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HAVBRUKS-Havbruk - en næring i vekst

Lipid metabolism in Atlantic salmon. Effect of dietary lipids on gene regulation and membrane function

Awarded: NOK 3.3 mill.

Project Number:

153090

Application Type:

Project Period:

2003 - 2006

The overall aim of the study is to gain knowledge about the molecular events that control the flux of nutrients (especially fatty acids) into, out of, and between compartments of important tissues in lipid metabolism, such as liver, muscle and adipose cel ls. In our research we will concentrate on the lipid uptake into cells, by studying the tissue expression and regulation of the various members of the LDL-receptor gene family and various scavenger receptors in Atlantic salmon. Moreover, the project will study the function of cytosolic fatty acid binding proteins (FABPs) which may act as acceptors for fatty acids within the cells. Inside the various cells, the fatty acids can be subjected to either catabolism, storage or secretion. In this study we will focus on the functionality of the factors regulating the fatty acid metabolism, principally PPARs, C/EBPs and leptin. A major objective is to reveal how various natural fatty acids influence the above-mentioned processes, in order to understand how alternative lipid sources may influence the total metabolism in salmon.

Funding scheme:

HAVBRUKS-Havbruk - en næring i vekst

Thematic Areas and Topics

No thematic area or topic related to the project