0 projects

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Small RNAs and DNA repair in Mycobacterium tuberculosis adaptive responses

Tuberkulose (TB) er en av verdens mest utbredte infeksjoner, som tar nesten 1.3 millioner liv og forårsaker 8.7 millioner infeksjonstilfeller årlig. Årsaken er Mycobacterium tuberculosis (Mtb), som infiserer 1/3 av verdens befolkning og har forårsaket flere dødsfall enn noen annen mikrobe. Behand...

Awarded: NOK 3.8 mill.

Project Period: 2011-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The adaptive evolution of arthropod and vertebrate aquaporins: Deciphering the differential basis of water homeostasis

Innledende studier fokusert på å identifisere de genomiske repertoar av akvaporiner i et bredt spekter av prokaryote og eukaryote organismer for å legge grunnlaget for å forstå den evolusjonære historien til superfamilen, og for å identifisere alle akvaporin gener i lakselusa og sin vert, den atl...

Awarded: NOK 9.6 mill.

Project Period: 2011-2015

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Arc and the molecular control of LTP consolidation in vivo

The brain extracts information about the world that shapes our behavior and ultimately influences who we are as individuals. The immense capacity and specificity of memory storage in the mammalian central nervous system is thought to depend on the plastic ity of synaptic connections. Recent break...

Awarded: NOK 8.0 mill.

Project Period: 2011-2015

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Collective behaviour of penned herring: Observing the collective behaviour and investigating the effect of various sound stimuli

Målet med prosjektet er å forstå samspelet mellom direkte stimuli og informasjonsoverføring mellom individ i ein fiskestim, og å forstå korleis dette påverkar den kollektive åtferda, med særlig vekt på støyindusert åtferd. I 2012 vidareutvikla vi ein metode for å observere fiskeåtferd frå mul...

Awarded: NOK 8.9 mill.

Project Period: 2011-2015

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Modeling the Engineered Heart: Coupled Electromechanical Simulations of Cardiac Regenerative Medicine in the Infarct Injured Ventricle

The loss of functional heart tissue resulting from serious myocardial infarctions is considered a largely intractable problem with a substantial health and economic burden in the industrialized world. However, new hope is emerging in the field of regener ative medicine, where transplanted stem c...

Awarded: NOK 1.4 mill.

Project Period: 2011-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Brain energy deprivation in epilepsy

«The Brain and Muscle energy group» har i perioden» 2011-2014 arbeidet med prosjektet-Brain energy deprivation in epilepsy- hvor vi har undersøkt energisituasjonen i hjernen ved epilepsi. Vi har tatt utgangspunkt i melkesyre som en viktig energikilde for hjernen, og vi har vist at hjernens melkes...

Awarded: NOK 6.5 mill.

Project Period: 2011-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Localisation, regulation and functional significance of the SMC-loading complex during eukaryotic cell division.

The strucural maintenance of chromosome (SMC)-complexes organise and stabilise higher order chromosomal conformations during normal cell division, e.g. condensation of chromosomes cell division or generation of inactive chromatin, cohesion of newly replic ated sister chromatids and stabilisation ...

Awarded: NOK 1.5 mill.

Project Period: 2011-2015

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

cAMP-mediated regulation of proliferation and cell death in normal and malignant cells

I prosjektperioden 20111001-20161130 har vi publisert 8 artikler direkte knyttet til prosjektet. I prosjektet knyttet til effekten av cAMP på DNA-skadeindusert celledød i akutt lymfoblastiske leukemi-celler (ALL-celler), har vi vist at cAMP-signalering fører til reduserte nivåer av DNA-skadeindus...

Awarded: NOK 3.8 mill.

Project Period: 2010-2017

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Traffic through and around the Golgi apparatus in epithelia -determine the apical and basolateral surface glycoproteomes

The cell surface is decorated with glycans attached to lipids and proteins. Different plasma membrane regions display a specific composition of glycanated proteins and contribute to the definition of interactions at the cell boundary. For epithelial cells , glycans (particularly glycosaminoglycan...

Awarded: NOK 5.0 mill.

