0 projects

PES-HORISONT-EU-PES Horisont Europa

Women TechEU - 1st Open Call miPCancer Target Identification and Development Platform

The Women inTech EU program can support our company: 1. Providing financial support to propel our platform development. Synthesizing and testing hits with functional assays before IP protection. 2. And expand our European network and provide valuable mentoring opportunities

Awarded: NOK 49,999

Project Period: 2024-2024

Location: Oslo

FRIPRO-Fri prosjektstøtte

Hub Molecules Of Life

I den innledende fasen av prosjektet etablerte vi først en detaljert plan for koordinering av våre felles aktiviteter under ISGSB-møtet i Innsbruck (sep 2022). Vi bestemte at i tillegg til vanlige digitale møter, skulle medlemmene i konsortiet møtes personlig minst 1-2 ganger i året. Dette har bl...

Awarded: NOK 12.5 mill.

Project Period: 2022-2028

Location: Vestland

FRIPRO-Fri prosjektstøtte

Establishing the HPF1/PARP1 complex as a potent cancer drug target

DNA i cellene våre er under konstant angrep, og tusenvis av DNA skader skapes hvert sekund. Skadet DNA må repareres for å hindre utvikling av kreft og andre sykdommer. For å bekjempe dette konstante angrepet er cellene i kroppen vår utstyrt med et omfattende utvalg av DNA-reparasjonsproteiner som...

Awarded: NOK 3.9 mill.

Project Period: 2021-2024

Location: Vestland

FORNY20-FORNY2020

Market validation of new sample preparation solutions for clinical diagnostic purposes

Målet med dette prosjekter er å validere markedet for en ny teknologi innenfor prøvepreparering til bruk i klinsk diagnostikk. Lybe Scientifics første produkt; NAxtra, ble brukt til diagnostikk av Covid-19 både nasjonalt og internasjonalt under pandemien. Teknologien har vist seg fungere bra til...

Awarded: NOK 5.0 mill.

Project Period: 2021-2022

Location: Trøndelag - Trööndelage

FRIPRO-Fri prosjektstøtte

Conidial NADase - a novel potential target to treat fungal infections

I perioden desember 2023-september 2024 har vi konsolidert resultatene fra de biokjemiske og strukturelle studiene. Denne innsatsen har gjort oss i stand til å etablere flere viktige og unike trekk ved sopp-NADaser. Viktig er at disse enzymene tilhører klassen av TNT-domeneproteiner (fra Tubercul...

Awarded: NOK 11.4 mill.

Project Period: 2020-2026

Location: Vestland

NANO2021-Nanoteknologi, nanovitenskap, mikroteknologi og avanserte materialer

Nanoformulated anti-fungals

Biosergen AS utvikler nye formuleringer basert på nano-partikler. De nye produkter i dette projektet vil være nye formuleringer av Biosergens utviklings produkt BSG005. Generelt utnyttes det, at nano formulerete legemidler kan nå andre mål enn tradisionelt formulerete produkter, og de kan dessute...

Awarded: NOK 9.3 mill.

Project Period: 2020-2024

Location: Trøndelag - Trööndelage

FRIPRO-Fri prosjektstøtte

Establishing a role for LTK as a regulator of the proteostasis network in response to folded proteins

Proteiner er de viktigste byggesteinene i vår celler. Derfor må cellens proteinbalansen reguleres av mange forskjellige prosesser som tilsammen heter Proteostase-netwerk. Det endoplasmatiske retikulum (ER) er den del av celler som er ansvarlig for å styre en stor del av den Proteostase-netwerk. V...

Awarded: NOK 10.6 mill.

Project Period: 2020-2024

Location: Oslo

EUROSTARS-EUROSTARS

A new take on cancer therapy: Developing inhibitors of activation induced cytidine deaminase (AID)

Kreft er sykdommer som utvikler som en konsekvens av endringer i genererer som kontrollerer cellevekst og vevsorganiseringen slik at enkelte celler får en vekstfordel. Utvikling av en kreftsvulst, tumor evolusjon, kan ta mange år og cellene vil gjennom denne tiden akkumulere nye genforandringer i...

Awarded: NOK 5.0 mill.

Project Period: 2020-2023

Location: Oslo

PES2020-Prosj.etabl.støtte H2020

Project Establishment Support for MiMir

EFFECTS OF MICRO- AND NANOPLASTIC EXPOSURE ON HUMAN HEALTH – A RISK ASSESSMENT (Abbreviation: MiMiR) relates to the topic “Micro- and nanoplastics in our environment: Understanding exposures and impacts on human health” (Call ID: H2020-SC1-BHC-36-2020) of the overall call “Better health and care,...

Awarded: NOK 79,999

Project Period: 2020-2020

Location: Troms - Romsa - Tromssa

PES2020-Prosj.etabl.støtte H2020

(PES) SpectroFlow: Instrument free Point-of-Care diagnostic system with central laboratory quality

WHAT DO YOU WANT TO DO? The partners will develop, validate and bring to the global market an easy-to-use, rapid, whole blood Point-of-Care system for near-patient testing, but with central laboratory quality. The system is based on innovative, patented SpectroFlow technology. This technology all...

