The overall objective of the PAPILA project (Prediction of Air Pollution in Latin America and the Caribbean) is to establish a sustained network of partners with complementary expertise, which will develop and implement an analysis and forecast system for air quality with downscaling capability for Latin America and the Caribbean region (LAC region), and assess the impact of air pollution (background and peaks) on health and on the economy. This forecast system will help decision-makers improve air quality and public health, and avoid the occurrence of acute air pollution episodes, particularly in urban areas. The project combines an ensemble of state-of-the-art models, high-resolution emission inventories, space observations and surface measurements to provide near real time forecasts and analysis of regional air pollution in the LAC region. To reach this objective, the project will bring together an interdisciplinary team of scientists from Europe, Latin America (Argentina, Bolivia, Brazil, Chile, Colombia, Mexico, Venezuela) and the Caribbean (Puerto Rico), and foster synergies between the groups involved in research and service activities. The project will co-develop with users and other stakeholders several products and services of importance for the LAC region. An important objective of the project is to make use of complementary competence to develop innovative ideas, to established sustained partnerships between research groups, to transfer information to the public, to develop educational activities and to create a dialogue with interested stakeholders. Societal impacts, specifically on human health, on crop production, on ecosystems, on the mountain snow cover and on the hydrological cycle as well as the economic benefits of mitigation policies will be assessed. Finally, the planned activities will provide the basis for sustained capacity building actions.