Project Period: 2010-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

New transgenic mouse models for studies of integrin function in fibroblastic cells

Cells interact with the extracellular matrix via cell surface receptors called integrins. During the 10 past years we have systematically worked on one particular integrin that we have identified and characterized, the alpha11beta1 integrin. In 2007 we pu blished a paper describing a tooth erupti...

Awarded: NOK 4.3 mill.

Project Period: 2010-2014

Location: Vestland

FRIBIO-Biologi og biomedisin

International Colloquium on Endocytobiology and Symbiosis 2010

The evolution of eukaryotic cells and with them all forms of higher organisms is intimately connected to the endosymbiotic uptake of bacterial cells some 1.5 billion years ago. The descendents of the original endosymbionts, namely plastids and mitochondri a, subsequently became enslaved by the ho...

Awarded: NOK 56,072

Project Period: 2010-2010

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Characterization of the role of the small GTPase Rab7b in intracellular traffic.

Intracellular trafficking is regulated by Rab proteins. More than 60 human Rabs have been identified but until now there has been no Rab assigned to the transport from TGN to late endosomes/lysosomes. In our recent work (Progida et al, under revision), we show that Rab7b is a strong candidate fo...

Awarded: NOK 3.4 mill.

Project Period: 2010-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EUROCORES: Community composition and gene expression of methane oxidising bacteria (methanotrophs) in high latitude terrestrial ecosystems:

Microbes are the catalysts and drivers of ecosystems on Earth. Despite their importance environmental microbial communities are not on the biodiversity conservation agenda. Nothing is known regarding the vulnerability and resilience of microbial communiti es a situation exacerbated by the inheren...

Awarded: NOK 3.0 mill.

Project Period: 2010-2013

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Surviving without oxygen - from the role of hypoxia inducible factor to rebuilding a naturally damaged brain

While medical science has had a very limited success in counteracting the deleterious effects of ischemia/hypoxia in humans, evolution has repeatedly solved this problem. The best studied examples of anoxia tolerant animals are some North American freshwa ter turtles (genera Trachemys and Chrysem...

Awarded: NOK 6.4 mill.

Project Period: 2010-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Phytoplankton size: Climatic adaptation and long-term evolution

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Awarded: NOK 4.5 mill.

Project Period: 2010-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Genome size, cell size and growth; searching for the causal links

We here aim both at exploring the causal links between growth rate, genome size and cell size and the evolutionary drivers for reduced genome size. There are likely several routes to genome size variability within and across taxa. Here, we are mainly inte rested in the observation that meiosis an...

Awarded: NOK 8.6 mill.

Project Period: 2010-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Roles of p62/SQSTM1 and novel ATG8-binding proteins in selective autophagy and cell signalling

Macroautophagy, here referred to as autophagy (greek: eating oneself), is a protein degradation pathway that involves lysosomal degradation of cytoplasm and organelles. Autophagy plays an important role in degradation of damaged organelles and toxic prote in aggregates which cannot be degraded by...

Awarded: NOK 6.3 mill.

Project Period: 2010-2013

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Tracking signatures of adaptive diversification during postglacial colonization: the build-up of genomic isolation in threespine stickleback

Trepigget stingsild er regnet som en opprinnelig marin art. Likevel har den invadert ferskvann gjentatte ganger etter den siste istid. Stingsild i ferskvann er ofte morfologisk forskjellig fra stingsild i sjøen; spesielt har de flere beinplater langs kroppssidene i saltvann enn i ferskvann. I en ...

Awarded: NOK 7.3 mill.

Project Period: 2010-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Dual band-pass filtering of information within cortical pyramidal neurons

Pyramidal neurons are the principal cells the main 'computational units' - of the cerebral cortex, but how they function remains enigmatic. The present proposal aims at elucidating novel functional principles within these cells that are likely to be impor tant at two different levels: at the fund...

Awarded: NOK 10.0 mill.

Project Period: 2010-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

DECIPHERING EMBRYONIC SEGMENTATION: GENES THAT CONTROL THE REPEAT PATTERN OF THE VERTEBRAL COLUMN

The segmented or metameric aspect of the body axis is a basic characteristic of vertebrates, and segmentation has long thought to be a key aspect of the basic design. Previous studies from our group have shown that the notochord of teleosts nucleates vert ebral development by forming the initial ...

Awarded: NOK 6.0 mill.