Awarded: NOK 99,999

Project Period: 2020-2020

Location: Østfold

NANO2021-Nanoteknologi, nanovitenskap, mikroteknologi og avanserte materialer

Glutamate Oxaloacetate Transaminase Nanoparticles targeted to the Brain for Neuroprotection in Ischemic Stroke - GOTTARG

Akutt hjerneslag fører årlig til om lag 6,5 millioner dødsfall og er en av de viktigste årsakene til dødsfall og uførhet i verden i dag, og bedre behandling er nødvendig. Hjerneslag blir i dag behandlet med blodproppoppløsende midler, men mange får ingen tilfredsstillende behandling og man regner...

Awarded: NOK 3.6 mill.

Project Period: 2020-2023

Location: Akershus

PES2020-Prosj.etabl.støtte H2020

Chemical synthesis of a new drug family to treat glioblastoma multiforme (GBM), the highest global unmet need in oncology

Hemispherian AS is developing a novel group of compounds to combat glioblastoma multiforme (GBM). These compounds have shown promising pre-clinical results and our lead compound GLIX1 will enter pre-IND studies by 2021. The current process of synthesis for these compounds is expensive and not eas...

Awarded: NOK 0.20 mill.

Project Period: 2019-2020

Location: Oslo

PES2020-Prosj.etabl.støtte H2020

An automatic cell incubator and analyser for liquid biopsies in cancer diagnosis and treatment

The overall objective of this Eurostars project is to develop our bench-top autonomous cell analyser, called GreinDCell, for clinical laboratories. The sub-objectives include the development of a miniaturised cell culture disc, metamaterial antenna array for continuous monitoring, and novel pepta...

Awarded: NOK 99,999

Project Period: 2019-2020

Location: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Filter for plasmaspytt

En god del mennesker sliter i dag med munntørrhet av diverse årsaker. Dette medfører orale helseplager som affiserer ikke bare tenner, orale slimhinner og tannkjøttet men kan også ramme helt basale funksjonelle aspekter som svelging, fordøyelse, snakking og spising. Dette medfører en sterkt nedsa...

Awarded: NOK 31,999

Project Period: 2019-2020

Location: Troms - Romsa - Tromssa

PES2020-Prosj.etabl.støtte H2020

Diagnostic test with novel ultra-sensitive technology

Gentian has invented a technique that allows measurement of low-concentration markers, and is both rapid and inexpensive. We obtained proof of concept for the technology, and at the moment the corresponding patent is under review.

Awarded: NOK 74,999

Project Period: 2019-2019

Location: Østfold

NAERINGSPH-Nærings-phd

Phenylketonuria as a paradigm disease to understand protein instability in conformational disorders and to develop chaperoning therapies

Fenylketonuri (PKU), også kjent som Føllingssykdom, er en sjelden, arvelig metabolismefeil som skyldes mutasjoner i genet som koder for fenylalanin hydroksylase (PAH). Dette enzymet bryter ned fenylalanin (Phe) og dersom sykdommen ikke behandles akkumuleres Phe, noe som kan forårsake fysisk- og m...

Awarded: NOK 2.1 mill.

Project Period: 2018-2022

Location: Vestland

BEDREHELSE-Bedre helse og livskvalitet

Antimicrobial peptides (bacteriocins) as alternative to conventional antibiotics

Mange hudinfeksjoner er forårsaket av bakterielle patogener, og behandling av disse infeksjonene har blitt stadig vanskeligere på grunn av økende antibiotikaresistens. Dette gjelder også for personer med spedalskhet eller diabetes som ofte lider av alvorlige infeksjoner i beina. Begge typer infek...

Awarded: NOK 7.8 mill.

Project Period: 2018-2023

Location: Akershus

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

The physiological and therapeutic regulation of protein-protein interactions for functional dopamine synthesis

Tyrosin hydroksylase (TH) er et enzym som har et essensielt rolle i syntese av signalstoffet (nevrotransmitter) dopamin i hjernen. I mennesker styrer dopamin bevegelser og er avgjørende for informasjonsbehandling og følelser. Defekter i TH eller i proteiner som regulerer TH aktivitet og syntese a...

Awarded: NOK 9.2 mill.

Project Period: 2017-2020

Location: Vestland

IS-TOPP-Toppfinans. av M.Curie-stipend

A New paradigm in drug use and human Health risk assessment: Sewage profiling at the community level

SEWPROF aims to develop inter-disciplinary and cross-sectoral research capability for the next generation of scientists working in the newly-emerging field of sewage epidemiology. It will provide an integrated approach towards public health monitoring at a community level based on innovative sewa...

Awarded: NOK 0.92 mill.

