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PROSBIO-Prosess- og biomedisinsk industri

Aided Interpretation of Quantitative Genomics via Literature Networks and High Throughput Screening Integration

Awarded: NOK 4.5 mill.

Project Manager:

Project Number:

168135

Project Period:

2005 - 2007

Organisation:

Subject Fields:

The scientific discipline of quantifying genomic variation using techniques such as QTL (Quantitative Trait Loci) and array-CGH (Cytogenic Genomic Hybridization) is increasingly being used with great success to unravel the genetic basis of complex traits. This growing field has the potential of enormous impact on systems biology, functional genomics and pharmacogenomics (personalized medicine) in human and veterinary medicine. However even with optimal use of the most superior genetic mapping techniques u sing the current state of the art technology, one will normally end up with several candidate genes in several chromosomal regions causative to the complex trait being studied. There is a burgeoning need for a new solution to limit the genes and mutations that can be targeted for drug discovery diagnostic biomarkers. This project will develop a Genomics Knowledge Discovery System which characterizes complex genotype to phenotype relationships. The system will integrate literature mining, quantitative ge nomic experimental data, as well as interactive user directed feedback from the domain expert. The system will be utilized in QTL and array-CGH scenarios, e.g. finding the mutations underlying QTL effects, analysis a chromosome segment which has been iden tified as having a major effect on milk production, scan of the bovine genome to detect QTL affecting clinical mastitis, identifying the driving factors in established cell lines, and aggregating array-CGH information from sarcomas. The two academic part icipants - CIGENE and the Norwegian Radium Hospital (DNR), will strengthen their international competitiveness within functional genomics by this development, and the two commercial participants - BoviBank Ltd, and PubGene AS will have direct economic ben efits from this development by reducing the time and efforts to find causative mutations in bovine complex traits and by selling the system, respectively.

Funding scheme:

PROSBIO-Prosess- og biomedisinsk industri

Thematic Areas and Topics

No thematic area or topic related to the project