Androgens have a pivotal role in the development and maintenance of the male reproductive system, the normal prostate, as well as the initiation and progression of prostate cancer . Prostate cancer is the most commonly diagnosed non-cutaneous cancer and s econd
leading cause of cancer death in men. Despite this high incidence rate and mortality, there is at present very limited information on the cellular and molecular alterations in prostate cancer. Androgens are one of the major factors in prostate cance r development and
progression. Despite the recognition of the importance of androgens for normal prostate and prostate cancer for over 60 years, the molecular mechanisms by which androgens influence the prostate cancer cell is not known. The goal of this research project is to
uncover some of the molecular details of androgen action as it relates to prostate cancer. The focus is on the androgen receptor, a ligand modulated transcription factor, that transduces the effect of androgens in the cell. In addit ion to structure/function studies on
the androgen receptor and its crosstalk with other signalling pathways, a major effort in the laboratory is on the identification, cloning, and characterization of androgen regulated and/or highly prostate enriched nov el genes.