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TU-Tungt utstyr

High Resolution Hyphenated Mass Spectrometry System

Awarded: NOK 3.0 mill.

The current application is for a high resolution hyphenated LC-MS and GC-MS system. Instrumentation, utilizing gas and liquid chromatographs, provide powerful analytical methods for separation and analysis of mixtures within the same system. Mass spectral data is now absolute requirement for solving research projects of most groups within Department of Chemistry. Mass spectral data, which are not achievable on our 20-year-old instrument, are required for publication in several peer-reviewed journals. At p resent, papers within Natural product chemistry and Organic synthesis lacking high resolution MS data are rejected by the journals. Several mass spectrometers exist in the geographical region, however, most of them are low resolution instruments. Limited access in Norway to high-resolution instrumentation with soft-ionization strongly restrain our research. The Natural product group is heavily engaged in bioprospecting activities and strategies for industrial utilization of natural compounds, including ch aracterization of novel anthocyanins and other flavonoids, and research on pharmaceutical functions. Current work in organic synthesis includes a variety of problems requiring highly detailed rapid analysis of crude reaction mixtures and purified products . The establishment of Pharmacy as part of the research and education activities at Department of Chemistry during 2003, further increases the urgent need for a modern high resolution MS system, which is the major analytical tool of this research field. A s part of the new research profile of the Department of Chemistry, Strategic Modernization Funds (SOP) have been allocated to the establishment of an inorganic heterogenic catalysis group, which will have considerable benefit from access to an up-dated ma ss spectrometry system. Resolution, analysis and modelling of GC/MS and LC/MS data represent an important research area for the chemometric group. Department of Chemistry offers regular courses in Mass Spectrometry.

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TU-Tungt utstyr

Thematic Areas and Topics

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