A swift transition to zero emissions and climate resilient transport systems requires that passenger and freight transport no longer are addressed separately and in isolation from one another. Passenger and freight transport must be addressed together so that policies, infrastructure (physical and digital), vehicles and energy sources serve both. These will be tackled in an integrated and coherent way in six urban nodes: from policy definition, to planning and implementation in the cities cooperating in MOVE21. The tested and integrated approach will then be disseminated across Europe. This integrated approach ensures that potential negative effects from applying zero emission solutions in one domain are not transferred to other domains, but are instead mitigated. It also ensures that European transport systems will become more resilient. Central to the integrated approach of MOVE21 are three Living Labs in Oslo, Gothenburg and Hamburg and three replicator cities: Munich, Bologna and Rome. In these, different types of mobility hubs and associated innovations are tested, and means to overcome barriers for clean and smart mobility are deployed. The Living Labs are based on an open innovation model with quadruple helix partners. The co-creation processes are supported by coherent policy measures and by increasing innovation capacity in city governments and local ecosystems. The proposed solutions will deliver new, close to market ready solutions that have been proven to work in different regulatory and governance settings. The Living Labs are designed to outlast MOVE21 by applying a self-sustaining partnership model that builds on already existing, strong partnerships for zero emission solutions. MOVE21 comprises 24 partners (six public authorities, two public transport companies owned by municipalities, six industry partners (two of which are SMEs), six research organisations and four network organisations) from seven different European countries.