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FRIMED-Klinisk medisin og folkehelse

Pathophysiological and Immunological Aspects of Meconium Aspiration Syndrom A search for new understanding and therapy

Awarded: NOK 1.8 mill.

Meconiumstained amniotic fluid is present in approximately 10-12% of all deliveries. Out of these approximately 5% develop respiratory problems called Meconium Aspiration Syndrom (MAS). This is caused by aspiration of fetal stools (meconium into the lungs ) and occur mainly in term or postterm infants. In severe cases this leads to pulmonary insufficiency with high morbidity and a mortality of 5-10%. Many need long time intensive high technology care for instance inhaled NO gas or extracorporeal membrane o xygenation. The group has for the first time shown that some of the toxic effects of meconium can be inhibited by adding albumin. We have for the first time shown a massive activation of the complementsystem in experimental MAS. These findings elevate ou r understanding and insight of the patophysiological mechanisms in MAS and might lead to new therapies for this feared condition. The following study is planned as two main parts constituting a doctoral thesis:. A) The effect of intrathracheally instil led albumin as rescue therapy on the course of experimental MAS B) The effect of complementinhibition on the pathophysiology of experimental MAS. To study the effect of complement inhibition by diluting meconium in dextran sulphate or nafamostate mesilate which both are known to inhibit complement, before instillation into the lungs. A subproject will be includ ed where inhibition of the meconiuminduced inflammatory reaction in vitro will be tested using both complement inhibitors and CD 14 blockers

Funding scheme:

FRIMED-Klinisk medisin og folkehelse

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