across the genome.

Understanding genetic architecture, the underlying basis of phenotypic traits, and its relationship to evolutionary change, is a major challenge for evolutionary biologists. Variation in gene expression is one of the most important factors causing phenoty pic variation. We will study the role of ...

Awarded: NOK 3.2 mill.

Project Period: 2011-2014

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Compartmentation of receptor-mediated cAMP and cGMP signalling in normal and failing hearts. Implications for treatment of heart failure

With an average 5-year survival rate of only about 30% and with a prevalence of 1-2% in the general population and nearly 10% in the elderly, the personal and societal consequences of heart failure (HF) are dramatic. Better treatment of HF is needed, and must rest upon a better understanding of t...

Awarded: NOK 7.7 mill.

Project Period: 2011-2018

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Cell-to-cell communication: Mechanism of tunneling nanotube formation and function

1: Recent findings of tunneling nanotube-like structures in vivo suggest that they fulfill important roles under physiological conditions. To develop markers to trace TNTs in vivo and to interfere with TNT-dependent diseases such as the spread of pathogens between cells, we first focused on key r...

Awarded: NOK 7.8 mill.

Project Period: 2011-2015

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

On the evolutionary genomics and behavioural ecology of homoploid hybrid speciation in Passer sparrows

Natural hybridisation is currently receiving much attention in evolutionary biology. Aided by novel sequencing technologies, researchers are discovering that a great number of sexually reproducing taxa previously thought to be good species exhibit genetic signals of admixture, and that the levels...

Awarded: NOK 7.0 mill.

Project Period: 2011-2015

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Biololgical methane oxidation by methanotrophic Verrucomicrobia under hot and acidic conditions; evolution of an ancient metabolic trait

Methylacidiphilum represents a novel lineage of extremophilic methane-oxidizing bacteria belonging to the phylum Verrucomicrobia. These bacteria are extremely acidophilic (acid loving) and grow in geothermal environments with pH down to 1 and below. They are moderately thermophilic (heat-loving)....

Awarded: NOK 3.3 mill.

Project Period: 2011-2015

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Elucidating the link between oxidative stress and neurodegeneration by merging plant, zebrafish and human research approaches

In this research program we have had five main projects. In project one we have shown that DJ-1 can bind copper and mercury at a cellular level and also trough the determination of its 3D structure. We have further shown that DJ-1 shows extensive cellular trafficking which is determined by its h...

Awarded: NOK 8.9 mill.

Project Period: 2011-2015

Location: Rogaland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Genome-wide chromatin regulatory signatures in an ultra-compact chordate genome

Chromatin is the template interface through which genetically encoded information is read out to orchestrate a wide diversity of cell and organismal functions. Histone H3 variants have a key role in chromatin: they dictate modes of chromatin assembly, and their post-transcriptional modifications ...

Awarded: NOK 4.1 mill.

Project Period: 2011-2017

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Base excision repair proteins in DNA repair and early steps of adaptive immunity

DNA is continuously damaged by cellular and environmental agents. Five main DNA repair pathways correct such lesions. These are important in cancer prevention, but surprisingly, also for adaptive immunity. Our research group concentrates on base excision repair (BER) and direct repair of damage....

Awarded: NOK 5.3 mill.

Project Period: 2011-2014

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Biophysical properties underlying the representation of space in entorhinal cortex

In 2004-2005, behavioral unit recordings of rats exploring large open fields demonstrated that medial entorhinal cortex (mEC) 'grid cells' fire in spatially specific locations which repeat at regular intervals and form a hexagonal shape of firing activity and potentially provide the basic buildi...

Awarded: NOK 1.6 mill.

Project Period: 2011-2014

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Regulation of chromatin remodeling and gene activity by A-kinase anchoring proteins

The nuclear matrix is essential for controlling gene expression in eukaryotic nuclei by organizing chromatin and orchestrating nuclear processes such as replication and transcription. AKAP95 is the major PKA and PP1-binding A-kinase anchoring protein (AKA P) of the nucleus; yet its function in in...

Awarded: NOK 4.5 mill.

Project Period: 2011-2014

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Neil3, a novel function for self-renewal and proliferation of neural progenitor cells

The major cell types comprising the mammalian central nervous system arise from neural stem cells (NSC) and progenitor cells (NPC), including neurons, astrocytes and oligodendrocytes. In this proposal we aim to characterize a novel gene function, Neil3, r equired for neural stem/progenitor cell m...

Awarded: NOK 3.8 mill.

Project Period: 2011-2015

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Determining the behavioral rules underlying collective behavior

Since last year's report, I have had one article published as a first author. Currently, the total cite count for my articles related to collective behavior is now 117, a number I overall am satisfied with. This has the effect that I have become a recogni zed name in the field, and am frequently ...

Awarded: NOK 2.3 mill.

Project Period: 2011-2015

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Parasites and infectious diseases in a changing world - 4th Scandinavian-Baltic Congress for Parasitology

The biennial research conference of the Scandinavian-Baltic Society for Parasitology (SBSP) is to be held at the University of Oslo, Blindern campus, and Natural History Museum, Tøyen, between the 19th and 22nd June 2011, with Professor T.A. Bakke (Natura l History Museum, University of Oslo) as ...

Awarded: NOK 44,831

Project Period: 2011-2011

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

CAUSES AND CONSEQUENCES OF FLUCTUATING SELECTION IN A STOCHASTIC ENVIRONMENT

Awarded: NOK 12.9 mill.

Project Period: 2011-2015

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Collective behaviour of penned herring: Observing the collective behaviour and investigating the effect of various sound stimuli

The primary objective is to understand the interaction between direct stimuli and information transfer between individuals in schooling fish and to understand how this affects the collective behaviour, with special emphasis on noise induced behaviour. In 2012 we further developed methodology t...

Awarded: NOK 8.9 mill.

Project Period: 2011-2015

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Defining the role of Axl in normal and malignant mammary stem cells

Metastasis accounts for >90% of cancer-related mortality. Malignant cells carry oncogenic mutations that engender uncontrolled growth and epigenetic activation of stem cell features, chemotherapeutic resistance, immune modulation and metastasis. Tumor cel l epithelial-to-mesenchymal transition (E...

Awarded: NOK 4.8 mill.

Project Period: 2011-2015

Location: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Brain energy deprivation in epilepsy

Epilepsy is a serious neurological disorder that affects approximately 1 % of the general population, making it one of the most common disorders of the central nervous system. Furthermore, up to 40 % of all patients with epilepsy cannot control their seizures with current medications. More effica...

Awarded: NOK 6.5 mill.

Project Period: 2011-2014

Location: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Localisation, regulation and functional significance of the SMC-loading complex during eukaryotic cell division.

The strucural maintenance of chromosome (SMC)-complexes organise and stabilise higher order chromosomal conformations during normal cell division, e.g. condensation of chromosomes cell division or generation of inactive chromatin, cohesion of newly replic ated sister chromatids and stabilisation ...

Awarded: NOK 1.5 mill.

Project Period: 2011-2015

Location: Ukjent Fylke

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Therapeutic Strategies to Interfere with Inhibition of Anti-tumor Immune Activity Mediated by Regulatory T cells

Awarded: NOK 7.8 mill.

Project Period: 2011-2015

Location: Oslo - Oslove

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