Project Period: 2010-2015

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Flexibility and constraints in animal movement patterns: ecology, evolution and annual cycles

Fuglearter har utviklet ulike strategier for storskala-forflytninger utenom hekkeperioden, og møter derfor ulike begrensinger i timing og fleksibilitet i forhold til mellomårsvariasjon og endringer i miljøet over tid. Gjennom fire ulike modellsystemer har vi plassert fenologi og forekomsten av in...

Awarded: NOK 10.8 mill.

Project Period: 2010-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Nuclear autophagy; Functions in neuroprotection and tumor suppression

Autophagy is a cytoplasmic renovation mechanism that causes degradation and clearance of macromolecules such as pathogens, defective organelles and protein aggregates. PML bodies, on the other hand, represent distinct nuclear compartments that are known t o function in apoptosis, differentiation ...

Awarded: NOK 6.4 mill.

Project Period: 2010-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EUROCORES: Genome-based analysis of C1 metabolism in bacilli and redesign of Bacillus subtilis into a methlotroph

One-carbon (C1) compounds such as methane and methanol are attractive, non-food and low-cost carbon and energy sources for microbial bioprocesses, which can be utilized by specialized groups of microorganisms; the methylotrophs. Research efforts with diff erent model strains revealed that methylo...

Awarded: NOK 3.0 mill.

Project Period: 2010-2013

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Structure-function studies of chitinases and cellulases - the molecular mechanism of enzymatic conversion of crystalline polysaccharides

Despite years of research there are still major holes in our understanding of how enzymatic machineries acting on recalcitrant polysccharides such as cellulose and chitin accomplish their degradative tasks. Chitin and cellulose are structurally similar an d cellulases face the same challenges dur...

Awarded: NOK 4.3 mill.

Project Period: 2010-2014

Location: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Functional in vivo analysis of Protein Kinase Cs and related kinases

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Awarded: NOK 7.4 mill.

Project Period: 2010-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Sperm, speciation and promiscuity - an integrated analysis of evolution in passerine birds

One of the great puzzles in evolutionary biology is how the extreme diversity of mating systems has evolved under the constraints of a basically invariable mode of sexual reproduction; the fusion of two haploid gametes. A good illustration of this enigma is the large variation in promiscuity amo...

Awarded: NOK 9.9 mill.

Project Period: 2010-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The AlkB family of hydroxylases; unique roles in DNA, RNA and histone hydroxylation/demethylation.

This project is partly based upon the intriguing phenotype and breeding pattern of Alkbh1, Alkbh4 and Alkbh7 (AlkB homolog 1, 4 and 7) targeted mice. Alkbh1 targeting in mice cause sex-ratio distortion and asymmetric left-right eye development. Alkbh1 is highly expressed in embryonic stem (ES) c...

Awarded: NOK 6.8 mill.

Project Period: 2010-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EUROCORES: The functions of phosphoinositides in tissue morphogenesis and cancer

Membrane dynamics modulate cell polarity, vesicular trafficking, migration, growth, proliferation, differentiation, and more. Of all membrane lipids, phosphoinositides play a central role in these processes (Wymann & Marone 2005 Curr Opin Cell Biol; Lindm o & Stenmark 2006 J Cell Sci; Simonsen & ...

Awarded: NOK 2.8 mill.

Project Period: 2010-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EVOLUTIONARY PROCESSES IN AGE-STRUCTURED MOOSE POPULATIONS: TOWARDS SUSTAINABLE MANAGEMENT STRATEGIES IN FLUCTUATING ENVIRONMENTS

We consider the Fennoscandian harvest regime of moose to represent a large-scale population manipulation experiment, which can be used to study how changes in the age- and sex-composition infer with evolutionary processes within populations and their abil ity to adapt to future environmental chan...

Awarded: NOK 8.2 mill.

Project Period: 2010-2014

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

2010 meetings of SFRR and EEMS in Oslo

The Society for Free Radical Research (Europe) and the European Environmental Mutagen Society independently decided to hold their annual meetings in Oslo, and asked Andrew Collins (University of Oslo) and Gunnar Brunborg (Norwegian Institute of Public Hea lth) to organise the meetings back-to-bac...

Awarded: NOK 0.20 mill.

Project Period: 2010-2010

Location: Oslo