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BIONÆR-Bionæringsprogram

Potential of black aronia berries (Aronia melanocarpa) in treatment of urinary tract infections

Awarded: NOK 4.6 mill.

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Urinary tract infections (UTI) is the most common infection among elderly people in Norway. Antibiotics have been successfully used to treat these illnesses, however with negative side effects. The economical arguments to reduce this use is considerable. Cranberry products have gained popularity in Norway due to the apparent effects on UTI. They are increasingly being recommended by medical doctors, and the turnover of imported cranberry products (juice and pills) in Norway was NOK 54,8 millions in 2006. Until lately the high content of ascorbic acid and other organic acids in cranberries was linked to its effects in UTI treatment. Recent scientific evaluations point on the content of certain flavonoids (type A-proanthocyanidins) to explain these effects. However, only a few inspections have been accomplished. Aronia melanocarpa (chokeberry), a traditional shrub to North America, produce berries highly enriched in flavonoids (anthocyanins and proanthocyanins) and ascorbic acid. The plants are well known b y landscapers in Norway. Moreover, the first Norwegian production of aronia juice, beverages and jam have been established in Buskerud and Rogaland. Provisional usage of the products by elderly people suffering from UTI together with preliminary chemical analyses indicate similarities to cranberries. The aim of this project is to gain evidence for these observations. Aronia berries (together with cranberries) will be analysed through bioactivity guided fractionation. The biological assays will consist of bacterial strains typical associated with UTI, whereas the active principles will undergo complete chemical inspections. Elderly people in nursing homes will be served an aronia (and cranberry) juice or beverage in a double-blind, placebo-controlled, rand omized, parallel-group experiment. In addition to UTI, effects on pneumonia and other infections will also be studied.

Funding scheme:

BIONÆR-Bionæringsprogram