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BIONÆR-Bionæringsprogram

Mapping and identification of genes associated with Symmetrical Lupoid Onychodystrophy (SLO) and hypothyreosis (HT) in dogs

Awarded: NOK 3.0 mill.

Project Manager:

Project Number:

207982

Project Period:

2011 - 2016

Funding received from:

Location:

Partner countries:

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The dog population harbour several inherited diseases, both diseases with a simple Mendelian inheritance and disorders with a complex genetic background. As a result of the sequencing of the canine genome, the development of state-of-the-art genetic tools , incl genomic SNP-arrays, expression arrays etc., it has become relatively easy to identify genes associated with canine diseases, incl compl. The genetic structure of the canine dog populations with long within breed LD and short between breed LD, combi ned witth a number of breeds with a significantly increased risk of specific inherited diseases, provide an optimal model for the identification of inherited disorders. The number of samples needed for identification of linked haplotypes to complex disord ers with a >5 fold risk is approx. 100 cases and 100 controls for initial association, as well as ~25 cases/controls from each of 1-2 other breeds for fine mapping. The Gordon setter, English setter are high risk breeds for the two autoimmune diseases , SLO and HT. The incidence of SLO in these breeds are ~10-15%, and preliminary data from collected samples indicate a similar high frequency of HT. All included dogs will be thoroughly clinical evaluated for SLO and HT-tested. We plan to perform a genom e wide association study using genomic SNP-microarrays in an effort to identify haplotypes linked to the two diseases. We have already collected the neccessary samples for the association study for SLO in Gordon/English setters, and with additional sampli ng we expect to be able to include HT in the same analysis. A close collaboration is established between NSVS, the Broad Institute, Univ of Uppsala and Univ of Bergen. The proved efficacy of the canine model in the identification of genes associated with simple and complex diseases, very intersting data from preliminary studies, the available samples and the high competence in the consortium should make a very high likelihood of success

Funding scheme:

BIONÆR-Bionæringsprogram