Project Period: 2016-2018

Location: Oslo

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

The intracellular pathway for MHC Class II antigen presentation.

MHC-molekyler kontrollerer de spesifikke immunresponsene mot fremmede antigen. Slike molekyler finnes på celleoverflaten av alle celler, mens immunceller som de hvite blodcellene; B-celler, monocytter, makrofager og dendrittiske celler har flere typer MHC. MHC er delt inn i to klasser, I og II. M...

Awarded: NOK 9.3 mill.

Project Period: 2014-2020

Location: Oslo

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

In silico drug discovery of Wnt signaling small molecule agonists and antagonists for normal and cancer stem cells

The studies of adult stem cells and stem cell niches regulation signals are among cutting edge research in modern molecular biology. The emerging field of research is devoted to the concept of "cancer stem cells" in which the lost of control on stem cells proliferation is considered as one of th...

Awarded: NOK 0.16 mill.

Project Period: 2010-2011

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Nuclear autophagy; Functions in neuroprotection and tumor suppression

Autophagy is a cytoplasmic renovation mechanism that causes degradation and clearance of macromolecules such as pathogens, defective organelles and protein aggregates. PML bodies, on the other hand, represent distinct nuclear compartments that are known t o function in apoptosis, differentiation ...

Awarded: NOK 6.4 mill.

Project Period: 2010-2014

Location: Oslo

IS-AUR-Samarb.progr. Norge Frankrike

Structure-function relation of Ferric uptake regulators and their new inhibitors

Globally, approximately one fourth of all human deaths are caused by bacterial infections. Overuse of antibiotics has induced the development of resistant pathogens, which is an increasing public health problem. The consequence is that new antibacterial c ompounds and new targets must be found Be...

Awarded: NOK 0.12 mill.

Project Period: 2010-2011

Location: Ukjent Fylke

IS-DAAD-Forskerutveksl. Norge-Tyskland

A Hybrid Approach to Motion Correction of Magnetic Resonance Imaging of Human Kidney - Self Navigation Techniques and Image Post Processing

Recent years have opened up the possibility to convert MRI data into reliable quantitative measures. Dynamic contrast enhanced MRI has proven to be a very promising tool for detailed spatial assessment of kidney function. In addition to explore optimal im age acquisition protocols, an important f...

Awarded: NOK 39,262

Project Period: 2010-2011

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Can Cysteine Metabolism Provide a Target to Treat Obesity?

Framdriftsrapport. Rapporteringsfrist: 20121001. Mottatt: 20130211. 197195 - Can Cysteine Metabolism Provide a Target to Treat Obesity? Side: 8 begrenset. Flere av de beskrevne prosjektene vil nå bli utvidet til også å inkludere aminosyre- og fettsy reprofilen, noe som vil markert heve kvaliteten...

Awarded: NOK 9.4 mill.

Project Period: 2010-2014

Location: Oslo

IS-TOPP-Toppfinans. av M.Curie-stipend

Understanding Hedgehog signalling in breast cancer and mammary gland stem cells using tissue specific expression of Gli1

Only a subset of tumour cells is capable of giving rise to new tumours. These so called "tumour stem-cells" are functionally similar to adult stem cells and have been identified in tumours of several tissues. Whether transformation of adult stem cells int o tumour stem cells is the event leading ...

Awarded: NOK 0.20 mill.

Project Period: 2009-2010

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Therapies for genetic diseases associated to aromatic amino acid hydroxylases

It is increasingly recognized that intracellular protein misfolding and aggregation are common to many disorders, notably associated to neurodegeneration. Many inherited diseases are also caused by the enhanced tendency of mutant proteins to misfold and t o undergo proteasomal degradation or dele...

Awarded: NOK 8.3 mill.

Project Period: 2008-2013

Location: Vestland

FRIBIO-Biologi og biomedisin

EGF-induced Formation of Clathrin Coated Pits

Growth factor receptors control cellular growth and differentiation by transmitting signals from outside the cell to the cell interior, particularly the nucleus. Signal transmission can be modulated in several ways. To control signalling, down-regulation of receptors from the cell surface is impo...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Therapeutic approaches for the correction of misfolding mutations in pterin-dependent enzymes

Many inherited diseases are caused by the enhanced tendency of the mutant variant proteins to misfold and to either undergo proteasomal degradation or deleterious aggregation with plaque formation. For several of these diseases evidence has been accumulat ed that chemical or pharmacologic chapero...

Awarded: NOK 3.2 mill.

Project Period: 2006-2012

Location: Vestland

FRIBIO-Biologi og biomedisin

Mechanisms of hyperglycemia-induced foam cell formation and atherosclerosis in type-2 diabetes. Role of the hexosamine biosynthetic pathway

Vascular disease is the most common cause of death in people suffering from type 2 diabetes. The high risk of atherosclerotic disease in type 2 diabetes can in part be accounted for by the diabetic state per se, such as hyperglycemia. Uptake of oxidised LDL and accumulation of cholesterol esters...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Oslo